Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia (original) (raw)

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Acknowledgements

This work was supported by grants to M.J. (BMBF-01GI0705), F.L.H. (SFB-TR43, Exc 25 and National Institutes of Neurological Disorders and Stroke R01 NS046006) and P.M.M. (US National Institutes of Health AG017617 and NS045205).

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Author notes

  1. Stefan A Grathwohl and Roland E Kälin: These authors contributed equally to this work.
  2. Frank L Heppner and Mathias Jucker: These authors jointly directed the study.

Authors and Affiliations

  1. Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
    Stefan A Grathwohl, Tristan Bolmont, Stephan A Kaeser, Jörg Odenthal, Rebecca Radde & Mathias Jucker
  2. German Center for Neurodegenerative Diseases, Tübingen, Germany
    Stefan A Grathwohl, Tristan Bolmont, Stephan A Kaeser, Jörg Odenthal, Rebecca Radde & Mathias Jucker
  3. Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany
    Stefan A Grathwohl
  4. Department of Neuropathology, Charité–Universitätsmedizin Berlin, Berlin, Germany
    Roland E Kälin, Stefan Prokop, Georg Winkelmann & Frank L Heppner
  5. Department of Radiation Oncology, University of Tübingen, Tübingen, Germany
    Therese Eldh
  6. Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
    Sam Gandy
  7. Department of Pathology, Institute of Neuropathology, University Hospital, Zürich, Switzerland
    Adriano Aguzzi
  8. Novartis Institutes for Biomedical Research, Nervous System Research, Basel, Switzerland
    Matthias Staufenbiel
  9. Nathan Kline Institute, Orangeburg, New York, USA
    Paul M Mathews
  10. Departments of Psychiatry, New York University School of Medicine, New York, New York, USA
    Paul M Mathews
  11. Department of Pathology, University of Tübingen, Tübingen, Germany
    Hartwig Wolburg

Authors

  1. Stefan A Grathwohl
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  2. Roland E Kälin
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  3. Tristan Bolmont
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  4. Stefan Prokop
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  5. Georg Winkelmann
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  6. Stephan A Kaeser
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  7. Jörg Odenthal
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  8. Rebecca Radde
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  9. Therese Eldh
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  10. Sam Gandy
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  11. Adriano Aguzzi
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  12. Matthias Staufenbiel
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  13. Paul M Mathews
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  14. Hartwig Wolburg
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  15. Frank L Heppner
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  16. Mathias Jucker
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Contributions

S.A.G., T.B., S.A.K., J.O., R.R., T.E., P.M.M. and H.W. performed the icv experiments. R.E.K., S.P. and G.W. carried out the oral treatment experiments. A.A., M.S. and S.G. provided mice and/or advice. Experimental design and manuscript preparation were mainly carried out by F.L.H. and M.J.

Corresponding authors

Correspondence toFrank L Heppner or Mathias Jucker.

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Grathwohl, S., Kälin, R., Bolmont, T. et al. Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia.Nat Neurosci 12, 1361–1363 (2009). https://doi.org/10.1038/nn.2432

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