Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1 (original) (raw)

• Goff, D.C. & Coyle, J.T. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am. J. Psychiatry 158, 1367–1377 (2001).
  Article CAS Google Scholar
• Moghaddam, B. Bringing order to the glutamate chaos in schizophrenia. Neuron 40, 881–884 (2003).
  Article CAS Google Scholar
• McCullumsmith, R.E., Clinton, S.M. & Meador-Woodruff, J.H. Schizophrenia as a disorder of neuroplasticity. Int. Rev. Neurobiol. 59, 19–45 (2004).
  Article CAS Google Scholar
• Glantz, L.A. & Lewis, D.A. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch. Gen. Psychiatry 57, 65–73 (2000).
  Article CAS Google Scholar
• Garey, L.J. et al. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J. Neurol. Neurosurg. Psychiatry 65, 446–453 (1998).
  Article CAS Google Scholar
• Maletic-Savatic, M., Malinow, R. & Svoboda, K. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science 283, 1923–1927 (1999).
  Article CAS Google Scholar
• Matsuzaki, M., Honkura, N., Ellis-Davies, G.C. & Kasai, H. Structural basis of long-term potentiation in single dendritic spines. Nature 429, 761–766 (2004).
  Article CAS Google Scholar
• Steen, R.G., Hamer, R.M. & Lieberman, J.A. Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology 30, 1949–1962 (2005).
  Article CAS Google Scholar
• Pilowsky, L.S. et al. First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Mol. Psychiatry 11, 118–119 (2006).
  Article CAS Google Scholar
• Mirnics, K., Middleton, F.A., Lewis, D.A. & Levitt, P. Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci. 24, 479–486 (2001).
  Article CAS Google Scholar
• Hill, J.J., Hashimoto, T. & Lewis, D.A. Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Mol. Psychiatry 11, 557–566 (2006).
  Article CAS Google Scholar
• Fischer, M., Kaech, S., Knutti, D. & Matus, A. Rapid actin-based plasticity in dendritic spines. Neuron 20, 847–854 (1998).
  Article CAS Google Scholar
• Carlisle, H.J. & Kennedy, M.B. Spine architecture and synaptic plasticity. Trends Neurosci. 28, 182–187 (2005).
  Article CAS Google Scholar
• Harrison, P.J. & West, V.A. Six degrees of separation: on the prior probability that schizophrenia susceptibility genes converge on synapses, glutamate and NMDA receptors. Mol. Psychiatry 11, 981–983 (2006).
  Article CAS Google Scholar
• Hashimoto, R., Tankou, S., Takeda, M. & Sawa, A. Postsynaptic density: a key convergent site for schizophrenia susceptibility factors and possible target for drug development. Drugs Today (Barc) 43, 645–654 (2007).
  Article CAS Google Scholar
• Sheng, M. & Hoogenraad, C.C. The postsynaptic architecture of excitatory synapses: a more quantitative view. Annu. Rev. Biochem. 76, 823–847 (2007).
  Article CAS Google Scholar
• Blanpied, T.A., Kerr, J.M. & Ehlers, M.D. Structural plasticity with preserved topology in the postsynaptic protein network. Proc. Natl. Acad. Sci. USA 105, 12587–12592 (2008).
  Article CAS Google Scholar
• St. Clair, D. et al. Association within a family of a balanced autosomal translocation with major mental illness. Lancet 336, 13–16 (1990).
  Article CAS Google Scholar
• Callicott, J.H. et al. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc. Natl. Acad. Sci. USA 102, 8627–8632 (2005).
  Article CAS Google Scholar
• Cannon, T.D. et al. Association of DISCC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch. Gen. Psychiatry 62, 1205–1213 (2005).
  Article CAS Google Scholar
• Ishizuka, K., Paek, M., Kamiya, A. & Sawa, A. A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol. Psychiatry 59, 1189–1197 (2006).
  Article CAS Google Scholar
• Chubb, J.E., Bradshaw, N.J., Soares, D.C., Porteous, D.J. & Millar, J.K. The DISC locus in psychiatric illness. Mol. Psychiatry 13, 36–64 (2008).
  Article CAS Google Scholar
• Kirkpatrick, B. et al. DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. J. Comp. Neurol. 497, 436–450 (2006).
