The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6 (original) (raw)
Beutler, B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature430, 257–263 (2004). CASPubMed Google Scholar
Ye, H. et al. Distinct molecular mechanism for initiating TRAF6 signalling. Nature418, 443–447 (2002). CASPubMed Google Scholar
Muzio, M., Ni, J., Feng, P. & Dixit, V.M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science278, 1612–1615 (1997). CASPubMed Google Scholar
Trompouki, E. et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature424, 793–796 (2003). CASPubMed Google Scholar
Boone, D.L. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat. Immunol.5, 1052–1060 (2004). CASPubMed Google Scholar
Shembade, N., Ma, A. & Harhaj, E.W. Inhibition of NF-κB signaling by A20 through disruption of ubiquitin enzyme complexes. Science327, 1135–1139 (2010). CASPubMedPubMed Central Google Scholar
Yuk, J.M. et al. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat. Immunol.12, 742–751 (2011). CASPubMed Google Scholar
Wu, Y. et al. HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination. Cell. Signal.21, 143–150 (2009). CASPubMed Google Scholar
Zhang, X., Zhang, J., Zhang, L., van Dam, H. & ten Dijke, P. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Res.23, 366–377 (2013). CASPubMedPubMed Central Google Scholar
Ceccarelli, D.F. et al. CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. J. Biol. Chem.286, 25056–25064 (2011). CASPubMedPubMed Central Google Scholar
Zhang, M. et al. Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure21, 680–688 (2013). CASPubMed Google Scholar
Qian, Z., Lin, C., Espinosa, R., LeBeau, M. & Rosner, M.R. Cloning and characterization of MST4, a novel Ste20-like kinase. J. Biol. Chem.276, 22439–22445 (2001). CASPubMed Google Scholar
Lin, J.L. et al. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene20, 6559–6569 (2001). CASPubMed Google Scholar
Liu, G. et al. Structure of MST2 SARAH domain provides insights into its interaction with RAPL. J. Struct. Biol.185, 366–374 (2014). CASPubMed Google Scholar
Jiao, S. et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell25, 166–180 (2014). CASPubMed Google Scholar
Chen, C. et al. Striatins contain a noncanonical coiled coil that binds PP2A A to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. J. Biol. Chem.289, 9651–9661 (2014). CASPubMedPubMed Central Google Scholar
Ma, X. et al. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. Mol. Biol. Cell18, 1965–1978 (2007). CASPubMedPubMed Central Google Scholar
ten Klooster, J.P. et al. Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev. Cell16, 551–562 (2009). CASPubMed Google Scholar
Kean, M.J. et al. Structure-function analysis of core STRIPAK proteins: a signaling complex implicated in Golgi polarization. J. Biol. Chem.286, 25065–25075 (2011). CASPubMedPubMed Central Google Scholar
Shi, Z. et al. Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure21, 449–461 (2013). CASPubMed Google Scholar
Xu, X., Wang, X., Zhang, Y., Wang, D.C. & Ding, J. Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III. Structure21, 1059–1066 (2013). CASPubMed Google Scholar
DeForge, L.E. & Remick, D.G. Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole blood. Biochem. Biophys. Res. Commun.174, 18–24 (1991). CASPubMed Google Scholar
Tang, E.D., Wang, C.Y., Xiong, Y. & Guan, K.L. A role for NF-κB essential modifier/IκB kinase-γ (NEMO/IKKγ) ubiquitination in the activation of the IκB kinase complex by tumor necrosis factor-α. J. Biol. Chem.278, 37297–37305 (2003). CASPubMed Google Scholar
Zhou, H. et al. Bcl10 activates the NF-κB pathway through ubiquitination of NEMO. Nature427, 167–171 (2004). CASPubMed Google Scholar
Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature412, 346–351 (2001). CASPubMed Google Scholar
Ea, C.K., Sun, L., Inoue, J. & Chen, Z.J. TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Proc. Natl. Acad. Sci. USA101, 15318–15323 (2004). CASPubMedPubMed Central Google Scholar
Ni, C.Z. et al. Molecular basis for CD40 signaling mediated by TRAF3. Proc. Natl. Acad. Sci. USA97, 10395–10399 (2000). CASPubMedPubMed Central Google Scholar
Janssens, S. & Beyaert, R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem. Sci.27, 474–482 (2002). CASPubMed Google Scholar
Wertz, I.E. et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature430, 694–699 (2004). CASPubMed Google Scholar
Allen, I.C. et al. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity34, 854–865 (2011). CASPubMedPubMed Central Google Scholar
Schneider, M. et al. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat. Immunol.13, 823–831 (2012). CASPubMedPubMed Central Google Scholar
Massoumi, R. Ubiquitin chain cleavage: CYLD at work. Trends Biochem. Sci.35, 392–399 (2010). CASPubMed Google Scholar
Hymowitz, S.G. & Wertz, I.E. A20: from ubiquitin editing to tumour suppression. Nat. Rev. Cancer10, 332–341 (2010). CASPubMed Google Scholar
Rosas, M. et al. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science344, 645–648 (2014). CASPubMedPubMed Central Google Scholar
Madsen, C.D. et al. STRIPAK components determine mode of cancer cell migration and metastasis. Nat. Cell Biol.17, 68–80 (2015). CASPubMed Google Scholar
Starczynowski, D.T. et al. TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. J. Clin. Invest.121, 4095–4105 (2011). CASPubMedPubMed Central Google Scholar
Mu, Y. et al. TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat. Comm.2, 330 (2011). Google Scholar
Liang, J. et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling. J. Exp. Med.207, 2959–2973 (2010). CASPubMedPubMed Central Google Scholar
Gudey, S.K. et al. TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1. Sci. Signal.7, ra2 (2014). PubMed Google Scholar
Ge, Q. et al. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. USA101, 8676–8681 (2004). CASPubMedPubMed Central Google Scholar
Williams, J.M. et al. The role of the Wnt family of secreted proteins in rat oval “stem” cell-based liver regeneration: Wnt1 drives differentiation. Am. J. Pathol.176, 2732–2742 (2010). CASPubMedPubMed Central Google Scholar
Wang, R., Xu, Y.J., Liu, X.S., Zeng, D.X. & Xiang, M. Knockdown of connective tissue growth factor by plasmid-based short hairpin RNA prevented pulmonary vascular remodeling in cigarette smoke-exposed rats. Arch. Biochem. Biophys.508, 93–100 (2011). CASPubMed Google Scholar
Liu, Y. et al. A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress. J. Cell Biol.201, 863–873 (2013). CASPubMedPubMed Central Google Scholar
Timchenko, L.T. et al. Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein β in old liver. J. Biol. Chem.281, 32806–32819 (2006). CASPubMed Google Scholar
Austyn, J.M. & Gordon, S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur. J. Immunol.11, 805–815 (1981). CASPubMed Google Scholar
Deng, L. et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell103, 351–361 (2000). CASPubMed Google Scholar
Lou, X. et al. Negative feedback regulation of NF-κB action by CITED2 in the nucleus. J. Immunol.186, 539–548 (2011). CASPubMed Google Scholar