- Swaroop, A., Chew, E.Y., Rickman, C.B. & Abecasis, G.R. Unravelling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu. Rev. Genomics Hum. Genet. 10, 19–43 (2009).
Article CAS Google Scholar
- Resnikoff, S. et al. Global data on visual impairment in the year 2002. Bull. World Health Organ. 82, 844–851 (2004).
Google Scholar
- Bressler, S.B., Maguire, M.G., Bressler, N.M. & Fine, S.L. Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group. Arch. Ophthalmol. 108, 1442–1447 (1990).
Article CAS Google Scholar
- Sarks, S.H., van Driel, D., Maxwell, L. & Killingsworth, M. Softening of drusen and subretinal neovascularization. Trans. Ophthalmol. Soc. U.K. 100, 414–422 (1980).
CAS Google Scholar
- Vinding, T. Occurrence of drusen, pigmentary changes, and exudative changes in the macula with reference to age-related macular degeneration. An epidemiological study of 1000 aged individuals. Acta Ophthalmol. (Copenh.) 68, 410–414 (1990).
Article CAS Google Scholar
- Holz, F.G., Bellman, C., Staudt, S., Schutt, F. & Volcker, H.E. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 42, 1051–1056 (2001).
CAS Google Scholar
- Seddon, J.M., George, S. & Rosner, B. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration. Arch. Ophthalmol. 124, 995–1001 (2006).
Article CAS Google Scholar
- Edwards, A.O. & Malek, G. Molecular genetics of AMD and current animal models. Angiogenesis 10, 119–132 (2007).
Article CAS Google Scholar
- Canter, J.A. et al. Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration. PLoS ONE 3, e2091 (2008).
Article Google Scholar
- Chen, Y., Bedell, M. & Zhang, K. Age-related macular degeneration: genetic and environmental factors of disease. Mol. Interv. 10, 271–281 (2010).
Article CAS Google Scholar
- Leveziel, N. et al. Genetic factors associated with age-related macular degeneration. Ophthalmologica 226, 87–102 (2011).
Article CAS Google Scholar
- Mariathasan, S. et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228–232 (2006).
Article CAS Google Scholar
- Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237–241 (2006).
Article CAS Google Scholar
- Halle, A. et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat. Immunol. 9, 857–865 (2008).
Article CAS Google Scholar
- Zhou, R., Yazdi, A.S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221–225 (2011).
Article CAS Google Scholar
- Gao, H. & Hollyfield, J.G. Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 33, 1–17 (1992).
CAS Google Scholar
- Iyer, S.S. et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc. Natl. Acad. Sci. USA 106, 20388–20393 (2009).
Article CAS Google Scholar
- Hollyfield, J.G. et al. Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat. Med. 14, 194–198 (2008).
Article CAS Google Scholar
- Gu, X. et al. Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J. Biol. Chem. 278, 42027–42035 (2003).
Article CAS Google Scholar
- Sakurai, E. et al. Macrophage depletion inhibits experimental choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 44, 3578–3585 (2003).
Article Google Scholar
- Campbell, M. et al. Systemic low molecular weight drug delivery to pre-selected neuronal regions. EMBO Mol. Med. 3, 235–245 (2011).
Article CAS Google Scholar
- Ma, W., Zhao, L., Fontainhas, A.M., Fariss, R.N. & Wong, W.T. Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD. PLoS ONE 4, e7945 (2009).
Article Google Scholar
- Anderson, D.H. et al. Characterization of β amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp. Eye Res. 78, 243–256 (2004).
Article CAS Google Scholar
- Luibl, V. et al. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J. Clin. Invest. 116, 378–385 (2006).
Article CAS Google Scholar
- Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357–1361 (2010).
Article CAS Google Scholar
- Masters, S.L. et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat. Immunol. 11, 897–904 (2010).
Article CAS Google Scholar
- Lin, H. et al. Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 52, 3521–3529 (2011).
Article CAS Google Scholar
- Wang, A.L. et al. Autophagy, exosomes and drusen formation in age-related macular degeneration. Autophagy 5, 563–564 (2009).
Article CAS Google Scholar
- Zarbin, M.A. Current concepts in the pathogenesis of age-related macular degeneration. Arch. Ophthalmol. 122, 598–614 (2004).
