Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity (original) (raw)

• Brooker, S. Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers—a review. Int. J. Parasitol. 40, 1137–1144 (2010).
  Article Google Scholar
• Finkelman, F.D. et al. Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol. Rev. 201, 139–155 (2004).
  Article CAS Google Scholar
• Locksley, R.M. Asthma and allergic inflammation. Cell 140, 777–783 (2010).
  Article CAS Google Scholar
• Fallon, P.G. et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105–1116 (2006).
  Article CAS Google Scholar
• Fort, M.M. et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15, 985–995 (2001).
  Article CAS Google Scholar
• Moro, K. et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540–544 (2010).
  Article CAS Google Scholar
• Neill, D.R. et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367–1370 (2010).
  Article CAS Google Scholar
• Price, A.E. et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl. Acad. Sci. USA 107, 11489–11494 (2010).
  Article CAS Google Scholar
• Urban, J.F. Jr. et al. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8, 255–264 (1998).
  Article CAS Google Scholar
• Fallon, P.G. et al. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17, 7–17 (2002).
  Article CAS Google Scholar
• McKenzie, G.J., Fallon, P.G., Emson, C.L., Grencis, R.K. & McKenzie, A.N. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J. Exp. Med. 189, 1565–1572 (1999).
  Article CAS Google Scholar
• Rankin, J.A. et al. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA 93, 7821–7825 (1996).
  Article CAS Google Scholar
• Fallon, P.G., Emson, C.L., Smith, P. & McKenzie, A.N. IL-13 overexpression predisposes to anaphylaxis following antigen sensitization. J. Immunol. 166, 2712–2716 (2001).
  Article CAS Google Scholar
• Munitz, A., Brandt, E.B., Mingler, M., Finkelman, F.D. & Rothenberg, M.E. Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis. Proc. Natl. Acad. Sci. USA 105, 7240–7245 (2008).
  Article CAS Google Scholar
• Wilson, C.B., Rowell, E. & Sekimata, M. Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol. 9, 91–105 (2009).
  Article CAS Google Scholar
• Grünig, G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261–2263 (1998).
  Article Google Scholar
• Perkins, C., Wills-Karp, M. & Finkelman, F.D. IL-4 induces IL-13-independent allergic airway inflammation. J. Allergy Clin. Immunol. 118, 410–419 (2006).
  Article CAS Google Scholar
• Gessner, A., Mohrs, K. & Mohrs, M. Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J. Immunol. 174, 1063–1072 (2005).
  Article CAS Google Scholar
• Stetson, D.B. et al. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J. Exp. Med. 198, 1069–1076 (2003).
  Article CAS Google Scholar
• Mohrs, K., Wakil, A.E., Killeen, N., Locksley, R.M. & Mohrs, M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity 23, 419–429 (2005).
  Article CAS Google Scholar
• Reinhardt, R.L., Liang, H.E. & Locksley, R.M. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 10, 385–393 (2009).
  Article CAS Google Scholar
• Voehringer, D., Liang, H.E. & Locksley, R.M. Homeostasis and effector function of lymphopenia-induced “memory-like” T cells in constitutively T cell-depleted mice. J. Immunol. 180, 4742–4753 (2008).
  Article CAS Google Scholar
• Voehringer, D., Reese, T.A., Huang, X., Shinkai, K. & Locksley, R.M. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J. Exp. Med. 203, 1435–1446 (2006).
  Article CAS Google Scholar
• Mohrs, M., Shinkai, K., Mohrs, K. & Locksley, R.M. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15, 303–311 (2001).
  Article CAS Google Scholar
• King, C. New insights into the differentiation and function of T follicular helper cells. Nat. Rev. Immunol. 9, 757–766 (2009).
  Article CAS Google Scholar
• Johnston, R.J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006–1010 (2009).
  Article CAS Google Scholar
• Yusuf, I. et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J. Immunol. 185, 190–202 (2010).
  Article CAS Google Scholar
• King, I.L. & Mohrs, M. IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J. Exp. Med. 206, 1001–1007 (2009).
  Article CAS Google Scholar
• Zaretsky, A.G. et al. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J. Exp. Med. 206, 991–999 (2009).
  Article CAS Google Scholar
• Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457–468 (2009).
  Article CAS Google Scholar
• Nurieva, R.I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001–1005 (2009).
  Article CAS Google Scholar
• Ho, I.C., Tai, T.S. & Pai, S.Y. GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat. Rev. Immunol. 9, 125–135 (2009).
  Article CAS Google Scholar
• Voehringer, D., Shinkai, K. & Locksley, R.M. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20, 267–277 (2004).
  Article CAS Google Scholar
• Matsuda, J.L. et al. Mouse Vα14i natural killer T cells are resistant to cytokine polarization in vivo. Proc. Natl. Acad. Sci. USA 100, 8395–8400 (2003).
  Article CAS Google Scholar
• Brown, D.R. et al. Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184, 1295–1304 (1996).
  Article CAS Google Scholar
• Cui, J. et al. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 190, 783–792 (1999).
  Article CAS Google Scholar
• Ohnmacht, C. et al. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 33, 364–374 (2010).
  Article CAS Google Scholar
• Sullivan, B.M. et al. Genetic analysis of basophil function in vivo. Nat. Immunol. 12, 527–535 (2011).
  Article CAS Google Scholar
• Pai, S.Y. et al. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19, 863–875 (2003).
  Article CAS Google Scholar
• Tanaka, S. et al. The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in TH2 cells. Nat. Immunol. 12, 77–85 (2011).
  Article CAS Google Scholar
• Ozawa, H. et al. Immune responses to Nippostrongylus brasiliensis and tuberculin protein in GATA-3-transgenic mice. Immunol. Lett. 99, 228–235 (2005).
  Article CAS Google Scholar
• Ouyang, W. et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12, 27–37 (2000).
  Article CAS Google Scholar
• Kusam, S., Toney, L.M., Sato, H. & Dent, A.L. Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J. Immunol. 170, 2435–2441 (2003).
  Article CAS Google Scholar
• Harris, M.B., Mostecki, J. & Rothman, P.B. Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. J. Biol. Chem. 280, 13114–13121 (2005).
  Article CAS Google Scholar