Asthma: an epidemic of dysregulated immunity (original) (raw)

• Cookson, W. The alliance of genes and environment in asthma and allergy. Nature 402, (Suppl. B) B5–10 (1999).
  CAS PubMed Google Scholar
• Van Eerdewegh, P. et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (doi:10.1038/nature00878, 10 July 2002).
• Fahy, J.V., Corry, D.B. & Boushey, H.A. Airway inflammation and remodeling in asthma. Curr. Opin. Pulm. Med. 6, 15–20 (2000).
  CAS PubMed Google Scholar
• von Mutius, E. The environmental predictors of allergic disease. J. Allergy Clin. Immunol. 105, 9–19 (2000).
  CAS PubMed Google Scholar
• Strachan, D.P. Hay fever, hygiene, and household size. Brit. Med. J. 299, 1259–1260 (1989).
  CAS PubMed PubMed Central Google Scholar
• von Mutius, E. et al. Skin test reactivity and number of siblings. Brit. Med. J. 308, 692–695 (1994).
  CAS PubMed PubMed Central Google Scholar
• Ball, T.M. et al. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N. Engl. J. Med. 343, 538–543 (2000).
  CAS PubMed Google Scholar
• Riedler, J. et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 358, 1129–1133 (2001).
  CAS PubMed Google Scholar
• Platts-Mills, T., Vaughan, J., Squillace, S., Woodfolk, J. & Sporik, R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 357, 752–756 (2001).
  CAS PubMed Google Scholar
• McKeever, T.M. et al. Early exposure to infections and antibiotics and the incidence of allergic disease: a birth cohort study with the West Midlands General Practice Research Database. J. Allergy Clin. Immunol. 109, 43–50 (2002).
  PubMed Google Scholar
• Shirakawa, T., Enomoto, T., Shimazu, S. & Hopkin, J.M. The inverse association between tuberculin responses and atopic disorder. Science 275, 77–79 (1997).
  CAS PubMed Google Scholar
• von Hertzen L. et al. Mycobacterium tuberculosis infection and the subsequent development of asthma and allergic conditions. J. Allergy Clin. Immunol. 104, 1211–1214 (1999).
  CAS PubMed Google Scholar
• Strannegard, I.L., Larsson, L.O., Wennergren, G. & Strannegard, O. Prevalence of allergy in children in relation to prior BCG vaccination and infection with atypical mycobacteria. Allergy 53, 249–254 (1998).
  CAS PubMed Google Scholar
• Lynch, N.R. et al. Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J. Allergy Clin. Immunol. 101, 217–221 (1998).
  CAS PubMed Google Scholar
• Gern, J.E. & Busse, W.W. Relationship of viral infections to wheezing illnesses and asthma. Nature Rev. Immunol. 2, 132–138 (2002).
  CAS Google Scholar
• Stein, R.T. et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354, 541–545 (1999).
  CAS PubMed Google Scholar
• Bjorksten, B., Naaber, P., Sepp, E. & Mikelsaar, M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin. Exp. Allergy 29, 342–346 (1999).
  CAS PubMed Google Scholar
• Kalliomaki, M. et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357, 1076–1079 (2001).
  CAS PubMed Google Scholar
• Gehring, U. et al. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. J. Allergy Clin. Immunol. 108, 847–854 (2001).
  CAS PubMed Google Scholar
• Lorenz, E. et al. Genes other than TLR4 are involved in the response to inhaled LPS. Am. J. Physiol. Lung Cell. Mol. Physiol. 281, (Suppl. 2) L1106–1114 (2001).
  CAS PubMed Google Scholar
• Matricardi, P.M. et al. Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. Brit. Med. J. 314, 999–1003 (1997).
  CAS PubMed PubMed Central Google Scholar
• Matricardi, P. et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. Brit. Med. J. 320, 412–417 (2000).
  CAS PubMed PubMed Central Google Scholar
• McIntire, J.J. et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nature Immunol. 2, 1109–1116 (2001).
  CAS Google Scholar
• Mosmann, T.R. & Coffman, R.L. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145–173 (1989).
  CAS PubMed Google Scholar
• Prescott, S.L. et al. Developing patterns of T cell memory to environmental allergens in the first two years of life. Int. Arch. Allergy Immunol. 113, 75–79 (1997).
  CAS PubMed Google Scholar
• Abbas, A.K., Murphy, K.M. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787–793 (1996).
  CAS PubMed Google Scholar
• Coffman, R.L. et al. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102, 5–28 (1988).
  CAS PubMed Google Scholar
• Iwamoto, I., Nakajima, H., Endo, H. & Yoshida, S. Interferon γ regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. J. Exp. Med. 177, 573–576 (1993).
  CAS PubMed Google Scholar
• Corrigan, C.J. & Kay, A.B. CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am. Rev. Respir. Dis. 141, 970–977 (1990).
