Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides (original) (raw)
References
Saunders, A.M. et al. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology43, 1467–1472 (1993). Article Google Scholar
Rebeck, G.W., Reiter, J.S., Strickland, D.K. & Hyman, B.T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron11, 575–580 (1993). Article Google Scholar
Strittmatter, W.J. et al. Binding of human apolipoprotein E to synthetic amyloid β peptide: isoform-specific effects and implications for late-onset alzheimer disease. Proc. Natl. Acad. Sci. USA90, 8098–8102 (1993). Article Google Scholar
Schmechel, D.E. et al. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset alzheimer disease. Proc. Natl. Acad. Sci. USA90, 9649–9653 (1993). Article Google Scholar
Bales, K.R. et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat. Genet.17, 263–264 (1997). Article Google Scholar
Bales, K.R. et al. Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA96, 15233–15238 (1999). Article Google Scholar
Holtzman, D.M. et al. Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease. J. Clin. Invest.103, R15–R21 (1999). Article Google Scholar
Fagan, A.M. et al. Human and murine apoE markedly influence Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol. Dis.9, 305–318 (2002). Article Google Scholar
Wyss-Coray, T. et al. TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice. Nat. Med.7, 612–618 (2001). Article Google Scholar
Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease. Nat. Med.6, 916–919 (2000). Article Google Scholar
Bacskai, B.J. et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-β in vivo by immunotherapy. J. Neurosci.22, 7873–7878 (2002). Article Google Scholar
Frackowiak, J. et al. Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce β-amyloid fibrils. Acta. Neuropathol. (Berl.)84, 225–233 (1992). Article Google Scholar
Rogers, J., Strohmeyer, R., Kovelowski, C.J. & Li, R. Microglia and inflammatory mechanisms in the clearance of amyloid β peptide. Glia40, 260–269 (2002). Article Google Scholar
Wisniewski, H.M., Wegiel, J., Wang, K.C., Kujawa, M. & Lach, B. Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can. J. Neurol. Sci.16, 535–542 (1989). Article Google Scholar
Wisniewski, H.M., Wegiel, J. & Kotula, L. Some neuropathological aspects of Alzheimer's disease and its relevance to other disciplines. Neuropathol. Appl. Neurobiol.22, 3–11 (1996). Article Google Scholar
Wegiel, J. et al. The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP(SW) mice. Neurobiol. Aging22, 49–61 (2001). Article Google Scholar
Meda, L. et al. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature374, 647–650 (1995). Article Google Scholar
Giulian, D. et al. Specific domains of β-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J. Neurosci.16, 6021–6037 (1996). Article Google Scholar
Qin, L. et al. Microglia enhance β-amyloid peptide–induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J. Neurochem.83, 973–983 (2002). Article Google Scholar
Shao, Y. & McCarthy, K.D. Plasticity of astrocytes. Glia11, 147–155 (1994). Article Google Scholar
Montgomery, D.L. Astrocytes: form, functions, and roles in disease. Vet. Pathol.31, 145–167 (1994). Article Google Scholar
Hatten, M.E., Liem, R.R.M., Shelanset, M.L. & Mason, C.A. Astroglia in CNS injury. Glia4, 233–243 (1991). Article Google Scholar
Al-Ali, S.Y. & Al-Hussain, S.M. An ultrastructural study of the phagocytic activity of astrocytes in adult rat brain. J. Anat.188, 257–262 (1996). PubMedPubMed Central Google Scholar
Guillaume, D., Bertrand, P., Dea, D. & Poirier, J. Apolipoprotein E and low-density lipoprotein binding and internalization in primary cultures of rat astrocytes: isoform specific alterations. J. Neurochem.66, 2410–2418 (1996). Article Google Scholar
Funato, H. et al. Astrocytes containing amyloid β-protein (Aβ)-positive granules are associated with Aβ40-positive diffuse plaques in the aged human brain. Am. J. Pathol.152, 983–992 (1998). PubMedPubMed Central Google Scholar
Matsunaga, W., Shirokawa, T. & Isobe, K. Specific uptake of Aβ1-40 in rat brain occurs in astrocyte, but not in microglia. Neurosci. Lett.342, 129–131 (2003). Article Google Scholar
Wegiel, J., Wang, K.C., Tarnawsk, M. & Lach, B. Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation. Acta. Neuropathol. (Berl).100, 356–364 (2000). Article Google Scholar
Wyss-Coray, T. et al. Adult mouse astrocytes degrade amyloid-β in vitro and in situ. Nat Med.9, 453–457 (2003). Article Google Scholar
Nitta, T., Yagita, H., Sato, K. & Okumura, K. Expression of Fc γ receptors on astroglial cell lines and their role in the central nervous system. Neurosurgery31, 83–87 (1992). PubMed Google Scholar
Warshawsky, I., Bu, G. & Schwartz, A.L. 39-kD protein inhibits tissue-type plasminogen activator clearance in vivo. J. Clin. Invest.92, 937–944 (1993). Article Google Scholar
Gylys, K.H., Fein, J.A., Tan, A.M. & Cole, G.M. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-β protein into synaptic terminals. J. Neurochem.84, 1442–1451 (2003). Article Google Scholar
Urmoneit, B. et al. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid β protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy. Lab. Invest.77, 157–166 (1997). PubMed Google Scholar
Thal, D.R. et al. Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex. Acta. Neuropathol.100, 608–617 (2000). Article Google Scholar
Yamaguchi, H., Sugihara, S., Ogawa, A., Saido, T.C. & Ihara, Y. Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques. Acta. Neuropathol.95, 217–222 (1998). Article Google Scholar
De Groot, C.J. et al. Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization. J. Neurosci. Res.49, 342–354 (1997). Article Google Scholar
Saura, J., Petegnief, V., Wu, X., Liang, Y. & Paul, S.M. Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide. J. Neurochem.85, 1455–1467 (2003). Article Google Scholar
Marr, R.A. et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J. Neurosci.23, 1992–1996 (2003). Article Google Scholar
Manders, E.E.M, Verbeek, F.J. & Aten, J.A. Measurement of co-localisation of objects in dual-colour images. J. Microsc.169, 375–382 (1993). Article Google Scholar