Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance (original) (raw)
Boden, G. & Shulman, G.I. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur. J. Clin. Invest.32, 14–23 (2002). ArticleCAS Google Scholar
McGarry, J.D. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes51, 7–18 (2002). ArticleCAS Google Scholar
Shulman, G.I. Cellular mechanisms of insulin resistance. J. Clin. Invest.106, 171–176 (2000). ArticleCAS Google Scholar
Buettner, R., Newgard, C.B., Rhodes, C.J. & O'Doherty, R.M. Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. Am. J. Physiol. Endocrinol. Metab.278, 563–569 (2000). Article Google Scholar
Higa, M. et al. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc. Natl. Acad. Sci. USA96, 11513–11518 (1999). ArticleCAS Google Scholar
Mayerson, A.B. et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes51, 797–802 (2002). ArticleCAS Google Scholar
Kim, J.K., Gavrilova, O., Chen, Y., Reitman, M.L. & Shulman, G.I. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J. Biol. Chem.275, 8456–8460 (2000). ArticleCAS Google Scholar
McGarry, J.D. et al. New insights into the mitochondrial carnitine palmitoyltransferase enzyme system. Biochimie73, 77–84 (1991). ArticleCAS Google Scholar
Mulder, H. et al. Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells. J. Biol. Chem.276, 6479–6484 (2001). ArticleCAS Google Scholar
Herz, J. & Gerard, R.D. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA90, 2812–2816 (1993). ArticleCAS Google Scholar
O'Doherty, R.M., Lehman, D.L., Telemaque-Potts, S. & Newgard, C.B. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes48, 2022–2027 (1999). ArticleCAS Google Scholar
Chu, A.C. et al. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Am. J. Physiol. (in the press).
Millington, D.S., Kodo, N., Norwood, D.L. & Roe, C.R. Tandem mass spectrometry: a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism. J. Inherit. Metab. Dis.13, 321–324 (1990). ArticleCAS Google Scholar
Holness, M.J. & Sugden, M.C. Glucose disposal by skeletal muscle in response to re-feeding after progressive starvation. Biochem. J.277 (part 2), 429–433 (1991). ArticleCAS Google Scholar
Ruderman, N.B., Goodman, M.N., Berger, M. & Hagg, S. Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter. Fed. Proc.36, 171–176 (1977). CAS Google Scholar
Goodpaster, B.H., He, J., Watkins, S. & Kelley, D.E. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab.86, 5755–5761 (2001). ArticleCAS Google Scholar
Hoppeler, H. et al. Endurance training in humans: aerobic capacity and structure of skeletal muscle. J. Appl. Physiol.59, 320–327 (1985). ArticleCAS Google Scholar
Yu, C. et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem.277, 50230–50236 (2002). ArticleCAS Google Scholar
Aguirre, V. et al. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem.277, 1531–1537 (2002). ArticleCAS Google Scholar
Leone, T.C., Weinheimer, C.J. & Kelly, D.P. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. USA96, 7473–7478 (1999). ArticleCAS Google Scholar
Guerre-Millo, M. et al. PPAR-α-null mice are protected from high-fat diet-induced insulin resistance. Diabetes50, 2809–2814 (2001). ArticleCAS Google Scholar
Tordjman, K. et al. PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J. Clin. Invest.107, 1025–1034 (2001). ArticleCAS Google Scholar
Muoio, D.M. et al. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice - Evidence for compensatory regulation by PPAR δ. J. Biol. Chem.277, 26089–26097 (2002). ArticleCAS Google Scholar
Randle, P.J., Newsholme, E.A. & Garland, P.B. Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem. J.93, 652–665 (1964). ArticleCAS Google Scholar
Singh, B.M., Krentz, A.J. & Nattrass, M. Insulin resistance in the regulation of lipolysis and ketone body metabolism in non-insulin dependent diabetes is apparent at very low insulin concentrations. Diabetes Res. Clin. Pract.20, 55–62 (1993). ArticleCAS Google Scholar
Russell, R.R., III & Taegtmeyer, H. Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate. J. Clin. Invest.87, 384–390 (1991). ArticleCAS Google Scholar
Russell, R.R., III & Taegtmeyer, H. Coenzyme A sequestration in rat hearts oxidizing ketone bodies. J. Clin. Invest.89, 968–973 (1992). ArticleCAS Google Scholar
Tardif, A. et al. Chronic exposure to beta-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes. Am. J. Physiol. Endocrinol. Metab.281, E1205–E1212 (2001). ArticleCAS Google Scholar
Patti, M.E. et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. USA100, 8466–8471 (2003). ArticleCAS Google Scholar
Petersen, K.F. et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science300, 1140–1142 (2003). ArticleCAS Google Scholar
Mascaro, C., Buesa, C., Ortiz, J.A., Haro, D. & Hegardt, F.G. Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase. Arch. Biochem. Biophys.317, 385–390 (1995). ArticleCAS Google Scholar
Abu-Elheiga, L., Oh, W., Kordari, P. & Wakil, S.J. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc. Natl. Acad. Sci. USA100, 10207–10212 (2003). ArticleCAS Google Scholar
Abu-Elheiga, L., Matzuk, M.M., Abo-Hashema, K.A. & Wakil, S.J. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science291, 2613–2616 (2001). ArticleCAS Google Scholar
Abu-Elheiga, L. et al. The subcellular localization of acetyl-CoA carboxylase 2. Proc. Natl. Acad. Sci. USA97, 1444–1449 (2000). ArticleCAS Google Scholar
Abel, E.D. et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature409, 729–733 (2001). ArticleCAS Google Scholar
Becker, T.C. et al. Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol.43, 161–189 (1994). ArticleCAS Google Scholar
Massague, J. & Guinovart, J.J. Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose. FEBS Lett.82, 317–320 (1977). ArticleCAS Google Scholar
Antinozzi, P.A., Segall, L., Prentki, M., McGarry, J.D. & Newgard, C.B. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis. J. Biol. Chem.273, 16146–16154 (1998). ArticleCAS Google Scholar
Lee, Y. et al. Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Diabetes46, 408–413 (1997). ArticleCAS Google Scholar
Yuan, M. et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science293, 1673–1677 (2001). ArticleCAS Google Scholar
Shao, J., Yamashita, H., Qiao, L. & Friedman, J.E. Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice. J. Endocrinol.167, 107–115 (2000). ArticleCAS Google Scholar
Summers, S.A., Whiteman, E.L., Cho, H., Lipfert, L. & Birnbaum, M.J. Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes. J. Biol. Chem.274, 23858–23867 (1999). ArticleCAS Google Scholar
Milburn, J.L. Jr. et al. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J. Biol. Chem.270, 1295–1299 (1995). ArticleCAS Google Scholar
Newgard, C.B., Moore, S.V., Foster, D.W. & McGarry, J.D. Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. J. Biol. Chem.259, 6958–6963 (1984). CAS Google Scholar
McGarry, J.D., Stark, M.J. & Foster, D.W. Hepatic malonyl-CoA levels of fed, fasted and diabetic rat liver as measured using a simple radioisotopic assay. J. Biol. Chem.253, 8291–8293 (1978). CAS Google Scholar