Article Google Scholar
- West, X.Z. et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 467, 972–976 (2010).
Article CAS Google Scholar
- Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085–2088 (1998).
Article CAS Google Scholar
- Hageman, G.S. & Mullins, R.F. Molecular composition of drusen as related to substructural phenotype. Mol. Vis. 5, 28–(1999).
- Nauta, A.J. et al. Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur. J. Immunol. 32, 1726–1736 (2002).
Article CAS Google Scholar
- Blanquet-Grossard, F., Thielens, N.M., Vendrely, C., Jamin, M. & Arlaud, G.J. Complement protein C1q recognizes a conformationally modified form of the prion protein. Biochemistry 44, 4349–4356 (2005).
Article CAS Google Scholar
- Hornung, V. et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9, 847–856 (2008).
Article CAS Google Scholar
- Zhou, R., Tardivel, A., Thorens, B., Choi, I. & Tschopp, J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136–140 (2010).
Article CAS Google Scholar
- Luo, X., Weber, G.A., Zheng, J., Gendelman, H.E. & Ikezu, T. C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease. J. Neuroimmunol. 135, 62–71 (2003).
Article CAS Google Scholar
- Ten, V.S. et al. Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury. J. Neurosci. 30, 2077–2087 (2010).
Article CAS Google Scholar
- McDonald, B. et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 330, 362–366 (2010).
Article CAS Google Scholar
- CATT Research Group. et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 364, 1897–1908 (2011).
- Crabb, J.W. et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc. Natl. Acad. Sci. USA 99, 14682–14687 (2002).
Article CAS Google Scholar
- Ishii, T., Haga, S., Yagishita, S. & Tateishi, J. The presence of complements in amyloid plaques of Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker disease. Appl. Pathol. 2, 370–379 (1984).
CAS Google Scholar
- Xu, H., Chen, M. & Forrester, J.V. Para-inflammation in the aging retina. Prog. Retin. Eye Res. 28, 348–368 (2009).
Article Google Scholar
- Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428–435 (2008).
Article CAS Google Scholar
- Arias, L. et al. Intravitreal infliximab in patients with macular degeneration who are nonresponders to antivascular endothelial growth factor therapy. Retina 30, 1601–1608 (2010).
Article Google Scholar
- Giganti, M. et al. Adverse events after intravitreal infliximab (Remicade). Retina 30, 71–80 (2010).
Article Google Scholar
- Dupaul-Chicoine, J. et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367–378 (2010).
Article CAS Google Scholar
- Allen, I.C. et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J. Exp. Med. 207, 1045–1056 (2010).
Article CAS Google Scholar
- Qiao, H. et al. Abnormal retinal vascular development in IL-18 knockout mice. Lab. Invest. 84, 973–980 (2004).
Article CAS Google Scholar
- Qiao, H. et al. Interleukin-18 regulates pathological intraocular neovascularization. J. Leukoc. Biol. 81, 1012–1021 (2007).
Article CAS Google Scholar
- Mallat, Z. et al. Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-induced neovascularization in mice hindlimb. Circ. Res. 91, 441–448 (2002).
Article CAS Google Scholar
- Coughlin, C.M. et al. Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J. Clin. Invest. 101, 1441–1452 (1998).
Article CAS Google Scholar
- Jiang, H.R. et al. IL-18 not required for IRBP peptide-induced EAU: studies in gene-deficient mice. Invest. Ophthalmol. Vis. Sci. 42, 177–182 (2001).
CAS Google Scholar
- Gu, X. et al. Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and peptide adduction chemistry. J. Org. Chem. 68, 3749–3761 (2003).
Article CAS Google Scholar
- Percopo, C.M., Hooks, J.J., Shinohara, T., Caspi, R. & Detrick, B. Cytokine-mediated activation of a neuronal retinal resident cell provokes antigen presentation. J. Immunol. 145, 4101–4107 (1990).
CAS Google Scholar
- Marmor, M.F. et al. ISCEV Standard for full-field clinical electroretinography (2008 update). Doc. Ophthalmol. 1, 69–77 (2009).
Article Google Scholar