Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 (original) (raw)
Kozutsumi, Y., Segal, M., Normington, K., Gething, M.J. & Sambrook, J. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature332, 462–464 (1988). ArticleCASPubMed Google Scholar
Patil, C. & Walter, P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell. Biol.13, 349–355 (2001). ArticleCASPubMed Google Scholar
Mori, K., Ma, W., Gething, M.J. & Sambrook, J. A transmembrane protein with a Cdc2/Cdc28-related kinase activity is required for signaling from the ER to the nucleus. Cell74, 743–756 (1993). ArticleCASPubMed Google Scholar
Cox, J.S., Shamu, C.E. & Walter, P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell73, 1197–1206 (1993). ArticleCASPubMed Google Scholar
Welihinda, A.A. & Kaufman, R.J. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and _trans_-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J. Biol. Chem.271, 18181–18187 (1996). ArticleCASPubMed Google Scholar
Shamu, C.E. & Walter, P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J.15, 3028–3039 (1996). ArticleCASPubMedPubMed Central Google Scholar
Ruegsegger, U., Leber, J.H. & Walter, P. Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell107, 103–114 (2001). ArticleCASPubMed Google Scholar
Cox, J.S. & Walter, P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell87, 391–404 (1996). ArticleCASPubMed Google Scholar
Sidrauski, C., Cox, J.S. & Walter, P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell87, 405–413 (1996). ArticleCASPubMed Google Scholar
Sidrauski, C. & Walter, P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell90, 1031–1039 (1997). ArticleCASPubMed Google Scholar
Tirasophon, W., Welihinda, A.A. & Kaufman, R.J. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev.12, 1812–1824 (1998). ArticleCASPubMedPubMed Central Google Scholar
Shi, Y. et al. Identification and characterization of pancreatic eukaryotic initiation factor 2α-subunit kinase, PEK, involved in translational control. Mol. Cell. Biol.18, 7499–7509 (1998). ArticleCASPubMedPubMed Central Google Scholar
Harding, H.P., Zhang, Y. & Ron, D. Protein translation and folding are coupled by an endoplasmic-reticulum–resident kinase. Nature397, 271–274 (1999). ArticleCASPubMed Google Scholar
Yoshida, H., Haze, K., Yanagi, H., Yura, T. & Mori, K. Identification of the _cis_-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose–regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem.273, 33741–33749 (1998). ArticleCASPubMed Google Scholar
Shen, X. et al. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell107, 893–903 (2001). ArticleCASPubMed Google Scholar
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell107, 881–891 (2001). ArticleCASPubMed Google Scholar
Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature415, 92–96 (2002). ArticleCASPubMed Google Scholar
Liou, H.-C. et al. A new member of the leucine zipper class of proteins that binds to the HLA DRα promoter. Science247, 1581–1584 (1990). ArticleCASPubMed Google Scholar
Clauss, I.M. et al. In situ hybridization studies suggest a role for the basic region–leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev. Dyn.197, 146–156 (1993). ArticleCASPubMed Google Scholar
Reimold, A.M. et al. Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. J. Exp. Med.183, 393–401 (1996). ArticleCASPubMed Google Scholar
Reimold, A.M. et al. Plasma cell differentiation requires transcription factor XBP-1. Nature412, 300–307 (2001). ArticleCASPubMed Google Scholar
Calame, K.L. Plasma cells: finding new light at the end of B cell development. Nat. Immunol.2, 1103–1108 (2001). ArticleCASPubMed Google Scholar
Gass, J.N., Gifford, N.M. & Brewer, J.W. Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J. Biol. Chem.277, 49045–49054 (2002). Article Google Scholar
Blackman, M.A., Tigges, M.A., Minie, M.E. & Koshland, M.E. A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain gene. Cell47, 609–617 (1986). ArticleCASPubMed Google Scholar
Turner, C.A. Jr., Mack, D.H. & Davis, M.M. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell77, 297–306 (1994). ArticleCASPubMed Google Scholar
