Basophils: what they 'can do' versus what they 'actually do' (original) (raw)
Iwasaki, H. & Akashi, K. Myeloid lineage commitment from the hematopoietic stem cell. Immunity26, 726–740 (2007). CASPubMed Google Scholar
Arinobu, Y. et al. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc. Natl. Acad. Sci. USA102, 18105–18110 (2005). CASPubMedPubMed Central Google Scholar
Mitre, E. & Nutman, T.B. Basophils, basophilia and helminth infections. Chem. Immunol. Allergy90, 141–156 (2006). CASPubMed Google Scholar
Falcone, F.H., Zillikens, D. & Gibbs, B.F. The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity. Exp. Dermatol.15, 855–864 (2006). CASPubMed Google Scholar
Mukai, K. et al. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity23, 191–202 (2005). An elegant study showing that basophils are critical mediators of chronic allergic inflammation. CASPubMed Google Scholar
Mack, M. et al. Identification of antigen-capturing cells as basophils. J. Immunol.174, 735–741 (2005). ArticleCASPubMed Google Scholar
Min, B. et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med.200, 507–517 (2004). The first study that identified mouse basophils as the main IL-4-producing cells during parasite infection. CASPubMedPubMed Central Google Scholar
Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol.9, 310–318 (2008). Study demonstrating basophil production of TH2-inducing cytokines such as IL-4 and thymic stromal lymphopoietin and their involvement inin vivoTH2 differentiation. CASPubMedPubMed Central Google Scholar
Denzel, A. et al. Basophils enhance immunological memory responses. Nat. Immunol.9, 733–742 (2008). CASPubMed Google Scholar
Tsujimura, Y. et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity28, 581–589 (2008). CASPubMed Google Scholar
Kennedy Norton, S. et al. IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo. J. Immunol.180, 2848–2854 (2008). CASPubMed Google Scholar
Lantz, C.S. et al. IgE regulates mouse basophil FcɛRI expression in vivo. J. Immunol.158, 2517–2521 (1997). CASPubMed Google Scholar
Yamaguchi, M. et al. Regulation of mouse mast cell surface FcɛRI expression by dexamethasone. Int. Immunol.13, 843–851 (2001). CASPubMed Google Scholar
Voehringer, D., Shinkai, K. & Locksley, R.M. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity20, 267–277 (2004). CASPubMed Google Scholar
Voehringer, D., van Rooijen, N. & Locksley, R.M. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J. Leukoc. Biol.81, 1434–1444 (2007). CASPubMed Google Scholar
Schroeder, J.T., MacGlashan, D.W., Jr & Lichtenstein, L.M. Human basophils: mediator release and cytokine production. Adv. Immunol.77, 93–122 (2001). CASPubMed Google Scholar
Paul, W.E. Interleukin-4 production by FcɛR+ cells. Skin Pharmacol.4 Suppl 1, 8–14 (1991). PubMed Google Scholar
Le Gros, G. et al. IL-3 promotes production of IL-4 by splenic non-B, non-T cells in response to Fc receptor cross-linkage. J. Immunol.145, 2500–2506 (1990). CASPubMed Google Scholar
Kurimoto, Y., de Weck, A.L. & Dahinden, C.A. Interleukin 3-dependent mediator release in basophils triggered by C5a. J. Exp. Med.170, 467–479 (1989). CASPubMed Google Scholar
MacDonald, S.M., Schleimer, R.P., Kagey-Sobotka, A., Gillis, S. & Lichtenstein, L.M. Recombinant IL-3 induces histamine release from human basophils. J. Immunol.142, 3527–3532 (1989). CASPubMed Google Scholar
Brunner, T., Heusser, C.H. & Dahinden, C.A. Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J. Exp. Med.177, 605–611 (1993). CASPubMed Google Scholar
Dahinden, C.A. et al. The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils. J. Exp. Med.170, 1787–1792 (1989). CASPubMed Google Scholar
Phillips, C., Coward, W.R., Pritchard, D.I. & Hewitt, C.R. Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites. J. Leukoc. Biol.73, 165–171 (2003). CASPubMed Google Scholar
Falcone, F.H. et al. Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen. Eur. J. Immunol.26, 1147–1155 (1996). CASPubMed Google Scholar
Bieneman, A.P., Chichester, K.L., Chen, Y.H. & Schroeder, J.T. Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion. J. Allergy Clin. Immunol.115, 295–301 (2005). CASPubMed Google Scholar
