The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer (original) (raw)

References

  1. Gauld, S.B., Dal Porto, J.M. & Cambier, J.C. B cell antigen receptor signaling: roles in cell development and disease. Science 296, 1641–1642 (2002).
    Article CAS Google Scholar
  2. Dal Porto, J.M. et al. B cell antigen receptor signaling 101. Mol. Immunol. 41, 599–613 (2004).
    Article CAS Google Scholar
  3. Jumaa, H., Hendriks, R.W. & Reth, M. B cell signaling and tumorigenesis. Annu. Rev. Immunol. 23, 415–445 (2005).
    Article CAS Google Scholar
  4. Reth, M. & Wienands, J. Initiation and processing of the signals from the B cell antigen receptor. Annu. Rev. Immunol. 15, 453–479 (1997).
    Article CAS Google Scholar
  5. Pierce, S.K. Lipid rafts and B-cell activation. Nat. Rev. Immunol. 2, 96–105 (2002).
    Article CAS Google Scholar
  6. Gil, D., Schamel, W.W., Montoya, M., Sanchez-Madrid, F. & Alarcon, B. Recruitment of Nck by CD3ε reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109, 901–912 (2002).
    Article CAS Google Scholar
  7. Sun, Z.J., Kim, K.S., Wagner, G. & Reinherz, E.L. Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3εγ heterodimer. Cell 105, 913–923 (2001).
    Article CAS Google Scholar
  8. Sigalov, A., Aivazian, D. & Stern, L. Homooligomerization of the cytoplasmic domain of the T cell receptor ζ chain and of other proteins containing the immunoreceptor tyrosine-based activation motif. Biochemistry 43, 2049–2061 (2004).
    Article CAS Google Scholar
  9. Zal, T. & Gascoigne, N.R. Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr. Opin. Immunol. 16, 674–683 (2004).
    CAS PubMed Google Scholar
  10. Erickson, M.G., Alseikhan, B.A., Peterson, B.Z. & Yue, D.T. Preassociation of calmodulin with voltage-gated Ca2+ channels revealed by FRET in single living cells. Neuron 31, 973–985 (2001).
    Article CAS Google Scholar
  11. Zal, T., Zal, M.A. & Gascoigne, N.R. Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity 16, 521–534 (2002).
    Article CAS Google Scholar
  12. Riven, I., Kalmanzon, E., Segev, L. & Reuveny, E. Conformational rearrangements associated with the gating of the G protein-coupled potassium channel revealed by FRET microscopy. Neuron 38, 225–235 (2003).
    Article CAS Google Scholar
  13. Tateyama, M., Abe, H., Nakata, H., Saito, O. & Kubo, Y. Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1α. Nat. Struct. Mol. Biol. 11, 637–642 (2004).
    Article CAS Google Scholar
  14. Kim, M., Carman, C.V. & Springer, T.A. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 301, 1720–1725 (2003).
    Article CAS Google Scholar
  15. Zacharias, D.A., Violin, J.D., Newton, A.C. & Tsien, R.Y. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296, 913–916 (2002).
    Article CAS Google Scholar
  16. Hombach, J., Tsubata, T., Leclercq, L., Stappert, H. & Reth, M. Molecular components of the B-cell antigen receptor complex of the IgM class. Nature 343, 760–762 (1990).
    Article CAS Google Scholar
  17. Reth, M. Antigen receptors on B lymphocytes. Annu. Rev. Immunol. 10, 97–121 (1992).
    Article CAS Google Scholar
  18. Schamel, W.W. & Reth, M. Monomeric and oligomeric complexes of the B cell antigen receptor. Immunity 13, 5–14 (2000).
    Article CAS Google Scholar
  19. van Rheenen, J., Langeslag, M. & Jalink, K. Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission. Biophys. J. 86, 2517–2529 (2004).
    Article CAS Google Scholar
  20. Zal, T. & Gascoigne, N.R. Photobleaching-corrected FRET efficiency imaging of live cells. Biophys. J. 86, 3923–3939 (2004).
    Article CAS Google Scholar
  21. Hoppe, A., Christensen, K. & Swanson, J.A. Fluorescence resonance energy transfer-based stoichiometry in living cells. Biophys. J. 83, 3652–3664 (2002).
