miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity (original) (raw)

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Acknowledgements

We thank J. Sharma and C. Runyan for feedback, G. Kreiman for assistance with data analysis, M. Constantine-Paton and her laboratory for sharing equipment and B. Karki for technical assistance. Supported by US National Eye Institute Ruth L. Kirschstein Postdoctoral Fellowship 1F32EY020066-01 (N.M.), Helmholtz Young Investigator program HZ-NG-607 (D.E.), a Simons Foundation postdoctoral fellowship (A.B.) and US National Institutes of Health EY017098 and EY007023 to M.S.

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Author notes

  1. Daniela Tropea
    Present address: Present address: Trinity College Dublin, St. James Hospital, Dublin, Ireland.,
  2. Nikolaos Mellios and Hiroki Sugihara: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nikolaos Mellios, Hiroki Sugihara, Jorge Castro, Abhishek Banerjee, Chuong Le, Arooshi Kumar, Benjamin Crawford, Daniela Tropea & Mriganka Sur
  2. DZNE - German Center for Neurodegenerative Diseases, Munich, Germany
    Julia Strathmann & Dieter Edbauer
  3. Biomicro Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Stuart S Levine

Authors

  1. Nikolaos Mellios
  2. Hiroki Sugihara
  3. Jorge Castro
  4. Abhishek Banerjee
  5. Chuong Le
  6. Arooshi Kumar
  7. Benjamin Crawford
  8. Julia Strathmann
  9. Daniela Tropea
  10. Stuart S Levine
  11. Dieter Edbauer
  12. Mriganka Sur

Contributions

N.M. conceived the hypothesis, designed and executed experiments, analyzed the data, and wrote the manuscript. H.S. conducted in vivo two-photon calcium imaging and analyzed the related data. J.C. conducted neonatal virus injections and structural analysis. A.B. carried out slice electrophysiology. A.B., C.L., A.K., B.C., J.C. and D.T. assisted in various experiments, data analysis and figure preparation. J.S. and D.E. constructed and tested lentivirus vectors and S.S.L. performed miRNA microarray experiments. M.S. supervised and orchestrated all of the experiments and wrote the manuscript with N.M.

Corresponding author

Correspondence toMriganka Sur.

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Competing interests

The authors declare no competing financial interests.

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Mellios, N., Sugihara, H., Castro, J. et al. miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.Nat Neurosci 14, 1240–1242 (2011). https://doi.org/10.1038/nn.2909

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