All in the family: IL-27 suppression of TH-17 cells (original) (raw)

Nature Immunology volume 7, pages 899–901 (2006)Cite this article

Interleukin 17 (IL-17)–producing T cells are associated with inflammatory conditions. Two studies now show that IL-27, an IL-12 family member with both pro- and anti-inflammatory properties, potently suppresses the development of IL-17-producing T cells.

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Figure 1: Regulation of CD4+ T cell differentiation by IL-27.

Kim Caesar

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Authors and Affiliations

  1. Department of Internal Medicine, University of Iowa, Iowa City, 52242, Iowa, USA
    John Colgan & Paul Rothman

Authors

  1. John Colgan
  2. Paul Rothman

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Colgan, J., Rothman, P. All in the family: IL-27 suppression of TH-17 cells.Nat Immunol 7, 899–901 (2006). https://doi.org/10.1038/ni0906-899

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