Pin-ning down immune responses to RNA viruses (original) (raw)

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Nature Immunology volume 7, pages 555–557 (2006)Cite this article

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To prevent RNA virus–dependent tissue damage caused by interferon-regulatory factor 3 (IRF3)–induced type I interferons, proteasome-dependent destruction of IRF3 is orchestrated by the cytoplasmic prolyl isomerase Pin1.

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Figure 1: Deactivation of IRF3 by Pin1.

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Authors and Affiliations

1. Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, 01605, Massachusetts, USA
   Nadege Goutagny, Martina Severa & Katherine A Fitzgerald

Authors

1. Nadege Goutagny
2. Martina Severa
3. Katherine A Fitzgerald

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Goutagny, N., Severa, M. & Fitzgerald, K. Pin-ning down immune responses to RNA viruses.Nat Immunol 7, 555–557 (2006). https://doi.org/10.1038/ni0606-555

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• Issue date: 01 June 2006
• DOI: https://doi.org/10.1038/ni0606-555

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