Sabroe, I., Jones, E.C., Usher, L.R., Whyte, M.K. & Dower, S.K. Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J. Immunol.168, 4701–4710 (2002). CASPubMed Google Scholar
Yoshimoto, T. & Nakanishi, K. Roles of IL-18 in basophils and mast cells. Allergol. Int.55, 105–113 (2006). CASPubMed Google Scholar
Oh, K., Shen, T., Le Gros, G. & Min, B. Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood109, 2921–2927 (2007). CASPubMed Google Scholar
Hida, S., Tadachi, M., Saito, T. & Taki, S. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood106, 2011–2017 (2005). CASPubMed Google Scholar
Lantz, C.S. et al. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature392, 90–93 (1998). Study identifying critical functions for IL-3 in increasing basophil production in response to parasite infection and demonstrating that IL-3 is paradoxically dispensable for maintaining homeostatic basophil numbers in the absence of parasite infection. CASPubMed Google Scholar
Wang, Y.H. et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J. Exp. Med.204, 1837–1847 (2007). CASPubMedPubMed Central Google Scholar
Hurst, S.D. et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol.169, 443–453 (2002). CASPubMed Google Scholar
Tamachi, T., Maezawa, Y., Ikeda, K., Iwamoto, I. & Nakajima, H. Interleukin 25 in allergic airway inflammation. Int. Arch. Allergy Immunol.140 Suppl 1, 59–62 (2006). CASPubMed Google Scholar
Yanagihara, Y. et al. Induction of human IgE synthesis in B cells by a basophilic cell line, KU812. Clin. Exp. Immunol.108, 295–301 (1997). CASPubMedPubMed Central Google Scholar
Yanagihara, Y. et al. Cultured basophils but not cultured mast cells induce human IgE synthesis in B cells after immunologic stimulation. Clin. Exp. Immunol.111, 136–143 (1998). CASPubMedPubMed Central Google Scholar
Gauchat, J.F. et al. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature365, 340–343 (1993). CASPubMed Google Scholar
Galli, S.J. & Franco, C.B. Basophils are back! Immunity28, 495–497 (2008). CASPubMed Google Scholar
Min, B. & Paul, W.E. Basophils: in the spotlight at last. Nat. Immunol.9, 223–225 (2008). CASPubMed Google Scholar
Shinkai, K., Mohrs, M. & Locksley, R.M. Helper T cells regulate type-2 innate immunity in vivo. Nature420, 825–829 (2002). CASPubMed Google Scholar
Hu-Li, J. et al. Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity14, 1–11 (2001). CASPubMed Google Scholar
Gessner, A., Mohrs, K. & Mohrs, M. Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J. Immunol.174, 1063–1072 (2005). CASPubMed Google Scholar
Gibbs, B.F. et al. Purified human peripheral blood basophils release interleukin-13 and preformed interleukin-4 following immunological activation. Eur. J. Immunol.26, 2493–2498 (1996). CASPubMed Google Scholar
Haas, H. et al. Early interleukin-4: its role in the switch towards a Th2 response and IgE-mediated allergy. Int. Arch. Allergy Immunol.119, 86–94 (1999). CASPubMed Google Scholar
Stetson, D.B. et al. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J. Exp. Med.198, 1069–1076 (2003). CASPubMedPubMed Central Google Scholar
Mohrs, K., Wakil, A.E., Killeen, N., Locksley, R.M. & Mohrs, M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity23, 419–429 (2005). CASPubMedPubMed Central Google Scholar
Brown, S.J., Galli, S.J., Gleich, G.J. & Askenase, P.W. Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs. J. Immunol.129, 790–796 (1982). CASPubMed Google Scholar
Kemp, D.H. & Bourne, A. Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvae–studies in vivo and in vitro. Parasitology80, 487–496 (1980). CASPubMed Google Scholar
Kierszenbaum, F., Ackerman, S.J. & Gleich, G.J. Destruction of bloodstream forms of Trypanosoma cruzi by eosinophil granule major basic protein. Am. J. Trop. Med. Hyg.30, 775–779 (1981). CASPubMed Google Scholar
Butterworth, A.E., Wassom, D.L., Gleich, G.J., Loegering, D.A. & David, J.R. Damage to schistosomula of Schistosoma mansoni induced directly by eosinophil major basic protein. J. Immunol.122, 221–229 (1979). CASPubMed Google Scholar
Obata, K. et al. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood110, 913–920 (2007). CASPubMed Google Scholar
