Human sebaceous tumors harbor inactivating mutations in LEF1 (original) (raw)

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Acknowledgements

We are grateful to the Cancer Research UK (CR-UK) Equipment Park staff for technical assistance with sequencing. We thank P. Bates and B. Ponder for comments, and M. van de Wetering and C. Lo Celso for reagents. This work was supported by CR-UK (to H.T., I.S. and F.M.W.), US National Institutes of Health grant AR02179 (to S.L.), Harvard Skin Disease Research Center grant P30AR042689 (to A.J.F.L.) and a Uehara Memorial Foundation Fellowship (to H.T.). C.C.Z.'s contribution to this work was to provide SZ95 cells; he is a co-author under the terms of a Materials Transfer Agreement with F.M.W.

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Author notes

  1. Hikaru Takeda
    Present address: Department of Dermatology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan

Authors and Affiliations

  1. Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK
    Hikaru Takeda, Ian Smyth & Fiona M Watt
  2. University of Massachusetts Medical School, 364 Plantation Street, Worcester, 01605, Massachusetts, USA
    Stephen Lyle
  3. University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, 77030-4009, Texas, USA
    Alexander J F Lazar
  4. Departments of Dermatology and Immunology, Dessau Medical Center, Dessau, 06847, Germany
    Christos C Zouboulis

Authors

  1. Hikaru Takeda
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  2. Stephen Lyle
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  3. Alexander J F Lazar
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  4. Christos C Zouboulis
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  5. Ian Smyth
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  6. Fiona M Watt
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Corresponding author

Correspondence toFiona M Watt.

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Competing interests

Christos C. Zouboulis is the owner of the patents 'Sebocytes, sebocyte cell line and uses thereof' EP1151082, DE19903920, AU200019804, and has filed patent applications US2002034820, CA2360762, CN1344314T, JP2002535984, IL144683D, PL350191, HU0200048 (international patent priority WO0046353 of 15.12.1999). The other authors declare that they have no competing financial interests.

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Takeda, H., Lyle, S., Lazar, A. et al. Human sebaceous tumors harbor inactivating mutations in LEF1.Nat Med 12, 395–397 (2006). https://doi.org/10.1038/nm1386

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