Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor (original) (raw)

• Satpathy, A.T. et al. Re(de)fining the dendritic cell lineage. Nat. Immunol. 13, 1145–1154 (2012).
  CAS PubMed PubMed Central Google Scholar
• Cervantes-Barragan, L. et al. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc. Natl. Acad. Sci. USA 109, 3012–3017 (2012).
  Article PubMed PubMed Central Google Scholar
• Reizis, B. et al. Plasmacytoid dendritic cells: recent progress and open questions. Annu. Rev. Immunol. 29, 163–183 (2011).
  CAS PubMed PubMed Central Google Scholar
• Vremec, D. et al. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164, 2978–2986 (2000).
  Article CAS PubMed Google Scholar
• Aliberti, J. et al. Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells. Blood 101, 305–310 (2003).
  Article CAS PubMed Google Scholar
• Tamura, T. et al. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J. Immunol. 174, 2573–2581 (2005).
  Article CAS PubMed Google Scholar
• Hildner, K. et al. Batf3 deficiency reveals a critical role for CD8α+ dendritic cells in cytotoxic T cell immunity. Science 322, 1097–1100 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Torti, N. et al. Batf3 transcription factor-dependent DC subsets in murine CMV infection: differential impact on T-cell priming and memory inflation. Eur. J. Immunol. 41, 2612–2618 (2011).
  Article CAS PubMed Google Scholar
• Persson, E.K. et al. IRF4 Transcription-factor-dependent CD103+CD11b+ dendritic cells drive hucosal T helper 17 cell differentiation. Immunity 38, 958–969 (2013).
  Article CAS PubMed Google Scholar
• Gao, Y. et al. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity 39, 722–732 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Schlitzer, A. et al. IRF4 Transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity 38, 970–983 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Merad, M. & Ginhoux, F. Dendritic cell genealogy: a new stem or just another branch? Nat. Immunol. 8, 1199–1201 (2007).
  Article CAS PubMed Google Scholar
• Onai, N. et al. Identification of clonogenic common Flt3+ M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 8, 1207–1216 (2007).
  Article CAS PubMed Google Scholar
• Naik, S.H. et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat. Immunol. 8, 1217–1226 (2007).
  Article CAS PubMed Google Scholar
• Schiavoni, G. et al. ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8α+ dendritic cells. J. Exp. Med. 196, 1415–1425 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Suzuki, S. et al. Critical roles of interferon regulatory factor 4 in CD11bhighCD8α− dendritic cell development. Proc. Natl. Acad. Sci. USA 101, 8981–8986 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Tailor, P. et al. The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood 111, 1942–1945 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Kantakamalakul, W. et al. Regulation of IFN consensus sequence binding protein expression in murine macrophages. J. Immunol. 162, 7417–7425 (1999).
  CAS PubMed Google Scholar
• Bornstein, C. et al. A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States. Mol. Cell 56, 749–762 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Vander, L.B. et al. Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation. Nat. Immunol. 15, 161–167 (2014).
  Article CAS Google Scholar
• Hacker, C. et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat. Immunol. 4, 380–386 (2003).
  Article CAS PubMed Google Scholar
• Spits, H. et al. Id2 and Id3 inhibit development of CD34+ stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2. J. Exp. Med. 192, 1775–1784 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Li, H.S. et al. The signal transducers STAT5 and STAT3 control expression of Id2 and E2–2 during dendritic cell development. Blood 120, 4363–4373 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Ghosh, H.S. et al. ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. J. Exp. Med. 211, 1623–1635 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Tussiwand, R. et al. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature 490, 502–507 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Glasmacher, E. et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science 338, 975–980 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Edelson, B.T. et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. J. Exp. Med. 207, 823–836 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Mashayekhi, M. et al. CD8α+ dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity 35, 249–259 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Medvedovic, J. et al. Pax5: a master regulator of B cell development and leukemogenesis. Adv. Immunol. 111, 179–206 (2011).
  Article CAS PubMed Google Scholar
• Veraksa, A., Del Campo, M. & McGinnis, W. Developmental patterning genes and their conserved functions: from model organisms to humans. Mol. Genet. Metab. 69, 85–100 (2000).
  Article CAS PubMed Google Scholar
• Ouyang, W. et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12, 27–37 (2000).
  Article CAS PubMed Google Scholar
• Boyer, L.A. et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947–956 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Fogg, D.K. et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311, 83–87 (2006).
  Article CAS PubMed Google Scholar
• Wang, H. et al. A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation. J. Immunol. 193, 1766–1777 (2014).
  Article CAS PubMed Google Scholar
• Liu, K. et al. In vivo analysis of dendritic cell development and homeostasis. Science 324, 392–397 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Onai, N. et al. A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity 38, 943–957 (2013).
  Article CAS PubMed Google Scholar
• Satpathy, A.T. et al. Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J. Exp. Med. 209, 1135–1152 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Naik, S.H. et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat. Immunol. 7, 663–671 (2006).
  Article CAS PubMed Google Scholar
• Whyte, W.A. et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153, 307–319 (2013).
  CAS PubMed PubMed Central Google Scholar
• Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934–947 (2013).
  Article CAS PubMed Google Scholar
• Zhu, H. et al. Unexpected characteristics of the IFN-γ reporters in nontransformed T cells. J. Immunol. 167, 855–865 (2001).
  Article CAS PubMed Google Scholar
• Schraml, B.U. et al. The AP-1 transcription factor Batf controls TH17 differentiation. Nature 460, 405–409 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Ise, W. et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat. Immunol. 12, 536–543 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Schönheit, J. et al. PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment. Cell Rep. 3, 1617–1628 (2013).
  Article CAS PubMed Google Scholar
• Reizis, B. et al. Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat. Rev. Immunol. 11, 558–565 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Ichikawa, E. et al. Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. Proc. Natl. Acad. Sci. USA 101, 3909–3914 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Nagasawa, M. et al. Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2–2 and the Ets factor Spi-B. Eur. J. Immunol. 38, 2389–2400 (2008).
  Article CAS PubMed Google Scholar
• Xiong, H. et al. Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression. J. Biol. Chem. 280, 23531–23539 (2005).
  Article CAS PubMed Google Scholar
• Edelson, B.T. et al. CD8α+ dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity 35, 236–248 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Naik, S.H. et al. Cutting edge: generation of splenic CD8+ and CD8– dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J. Immunol. 174, 6592–6597 (2005).
  Article CAS PubMed Google Scholar
• Kanbe, E. & Zhang, D.E. A simple and quick method to concentrate MSCV retrovirus. Blood Cells Mol. Dis. 33, 64–67 (2004).
  Article CAS PubMed Google Scholar
• Shooshtari, P. et al. Correlation analysis of intracellular and secreted cytokines via the generalized integrated mean fluorescence intensity. Cytometry A 77, 873–880 (2010).
  Article PubMed PubMed Central Google Scholar
• Darrah, P.A. et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat. Med. 13, 843–850 (2007).
  Article CAS PubMed Google Scholar
• KC, W, et al. L-Myc expression by dendritic cells is required for optimal T-cell priming. Nature 507, 243–247 (2014).
  Article CAS Google Scholar
• Langmead, B. et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009).
  PubMed PubMed Central Google Scholar
• Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078–2079 (2009).
  PubMed PubMed Central Google Scholar
• ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57–74 (2012).
• Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576–589 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Bailey, T.L. et al. MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res. 37, W202–W208 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Lovén, J. et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 153, 320–334 (2013).
  Article CAS PubMed PubMed Central Google Scholar