Kojima, T. et al. Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J. Immunol.179, 7093–7100 (2007). CASPubMed Google Scholar
Aoki, I., Kinzer, C., Shirai, A., Paul, W.E. & Klinman, D.M. IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice . Proc. Natl. Acad. Sci. USA92, 2534–2538 (1995). CASPubMedPubMed Central Google Scholar
Khodoun, M.V., Orekhova, T., Potter, C., Morris, S. & Finkelman, F.D. Basophils initiate IL-4 production during a memory T-dependent response. J. Exp. Med.200, 857–870 (2004). CASPubMedPubMed Central Google Scholar
Falcone, F.H., Morroll, S. & Gibbs, B.F. Lack of protease activated receptor (PAR) expression in purified human basophils. Inflamm. Res.54 Suppl 1, S13–S14 (2005). CASPubMed Google Scholar
Schulz, O., Sewell, H.F. & Shakib, F. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. J. Exp. Med.187, 271–275 (1998). CASPubMedPubMed Central Google Scholar
Shakib, F., Schulz, O. & Sewell, H. A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity. Immunol. Today19, 313–316 (1998). CASPubMed Google Scholar
Agis, H. et al. Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. Immunology87, 535–543 (1996). CASPubMedPubMed Central Google Scholar
Furmonaviciene, R. et al. The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses. Clin. Exp. Allergy37, 231–242 (2007). CASPubMed Google Scholar
Marsland, B.J., Camberis, M. & Le Gros, G. Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response. Immunol. Cell Biol.83, 40–47 (2005). CASPubMed Google Scholar
Balic, A., Harcus, Y., Holland, M.J. & Maizels, R.M. Selective maturation of dendritic cells by _Nippostrongylus brasiliensis_-secreted proteins drives Th2 immune responses. Eur. J. Immunol.34, 3047–3059 (2004). CASPubMed Google Scholar
Schramm, G. et al. Cutting edge: IPSE/α-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J. Immunol.178, 6023–6027 (2007). CASPubMed Google Scholar
Shen, T. et al. T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival. Int. Immunol.20, 1201–1209 (2008). CASPubMed Google Scholar
Else, K.J., Entwistle, G.M. & Grencis, R.K. Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris. Parasite Immunol.15, 595–600 (1993). CASPubMed Google Scholar
Schmitz, J. et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity23, 479–490 (2005). CASPubMed Google Scholar
Kondo, Y. et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int. Immunol.20, 791–800 (2008). CASPubMed Google Scholar
Gibbs, B.F., Papenfuss, K. & Falcone, F.H. A rapid two-step procedure for the purification of human peripheral blood basophils to near homogeneity. Clin. Exp. Allergy38, 480–485 (2008). CASPubMed Google Scholar
Nielsen, B.W. et al. Immune responses to nematode exoantigens: sensitizing antibodies and basophil histamine release. Allergy49, 427–435 (1994). CASPubMed Google Scholar
Gonzalez-Munoz, M., Garate, T., Puente, S., Subirats, M. & Moneo, I. Induction of histamine release in parasitized individuals by somatic and cuticular antigens from Onchocerca volvulus. Am. J. Trop. Med. Hyg.60, 974–979 (1999). CASPubMed Google Scholar
Genta, R.M. et al. Specific allergic sensitization to Strongyloides antigens in human strongyloidiasis. Lab. Invest.48, 633–638 (1983). CASPubMed Google Scholar
Mitre, E., Taylor, R.T., Kubofcik, J. & Nutman, T.B. Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections. J. Immunol.172, 2439–2445 (2004). CASPubMed Google Scholar
Haisch, K. et al. A glycoprotein from Schistosoma mansoni eggs binds non-antigen-specific immunoglobulin E and releases interleukin-4 from human basophils. Parasite Immunol.23, 427–434 (2001). CASPubMed Google Scholar
Mitre, E. & Nutman, T.B. Lack of basophilia in human parasitic infections. Am. J. Trop. Med. Hyg.69, 87–91 (2003). PubMed Google Scholar
Marone, G., Florio, G., Petraroli, A., Triggiani, M. & de Paulis, A. Role of human FcɛRI+ cells in HIV-1 infection. Immunol. Rev.179, 128–138 (2001). An excellent review proposing a new function for basophils during HIV-1 infection in human. CASPubMed Google Scholar
Marone, G., Florio, G., Petraroli, A., Triggiani, M. & de Paulis, A. Human mast cells and basophils in HIV-1 infection. Trends Immunol.22, 229–232 (2001). CASPubMed Google Scholar
