Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma (original) (raw)
Schubbert, S., Shannon, K. & Bollag, G. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. CancerNatl. Rev.7, 295–308 (2007). ArticleCAS Google Scholar
Jakob, J.A. et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer118, 4013–4023 (2011). Google Scholar
Gilmartin, A.G. et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin. Cancer Res.17, 989–1000 (2011). ArticleCASPubMed Google Scholar
Bollag, G. et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature467, 596–599 (2010). ArticleCASPubMedPubMed Central Google Scholar
Flaherty, K.T. et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. New Engl. J. Med.367, 107–114 (2012). ArticleCASPubMed Google Scholar
Falchook, G.S. et al. Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol.13, 782–789 (2012). ArticleCASPubMedPubMed Central Google Scholar
Kirkwood, J.M. Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma. Clin. Cancer Res.18, 555–567 (2012). ArticleCASPubMed Google Scholar
Ascierto, P.A. et al. Efficacy and safety of oral MEK162 in patients with locally advanced and unresectable or metastatic cutaneous melanoma harboring BRAFV600 or NRAS mutations. J. Clin. Oncol.30, suppl; abstr 8511 (2012). Google Scholar
Hatzivassiliou, G. et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature464, 431–435 (2010). ArticleCASPubMed Google Scholar
Poulikakos, P.I., Zhang, C., Bollag, G., Shokat, K.M. & Rosen, N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature464, 427–430 (2010). ArticleCASPubMedPubMed Central Google Scholar
Su, F. et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N. Engl. J. Med.366, 207–215 (2012). ArticleCASPubMedPubMed Central Google Scholar
Villanueva, J. et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell18, 683–695 (2010). ArticleCASPubMedPubMed Central Google Scholar
Paraiso, K.H. et al. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br. J. Cancer102, 1724–1730 (2010). ArticleCASPubMedPubMed Central Google Scholar
Morris, M.K., Saez-Rodriguez, J., Sorger, P.K. & Lauffenburger, D.A. Logic-based models for the analysis of cell signaling networks. Biochemistry49, 3216–3224 (2010). ArticleCASPubMed Google Scholar
Sachs, K., Gifford, D., Jaakkola, T., Sorger, P. & Lauffenburger, D.A. Bayesian network approach to cell signaling pathway modeling. Sci. STKE2002, pe38 (2002). PubMed Google Scholar
Della Gatta, G. et al. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nat. Med18, 436–440 (2012). ArticleCASPubMed Google Scholar
Belcastro, V. et al. Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function. Nucleic Acids Res.39, 8677–8688 (2011). ArticleCASPubMedPubMed Central Google Scholar
Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature400, 468–472 (1999). ArticleCASPubMed Google Scholar
Yeh, T.C. et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin. Cancer Res.13, 1576–1583 (2007). ArticleCASPubMed Google Scholar
Solit, D.B. et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature439, 358–362 (2006). ArticleCASPubMed Google Scholar
Pratilas, C.A. et al. (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc. Natl. Acad. Sci. USA106, 4519–4524 (2009). ArticleCASPubMedPubMed Central Google Scholar
Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA102, 15545–15550 (2005). ArticleCASPubMedPubMed Central Google Scholar
Luo, J. et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell137, 835–848 (2009). ArticleCASPubMedPubMed Central Google Scholar
VanBrocklin, M.W., Verhaegen, M., Soengas, M.S. & Holmen, S.L. Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma. Cancer Res.69, 1985–1994 (2009). ArticleCASPubMedPubMed Central Google Scholar
Fry, D.W. et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol. Cancer Ther.3, 1427–1438 (2004). CASPubMed Google Scholar
Shapiro, G.I. Cyclin-dependent kinase pathways as targets for cancer treatment. J. Clin. Oncol.24, 1770–1783 (2006). ArticleCASPubMed Google Scholar
Lens, S.M., Voest, E.E. & Medema, R.H. Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat. Rev. CancerNatl. Rev.10, 825–841 (2010). ArticleCAS Google Scholar
Joseph, E.W. et al. The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner. Proc. Natl. Acad. Sci. USA107, 14903–14908 (2010). ArticleCASPubMedPubMed Central Google Scholar
Packer, L.M., East, P., Reis-Filho, J.S. & Marais, R. Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma. Pigment Cell Melanoma Res.22, 785–798 (2009). ArticleCASPubMed Google Scholar
Hoeflich, K.P. et al. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res.69, 3042–3051 (2009). ArticleCASPubMed Google Scholar
Dry, J.R. et al. Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Res.70, 2264–2273 (2010). ArticleCASPubMedPubMed Central Google Scholar
Puyol, M. et al. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell18, 63–73 (2010). ArticleCASPubMed Google Scholar
Haigis, K.M. et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat. Genet.40, 600–608 (2008). ArticleCASPubMedPubMed Central Google Scholar
Adjei, A.A. et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J. Clin. Oncol.26, 2139–2146 (2008). ArticleCASPubMed Google Scholar
Schwartz, G.K. et al. Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1). Br. J. Cancer104, 1862–1868 (2011). ArticleCASPubMedPubMed Central Google Scholar
Paweletz, C.P. et al. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene20, 1981–1989 (2001). ArticleCASPubMed Google Scholar
Serrano, M. et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell85, 27–37 (1996). ArticleCASPubMed Google Scholar
Vaira, V. et al. Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors. Proc. Natl. Acad. Sci. USA107, 8352–8356 (2010). ArticleCASPubMedPubMed Central Google Scholar
Smyth, G.K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol.3, Article3 (2004). Article Google Scholar
Irizarry, R.A. et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics4, 249–264 (2003). ArticlePubMed Google Scholar
Faith, J.J. et al. Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. PLoS Biol.5, e8 (2007). ArticlePubMedPubMed Central Google Scholar
Opsahl, T., Agneessens, F. & Skvoretz, J. Node centrality in weighted networks: Generalizing degree and shortest paths. Soc. Networks32, 245–251 (2010). Article Google Scholar