Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia (original) (raw)
Karin, M. & Greten, F.R. NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol.5, 749–759 (2005). ArticleCAS Google Scholar
Karin, M. Nuclear factor-κB in cancer development and progression. Nature441, 431–436 (2006). ArticleCAS Google Scholar
Portis, T., Harding, J.C. & Ratner, L. The contribution of NF-κB activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. Blood98, 1200–1208 (2001). ArticleCAS Google Scholar
Carrasco, D., Rizzo, C.A., Dorfman, K. & Bravo, R. The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice. EMBO J.15, 3640–3650 (1996). ArticleCAS Google Scholar
Bellavia, D. et al. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J.19, 3337–3348 (2000). ArticleCAS Google Scholar
Mandal, M. et al. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med.201, 603–614 (2005). ArticleCAS Google Scholar
Vacca, A. et al. Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia. EMBO J.25, 1000–1008 (2006). ArticleCAS Google Scholar
Wilson, J.J. & Kovall, R.A. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell124, 985–996 (2006). ArticleCAS Google Scholar
Nam, Y., Sliz, P., Song, L., Aster, J.C. & Blacklow, S.C. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell124, 973–983 (2006). ArticleCAS Google Scholar
Radtke, F., Schweisguth, F. & Pear, W. The Notch 'gospel'. EMBO Rep.6, 1120–1125 (2005). ArticleCAS Google Scholar
Pear, W.S. et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med.183, 2283–2291 (1996). ArticleCAS Google Scholar
Allman, D., Li, J. & Hardy, R.R. Commitment to the B lymphoid lineage occurs before DH-JH recombination. J. Exp. Med.189, 735–740 (1999). ArticleCAS Google Scholar
Beverly, L.J. & Capobianco, A.J. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell3, 551–564 (2003). ArticleCAS Google Scholar
Weng, A.P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science306, 269–271 (2004). ArticleCAS Google Scholar
O'Neil, J. et al. Activating Notch1 mutations in mouse models of T-ALL. Blood107, 781–785 (2006). ArticleCAS Google Scholar
Pui, J.C. et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity11, 299–308 (1999). ArticleCAS Google Scholar
Allman, D. et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J. Exp. Med.194, 99–106 (2001). ArticleCAS Google Scholar
Schmitt, T.M., Ciofani, M., Petrie, H.T. & Zuniga-Pflucker, J.C. Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J. Exp. Med.200, 469–479 (2004). ArticleCAS Google Scholar
Aifantis, I., Gounari, F., Scorrano, L., Borowski, C. & von Boehmer, H. Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT. Nat. Immunol.2, 403–409 (2001). ArticleCAS Google Scholar
Voll, R.E. et al. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity13, 677–689 (2000). ArticleCAS Google Scholar
Reizis, B. & Leder, P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev.16, 295–300 (2002). ArticleCAS Google Scholar
Fan, Y., Rayet, B. & Gelinas, C. Divergent C-terminal transactivation domains of Rel/NF-κB proteins are critical determinants of their oncogenic potential in lymphocytes. Oncogene23, 1030–1042 (2004). ArticleCAS Google Scholar
Maillard, I. et al. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood104, 1696–1702 (2004). ArticleCAS Google Scholar
Oswald, F., Liptay, S., Adler, G. & Schmid, R.M. NF-κB2 is a putative target gene of activated Notch-1 via RBP-Jκ. Mol. Cell. Biol.18, 2077–2088 (1998). ArticleCAS Google Scholar
Palomero, T. et al. CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to γ-secretase inhibitors. Leukemia20, 1279–1287 (2006). ArticleCAS Google Scholar
Burke, J.R. et al. BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF-κB-dependent transcription in mice. J. Biol. Chem.278, 1450–1456 (2003). ArticleCAS Google Scholar
Wahl, C., Liptay, S., Adler, G. & Schmid, R.M. Sulfasalazine: a potent and specific inhibitor of nuclear factor κB. J. Clin. Invest.101, 1163–1174 (1998). ArticleCAS Google Scholar
Spano, J.P., Bay, J.O., Blay, J.Y. & Rixe, O. Proteasome inhibition: a new approach for the treatment of malignancies. Bull. Cancer92, 945–952 (2005). CAS Google Scholar
Chauhan, D., Hideshima, T., Mitsiades, C., Richardson, P. & Anderson, K.C. Proteasome inhibitor therapy in multiple myeloma. Mol. Cancer Ther.4, 686–692 (2005). ArticleCAS Google Scholar
Boothby, M.R., Mora, A.L., Scherer, D.C., Brockman, J.A. & Ballard, D.W. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB. J. Exp. Med.185, 1897–1907 (1997). ArticleCAS Google Scholar
Weng, A.P. et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev.20, 2096–2109 (2006). ArticleCAS Google Scholar
Klinakis, A. et al. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl. Acad. Sci. USA103, 9262–9267 (2006). ArticleCAS Google Scholar
Wang, J. et al. Human Notch-1 inhibits NF-κB activity in the nucleus through a direct interaction involving a novel domain. J. Immunol.167, 289–295 (2001). ArticleCAS Google Scholar
Espinosa, L., Ingles-Esteve, J., Robert-Moreno, A. & Bigas, A. IκBα and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFκB pathways. Mol. Biol. Cell14, 491–502 (2003). ArticleCAS Google Scholar
Oakley, F. et al. Basal expression of IκBα is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. J. Biol. Chem.278, 24359–24370 (2003). ArticleCAS Google Scholar
Shin, H.M. et al. Notch1 augments NF-κB activity by facilitating its nuclear retention. EMBO J.25, 129–138 (2006). ArticleCAS Google Scholar
Aster, J.C. Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities. Int. J. Hematol.82, 295–301 (2005). ArticleCAS Google Scholar
Grabher, C., von Boehmer, H. & Look, A.T. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat. Rev. Cancer.6, 347–359 (2006). ArticleCAS Google Scholar
Fehling, H.J., Krotkova, A., Saint-Ruf, C. & von Boehmer, H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature375, 795–798 (1995). ArticleCAS Google Scholar
Campese, A.F. et al. Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. Blood108, 305–310 (2006). ArticleCAS Google Scholar
Ory, D.S., Neugeboren, B.A. & Mulligan, R.C. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc. Natl. Acad. Sci. USA93, 11400–11406 (1996). ArticleCAS Google Scholar
Borowski, C., Li, X., Aifantis, I., Gounari, F. & Von Boehmer, H. Pre-TCRα and TCRα are not interchangeable partners of TCRβ during T lymphocyte development. J. Exp. Med.199, 607–615 (2004). ArticleCAS Google Scholar
El Andaloussi, A. et al. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat. Immunol.7, 418–426 (2006). ArticleCAS Google Scholar
Palomero, T. et al. Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood108, 986–992 (2006). ArticleCAS Google Scholar
Nickoloff, B.J. et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ. Cell Death Differ.9, 842–855 (2002). ArticleCAS Google Scholar