Finding a way out: lymphocyte egress from lymphoid organs (original) (raw)
Gowans, J.L. The lymphocyte—a disgraceful gap in medical knowledge. Immunol. Today17, 288–291 (1996). CASPubMed Google Scholar
von Andrian, U.H. & Mempel, T.R. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol.3, 867–878 (2003). ArticleCASPubMed Google Scholar
Cyster, J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol.23, 127–159 (2005). CASPubMed Google Scholar
Chaffin, K.E. & Perlmutter, R.M. A pertussis toxin-sensitive process controls thymocyte emigration. Eur. J. Immunol.21, 2565–2573 (1991). CASPubMed Google Scholar
Adachi, K. et al. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant, FTY720. Bioorg. Med. Chem. Lett.5, 853–856 (1995). CAS Google Scholar
Brinkmann, V. & Lynch, K.R. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr. Opin. Immunol.14, 569–575 (2002). CASPubMed Google Scholar
Chiba, K. et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol.160, 5037–5044 (1998). CASPubMed Google Scholar
Mandala, S. et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science296, 346–349 (2002). CASPubMed Google Scholar
Zemann, B. et al. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood107, 1454–1458 (2006). CASPubMed Google Scholar
Kharel, Y. et al. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J. Biol. Chem.280, 36865–36872 (2005). CASPubMed Google Scholar
Brinkmann, V. et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem.277, 21453–21457 (2002). ArticleCASPubMed Google Scholar
Liu, Y. et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest.106, 951–961 (2000). CASPubMedPubMed Central Google Scholar
Allende, M.L., Dreier, J.L., Mandala, S. & Proia, R.L. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem.279, 15396–15401 (2004). CASPubMed Google Scholar
Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature427, 355–360 (2004). CASPubMed Google Scholar
Lo, C.G., Xu, Y., Proia, R.L. & Cyster, J.G. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med.201, 291–301 (2005). CASPubMedPubMed Central Google Scholar
Sanna, M.G. et al. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem.279, 13839–13848 (2004). CASPubMed Google Scholar
Forrest, M. et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor sub-types. J. Pharmacol. Exp. Ther.309, 758–768 (2004). CASPubMed Google Scholar
Rosen, H. & Goetzl, E.J. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol.5, 560–570 (2005). CASPubMed Google Scholar
Rosen, H., Sanna, M.G., Cahalan, S.M. & Gonzalez-Cabrera, P.J. Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends Immunol.28, 102–107 (2007). CASPubMed Google Scholar
Wei, S.H. et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol.6, 1228–1235 (2005). CASPubMed Google Scholar
Carlson, C.M. et al. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature442, 299–302 (2006). CASPubMed Google Scholar
Nombela-Arrieta, C. et al. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J. Exp. Med.204, 497–510 (2007). CASPubMedPubMed Central Google Scholar
Ishizaki, H. et al. Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta. J. Immunol.177, 8512–8521 (2006). CASPubMed Google Scholar
Sakata, D. et al. Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J. Exp. Med.204, 2031–2038 (2007). CASPubMedPubMed Central Google Scholar
Lee, M.J. et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science279, 1552–1555 (1998). CASPubMed Google Scholar
Hannun, Y.A., Luberto, C. & Argraves, K.M. Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry40, 4893–4903 (2001). CASPubMed Google Scholar
Spiegel, S. & Milstien, S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol.4, 397–407 (2003). CASPubMed Google Scholar
Saba, J.D. & Hla, T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ. Res.94, 724–734 (2004). CASPubMed Google Scholar
Schwab, S.R. et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science309, 1735–1739 (2005). CASPubMed Google Scholar
Pappu, R. et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science316, 295–298 (2007). CASPubMed Google Scholar
Allende, M.L. et al. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J. Biol. Chem.279, 52487–52492 (2004). CASPubMed Google Scholar
Mizugishi, K. et al. Essential role for sphingosine kinases in neural and vascular development. Mol. Cell. Biol.25, 11113–11121 (2005). CASPubMedPubMed Central Google Scholar
Ito, K. et al. Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. Biochem. Biophys. Res. Commun.357, 212–217 (2007). CASPubMed Google Scholar
Murata, N. et al. Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. Biochem. J.352, 809–815 (2000). CASPubMedPubMed Central Google Scholar
Mitra, P. et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc. Natl. Acad. Sci. USA103, 16394–16399 (2006). CASPubMedPubMed Central Google Scholar
Kobayashi, N. et al. Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. J. Lipid Res.47, 614–621 (2006). CASPubMed Google Scholar
Kuo, C.T., Veselits, M.L. & Leiden, J.M. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science277, 1986–1990 (1997). CASPubMed Google Scholar
Hall, J.G. & Morris, B. The immediate effect of antigens on the cell output of a lymph node. Br. J. Exp. Pathol.46, 450–454 (1965). CASPubMedPubMed Central Google Scholar
Shiow, L.R. et al. CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature440, 540–544 (2006). CASPubMed Google Scholar
Feng, C. et al. A potential role for CD69 in thymocyte emigration. Int. Immunol.14, 535–544 (2002). CASPubMed Google Scholar
Nakayama, T. et al. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol.168, 87–94 (2002). CASPubMed Google Scholar
Chu, P. et al. Systematic identification of regulatory proteins critical for T-cell activation. J. Biol.2, 21 (2003). PubMedPubMed Central Google Scholar
Risso, A. et al. CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression. J. Immunol.146, 4105–4114 (1991). CASPubMed Google Scholar