    Article CAS Google Scholar
  22. Kenworthy, A.K. & Edidin, M. Distribution of a glycosylphosphatidylinositol-anchored protein at the apical surface of MDCK cells examined at a resolution of <100 Å using imaging fluorescence resonance energy transfer. J. Cell Biol. 142, 69–84 (1998).
    Article CAS Google Scholar
  23. Martin, S.W. & Goodnow, C.C. Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory. Nat. Immunol. 3, 182–188 (2002).
    Article CAS Google Scholar
  24. Wakabayashi, C., Adachi, T., Wienands, J. & Tsubata, T. A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science 298, 2392–2395 (2002).
    Article CAS Google Scholar
  25. Hanke, J.H. et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271, 695–701 (1996).
    CAS Google Scholar
  26. Oliver, J.M., Burg, D.L., Wilson, B.S., McLaughlin, J.L. & Geahlen, R.L. Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J. Biol. Chem. 269, 29697–29703 (1994).
    CAS PubMed Google Scholar
  27. Futterer, K., Wong, J., Grucza, R.A., Chan, A.C. & Waksman, G. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. J. Mol. Biol. 281, 523–537 (1998).
    Article CAS Google Scholar
  28. Simons, K. & Toomre, D. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31–39 (2000).
    Article CAS Google Scholar
  29. Brown, B.K. & Song, W. The actin cytoskeleton is required for the trafficking of the B cell antigen receptor to the late endosomes. Traffic 2, 414–427 (2001).
    Article CAS Google Scholar
  30. Niiro, H. et al. The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. J. Immunol. 173, 5601–5609 (2004).
    Article CAS Google Scholar
  31. Reth, M. Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes. Trends Immunol. 22, 356–360 (2001).
    Article CAS Google Scholar
  32. Vilen, B.J., Burke, K.M., Sleater, M. & Cambier, J.C. Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells. J. Immunol. 168, 4344–4351 (2002).
    Article CAS Google Scholar
  33. Vilen, B.J., Nakamura, T. & Cambier, J.C. Antigen-stimulated dissociation of BCR mIg from Ig-α/Ig-β: implications for receptor desensitization. Immunity 10, 239–248 (1999).
    Article CAS Google Scholar
  34. Singh, D.K. et al. The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121, 281–293 (2005).
    Article CAS Google Scholar
  35. Cheng, P.C., Dykstra, M.L., Mitchell, R.N. & Pierce, S.K. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J. Exp. Med. 190, 1549–1560 (1999).
    Article CAS Google Scholar
  36. Justement, L.B., Campbell, K.S., Chien, N.C. & Cambier, J.C. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science 252, 1839–1842 (1991).
    Article CAS Google Scholar
  37. Pao, L.I., Bedzyk, W.D., Persin, C. & Cambier, J.C. Molecular targets of CD45 in B cell antigen receptor signal transduction. J. Immunol. 158, 1116–1124 (1997).
    CAS PubMed Google Scholar
  38. Adachi, T. et al. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J. Biol. Chem. 276, 26648–26655 (2001).
    Article CAS Google Scholar
  39. Oi, V.T., Morrison, S.L., Herzenberg, L.A. & Berg, P. Immunoglobulin gene expression in transformed lymphoid cells. Proc. Natl. Acad. Sci. USA 80, 825–829 (1983).
    Article CAS Google Scholar
  40. Dal Porto, J.M., Haberman, A.M., Shlomchik, M.J. & Kelsoe, G. Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. J. Immunol. 161, 5373–5381 (1998).
    CAS PubMed Google Scholar
  41. Patterson, G.H., Piston, D.W. & Barisas, B.G. Forster distances between green fluorescent protein pairs. Anal. Biochem. 284, 438–440 (2000).
    Article CAS Google Scholar

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