Calcium dynamics in astrocyte processes during neurovascular coupling (original) (raw)

• Iadecola, C. & Nedergaard, M. Glial regulation of the cerebral microvasculature. Nat. Neurosci. 10, 1369–1376 (2007).
  Article CAS PubMed Google Scholar
• Attwell, D., Buchan, A. & Charpak, S. Glial and neuronal control of brain blood flow. Nature 468, 232–243 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Dunn, K.M. & Nelson, M.T. Neurovascular signaling in the brain and the pathological consequences of hypertension. Am. J. Physiol. Heart Circ. Physiol. 306, H1–H14 (2014).
  Article CAS PubMed Google Scholar
• Peppiatt, C.M., Howarth, C., Mobbs, P. & Attwell, D. Bidirectional control of CNS capillary diameter by pericytes. Nature 443, 700–704 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Bell, R.D. et al. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409–427 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Hall, C.N. et al. Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508, 55–60 (2014).
  CAS PubMed PubMed Central Google Scholar
• Masamoto, K. & Kanno, I. Anesthesia and the quantitative evaluation of neurovascular coupling. J. Cereb. Blood Flow Metab. 32, 1233–1247 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, X. et al. Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo. Nat. Neurosci. 9, 816–823 (2006).
  Article CAS PubMed Google Scholar
• Schummers, J., Yu, H. & Sur, M. Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science 320, 1638–1643 (2008).
  Article CAS PubMed Google Scholar
• Schulz, K. et al. Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex. Nat. Methods 9, 597–602 (2012).
  Article CAS PubMed Google Scholar
• Nizar, K. et al. In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J. Neurosci. 33, 8411–8422 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Mulligan, S.J. & MacVicar, B.A. Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature 431, 195–199 (2004).
  Article CAS PubMed Google Scholar
• Panatier, A. et al. Astrocytes are endogenous regulators of basal transmission at central synapses. Cell 146, 785–798 (2011).
  Article CAS PubMed Google Scholar
• Di Castro, M.A. et al. Local Ca2+ detection and modulation of synaptic release by astrocytes. Nat. Neurosci. 14, 1276–1284 (2011).
  Article CAS PubMed Google Scholar
• Shigetomi, E. & Kracun, S. A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nat. Neurosci. 13, 759–766 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Shigetomi, E. et al. Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J. Gen. Physiol. 141, 633–647 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Volterra, A., Liaudet, N. & Savtchouk, I. Astrocyte Ca2+ signalling: an unexpected complexity. Nat. Rev. Neurosci. 15, 327–335 (2014).
  Article CAS PubMed Google Scholar
• Haustein, M.D. et al. Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. Neuron 82, 413–429 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Rusakov, D.A.a, Bard, L., Stewart, M.G. & Henneberger, C. Diversity of astroglial functions alludes to subcellular specialisation. Trends Neurosci. 37, 228–242 (2014).
  Article CAS PubMed Google Scholar
• Paukert, M. et al. Norepinephrine controls astroglial responsiveness to local circuit activity. Neuron 82, 1263–1270 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Calcinaghi, N. et al. Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response. J. Cereb. Blood Flow Metab. 31, e1–e10 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Sun, W. et al. Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science (80-.). 339, 197–200 (2013).
  Article CAS PubMed Central Google Scholar
• Jego, P., Pacheco-Torres, J., Araque, A. & Canals, S. Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes. J. Cereb. Blood Flow Metab. 34, 1599–1603 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Fiacco, T.A. et al. Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity. Neuron 54, 611–626 (2007).
  Article CAS PubMed Google Scholar
• Gurden, H., Uchida, N. & Mainen, Z.F. Sensory-evoked intrinsic optical signals in the olfactory bulb are coupled to glutamate release and uptake. Neuron 52, 335–345 (2006).
  Article CAS PubMed Google Scholar
• Petzold, G.C., Albeanu, D.F., Sato, T.F. & Murthy, V.N. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. Neuron 58, 897–910 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Chaigneau, E. et al. The relationship between blood flow and neuronal activity in the rodent olfactory bulb. J. Neurosci. 27, 6452–6460 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Shepherd, G.M., Chen, W.R. & Greer, C.A. in The Synaptic Organization of the Brain (ed. Shepherd, G.M.) 165–216 (Oxford University Press, 2004).
