TLR4 enhances TGF-β signaling and hepatic fibrosis (original) (raw)

• Bataller, R. & Brenner, D.A. Liver fibrosis. J. Clin. Invest. 115, 209–218 (2005).
  Article CAS Google Scholar
• Friedman, S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275, 2247–2250 (2000).
  Article CAS Google Scholar
• Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499–511 (2004).
  Article CAS Google Scholar
• Jiang, D. et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 11, 1173–1179 (2005).
  Article CAS Google Scholar
• Bjorkbacka, H. et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat. Med. 10, 416–421 (2004).
  Article Google Scholar
• Zhai, Y. et al. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3–dependent MyD88-independent pathway. J. Immunol. 173, 7115–7119 (2004).
  Article CAS Google Scholar
• Tsung, A. et al. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J. Immunol. 175, 7661–7668 (2005).
  Article CAS Google Scholar
• Uesugi, T., Froh, M., Arteel, G.E., Bradford, B.U. & Thurman, R.G. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 34, 101–108 (2001).
  Article CAS Google Scholar
• Seki, E. et al. Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology 41, 443–450 (2005).
  Article CAS Google Scholar
• Schwabe, R.F., Seki, E. & Brenner, D.A. Toll-like receptor signaling in the liver. Gastroenterology 130, 1886–1900 (2006).
  Article CAS Google Scholar
• Seki, E. et al. Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β. J. Immunol. 166, 2651–2657 (2001).
  Article CAS Google Scholar
• Duffield, J.S. et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 115, 56–65 (2005).
  Article CAS Google Scholar
• Rivera, C.A. et al. Attenuation of CCl4-induced hepatic fibrosis by GdCl3 treatment or dietary glycine. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G200–G207 (2001).
  Article CAS Google Scholar
• Paik, Y.H. et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37, 1043–1055 (2003).
  Article CAS Google Scholar
• Brun, P., Castagliuolo, I., Pinzani, M., Palu, G. & Martines, D. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G571–G578 (2005).
  Article CAS Google Scholar
• Muhlbauer, M. et al. LPS-mediated NF-κB activation varies between activated human hepatic stellate cells from different donors. Biochem. Biophys. Res. Commun. 325, 191–197 (2004).
  Article Google Scholar
• Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229–241 (2004).
  Article CAS Google Scholar
• Magilavy, D.B. & Rothstein, J.L. Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice. J. Exp. Med. 168, 789–794 (1988).
  Article CAS Google Scholar
• Yata, Y. et al. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology 37, 267–276 (2003).
  Article CAS Google Scholar
• Onichtchouk, D. et al. Silencing of TGF-β signalling by the pseudoreceptor Bambi. Nature 401, 480–485 (1999).
  Article CAS Google Scholar
• Iimuro, Y. et al. NF-κB prevents apoptosis and liver dysfunction during liver regeneration. J. Clin. Invest. 101, 802–811 (1998).
  Article CAS Google Scholar
• Maeda, S., Kamata, H., Luo, J.L., Leffert, H. & Karin, M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121, 977–990 (2005).
  Article CAS Google Scholar
• Pikarsky, E. et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 431, 461–466 (2004).
  Article CAS Google Scholar
• Isogawa, M., Robek, M.D., Furuichi, Y. & Chisari, F.V. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J. Virol. 79, 7269–7272 (2005).
  Article CAS Google Scholar
• Izuishi, K. et al. Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J. Immunol. 176, 7154–7158 (2006).
  Article CAS Google Scholar
• Lotze, M.T. & Tracey, K.J. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat. Rev. Immunol. 5, 331–342 (2005).
  Article CAS Google Scholar
• Termeer, C. et al. Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor 4. J. Exp. Med. 195, 99–111 (2002).
  Article CAS Google Scholar
• Tsung, A. et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 201, 1135–1143 (2005).
  Article CAS Google Scholar
• Isayama, F. et al. LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1318–G1328 (2006).
  Article CAS Google Scholar
• Friedman, S.L. & Arthur, M.J. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J. Clin. Invest. 84, 1780–1785 (1989).
  Article CAS Google Scholar
• De Minicis, S. et al. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 132, 1937–1946 (2007).
  Article CAS Google Scholar
• Sasaki, T., Sasahira, T., Shimura, H., Ikeda, S. & Kuniyasu, H. Effect of Nma on growth inhibition by TGF-β in human gastric carcinoma cell lines. Oncol. Rep. 11, 1219–1223 (2004).
  CAS PubMed Google Scholar
• Tsang, M. et al. Zebrafish nma is involved in TGF-β family signaling. Genesis 28, 47–57 (2000).
  Article CAS Google Scholar
• Sekiya, T. et al. Identification of BMP and activin membrane-bound inhibitor (Bambi), an inhibitor of transforming growth factor-β signaling, as a target of the β-catenin pathway in colorectal tumor cells. J. Biol. Chem. 279, 6840–6846 (2004).
  Article CAS Google Scholar
• Sekiya, T., Oda, T., Matsuura, K. & Akiyama, T. Transcriptional regulation of the TGF-β pseudoreceptor Bambi by TGF-β signaling. Biochem. Biophys. Res. Commun. 320, 680–684 (2004).
  Article CAS Google Scholar
• Oakley, F. et al. Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 128, 108–120 (2005).
  Article CAS Google Scholar
• Thurman, R.G. et al. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J. Gastroenterol. Hepatol. 13 Suppl, S39–S50 (1998).
  Article CAS Google Scholar
• Diehl, A.M., Li, Z.P., Lin, H.Z. & Yang, S.Q. Cytokines and the pathogenesis of non-alcoholic steatohepatitis. Gut 54, 303–306 (2005).
  Article CAS Google Scholar
• Campbell, J.S. et al. Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. J. Immunol. 176, 2522–2528 (2006).
  Article CAS Google Scholar
• Huang, H. et al. A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology, 46, 297–306 (2007).
  Article CAS Google Scholar
• Hoebe, K. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424, 743–748 (2003).
  Article CAS Google Scholar
• Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143–150 (1998).
  Article CAS Google Scholar
• Kisseleva, T. et al. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J. Hepatol. 45, 429–438 (2006).
  Article CAS Google Scholar
• Kennedy, D.W. & Abkowitz, J.L. Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90, 986–993 (1997).
  CAS PubMed Google Scholar
• Van Rooijen, N. & Sanders, A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J. Immunol. Methods 174, 83–93 (1994).
  Article CAS Google Scholar
• Bataller, R. et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J. Clin. Invest. 112, 1383–1394 (2003).
  Article CAS Google Scholar
• Siegmund, S.V., Uchinami, H., Osawa, Y., Brenner, D.A. & Schwabe, R.F. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology 41, 1085–1095 (2005).
  Article CAS Google Scholar