Folkman J., Watson K., Ingber D. & Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature339, 58–61 (1989). ArticleCASPubMed Google Scholar
Gimbrone, M., Leapman, S., Cotran, R. & Folkman, J. Tumor dormancy in vivo by prevention of neovascularization. J. Exp. Med.136, 261–276 (1972). ArticlePubMedPubMed Central Google Scholar
Nicosia R.F., Tchao R. & Leighton J. Interaction between newly formed endothelial channels and carcinoma cells in plasma clot culture. Clin. Exp. Metastasis4, 91–104 (1986). ArticleCASPubMed Google Scholar
Hamada, J., Cavanaugh, P.G., Lotan, O. & Nicolson, G. Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial Cells derived from target organs for metastasis. Br. J. Cancer66, 349–354 (1992). ArticleCASPubMedPubMed Central Google Scholar
Rak, J.W., Filmus, J. & Kerbel, R.S. Reciprocal paracrine interactions between tumour cells and endothelial cells: The ‘angiogenesis progression’ hypothesis. Eur. J. Cancer32A, 2438–2450 (1996). ArticleCASPubMed Google Scholar
Liotta, L., Kleinerman, J. & Saidel F. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res.34, 997–1004 (1974). CASPubMed Google Scholar
Larcher, F. et al. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res.56, 5391–5396 (1996). CASPubMed Google Scholar
Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell86, 353–364 (1996). ArticleCASPubMed Google Scholar
Christofori, G. & Hanahan, D. Molecular dissection of multistage tumorigenesis in transgenic mice. Semin. Cancer Biol.5, 3–21 (1994). CASPubMed Google Scholar
Brooks, P.C. et al. Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest.96, 1815–1822 (1995). ArticleCASPubMedPubMed Central Google Scholar
Ferrara, N. & Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun.161, 851–858 (1989). ArticleCASPubMed Google Scholar
Dvorak H.F., Brown L.F., Detmar, M. & Dvorak, A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol.146, 1029–1039 (1995). CASPubMedPubMed Central Google Scholar
Alon T. et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med.1, 1024–1028 (1995). ArticleCASPubMed Google Scholar
Terman B.I. & Dougher-Vermazen M. Biological properties of VEGF/VPF receptors. Cancer Metastasis Rev.15 159–163 (1996). ArticleCASPubMed Google Scholar
Kim K.J. et al. Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumour growth in vivo. Nature362, 841–844 (1993). ArticleCASPubMed Google Scholar
Cheng, S.-Y. et al. Suppression of glioblastoma angiogenicity and tumoriogenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc. Natl. Acad. Sci. USA93, 8502–8507 (1996). ArticleCASPubMedPubMed Central Google Scholar
Millauer, B., Shawver, L.K., Plate, K.H., Risau, W. & Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative flk-1 mutant. Nature367, 576–579 (1994). ArticleCASPubMed Google Scholar
Millauer, B. et al. Dominant-negative inhibition of flk-1 suppresses the growth of many tumor types in vivo. Cancer Res.56, 1615–1620 (1996). CASPubMed Google Scholar
Warren, R.S., Yuan, H., Matli, M.R., Gillett, N.A. & Ferrara, N. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J. Clin. Invest.95, 1789–1797 (1995). ArticleCASPubMedPubMed Central Google Scholar
Ferrara, N. et al. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J. Clin. Invest.91, 160–170 (1993). ArticleCASPubMedPubMed Central Google Scholar
Zhang, H.-T. et al. Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J. Natl. Cancer Inst.87, 213–219 (1995). ArticleCASPubMed Google Scholar
Claffey, K.P. et al. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis and experimental metastasis. Cancer Res.56, 172–181 (1996). CASPubMed Google Scholar
Detmar, M. Molecular regulation of angiogenesis in the skin. J. Invest. Dermatol.106, 207–208 (1996). ArticleCASPubMed Google Scholar
Boukamp, P. et al. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol.106, 761–771 (1988). ArticleCASPubMed Google Scholar
Boukamp, P., Stanbridge, E.J., Foo, D.Y., Cerutti, P.A. & Fusenig, N.E. c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res.50, 2840–2847 (1990). CASPubMed Google Scholar
Boukamp, P. et al. Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss. Oncogene11, 961–969 (1995). CASPubMed Google Scholar
Fusenig, N.E., Breitkreutz, D., Bohnert, A. & Mackenzie, I.C. Epithelial-mesenchymal interactions in tissue homeostasis and malignant transformation. in: Oral Cancer (ed. Johnson, N. W.) 218–248 (Cambridge Univ. Press, Cambridge, 1991). Google Scholar
Breitkreutz, D. et al. Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line. Cancer Res.51, 4402–4409 (1991). CASPubMed Google Scholar
Rockwell, P., Neufeld, G., Classman, A., Caron, D. & Goldstein, N. In vitro neutralization of vascular endothelial growth factor activation of flk-1 by a monoclonal antibody. Mol. Cell Differ.3(1) 91–109 (1995). CAS Google Scholar
Saez, E. et al. C-fos is required for malignant progression of skin tumors. Cell82, 721–732 (1995). ArticleCASPubMed Google Scholar
Parangi, S. et al. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc. Natl. Acad. Sci. USA93, 2002–2007 (1996). ArticleCASPubMedPubMed Central Google Scholar
Relf M. et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor β-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res.57, 963–969 (1997). CASPubMed Google Scholar
Mandriota, S.J., Menoud, A.-P. & Pepper, M.S. Transforming growth factor β1 downregulates vascular endothelial growth factor receptor 2/flk-1 in vascular endothelial cells. J. Biol. Chem.271, 11500–11505 (1996). ArticleCASPubMed Google Scholar
Patterson, C. et al. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor a in cultured human vascular endothelial cells. J. Clin. Invest.98, 490–496 (1996). ArticleCASPubMedPubMed Central Google Scholar
Yoshida, A., Anandapte, B. & Zetter, B.R. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor. Growth Factors13, 57–64 (1996). ArticleCASPubMed Google Scholar
Holmgren, L., O'Reilly, M.S. & Folkman, J. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med1, 149–153 (1995). ArticleCASPubMed Google Scholar
Tischer, E. et al. The human gene for vascular endothelial growth factor: Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem.266, 11947–11954 (1991). CASPubMed Google Scholar
Millauer, B. et al. High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell72, 835–846 (1993). ArticleCASPubMed Google Scholar
Moorman, A.F.M., De-Boer, P.A.J., Vermeulen, J. Vermeulen, J.L.M. Lamers W.H. Practical aspects of radio-isotopic in situ hybridization on RNA. Histochem. J.25, 251–266 (1992). Article Google Scholar