  Article Google Scholar
• Kvajo, M. et al. A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc. Natl. Acad. Sci. USA 105, 7076–7081 (2008).
  Article CAS Google Scholar
• Kamiya, A. et al. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat. Cell Biol. 7, 1167–1178 (2005).
  Article Google Scholar
• Shi, S.H. et al. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284, 1811–1816 (1999).
  Article CAS Google Scholar
• Xie, Z. et al. Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines. Neuron 56, 640–656 (2007).
  Article CAS Google Scholar
• Ma, X.M., Wang, Y., Ferraro, F., Mains, R.E. & Eipper, B.A. Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons. J. Neurosci. 28, 711–724 (2008).
  Article CAS Google Scholar
• Cahill, M. et al. Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proc. Natl. Acad. Sci. USA 106, 13058–13063 (2009).
  Article CAS Google Scholar
• Saneyoshi, T. et al. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron 57, 94–107 (2008).
  Article CAS Google Scholar
• Tolias, K.F. et al. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron 45, 525–538 (2005).
  Article CAS Google Scholar
• Bolger, G.B. et al. Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem. J. 398, 23–36 (2006).
  Article CAS Google Scholar
• Millar, J.K. et al. Drosoph. Inf. Serv.C1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310, 1187–1191 (2005).
  Article CAS Google Scholar
• Murdoch, H. et al. Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. J. Neurosci. 27, 9513–9524 (2007).
  Article CAS Google Scholar
• Taya, S. et al. DISC1 regulates the transport of the NUDEL/LIS1/14–3-3epsilon complex through kinesin-1. J. Neurosci. 27, 15–26 (2007).
  Article CAS Google Scholar
• Steward, O. & Worley, P.F. Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30, 227–240 (2001).
  Article CAS Google Scholar
• Hsueh, Y.P., Kim, E. & Sheng, M. Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. Neuron 18, 803–814 (1997).
  Article CAS Google Scholar
• Djinovic-Carugo, K., Gautel, M., Ylanne, J. & Young, P. The spectrin repeat: a structural platform for cytoskeletal protein assemblies. FEBS Lett. 513, 119–123 (2002).
  Article CAS Google Scholar
• Rabiner, C.A., Mains, R.E. & Eipper, B.A. Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts. Neuroscientist 11, 148–160 (2005).
  Article CAS Google Scholar
• Luo, L. et al. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379, 837–840 (1996).
  Article CAS Google Scholar
• Tashiro, A., Minden, A. & Yuste, R. Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho. Cereb. Cortex 10, 927–938 (2000).
  Article CAS Google Scholar
• Camargo, L.M. et al. Disrupted in Schizophrenia 1 interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol. Psychiatry 12, 74–86 (2007).
  Article CAS Google Scholar
• Ishizuka, K. et al. Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Mol. Psychiatry 12, 897–899 (2007).
  Article CAS Google Scholar
• Jaaro-Peled, H. et al. Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through Neuregulin-1 and DISC1. Trends Neurosci. 32, 485–495 (2009).
  Article CAS Google Scholar
• McGlashan, T.H. & Hoffman, R.E. Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Arch. Gen. Psychiatry 57, 637–648 (2000).
  Article CAS Google Scholar
• Schurov, I.L., Handford, E.J., Brandon, N.J. & Whiting, P.J. Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol. Psychiatry 9, 1100–1110 (2004).
  Article CAS Google Scholar
• Holtmaat, A.J. et al. Transient and persistent dendritic spines in the neocortex in vivo. Neuron 45, 279–291 (2005).
  Article CAS Google Scholar
• McGlashan, T.H. & Johannessen, J.O. Early detection and intervention with schizophrenia: rationale. Schizophr. Bull. 22, 201–222 (1996).
  Article CAS Google Scholar
• Koike, H., Arguello, P.A., Kvajo, M., Karayiorgou, M. & Gogos, J.A. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc. Natl. Acad. Sci. USA 103, 3693–3697 (2006).
  Article CAS Google Scholar
• Cai, X., Gu, Z., Zhong, P., Ren, Y. & Yan, Z. Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons. J. Biol. Chem. 277, 36553–36562.