Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system (original) (raw)

Nature Medicine volume 18, pages 344–346 (2012)Cite this article

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To the Editor:

On the basis of data published in Nature Medicine, the research groups of Zitvogel and Kroemer have hypothesized that the adaptive immune system dictates the therapeutic efficacy of certain chemotherapeutics1,2,3. Using in vitro systems and tumor transplantation models, they showed that cancer cells undergo immunogenic cell death in response to certain commonly used chemotherapeutics, specifically anthracyclines and oxaliplatin1,2,3, which leads to activation of effective antitumor T cell responses1,2,3. Consistent with these observations, the authors showed that anthracyclines and oxaliplatin lose their therapeutic efficacy on tumor cell line outgrowths in mice with defective adaptive immune cell function1,2,3.

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Acknowledgements

We thank T.N. Schumacher for helpful discussions. We thank the protein facility at the Netherlands Cancer Institute for providing the antibody against CD8. Research described in this Correspondence was supported by grants from the Dutch Cancer Society (KWF grants 2006-3715 and 2011-5004 to K.E.d.V. and J.J.), the Netherlands organization for Scientific Research (NWO grant VIDI 917.96.307 to K.E.d.V.) and the Association for International Cancer Research (AICR grant 11-0677 to K.E.d.V.).

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Authors and Affiliations

  1. Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    Metamia Ciampricotti, Cheei-Sing Hau, Chris W Doornebal, Jos Jonkers & Karin E de Visser

Authors

  1. Metamia Ciampricotti
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  2. Cheei-Sing Hau
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  3. Chris W Doornebal
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  4. Jos Jonkers
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  5. Karin E de Visser
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Contributions

J.J. and K.E.d.V. designed the study. M.C., C.-S.H. and C.W.D. performed the experiments. K.E.d.V. took the initiative for this Correspondence and wrote the manuscript. All coauthors provided comments that helped shape the final submission.

Corresponding author

Correspondence toKarin E de Visser.

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The authors declare no competing financial interests.

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Ciampricotti, M., Hau, CS., Doornebal, C. et al. Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system.Nat Med 18, 344–346 (2012). https://doi.org/10.1038/nm.2652

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