Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells (original) (raw)

• Wills-Karp, M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255–281 (1999).
  Article CAS Google Scholar
• Adriaensen, D. & Timmermans, J.P. Purinergic signalling in the lung: important in asthma and COPD? Curr. Opin. Pharmacol. 4, 207–214 (2004).
  Article CAS Google Scholar
• Spicuzza, L., Di Maria, G. & Polosa, R. Adenosine in the airways: implications and applications. Eur. J. Pharmacol. 533, 77–88 (2006).
  Article CAS Google Scholar
• Mohsenin, A. & Blackburn, M.R. Adenosine signaling in asthma and chronic obstructive pulmonary disease. Curr. Opin. Pulm. Med. 12, 54–59 (2006).
  Article CAS Google Scholar
• van den Berge, M., Polosa, R., Kerstjens, H.A. & Postma, D.S. The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 114, 737–746 (2004).
  Article CAS Google Scholar
• Burnstock, G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev. 58, 58–86 (2006).
  Article CAS Google Scholar
• Khakh, B.S. & North, R.A. P2X receptors as cell-surface ATP sensors in health and disease. Nature 442, 527–532 (2006).
  Article CAS Google Scholar
• Bours, M.J., Swennen, E.L., Di Virgilio, F., Cronstein, B.N. & Dagnelie, P.C. Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol. Ther. 112, 358–404 (2006).
  Article CAS Google Scholar
• Ferrari, D. et al. Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 159, 1451–1458 (1997).
  CAS PubMed Google Scholar
• Pelleg, A. & Schulman, E.S. Adenosine 5′-triphosphate axis in obstructive airway diseases. Am. J. Ther. 9, 454–464 (2002).
  Article Google Scholar
• Idzko, M. et al. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood 100, 925–932 (2002).
  Article CAS Google Scholar
• la Sala, A. et al. Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses. J. Immunol. 166, 1611–1617 (2001).
  Article CAS Google Scholar
• la Sala, A. et al. Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes. Blood 99, 1715–1722 (2002).
  Article CAS Google Scholar
• Wilkin, F., Stordeur, P., Goldman, M., Boeynaems, J.M. & Robaye, B. Extracellular adenine nucleotides modulate cytokine production by human monocyte-derived dendritic cells: dual effect on IL-12 and stimulation of IL-10. Eur. J. Immunol. 32, 2409–2417 (2002).
  Article CAS Google Scholar
• Ferrari, D. et al. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 176, 3877–3883 (2006).
  Article CAS Google Scholar
• Idzko, M. et al. Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br. J. Pharmacol. 138, 1244–1250 (2003).
  Article CAS Google Scholar
• Coade, S.B. & Pearson, J.D. Metabolism of adenine nucleotides in human blood. Circ. Res. 65, 531–537 (1989).
  Article CAS Google Scholar
• Di Virgilio, F. et al. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97, 587–600 (2001).
  Article CAS Google Scholar
• Schnurr, M. et al. Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells. J. Immunol. 165, 4704–4709 (2000).
  Article CAS Google Scholar
• de Heer, H.J. et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J. Exp. Med. 200, 89–98 (2004).
  Article CAS Google Scholar
• Lambrecht, B.N. et al. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest. 106, 551–559 (2000).
  Article CAS Google Scholar
• Lambrecht, B.N. & Hammad, H. Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat. Rev. Immunol. 3, 994–1003 (2003).
  Article CAS Google Scholar
• van Rijt, L.S. et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201, 981–991 (2005).
  Article CAS Google Scholar
• Idzko, M. et al. Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J. Clin. Invest. 116, 2935–2944 (2006).
  Article CAS Google Scholar
• Abbracchio, M.P. et al. International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 58, 281–341 (2006).
  Article CAS Google Scholar
• Vermaelen, K.Y., Carro-Muino, I., Lambrecht, B.N. & Pauwels, R.A. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193, 51–60 (2001).
  Article CAS Google Scholar
• la Sala, A. et al. Alerting and tuning the immune response by extracellular nucleotides. J. Leukoc. Biol. 73, 339–343 (2003).
