- Miller, J.F. Immunological function of the thymus. Lancet 2, 748–749 (1961).
Article CAS Google Scholar
- Itoh, M. et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162, 5317–5326 (1999).
CAS Google Scholar
- King, C.C. et al. Viral infection of the thymus. J. Virol. 66, 3155–3160 (1992).
CAS PubMed PubMed Central Google Scholar
- Anz, D. et al. Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J. Immunol. 182, 6044–6050 (2009).
Article CAS Google Scholar
- Aronson, M. Hypothesis: involution of the thymus with aging–programmed and beneficial. Thymus 18, 7–13 (1991).
CAS PubMed Google Scholar
- Dowling, M.R. & Hodgkin, P.D. Why does the thymus involute? A selection-based hypothesis. Trends Immunol. 30, 295–300 (2009).
Article CAS Google Scholar
- Fu, Y., Paul, R.D., Wang, Y. & Lopez, D.M. Thymic involution and thymocyte phenotypic alterations induced by murine mammary adenocarcinomas. J. Immunol. 143, 4300–4307 (1989).
CAS PubMed Google Scholar
- Olsen, N.J., Olson, G., Viselli, S.M., Gu, X. & Kovacs, W.J. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 142, 1278–1283 (2001).
Article CAS Google Scholar
- Sutherland, J.S. et al. Activation of thymic regeneration in mice and humans following androgen blockade. J. Immunol. 175, 2741–2753 (2005).
Article CAS Google Scholar
- Domínguez-Gerpe, L. & Rey-Mendez, M. Time-course of the murine lymphoid tissue involution during and following stressor exposure. Life Sci. 61, 1019–1027 (1997).
Article Google Scholar
- Sasaki, S., Ishida, Y., Nishio, N., Ito, S. & Isobe, K. Thymic involution correlates with severe ulcerative colitis induced by oral administration of dextran sulphate sodium in C57BL/6 mice but not in BALB/c mice. Inflammation 31, 319–328 (2008).
Article CAS Google Scholar
- Rodriguez, A. et al. Requirement of bic/microRNA-155 for normal immune function. Science 316, 608–611 (2007).
Article CAS Google Scholar
- Martinez-Nunez, R.T., Louafi, F., Friedmann, P.S. & Sanchez-Elsner, T. MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN). J. Biol. Chem. 284, 16334–16342 (2009).
Article CAS Google Scholar
- Taganov, K.D., Boldin, M.P., Chang, K.J. & Baltimore, D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 103, 12481–12486 (2006).
Article CAS Google Scholar
- Liu, G. et al. miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc. Natl. Acad. Sci. USA 106, 15819–15824 (2009).
Article CAS Google Scholar
- Sheedy, F.J. et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat. Immunol. 11, 141–147 (2010).
Article CAS Google Scholar
- Androulidaki, A. et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31, 220–231 (2009).
Article CAS Google Scholar
- Liston, A., Linterman, M. & Lu, L.F. MicroRNA in the adaptive immune system, in sickness and in health. J. Clin. Immunol. 30, 339–346 (2010).
Article CAS Google Scholar
- Hou, J. et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183, 2150–2158 (2009).
Article CAS Google Scholar
- Liston, A. et al. Lack of Foxp3 function and expression in the thymic epithelium. J. Exp. Med. 204, 475–480 (2007).
Article CAS Google Scholar
- Yi, R. et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat. Genet. 38, 356–362 (2006).
Article CAS Google Scholar
- Betel, D., Wilson, M., Gabow, A., Marks, D.S. & Sander, C. The microRNA.org resource: targets and expression. Nucleic Acids Res. 36, D149–D153 (2008).
Article CAS Google Scholar
- Hwang, H.W., Wentzel, E.A. & Mendell, J.T. A hexanucleotide element directs microRNA nuclear import. Science 315, 97–100 (2007).