Rosen, H., Alfonso, C., Surh, C.D. & McHeyzer-Williams, M.G. Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist. Proc. Natl. Acad. Sci. USA100, 10907–10912 (2003). CASPubMedPubMed Central Google Scholar
Sprent, J., Miller, J.F. & Mitchell, G.F. Antigen-induced selective recruitment of circulating lymphocytes. Cell. Immunol.2, 171–181 (1971). CASPubMed Google Scholar
Hay, J.B., Cahill, R.N. & Trnka, Z. The kinetics of antigen-reactive cells during lymphocyte recruitment. Cell. Immunol.10, 145–153 (1974). CASPubMed Google Scholar
Graeler, M. & Goetzl, E.J. Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J.16, 1874–1878 (2002). CASPubMed Google Scholar
Bai, A., Hu, H., Yeung, M. & Chen, J. Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription. J. Immunol.178, 7632–7639 (2007). CASPubMed Google Scholar
Chi, H. & Flavell, R.A. Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. J. Immunol.174, 2485–2488 (2005). CASPubMed Google Scholar
Graler, M.H., Huang, M.C., Watson, S. & Goetzl, E.J. Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes. J. Immunol.174, 1997–2003 (2005). PubMed Google Scholar
Kabashima, K. et al. Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J. Exp. Med.203, 2683–2690 (2006). CASPubMedPubMed Central Google Scholar
Lee, M.J. et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell99, 301–312 (1999). CASPubMed Google Scholar
Sanna, M.G. et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat. Chem. Biol.2, 434–441 (2006). CASPubMed Google Scholar
Foss, F.W., Jr et al. Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg. Med. Chem.15, 663–677 (2007). CASPubMed Google Scholar
Visentin, B. et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell9, 225–238 (2006). CASPubMed Google Scholar
Oo, M.L. et al. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J. Biol. Chem.282, 9082–9089 (2007). CASPubMed Google Scholar
Gonzalez-Cabrera, P.J., Hla, T. & Rosen, H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. J. Biol. Chem.282, 7254–7264 (2007). CASPubMed Google Scholar
Graler, M.H. & Goetzl, E.J. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J.18, 551–553 (2004). CASPubMed Google Scholar
Halin, C. et al. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood106, 1314–1322 (2005). CASPubMedPubMed Central Google Scholar
Pabst, O. et al. Enhanced FTY720-mediated lymphocyte homing requires Gαi signaling and depends on β2 and β7 integrin. J. Immunol.176, 1474–1480 (2006). CASPubMed Google Scholar
Cinamon, G. et al. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat. Immunol.5, 713–720 (2004). CASPubMed Google Scholar
Cinamon, G., Zachariah, M., Lam, O. & Cyster, J.G. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat. Immunol. (in the press).
Walzer, T. et al. Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nat. Immunol.8, 1337–1344 (2007). CASPubMed Google Scholar
Olivera, A. et al. The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity26, 287–297 (2007). CASPubMed Google Scholar
Jolly, P.S. et al. Transactivation of sphingosine-1-phosphate receptors by FcɛRI triggering is required for normal mast cell degranulation and chemotaxis. J. Exp. Med.199, 959–970 (2004). CASPubMedPubMed Central Google Scholar
Huang, M.C., Watson, S.R., Liao, J.J. & Goetzl, E.J. Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. J. Immunol.178, 6806–6813 (2007). CASPubMed Google Scholar
Czeloth, N., Bernhardt, G., Hofmann, F., Genth, H. & Forster, R. Sphingosine-1-phosphate mediates migration of mature dendritic cells. J. Immunol.175, 2960–2967 (2005). CASPubMed Google Scholar
Idzko, M. et al. Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J. Clin. Invest.116, 2935–2944 (2006). CASPubMedPubMed Central Google Scholar
Muller, H. et al. The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells. Eur. J. Immunol.35, 533–545 (2005). PubMed Google Scholar
Maeda, Y. et al. Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. J. Immunol.178, 3437–3446 (2007). CASPubMed Google Scholar
Daniel, C. et al. FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. J. Immunol.178, 2458–2468 (2007). CASPubMed Google Scholar
Sawicka, E. et al. The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity. J. Immunol.175, 7973–7980 (2005). CASPubMed Google Scholar
Kato, S. Thymic microvascular system. Microsc. Res. Tech.38, 287–299 (1997). CASPubMed Google Scholar
Ueno, T. et al. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity16, 205–218 (2002). CASPubMed Google Scholar
Hofmann, M., Brinkmann, V. & Zerwes, H.G. FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs. Int. Immunopharmacol.6, 1902–1910 (2006). CASPubMed Google Scholar
Morris, M.A. et al. Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720. Eur. J. Immunol.35, 3570–3580 (2005). CASPubMed Google Scholar
Don, A.S. et al. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. J. Biol. Chem.282, 15833–15842 (2007). CASPubMed Google Scholar
Kunisawa, J. et al. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood109, 3749–3756 (2007). CASPubMed Google Scholar
Pinschewer, D.D. et al. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J. Immunol.164, 5761–5770 (2000). CASPubMed Google Scholar
Han, S. et al. FTY720 suppresses humoral immunity by inhibiting germinal center reaction. Blood104, 4129–4133 (2004). CASPubMed Google Scholar
Vora, K.A. et al. Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement. J. Leukoc. Biol.78, 471–480 (2005). CASPubMed Google Scholar
Xie, J.H. et al. Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells. J. Immunol.170, 3662–3670 (2003). CASPubMed Google Scholar
Kappos, L. et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N. Engl. J. Med.355, 1124–1140 (2006). CASPubMed Google Scholar
Brinkmann, V. Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol. Ther.115, 84–105 (2007). CASPubMed Google Scholar
Ishii, I., Fukushima, N., Ye, X. & Chun, J. Lysophospholipid receptors: signaling and biology. Annu. Rev. Biochem.73, 321–354 (2004). CASPubMed Google Scholar