Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia (original) (raw)
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Acknowledgements
This work was supported by grants to M.J. (BMBF-01GI0705), F.L.H. (SFB-TR43, Exc 25 and National Institutes of Neurological Disorders and Stroke R01 NS046006) and P.M.M. (US National Institutes of Health AG017617 and NS045205).
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Author notes
- Stefan A Grathwohl and Roland E Kälin: These authors contributed equally to this work.
- Frank L Heppner and Mathias Jucker: These authors jointly directed the study.
Authors and Affiliations
- Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
Stefan A Grathwohl, Tristan Bolmont, Stephan A Kaeser, Jörg Odenthal, Rebecca Radde & Mathias Jucker - German Center for Neurodegenerative Diseases, Tübingen, Germany
Stefan A Grathwohl, Tristan Bolmont, Stephan A Kaeser, Jörg Odenthal, Rebecca Radde & Mathias Jucker - Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany
Stefan A Grathwohl - Department of Neuropathology, Charité–Universitätsmedizin Berlin, Berlin, Germany
Roland E Kälin, Stefan Prokop, Georg Winkelmann & Frank L Heppner - Department of Radiation Oncology, University of Tübingen, Tübingen, Germany
Therese Eldh - Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
Sam Gandy - Department of Pathology, Institute of Neuropathology, University Hospital, Zürich, Switzerland
Adriano Aguzzi - Novartis Institutes for Biomedical Research, Nervous System Research, Basel, Switzerland
Matthias Staufenbiel - Nathan Kline Institute, Orangeburg, New York, USA
Paul M Mathews - Departments of Psychiatry, New York University School of Medicine, New York, New York, USA
Paul M Mathews - Department of Pathology, University of Tübingen, Tübingen, Germany
Hartwig Wolburg
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- Stefan A Grathwohl
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Contributions
S.A.G., T.B., S.A.K., J.O., R.R., T.E., P.M.M. and H.W. performed the icv experiments. R.E.K., S.P. and G.W. carried out the oral treatment experiments. A.A., M.S. and S.G. provided mice and/or advice. Experimental design and manuscript preparation were mainly carried out by F.L.H. and M.J.
Corresponding authors
Correspondence toFrank L Heppner or Mathias Jucker.
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Grathwohl, S., Kälin, R., Bolmont, T. et al. Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia.Nat Neurosci 12, 1361–1363 (2009). https://doi.org/10.1038/nn.2432
- Received: 12 June 2009
- Accepted: 24 September 2009
- Published: 18 October 2009
- Issue Date: November 2009
- DOI: https://doi.org/10.1038/nn.2432