  CAS PubMed Google Scholar
• Cembrzynska-Nowak, M., Szklarz, E., Inglot, A.D. & Teodorczyk-Injeyan, J.A. Elevated release of tumor necrosis factor-α and interferon-γ by bronchoalveolar leukocytes from patients with bronchial asthma. Am. Rev. Respir. Dis. 147, 291–295 (1993).
  CAS PubMed Google Scholar
• Hansen, G., Berry, G., DeKruyff, R.H. & Umetsu, D.T. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103, 175–183 (1999).
  CAS PubMed PubMed Central Google Scholar
• Lafaille, J.J. et al. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186, 307–312 (1997).
  CAS PubMed PubMed Central Google Scholar
• Pakala, S.V., Kurrer, M.O. & Katz, J.D. T helper 2 cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic mice. J. Exp. Med. 186, 299–206 (1997).
  CAS PubMed PubMed Central Google Scholar
• Genain, C.P. et al. Late complications of immune deviation therapy in a nonhuman primate. Science 274, 2054–2056 (1996).
  CAS PubMed Google Scholar
• Seymour, B.W., Gershwin, L.J. & Coffman, R.L. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-γ/δ+ T cells or interferon (IFN)-γ in a murine model of allergen sensitization. J. Exp. Med. 187, 721–731 (1998).
  CAS PubMed PubMed Central Google Scholar
• Tsitoura, D.C., DeKruyff, R.H., Lamb, J.R. & Umetsu, D.T. Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells. J. Immunol. 163, 2592–2600 (1999).
  CAS PubMed Google Scholar
• Tsitoura, D.C., Blumenthal, R.L., Berry, G., DeKruyff, R.H. & Umetsu, D.T. Mechanisms preventing allergen-induced airways hyperreactivity: Role of immune deviation and tolerance. J. Allergy Clin. Immunol. 106, 239–246 (2000).
  CAS PubMed Google Scholar
• Chen, Y., Kuchroo, V.K., Inobe, J., Hafler, D.A. & Weiner, H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237–1240 (1994).
  CAS PubMed Google Scholar
• Chen, Y. et al. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376, 177–180 (1995).
  CAS PubMed Google Scholar
• Hansen, G. et al. CD4+ Th cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation. J. Clin. Invest. 11, 89–96 (2000).
  Google Scholar
• McWilliam, A.S. et al. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J. Exp. Med. 184, 2429–2432 (1996).
  CAS PubMed PubMed Central Google Scholar
• Akbari, O., DeKruyff, R.H. & Umetsu, D.T. Pulmonary dendritic cells secreting IL-10 mediate T cell tolerance induced by respiratory exposure to antigen. Nature Immunol. 2, 725–731 (2001).
  CAS Google Scholar
• Tsitoura, D.C., Yeung, V.P., DeKruyff, R.H. & Umetsu, D.T. Critical role of B cells in the development of T cell tolerance to aeroallergens. Int. Immunol. 14, 513–523 (2002).
  Google Scholar
• Akbari, O. et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nature Med. (in the press, 2002).
• McAdam, A.J. et al. ICOS is critical for CD40-mediated antibody class switching. Nature 409, 102–105 (2001).
  CAS PubMed Google Scholar
• Nakajima, A. et al. Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells. Int. Immunol. 9, 637–644 (1997).
  CAS PubMed Google Scholar
• Groux, H. et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737–742 (1997).
  CAS PubMed Google Scholar
• Barrat, F.J. et al. In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195, 603–616 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Jonuleit, H. et al. Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193, 1285–1294 (2001).
  CAS PubMed PubMed Central Google Scholar
• Huang, F.P. et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 191, 435–444 (2000).
  CAS PubMed PubMed Central Google Scholar
• Sauter, B. et al. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191, 423–434 (2000).
  CAS PubMed PubMed Central Google Scholar
• Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). J. Immunol. 160, 1151–1164 (1995).
  Google Scholar
• Thornton, A. & Shevach, E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188, 287–296 (1998).
  CAS PubMed PubMed Central Google Scholar
• Tivol, E.A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multi-organ tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541–547 (1995).
  CAS PubMed Google Scholar
• Zuany-Amorim C et al. Suppression of airway eosinophilia by killed _Mycobacterium vaccae_-induced allergen-specific regulatory T-cells. Nature Med. 8, 8625–8629 (2002).
  Google Scholar
• Weiner, H.L. The mucosal milieu creates tolerogenic dendritic cells and Tr1 and Th3 regulatory cells. Nature Immunol. 2, 671–672 (2001).
  CAS Google Scholar
• Coffman, R.L., Varkila, K., Scott, P. & Chatelain, R. Role of cytokines in the differentiation of CD4+ T-cell subsets in vivo. Immunol. Rev. 123, 189–207 (1991).
  CAS PubMed Google Scholar
• Makela, M.J. et al. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc. Natl. Acad. Sci. USA 97, 6007–6012 (2000).
  CAS PubMed PubMed Central Google Scholar
• Levings, M.K. & Roncarolo, M.G. T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties. J. Allergy Clin. Immunol. 106, (Suppl. S) 109–112 (2000).
