PI3K-mediated negative feedback regulation of IL-12 production in DCs (original) (raw)

• Medzhitov, R. & Janeway, C.A. Jr. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9, 4–9 (1997).
  Article CAS Google Scholar
• Trinchieri, G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251–276 (1995).
  Article CAS Google Scholar
• Moser, M. & Murphy, K.M. Dendritic cell regulation of TH1-TH2 development. Nature Immunol. 1, 199–205 (2000).
  Article CAS Google Scholar
• Banchereau, J. et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767–811 (2000).
  Article CAS Google Scholar
• Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunol. 2, 675–680 (2001).
  Article CAS Google Scholar
• Boehm, U., Klamp, T., Groot, M. & Howard, J.C. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15, 749–795 (1997).
  Article CAS PubMed Central Google Scholar
• Ohteki, T. & Koyasu, S. Role of antigen presenting cells in innate immune system. Arch. Immunol. Ther. Exp. 49, 47–52 (2001).
  Google Scholar
• Frucht, D.M. et al. IFN-γ production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22, 556–560 (2001).
  Article CAS Google Scholar
• Murphy, K.M. et al. Signalling and transcription in T helper development. Annu. Rev. Immunol. 18, 451–494 (2000).
  Article CAS Google Scholar
• Gately, M.K. et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16, 495–521 (1998).
  Article CAS Google Scholar
• Ulevitch, R.J. & Tobias, P.S. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13, 437–457 (1995).
  Article CAS Google Scholar
• Falcone, M. & Sarvetnick, N. Cytokines that regulate autoimmune responses. Curr. Opin. Immunol. 11, 670–676 (1999).
  Article CAS Google Scholar
• Li, W. et al. IL-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance. J. Immunol. 166, 5619–5628 (2001).
  Article CAS Google Scholar
• Finkelman, F.D. et al. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models. Annu. Rev. Immunol. 15, 505–533 (1997).
  Article CAS Google Scholar
• Toker, A. & Cantley, L.C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673–676 (1997).
  Article CAS Google Scholar
• Katso, R. et al. Functions of phosphoinositide 3-kinases: implications for development, immunity, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 17, 615–675 (2001).
  Article CAS Google Scholar
• Terauchi, Y. et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase. Nature Genet. 21, 230–235 (1999).
  Article CAS Google Scholar
• Suzuki, H. et al. _Xid_-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase. Science 283, 390–392 (1999).
  Article CAS Google Scholar
• Fukao, T. et al. Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nature Immunol. 3, 295–304 (2002).
  Article CAS Google Scholar
• Louis, J., Himmelrich, H., Parra-Lopez, C., Tacchini-Cottier, F. & Launois, P. Regulation of protective immunity against Leishmania major in mice. Curr. Opin. Immunol. 10, 459–464 (1998).
  Article CAS PubMed Central Google Scholar
• Herrera-Velit, P., Knutson, K. L. & Reiner, N. E. Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-ζ in bacterial lipopolysaccharide-treated human monocytes. J. Biol. Chem. 272, 16445–16452 (1997).
  Article CAS PubMed Central Google Scholar
• Arbibe, L. et al. Toll-like receptor 2-mediated NF-κB activation requires a Rac1-dependent pathway. Nature Immunol. 1, 533–540 (2000).
  Article CAS Google Scholar
• Baek, K.H., Ha, S.J. & Sung, Y.C. A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages. J. Immunol. 167, 2847–2854 (2001).
  Article CAS PubMed Central Google Scholar
• Ren, C.L., Morio, T., Fu, S.M. & Geha, R.S. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J. Exp. Med. 179, 673–680 (1994).
  Article CAS Google Scholar
• Wong, B.R. et al. TRANCE, a TNF family member, activates Akt/PKB through a signalling complex involving TRAF6 and c-Src. Mol. Cell 4, 1041–1049 (1999).
  Article CAS Google Scholar
• Schulz, O. et al. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13, 453–462 (2000).
  Article CAS Google Scholar
• Hochrein, H. et al. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J. Exp. Med. 192, 823–833 (2000).
  Article CAS PubMed Central Google Scholar
• Hacker, H. et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17, 6230–6240 (1998).
  Article CAS PubMed Central Google Scholar
• Lu, H.T. et al. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18, 1845–1857 (1999).
  Article CAS PubMed Central Google Scholar
• Langenkamp, A., Messi, M., Lanzavecchia, A. & Sallusto, F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nature Immunol. 1, 311–316 (2000).
  Article CAS Google Scholar
• Datta, S.R., Brunet, A. & Greenberg, M.E. Cellular survival: a play in three Akts. Genes. Dev. 13, 2905–2927 (1999).
  Article CAS Google Scholar
• Reis e Sousa, C. et al. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology. Immunity 11, 637–647 (1999).
  Article CAS Google Scholar
• Aliberti, J., Hieny, S., Reis e Sousa, C., Serhan, C. N. & Sher, A. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nature Immunol. 3, 76–82 (2002).
  Article CAS Google Scholar
• Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263–274 (1993).
  Article CAS Google Scholar
• Rennick, D.M., Fort, M.M. & Davidson, N.J. Studies with IL-10−/− mice: an overview. J. Leukoc. Biol. 61, 389–396 (1997).
  Article CAS Google Scholar
• Moulin, V. et al. B lymphocytes regulate dendritic cell (DC) function in vivo: increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation. J. Exp. Med. 192, 475–482 (2000).
  Article CAS PubMed Central Google Scholar
• Kim, A.H., Khursigara, G., Sun, X., Franke, T.F. & Chao, M.V. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol. Cell. Biol. 21, 893–901 (2001).
  Article CAS PubMed Central Google Scholar
• Gratton, J.P. et al. Akt down-regulation of p38 signalling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J. Biol. Chem. 276, 30359–30365 (2001).
  Article CAS Google Scholar
• Athie-M, V., Flotow, H., Hilyard, K.L. & Cantrell, D.A. IL-12 selectively regulates STAT4 via phosphatidylinositol 3-kinase and Ras-independent signal transduction pathways. Eur. J. Immunol. 30, 1425–1434 (2000).
  Article CAS Google Scholar
• He, J., Gurunathan, S., Iwasaki, A., Ash-Shaheed, B. & Kelsall, B.L. Primary role for Gi protein signalling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses. J. Exp. Med. 191, 1605–1610 (2000).
  Article CAS PubMed Central Google Scholar
• Braun, M.C., Lahey, E. & Kelsall, B.L. Selective suppression of IL-12 production by chemoattractants. J. Immunol. 164, 3009–3017 (2000).
  Article CAS PubMed Central Google Scholar
• Sotsios, Y. & Ward, S.G. Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines. Immunol. Rev. 177, 217–235 (2000).
  Article CAS PubMed Central Google Scholar
• Wilson, M., Burt, A.R., Milligan, G. & Anderson N.G. Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptors. J. Biol. Chem. 271, 8537–8540 (1996).
  Article CAS PubMed Central Google Scholar
• Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740–745 (2000).
  Article CAS PubMed Central Google Scholar
• Fukao, T. & Koyasu S. Expression of functional IL-2 receptors on mature splenic dendritic cells. Eur. J. Immunol. 30, 1453–1457 (2000).
  Article CAS PubMed Central Google Scholar
• Fukao, T. et al. Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J. Immunol. 166, 4446–4455 (2001).
  Article CAS PubMed Central Google Scholar
• Inaba, K. et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176, 1693–1702 (1992).
  Article CAS Google Scholar
• Afonso, L.C. et al. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263, 235–237 (1994).
  Article CAS Google Scholar