Karray, S. & Zouali, M. Identification of the B cell superantigen-binding site of HIV-1 gp120. Proc. Natl. Acad. Sci. USA94, 1356–1360 (1997). CASPubMedPubMed Central Google Scholar
Florio, G., Petraroli, A., Patella, V., Triggiani, M. & Marone, G. The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. Aids14, 931–938 (2000). CASPubMed Google Scholar
Ensoli, B., Barillari, G., Salahuddin, S.Z., Gallo, R.C. & Wong-Staal, F. Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature345, 84–86 (1990). CASPubMed Google Scholar
de Paulis, A. et al. Tat protein is an HIV-1-encoded beta-chemokine homolog that promotes migration and up-regulates CCR3 expression on human FcɛRI+ cells. J. Immunol.165, 7171–7179 (2000). CASPubMed Google Scholar
Jinquan, T. et al. Chemokine stromal cell-derived factor 1α activates basophils by means of CXCR4. J. Allergy Clin. Immunol.106, 313–320 (2000). CASPubMed Google Scholar
Moore, J.P. Coreceptors: implications for HIV pathogenesis and therapy. Science276, 51–52 (1997). CASPubMed Google Scholar
Li, Y. et al. Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4. Blood97, 3484–3490 (2001). CASPubMed Google Scholar
Marone, G., Triggiani, M. & de Paulis, A. Mast cells and basophils: friends as well as foes in bronchial asthma? Trends Immunol.26, 25–31 (2005). CASPubMed Google Scholar
Macfarlane, A.J. et al. Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin. J. Allergy Clin. Immunol.105, 99–107 (2000). CASPubMed Google Scholar
Gauvreau, G.M. et al. Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am. J. Respir. Crit. Care Med.161, 1473–1478 (2000). CASPubMed Google Scholar
Koshino, T. et al. Airway basophil and mast cell density in patients with bronchial asthma: relationship to bronchial hyperresponsiveness. J. Asthma33, 89–95 (1996). CASPubMed Google Scholar
Irani, A.M. et al. Immunohistochemical detection of human basophils in late-phase skin reactions. J. Allergy Clin. Immunol.101, 354–362 (1998). CASPubMed Google Scholar
Kepley, C.L., Craig, S.S. & Schwartz, L.B. Identification and partial characterization of a unique marker for human basophils. J. Immunol.154, 6548–6555 (1995). CASPubMed Google Scholar
Nouri-Aria, K.T. et al. Basophil recruitment and IL-4 production during human allergen-induced late asthma. J. Allergy Clin. Immunol.108, 205–211 (2001). CASPubMed Google Scholar
Devouassoux, G., Foster, B., Scott, L.M., Metcalfe, D.D. & Prussin, C. Frequency and characterization of antigen-specific IL-4- and IL-13- producing basophils and T cells in peripheral blood of healthy and asthmatic subjects. J. Allergy Clin. Immunol.104, 811–819 (1999). CASPubMed Google Scholar
Juhlin, L. & Michaelsson, G. A new syndrome characterised by absence of eosinophils and basophils. Lancet1, 1233–1235 (1977). CASPubMed Google Scholar
Tracey, R. & Smith, H. An inherited anomaly of human eosinophils and basophils. Blood Cells4, 291–300 (1978). CASPubMed Google Scholar
Youssef, L.A. et al. Histamine release from the basophils of control and asthmatic subjects and a comparison of gene expression between “releaser” and “nonreleaser” basophils. J. Immunol.178, 4584–4594 (2007). CASPubMed Google Scholar
Buhring, H.J., Streble, A. & Valent, P. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int. Arch. Allergy Immunol.133, 317–329 (2004). PubMed Google Scholar
Eberlein-Konig, B. et al. Comparison of basophil activation tests using CD63 or CD203c expression in patients with insect venom allergy. Allergy61, 1084–1085 (2006). CASPubMed Google Scholar
Boumiza, R. et al. Marked improvement of the basophil activation test by detecting CD203c instead of CD63. Clin. Exp. Allergy33, 259–265 (2003). CASPubMed Google Scholar
Ansel, K.M., Djuretic, I., Tanasa, B. & Rao, A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol.24, 607–656 (2006). CASPubMed Google Scholar
Yagi, R., Tanaka, S., Motomura, Y. & Kubo, M. Regulation of the Il4 gene is independently controlled by proximal and distal 3′ enhancers in mast cells and basophils. Mol. Cell. Biol.27, 8087–8097 (2007). CASPubMedPubMed Central Google Scholar