  Google Scholar
• Akdis, C.A., Blesken, T., Akdis, M., Wuthrich, B. & Blaser, K. Role of interleukin 10 in specific immunotherapy. J. Clin. Invest. 102, 98–106 (1998).
  CAS PubMed PubMed Central Google Scholar
• Oh, J.W. et al. CD4 T helper cells engineered to produce IL-10 reverse allergen-induced airway hyperreactivity and inflammation. J. Allergy Clin. Immunol. (in the press, 2002).
• Hutloff, A. et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397, 263–266 (1999).
  CAS PubMed Google Scholar
• Aicher, A. et al. Characterization of human inducible costimulator ligand expression and function. J. Immunol. 164, 4689–4696 (2000).
  CAS PubMed Google Scholar
• Mages, H.W. et al. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur. J. Immunol. 30, 1040–1047 (2000).
  CAS PubMed Google Scholar
• Swallow, M.M., Wallin, J.J. & Sha, W.C. B7h, a novel costimulatory homolog of B7. 1 and B7. 2, is induced by TNFα. Immunity 11, 423–432 (1999).
  CAS PubMed Google Scholar
• Gonzalo, J.A. et al. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nature Immunol. 2, 597–604 (2001).
  CAS Google Scholar
• Coyle, A.J. et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13, 95–105 (2000).
  CAS PubMed Google Scholar
• Dong, C. et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409, 97–101 (2001).
  CAS PubMed Google Scholar
• Rottman, J.B. et al. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nature Immunol. 2, 605–611 (2001).
  CAS Google Scholar
• Umetsu, D.T. & DeKruyff, R.H. Th1 and Th2 CD4+ cells in human allergic diseases. J. Allergy Clin. Immunol. 100, 1–6 (1997).
  CAS PubMed Google Scholar
• Haneda, K. et al. TGF-β induced by oral tolerance ameliorates experimental tracheal eosinophilia. J. Immunol. 159, 4484–4490 (1997).
  CAS PubMed Google Scholar
• Russo, M. et al. Suppression of asthma-like responses in different mouse strains by oral tolerance. Am. J. Respir. Cell. Mol. Biol. 24, 518–526 (2001).
  CAS PubMed Google Scholar
• Gerosa, F. et al. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183, 2559–2569 (1996).
  CAS PubMed Google Scholar
• Tsitoura, D.C. et al. Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens. J. Immunol. 165, 3484–3491 (2000).
  CAS PubMed Google Scholar
• Hurst, S.D., Seymour, B.W., Muchamuel, T., Kurup, V.P. & Coffman, R.L. Modulation of inhaled antigen-induced IgE tolerance by ongoing Th2 responses in the lung. J. Immunol. 166, 4922–4930 (2001).
  CAS PubMed Google Scholar
• Wannemuehler, M.J., Kiyono, H., Babb, J.L., Michalek, S.M. & McGhee, J.R. Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction. J. Immunol. 129, 959–965 (1982).
  CAS PubMed Google Scholar
• Sudo, N. et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 159, 1739–1745 (1997).
  CAS PubMed Google Scholar
• Ogura, Y. et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276, 4812–4818 (2001).
  CAS PubMed Google Scholar
• Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603–606 (2001).
  CAS PubMed Google Scholar
• Hugot, J.P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599–603 (2001).
  CAS PubMed Google Scholar
• Neish, A.S. et al. Prokaryotic regulation of epithelial responses by inhibition of IκBα ubiquitination. Science 289, 1560–1563 (2000).
  CAS PubMed Google Scholar
• Mahanty, S. et al. High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis. J. Infect. Dis. 173, 769–773 (1996).
  CAS PubMed Google Scholar
• Yazdanbakhsh, M., Kremsner, P.G. & van Ree, R. Allergy, parasites, and the hygiene hypothesis. Science 296, 490–494 (2002).
  CAS PubMed Google Scholar
• Diez-Gonzalez, F., Callaway, T.R., Kizoulis, M.G. & Russell, J.B. Grain feeding and the dissemination of acid-resistant Escherichia coli from cattle. Science 281, 1666–1668 (1998).
  CAS PubMed Google Scholar
• Passalacqua, G. et al. Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: A double-blind, placebo-controlled trial. J. Allergy Clin. Immunol. 104, 964–968 (1999).
  CAS PubMed Google Scholar
• Moller, C. et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J. Allergy Clin. Immunol. 109, 251–256 (2002).
  PubMed Google Scholar
• Secrist, H., Chelen, C.J., Wen, Y., Marshall, J.D. & Umetsu, D.T. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J. Exp. Med. 178, 2123–2130 (1993).
  CAS PubMed Google Scholar
• Durham, S.R. et al. Long-term clinical efficacy of grass-pollen immunotherapy. New Engl. J. Med. 341, 468–475 (1999).
  CAS PubMed Google Scholar
• Tighe, H. et al. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J. Allergy Clin. Immunol. 106, 124–134 (2000).
  CAS PubMed Google Scholar