• Dong, H.-W., Hayar, A. & Ennis, M. Activation of group I metabotropic glutamate receptors on main olfactory bulb granule cells and periglomerular cells enhances synaptic inhibition of mitral cells. J. Neurosci. 27, 5654–5663 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Jian, K., Cifelli, P., Pignatelli, A., Frigato, E. & Belluzzi, O. Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function. Brain Res. 1354, 47–63 (2010).
  Article CAS PubMed Google Scholar
• Kosaka, T. & Kosaka, K. “Interneurons” in the olfactory bulb revisited. Neurosci. Res. 69, 93–99 (2011).
  Article CAS PubMed Google Scholar
• Kunzelmann, P. et al. Late onset and increasing expression of the gap junction protein connexin30 in adult murine brain and long-term cultured astrocytes. Glia 25, 111–119 (1999).
  Article CAS PubMed Google Scholar
• Yang, Y. et al. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia 59, 200–207 (2011).
  Article PubMed PubMed Central Google Scholar
• Jabaudon, D. et al. Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc. Natl. Acad. Sci. USA 96, 8733–8738 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Van den Pol, A.N. Presynaptic metabotropic glutamate receptors in adult and developing neurons: autoexcitation in the olfactory bulb. J. Comp. Neurol. 359, 253–271 (1995).
  Article CAS PubMed Google Scholar
• Slezak, M. et al. Transgenic mice for conditional gene manipulation in astroglial cells. Glia 55, 1565–1576 (2007).
  Article PubMed Google Scholar
• Bonfanti, L. & Peretto, P. Radial glial origin of the adult neural stem cells in the subventricular zone. Prog. Neurobiol. 83, 24–36 (2007).
  Article CAS PubMed Google Scholar
• Oheim, M. et al. New red-fluorescent calcium indicators for optogenetics, photoactivation and multi-color imaging. Biochim. Biophys. Acta 1843, 2284–2306 (2014).
  Article CAS PubMed Google Scholar
• Roux, L., Benchenane, K., Rothstein, J.D., Bonvento, G. & Giaume, C. Plasticity of astroglial networks in olfactory glomeruli. Proc. Natl. Acad. Sci. USA 108, 18442–18446 (2011).
  Article PubMed PubMed Central Google Scholar
• Lecoq, J., Tiret, P. & Charpak, S. Peripheral adaptation codes for high odor concentration in glomeruli. J. Neurosci. 29, 3067–3072 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Reeves, A.M.B., Shigetomi, E. & Khakh, B.S. Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps. J. Neurosci. 31, 9353–9358 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Winship, I.R., Plaa, N. & Murphy, T.H. Rapid astrocyte calcium signals correlate with neuronal activity and onset of the hemodynamic response in vivo. J. Neurosci. 27, 6268–6272 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Lind, B.L., Brazhe, R., Jessen, S.B., Tan, F.C.C. & Lauritzen, M.J. Rapid stimulus-evoked astrocyte Ca2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo. Proc. Natl. Acad. Sci. USA 110, E4678–E4687 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Winpenny, E. et al. Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells. Neural Dev. 6, 12 (2011).
  Article PubMed PubMed Central Google Scholar
• Nissant, A. & Pallotto, M. Integration and maturation of newborn neurons in the adult olfactory bulb–from synapses to function. Eur. J. Neurosci. 33, 1069–1077 (2011).
  Article PubMed Google Scholar
• Hartfuss, E., Galli, R., Heins, N. & Götz, M. Characterization of CNS precursor subtypes and radial glia. Dev. Biol. 229, 15–30 (2001).
  Article CAS PubMed Google Scholar
• Takata, N. et al. Cerebral blood flow modulation by basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes. PLoS ONE 8, e66525 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Bonder, D.E. & McCarthy, K.D. Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivo. J. Neurosci. 34, 13139–13150 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Kleinfeld, D., Mitra, P.P., Helmchen, F. & Denk, W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc. Natl. Acad. Sci. USA 95, 15741–15746 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Jukovskaya, N., Tiret, P., Lecoq, J. & Charpak, S. What does local functional hyperemia tell about local neuronal activation? J. Neurosci. 31, 1579–1582 (2011).
  Article CAS PubMed PubMed Central Google Scholar