Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells (original) (raw)
- Brief Communication
- Published: 18 May 2003
- Joleen Kajdas1,
- Diana Finzi2,
- Thomas C Quinn1,2,
- Karen Chadwick3,
- Joseph B Margolick3,
- Colin Kovacs4,
- Stephen J Gange5 &
- …
- Robert F Siliciano1
Nature Medicine volume 9, pages 727–728 (2003)Cite this article
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Abstract
Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t1/2 = 44 months) that eradication is unlikely.
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Figure 1: Extremely slow decay of the latent reservoir in patients on HAART.
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Acknowledgements
We thank S. Barnett for coordinating patient visits. This work was supported by National Institutes of Health grant AI43222 to R.F.S. and by a grant from the Doris Duke Charitable Foundation.
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Authors and Affiliations
- Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA
Janet D Siliciano, Joleen Kajdas, Thomas C Quinn & Robert F Siliciano - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA
Diana Finzi & Thomas C Quinn - Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, 21205, Maryland, USA
Karen Chadwick & Joseph B Margolick - Department of Medicine, University of Toronto, Toronto, M5B 1L6, Ontario, Canada
Colin Kovacs - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, 21205, Maryland, USA
Stephen J Gange
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- Janet D Siliciano
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Correspondence toRobert F Siliciano.
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Siliciano, J., Kajdas, J., Finzi, D. et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.Nat Med 9, 727–728 (2003). https://doi.org/10.1038/nm880
- Received: 11 February 2003
- Accepted: 22 April 2003
- Published: 18 May 2003
- Issue Date: 01 June 2003
- DOI: https://doi.org/10.1038/nm880