  Article CAS Google Scholar
• Beigi, R., Kobatake, E., Aizawa, M. & Dubyak, G.R. Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase. Am. J. Physiol. 276, C267–C278 (1999).
  Article CAS Google Scholar
• Pitchford, S.C. & Page, C.P. Platelet activation in asthma: integral to the inflammatory response. Clin. Exp. Allergy 36, 399–401 (2006).
  Article CAS Google Scholar
• Kowal, K., Pampuch, A., Kowal-Bielecka, O., DuBuske, L.M. & Bodzenta-Lukaszyk, A. Platelet activation in allergic asthma patients during allergen challenge with Dermatophagoides pteronyssinus. Clin. Exp. Allergy 36, 426–432 (2006).
  Article CAS Google Scholar
• Robson, S.C. et al. Loss of ATP diphosphohydrolase activity with endothelial cell activation. J. Exp. Med. 185, 153–163 (1997).
  Article CAS Google Scholar
• Chen, Y. et al. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 314, 1792–1795 (2006).
  Article CAS Google Scholar
• Huh, J.C. et al. Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J. Exp. Med. 198, 19–30 (2003).
  Article CAS Google Scholar
• Kohl, J. et al. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J. Clin. Invest. 116, 783–796 (2006).
  Article CAS Google Scholar
• Zhou, B. et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat. Immunol. 6, 1047–1053 (2005).
  Article CAS Google Scholar
• Harris, N.L., Watt, V., Ronchese, F. & Le Gros, G. Differential T cell function and fate in lymph node and nonlymphoid tissues. J. Exp. Med. 195, 317–326 (2002).
  Article CAS Google Scholar
• Ferrari, D. et al. Activation of human eosinophils via P2 receptors: novel findings and future perspectives. J. Leukoc. Biol. 79, 7–15 (2006).
  Article CAS Google Scholar
• Piggott, D.A. et al. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J. Clin. Invest. 115, 459–467 (2005).
  Article CAS Google Scholar
• Granstein, R.D. et al. Augmentation of cutaneous immune responses by ATP gamma S: purinergic agonists define a novel class of immunologic adjuvants. J. Immunol. 174, 7725–7731 (2005).
  Article CAS Google Scholar
• Gallucci, S. & Matzinger, P. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 13, 114–119 (2001).
  Article CAS Google Scholar
• Di Virgilio, F. Purinergic mechanism in the immune system: a signal of danger for dendritic cells. Purinergic Signal. 1, 205–209 (2005).
  Article CAS Google Scholar
• Mizumoto, N. et al. CD39 is the dominant Langerhans cell–associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat. Med. 8, 358–365 (2002).
  Article CAS Google Scholar
• Hollander, G.A., Zuklys, S., Forster, E. & Krenger, W. On costimulatory signals and T cell tolerance: relevance for transplantation immunity. Transplant. Proc. 31, 25S–31S (1999).
  Article CAS Google Scholar
• Laubinger, W., Tulapurkar, M.E., Schafer, R. & Reiser, G. Distinct mono- and dinucleotide-specific P2Y receptors in A549 lung epithelial cells: different control of arachidonic acid release and nitric oxide synthase expression. Eur. J. Pharmacol. 543, 1–7 (2006).
  Article CAS Google Scholar
• Muller, T. et al. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. Am. J. Respir. Cell Mol. Biol. 33, 601–609 (2005).
  Article Google Scholar
• Douillet, C.D., Robinson, W.P., III, Milano, P.M., Boucher, R.C. & Rich, P.B. Nucleotides induce IL-6 release from human airway epithelia via P2Y2 and p38 MAPK-dependent pathways. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L734–L746 (2006).
  Article CAS Google Scholar
• Mariathasan, S. et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228–232 (2006).
  Article CAS Google Scholar
• Ogura, Y., Sutterwala, F.S. & Flavell, R.A. The inflammasome: first line of the immune response to cell stress. Cell 126, 659–662 (2006).
  Article CAS Google Scholar
• Lommatzsch, M. et al. The course of allergen-induced leukocyte infiltration in human and experimental asthma. J. Allergy Clin. Immunol. 118, 91–97 (2006).
  Article CAS Google Scholar