RIPK3 as a potential therapeutic target for Gaucher's disease (original) (raw)
Futerman, A.H. & van Meer, G. The cell biology of lysosomal storage disorders. Nat. Rev. Mol. Cell Biol.5, 554–565 (2004). ArticleCASPubMed Google Scholar
Eblan, M.J., Walker, J.M. & Sidransky, E. The glucocerebrosidase gene and Parkinson′s disease in Ashkenazi Jews. N. Engl. J. Med.352, 728–731 (2005). ArticleCASPubMed Google Scholar
Cox, T.M. Competing for the treasure in exceptions. Am. J. Hematol.88, 163–165 (2013). ArticlePubMed Google Scholar
Wong, K. et al. Neuropathology provides clues to the pathophysiology of Gaucher disease. Mol. Genet. Metab.82, 192–207 (2004). ArticleCASPubMed Google Scholar
Farfel-Becker, T. et al. Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease. Hum. Mol. Genet.20, 1375–1386 (2011). ArticleCASPubMed Google Scholar
Vitner, E.B., Farfel-Becker, T., Eilam, R., Biton, I. & Futerman, A.H. Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher′s disease. Brain135, 1724–1735 (2012). ArticlePubMed Google Scholar
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T. & Kroemer, G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol.11, 700–714 (2010). ArticleCASPubMed Google Scholar
Feoktistova, M. et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell43, 449–463 (2011). ArticleCASPubMedPubMed Central Google Scholar
Tenev, T. et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell43, 432–448 (2011). ArticleCASPubMed Google Scholar
Lin, Y., Devin, A., Rodriguez, Y. & Liu, Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev.13, 2514–2526 (1999). ArticleCASPubMedPubMed Central Google Scholar
Zhang, D.-W. et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science325, 332–336 (2009). ArticleCASPubMed Google Scholar
Trichonas, G. et al. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc. Natl. Acad. Sci. USA107, 21695–21700 (2010). ArticleCASPubMedPubMed Central Google Scholar
Lin, J. et al. A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep.3, 200–210 (2013). ArticleCASPubMed Google Scholar
Cho, Y.S. et al. Phosphorylation-driven assembly of the RIP1–RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell137, 1112–1123 (2009). ArticleCASPubMedPubMed Central Google Scholar
Duprez, L. et al. RIP kinase–dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity35, 908–918 (2011). ArticleCASPubMed Google Scholar
Roychowdhury, S., McMullen, M.R., Pisano, S.G., Liu, X. & Nagy, L.E. Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology57, 1773–1783 (2013). ArticleCASPubMed Google Scholar
Kang, T.-B., Yang, S.-H., Toth, B., Kovalenko, A. & Wallach, D. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity38, 27–40 (2013). ArticleCASPubMed Google Scholar
Kovalenko, A. et al. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J. Exp. Med.206, 2161–2177 (2009). ArticleCASPubMedPubMed Central Google Scholar
Lee, P. et al. Dynamic expression of epidermal caspase 8 simulates a wound healing response. Nature458, 519–523 (2009). ArticleCASPubMed Google Scholar
Yang, Y., Ma, J., Chen, Y. & Wu, M. Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3. J. Biol. Chem.279, 38820–38829 (2004). ArticleCASPubMed Google Scholar
Suzuki, K. & Taniike, M. Murine model of genetic demyelinating disease: the twitcher mouse. Microsc. Res. Tech.32, 204–214 (1995). ArticleCASPubMed Google Scholar
Vitner, E.B., Platt, F.M. & Futerman, A.H. Common and uncommon pathogenic cascades in lysosomal storage diseases. J. Biol. Chem.285, 20423–20427 (2010). ArticleCASPubMedPubMed Central Google Scholar
Vitner, E.B. et al. Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses. Hum. Mol. Genet.19, 3583–3590 (2010). ArticleCASPubMed Google Scholar
Kelliher, M.A. et al. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity8, 297–303 (1998). ArticleCASPubMed Google Scholar
Newton, K., Sun, X. & Dixit, V.M. Kinase RIP3 is dispensable for normal NF-κ Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol. Cell. Biol.24, 1464–1469 (2004). ArticleCASPubMedPubMed Central Google Scholar
Wallach, D., Kovalenko, A. & Kang, T.-B. 'Necrosome'-induced inflammation: must cells die for it? Trends Immunol.32, 505–509 (2011). ArticleCASPubMed Google Scholar
Chavez-Valdez, R., Martin, L.J., Flock, D.L. & Northington, F.J. Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia. Neuroscience219, 192–203 (2012). ArticleCASPubMed Google Scholar
Rosenbaum, D.M. et al. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J. Neurosci. Res.88, 1569–1576 (2010). CASPubMedPubMed Central Google Scholar
You, Z. et al. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J. Cereb. Blood Flow Metab.28, 1564–1573 (2008). ArticleCASPubMed Google Scholar
Jagtap, P.G. et al. Structure-activity relationship study of tricyclic necroptosis inhibitors. J. Med. Chem.50, 1886–1895 (2007). ArticleCASPubMed Google Scholar
Zhu, S., Zhang, Y., Bai, G. & Li, H. Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington′s disease. Cell Death Dis.2, e115 (2011). ArticleCASPubMedPubMed Central Google Scholar
Sun, L. et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell148, 213–227 (2012). ArticleCASPubMed Google Scholar
Farfel-Becker, T. et al. No evidence for activation of the unfolded protein response in neuronopathic models of Gaucher disease. Hum. Mol. Genet.18, 1482–1488 (2009). ArticleCASPubMed Google Scholar
Sango, K. et al. Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat. Genet.11, 170–176 (1995). ArticleCASPubMed Google Scholar
Hahn, C.N. et al. Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid β-galactosidase. Hum. Mol. Genet.6, 205–211 (1997). ArticleCASPubMed Google Scholar
Pentchev, P.G. et al. A genetic storage disorder in BALB/C mice with a metabolic block in esterification of exogenous cholesterol. J. Biol. Chem.259, 5784–5791 (1984). CASPubMed Google Scholar
Narayan, N. et al. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature492, 199–204 (2012). ArticleCASPubMed Google Scholar
Lopez, M.E., Klein, A.D., Dimbil, U.J. & Scott, M.P. Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J. Neurosci.31, 4367–4378 (2011). ArticleCASPubMedPubMed Central Google Scholar
van Raam, B.J., Ehrnhoefer, D.E., Hayden, M.R. & Salvesen, G.S. Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. Cell Death Differ.20, 86–96 (2013). ArticleCASPubMed Google Scholar