Article CAS Google Scholar
- Sheehan, K.C.F. et al. Blocking monoclonal antibodies specific for mouse IFN-α/β receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection. J. Interferon Cytokine Res. 26, 804–819 (2006).
Article CAS Google Scholar
- Muljo, S.A. et al. Aberrant T cell differentiation in the absence of Dicer. J. Exp. Med. 202, 261–269 (2005).
Article CAS Google Scholar
- Cobb, B.S. et al. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J. Exp. Med. 201, 1367–1373 (2005).
Article CAS Google Scholar
- Koralov, S.B. et al. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell 132, 860–874 (2008).
Article CAS Google Scholar
- Kuipers, H., Schnorfeil, F.M., Fehling, H.J., Bartels, H. & Brocker, T. Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo. J. Immunol. 185, 400–409 (2010).
Article CAS Google Scholar
- Liston, A., Lu, L.F., O'Carroll, D., Tarakhovsky, A. & Rudensky, A.Y. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J. Exp. Med. 205, 1993–2004 (2008).
Article CAS Google Scholar
- Rodewald, H.R., Paul, S., Haller, C., Bluethmann, H. & Blum, C. Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature 414, 763–768 (2001).
Article CAS Google Scholar
- Sato, T. et al. Surface molecules essential for positive selection are retained but interfered in thymic epithelial cells after monolayer culture. Cell. Immunol. 211, 71–79 (2001).
Article CAS Google Scholar
- Flomerfelt, F.A., Kim, M.G. & Schwartz, R.H. Spatial, a gene expressed in thymic stromal cells, depends on three-dimensional thymus organization for its expression. Genes Immun. 1, 391–401 (2000).
Article CAS Google Scholar
- Fukagawa, T. et al. Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat. Cell Biol. 6, 784–791 (2004).
Article CAS Google Scholar
- Anderson, G., Pongracz, J., Parnell, S. & Jenkinson, E.J. Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling. Eur. J. Immunol. 31, 3349–3354 (2001).
Article CAS Google Scholar
- Wilson, A., MacDonald, H.R. & Radtke, F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. 194, 1003–1012 (2001).
Article CAS Google Scholar
- Bix, M. & Raulet, D. Inefficient positive selection of T cells directed by haematopoietic cells. Nature 359, 330–333 (1992).
Article CAS Google Scholar
- Lu, L.F. & Liston, A. MicroRNA in the immune system, microRNA as an immune system. Immunology 127, 291–298 (2009).
Article CAS Google Scholar
- Fedeli, M. et al. Dicer-dependent microRNA pathway controls invariant NKT cell development. J. Immunol. 183, 2506–2512 (2009).
Article CAS Google Scholar
- Lynn, F.C. et al. MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes 56, 2938–2945 (2007).
Article CAS Google Scholar
- Wiesen, J.L. & Tomasi, T.B. Dicer is regulated by cellular stresses and interferons. Mol. Immunol. 46, 1222–1228 (2009).
Article CAS Google Scholar
- Gordon, J. et al. Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev. Biol. 7, 69 (2007).
Article Google Scholar
- Geboes, L. et al. Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. Arthritis Rheum. 60, 390–395 (2009).
Article CAS Google Scholar
- Kelchtermans, H. et al. Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma. Arthritis Res. Ther. 7, R402–R415 (2005).
Article CAS Google Scholar
- Dooley, J., Erickson, M. & Farr, A.G. Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation. J. Immunol. 181, 5225–5232 (2008).
Article CAS Google Scholar
- Silahtaroglu, A.N. et al. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat. Protoc. 2, 2520–2528 (2007).
Article CAS Google Scholar
- Dooley, J., Erickson, M. & Farr, A.G. An organized medullary epithelial structure in the normal thymus expresses molecules of respiratory epithelium and resembles the epithelial thymic rudiment of nude mice. J. Immunol. 175, 4331–4337 (2005).
Article CAS Google Scholar
- Livak, K.J. & Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT Method. Methods 25, 402–408 (2001).
Article CAS Google Scholar