Sizing up miRNAs as cancer genes (original) (raw)

Nature Medicine volume 11, pages 712–714 (2005)Cite this article

Findings over the last year or so have built the case that microRNAs might contribute to cancer. Three studies now definitively show this to be the case and also suggest that these small RNAs could be used to categorize tumors.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: A model of miRNA involvement in cancer by modulation of expression of tumor suppressor genes and oncogenes.

Katie Ris

References

  1. He, L. et al. Nature 435, 828–833 (2005).
    Article CAS Google Scholar
  2. O'Donnell K.A. et al. Nature 435, 839–843 (2005).
    Article CAS Google Scholar
  3. Lu, J. et al. Nature 435, 834–838 (2005).
    Article CAS Google Scholar
  4. Bartel, D.P. Cell 116, 281–297 (2004).
    Article CAS Google Scholar
  5. He, L. et al. Nat. Rev. Genet. 5, 522–531 (2004).
    Article CAS Google Scholar
  6. Ambros, V. Nature 431, 350–355 (2004).
    Article CAS Google Scholar
  7. Lee, R.C. et al. Cell 75, 843–854 (1993).
    Article CAS Google Scholar
  8. Reinhart, B.J. et al. Nature 403, 901–906 (2000).
    Article CAS Google Scholar
  9. Berezikov, E. et al. Cell 120, 21–24 (2005).
    Article CAS Google Scholar
  10. Lewis, B.P. et al. Cell 120, 15–20 (2005).
    Article CAS Google Scholar
  11. Krek, A. et al. Nat. Genet. 37, 495–500 (2005).
    Article CAS Google Scholar
  12. Calin, G.A. et al. Proc. Natl. Acad. Sci. USA 99, 15524–15529 (2002).
    Article CAS Google Scholar
  13. Michael, M.Z. et al. Mol. Cancer Res. 1, 882–891 (2003).
    CAS PubMed Google Scholar
  14. Johnson, S.M. et al. Cell 120, 635–647 (2005).
    Article CAS Google Scholar
  15. Dimova, D.K. et al. Oncogene 24, 2810–2826 (2005).
    Article CAS Google Scholar
  16. Meltzer, P.S. Nature 435, 745–746 (2005).
    Article CAS Google Scholar
  17. Weinberg, R.A. Cell 85, 457–459 (1996).
    Article CAS Google Scholar
  18. Weinholds, E. et al. Science published online 26 May 2005 (10.1126/science.1114519).
  19. Iwai, N. et al. Biochem. Biophys. Res. Commun. 331, 1439–1444 (2005).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Oncology, Cancer Genomics Program, University of Cambridge and Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, CB2 2XZ, UK
    Carlos Caldas & James D Brenton

Authors

  1. Carlos Caldas
    You can also search for this author inPubMed Google Scholar
  2. James D Brenton
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Caldas, C., Brenton, J. Sizing up miRNAs as cancer genes.Nat Med 11, 712–714 (2005). https://doi.org/10.1038/nm0705-712

Download citation

This article is cited by