Lin, Y., Wong, K. & Calame, K. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science276, 596–599 (1997). ArticleCASPubMed Google Scholar
Lemaire, C., Andreau, K., Souvannavong, V. & Adam, A. Specific dual effect of cycloheximide on B lymphocyte apoptosis: involvement of CPP32/caspase-3. Biochem. Pharmacol.58, 85–93 (1999). ArticleCASPubMed Google Scholar
Lam, K.P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell90, 1073–1083 (1997). ArticleCASPubMed Google Scholar
Peitz, M., Pfannkuche, K., Rajewsky, K. & Edenhofer, F. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc. Natl. Acad. Sci. USA99, 4489–4494 (2002). ArticleCASPubMedPubMed Central Google Scholar
Kawahara, T., Yanagi, H., Yura, T. & Mori, K. Unconventional splicing of HAC1/ERN4 mRNA required for the unfolded protein response. Sequence-specific and non-sequential cleavage of the splice sites. J. Biol. Chem.273, 1802–1807 (1998). ArticleCASPubMed Google Scholar
Gonzalez, T.N., Sidrauski, C., Dorfler, S. & Walter, P. Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J.18, 3119–3132 (1999). ArticleCASPubMedPubMed Central Google Scholar
Hirano, T. & Kishimoto, T. Interleukin 6 and plasma cell neoplasias. Prog. Growth Factor Res.1, 133–142 (1989). ArticleCASPubMed Google Scholar
Hallek, M., Bergsagel, P.L. & Anderson, K.C. Multiple myeloma: increasing evidence for a multistep transformation process. Blood91, 3–21 (1998). ArticleCASPubMed Google Scholar
Wen, X.Y. et al. Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells. Int. J. Oncol.15, 173–178 (1999). CASPubMed Google Scholar
Burdin, N. et al. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol.154, 2533–2544 (1995). ArticleCASPubMed Google Scholar
Nelms, K., Keegan, A.D., Zamorano, J., Ryan, J.J. & Paul, W.E. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol.17, 701–738 (1999). ArticleCASPubMed Google Scholar
Rudge, E.U., Cutler, A.J., Pritchard, N.R. & Smith, K.G. Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and FcγRII-mediated B cell suppression. J. Exp. Med.195, 1079–1085 (2002). ArticleCASPubMedPubMed Central Google Scholar
Brewer, J.W., Cleveland, J.L. & Hendershot, L.M. A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells. EMBO J.16, 7207–7216 (1997). ArticleCASPubMedPubMed Central Google Scholar
Kopf, M., Le Gros, G., Coyle, A.J., Kosco-Vilbois, M. & Brombacher, F. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol Rev.148, 45–69 (1995). ArticleCASPubMed Google Scholar
Liu, C.Y., Wong, H.N., Schauerte, J.A. & Kaufman, R.J. The protein kinase/endoribonuclease IRE1α that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J. Biol. Chem.277, 18346–18356 (2002). ArticleCASPubMed Google Scholar
Bertolotti, A., Zhang, Y., Hendershot, L.M., Harding, H.P. & Ron, D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol.2, 326–332 (2000). ArticleCASPubMed Google Scholar
Haas, I.G. & Wabl, M. Immunoglobulin heavy chain binding protein. Nature306, 387–389 (1983). ArticleCASPubMed Google Scholar
Lee, K. et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev.16, 452–466 (2002). ArticleCASPubMedPubMed Central Google Scholar
Urano, F., Bertolotti, A. & Ron, D. IRE1 and efferent signaling from the endoplasmic reticulum. J. Cell Sci.113, 3697–3702 (2000). ArticleCASPubMed Google Scholar
Urano, F. et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science287, 664–666 (2000). ArticleCASPubMed Google Scholar
Akira, S. & Kishimoto, T. NF-IL6 and NF-κB in cytokine gene regulation. Adv. Immunol.65, 1–46 (1997). CASPubMed Google Scholar
Kopf, M. et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature368, 339–342 (1994). ArticleCASPubMed Google Scholar
Cressman, D.E. et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science274, 1379–1383 (1996). ArticleCASPubMed Google Scholar
Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell100, 655–669 (2000). ArticleCASPubMed Google Scholar
Rengarajan, J. et al. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Immunity12, 293–300 (2000). ArticleCASPubMed Google Scholar
Lee, K. et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev.16, 452–466 (2002). ArticleCASPubMedPubMed Central Google Scholar