Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus (original) (raw)

• Palmer, E. Negative selection–clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3, 383–391 (2003).
  Article CAS Google Scholar
• Jordan, M.S. et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301–306 (2001).
  Article CAS Google Scholar
• Sakaguchi, S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531–562 (2004).
  Article CAS Google Scholar
• Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395–1401 (2002).
  Article CAS Google Scholar
• Kyewski, B. & Derbinski, J. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4, 688–698 (2004).
  Article CAS Google Scholar
• Banchereau, J. et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767–811 (2000).
  Article CAS Google Scholar
• Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685–711 (2003).
  Article CAS Google Scholar
• Cavanagh, L.L. et al. Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat. Immunol. 6, 1029–1037 (2005).
  Article CAS Google Scholar
• Bonasio, R. & von Andrian, U.H. Generation, migration and function of circulating dendritic cells. Curr. Opin. Immunol. 18, 503–511 (2006).
  Article CAS Google Scholar
• Wu, L. & Shortman, K. Heterogeneity of thymic dendritic cells. Semin. Immunol. 17, 304–312 (2005).
  Article CAS Google Scholar
• Shortman, K. & Liu, Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2, 151–161 (2002).
  Article CAS Google Scholar
• Iwasaki, A. & Kelsall, B.L. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3α, MIP-3β, and secondary lymphoid organ chemokine. J. Exp. Med. 191, 1381–1394 (2000).
  Article CAS Google Scholar
• Mora, J.R. et al. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J. Exp. Med. 201, 303–316 (2005).
  Article CAS Google Scholar
• Cavanagh, L.L. & von Andrian, U.H. Travellers in many guises: The origins and destinations of dendritic cells. Immunol. Cell Biol. 80, 448–462 (2002).
  Article Google Scholar
• von Andrian, U.H. & Mackay, C.R. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343, 1020–1034 (2000).
  Article CAS Google Scholar
• Berlin, C. et al. α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80, 413–422 (1995).
  Article CAS Google Scholar
• Mazo, I.B. et al. Hematopoietic progenitor cell rolling in bone marrow microvessels: Parallel contributions by endothelial selectins and VCAM-1. J. Exp. Med. 188, 465–474 (1998).
  Article CAS Google Scholar
• Barnden, M.J., Allison, J., Heath, W.R. & Carbone, F.R. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76, 34–40 (1998).
  Article CAS Google Scholar
• Martin, S. & Bevan, M.J. Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur. J. Immunol. 27, 2726–2736 (1997).
  Article CAS Google Scholar
• van Santen, H.M., Benoist, C. & Mathis, D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200, 1221–1230 (2004).
  Article CAS Google Scholar
• Donskoy, E. & Goldschneider, I. Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions. J. Immunol. 170, 3514–3521 (2003).
  Article CAS Google Scholar
• Randolph, G.J., Angeli, V. & Swartz, M.A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 5, 617–628 (2005).
  Article CAS Google Scholar
• Grabie, N. et al. IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis. J. Clin. Invest. 111, 671–680 (2003).
  Article CAS Google Scholar
• Volkmann, A., Zal, T. & Stockinger, B. Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen. J. Immunol. 158, 693–706 (1997).
  CAS PubMed Google Scholar
• Gallegos, A.M. & Bevan, M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200, 1039–1049 (2004).
  Article CAS Google Scholar
• Balazs, M., Martin, F., Zhou, T. & Kearney, J. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17, 341–352 (2002).
  Article CAS Google Scholar
• del Hoyo, G.M. et al. Characterization of a common precursor population for dendritic cells. Nature 415, 1043–1047 (2002).
  Article Google Scholar
• Naik, S.H. et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat. Immunol. 7, 663–671 (2006).
  Article CAS Google Scholar
• Nakano, H., Yanagita, M. & Gunn, M.D. CD11c+B220+Gr-1+ cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194, 1171–1178 (2001).
  Article CAS Google Scholar
• Fong, L., Brockstedt, D., Benike, C., Wu, L. & Engleman, E.G. Dendritic cells injected via different routes induce immunity in cancer patients. J. Immunol. 166, 4254–4259 (2001).
  Article CAS Google Scholar
• Thurner, B. et al. Vaccination with Mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J. Exp. Med. 190, 1669–1678 (1999).
  Article CAS Google Scholar
• Duncan, S.R., Capetanakis, N.G., Lawson, B.R. & Theofilopoulos, A.N. Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival. J. Clin. Invest. 109, 755–764 (2002).
  Article CAS Google Scholar
• Scimone, M.L., Aifantis, I., Apostolou, I., von Boehmer, H. & von Andrian, U.H. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc. Natl. Acad. Sci. USA 103, 7006–7011 (2006).
  Article CAS Google Scholar
• Matzinger, P. & Guerder, S. Does T-cell tolerance require a dedicated antigen-presenting cell? Nature 338, 74–76 (1989).
  Article CAS Google Scholar
• Ardavin, C., Wu, L., Li, C.L. & Shortman, K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362, 761–763 (1993).
  Article CAS Google Scholar
• Goldschneider, I. & Cone, R.E. A central role for peripheral dendritic cells in the induction of acquired thymic tolerance. Trends Immunol. 24, 77–81 (2003).
  Article CAS Google Scholar
• Kamath, A.T., Henri, S., Battye, F., Tough, D.F. & Shortman, K. Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood 100, 1734–1741 (2002).
  CAS PubMed Google Scholar
• Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. & Parker, I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA 101, 998–1003 (2004).
  Article CAS Google Scholar
• Kurts, C., Kosaka, H., Carbone, F.R., Miller, J.F. & Heath, W.R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med. 186, 239–245 (1997).
  Article CAS Google Scholar
• Klein, L., Klugmann, M., Nave, K.A., Tuohy, V.K. & Kyewski, B. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6, 56–61 (2000).
  Article CAS Google Scholar
• Huseby, E.S., Sather, B., Huseby, P.G. & Goverman, J. Age-dependent T cell tolerance and autoimmunity to myelin basic protein. Immunity 14, 471–481 (2001).
  Article CAS Google Scholar
• Bullard, D.C. et al. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J. Clin. Invest. 95, 1782–1788 (1995).
  Article CAS Google Scholar
• Mayadas, T.N., Johnson, R.C., Rayburn, H., Hynes, R.O. & Wagner, D.D. Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell 74, 541–554 (1993).
  Article CAS Google Scholar
• Koni, P.A. et al. Conditional vascular cell adhesion molecule 1 deletion in mice. Impaired lymphocyte migration to bone marrow. J. Exp. Med. 193, 741–754 (2001).
  Article CAS Google Scholar
• Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869–877 (1992).
  Article CAS Google Scholar
• Boes, M. et al. T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner. J. Immunol. 171, 4081–4088 (2003).
  Article CAS Google Scholar
• Mora, J.R. et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424, 88–93 (2003).
  Article CAS Google Scholar
• Porritt, H.E., Gordon, K. & Petrie, H.T. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J. Exp. Med. 198, 957–962 (2003).
  Article CAS Google Scholar
• Farr, A.G. & Anderson, S.K. Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells. J. Immunol. 134, 2971–2977 (1985).
  CAS PubMed Google Scholar
• Wright, D.E., Wagers, A.J., Gulati, A.P., Johnson, F.L. & Weissman, I.L. Physiological migration of hematopoietic stem and progenitor cells. Science 294, 1933–1936 (2001).
  Article CAS Google Scholar