Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia (original) (raw)

• Lewis, D.A. & Levitt, P. Schizophrenia as a disorder of neurodevelopment. Annu. Rev. Neurosci. 25, 409–432 (2002).
  Article CAS PubMed Google Scholar
• Lewis, D.A. & Lieberman, J.A. Catching up on schizophrenia: natural history and neurobiology. Neuron 28, 325–334 (2000).
  Article CAS PubMed Google Scholar
• Tsuang, M.T., Stone, W.S. & Faraone, S.V. Genes, environment and schizophrenia. Br. J. Psychiatry Suppl. 40, s18–24 (2001).
  Article CAS Google Scholar
• Sklar, P. Linkage analysis in psychiatric disorders: the emerging picture. Annu. Rev. Genomics Hum. Genet. 3, 371–413 (2002).
  Article CAS PubMed Google Scholar
• Buonanno, A. & Fischbach, G.D. Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr. Opin. Neurobiol. 11, 287–296 (2001).
  Article CAS PubMed Google Scholar
• Corfas, G., Rosen, K.M., Aratake, H., Krauss, R. & Fischbach, G.D. Differential expression of ARIA isoforms in the rat brain. Neuron 14, 103–115 (1995).
  Article CAS PubMed Google Scholar
• Falls, D.L., Rosen, K.M., Corfas, G., Lane, W.S. & Fischbach, G.D. ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell 72, 801–815 (1993).
  Article CAS PubMed Google Scholar
• Marchionni, M.A. et al. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362, 312–318 (1993).
  Article CAS PubMed Google Scholar
• Rio, C., Rieff, H.I., Qi, P., Khurana, T.S. & Corfas, G. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron 19, 39–50 (1997).
  Article CAS PubMed Google Scholar
• Anton, E.S., Marchionni, M.A., Lee, K.F. & Rakic, P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 124, 3501–3510 (1997).
  CAS PubMed Google Scholar
• Steiner, H., Blum, M., Kitai, S.T. & Fedi, P. Differential expression of ErbB3 and ErbB4 neuregulin receptors in dopamine neurons and forebrain areas of the adult rat. Exp. Neurol. 159, 494–503 (1999).
  Article CAS PubMed Google Scholar
• Yau, H.J., Wang, H.F., Lai, C. & Liu, F.C. Neural development of the neuregulin receptor ErbB4 in the cerebral cortex and the hippocampus: preferential expression by interneurons tangentially migrating from the ganglionic eminences. Cereb. Cortex 13, 252–264 (2003).
  Article PubMed Google Scholar
• Prevot, V. et al. Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes. J. Neurosci. 23, 230–239 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, Y., Ford, B., Mann, M.A. & Fischbach, G.D. Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus. J. Neurosci. 21, 5660–5669 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Ozaki, M., Sasner, M., Yano, R., Lu, H.S. & Buonanno, A. Neuregulin-beta induces expression of an NMDA-receptor subunit. Nature 390, 691–694 (1997).
  Article CAS PubMed Google Scholar
• Okada, M. & Corfas, G. Neuregulin1 down-regulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse. Hippocampus, DOI: 10.1002/hipo.10185 (2003).
• Stefansson, H. et al. Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877–892 (2002).
  Article PubMed PubMed Central Google Scholar
• Rieff, H.I. et al. Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells. J. Neurosci. 19, 10757–10766 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Cannella, B., Pitt, D., Marchionni, M. & Raine, C.S. Neuregulin and erbB receptor expression in normal and diseased human white matter. J. Neuroimmunol. 100, 233–242 (1999).
  Article CAS PubMed Google Scholar
• Vartanian, T., Fischbach, G. & Miller, R. Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. Proc. Natl. Acad. Sci. USA 96, 731–735 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Fernandez, P.A. et al. Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron 28, 81–90 (2000).
  Article CAS PubMed Google Scholar
• Calaora, V. et al. Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J. Neurosci. 21, 4740–4751 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Schmucker, J. et al. erbB3 is dispensable for oligodendrocyte development in vitro and in vivo. Glia 44, 67–75 (2003).
  Article PubMed Google Scholar
• Vartanian, T., Corfas, G., Li, Y., Fischbach, G.D. & Stefansson, K. A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. Proc. Natl. Acad. Sci. USA 91, 11626–11630 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Canoll, P.D. et al. GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron 17, 229–243 (1996).
  Article CAS PubMed Google Scholar
• Akbarian, S. et al. Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients. Arch. Gen. Psychiatry 53, 425–436 (1996).
  Article CAS PubMed Google Scholar
• Akbarian, S. et al. Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics. J. Neurosci. 16, 19–30 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Rioux, L., Nissanov, J., Lauber, K., Bilker, W.B. & Arnold, S.E. Distribution of microtubule-associated protein MAP2-immunoreactive interstitial neurons in the parahippocampal white matter in subjects with schizophrenia. Am. J. Psychiatry 160, 149–155 (2003).
  Article PubMed Google Scholar
• Zavitsanou, K., Ward, P.B. & Huang, X.F. Selective alterations in ionotropic glutamate receptors in the anterior cingulate cortex in schizophrenia. Neuropsychopharmacology 27, 826–833 (2002).
  Article CAS PubMed Google Scholar
• Mohn, A.R., Gainetdinov, R.R., Caron, M.G. & Koller, B.H. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98, 427–436 (1999).
  Article CAS PubMed Google Scholar
• Huntsman, M.M., Tran, B.V., Potkin, S.G., Bunney, W.E., Jr. & Jones, E.G. Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics. Proc. Natl. Acad. Sci. USA 95, 15066–15071 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Hakak, Y. et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. USA 98, 4746–4751 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Mirnics, K., Middleton, F.A., Marquez, A., Lewis, D.A. & Levitt, P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28, 53–67 (2000).
  Article CAS PubMed Google Scholar
• Volk, D.W., Austin, M.C., Pierri, J.N., Sampson, A.R. & Lewis, D.A. Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch. Gen. Psychiatry 57, 237–245 (2000).
  Article CAS PubMed Google Scholar
• Volk, D., Austin, M., Pierri, J., Sampson, A. & Lewis, D. GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: decreased expression in a subset of neurons. Am. J. Psychiatry 158, 256–265 (2001).
  Article CAS PubMed Google Scholar
• Uranova, N. et al. Electron microscopy of oligodendroglia in severe mental illness. Brain Res. Bull. 55, 597–610 (2001).
  Article CAS PubMed Google Scholar
• Tkachev, D. et al. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 362, 798–805 (2003).
  Article CAS PubMed Google Scholar
• Hof, P.R., Haroutunian, V., Copland, C., Davis, K.L. & Buxbaum, J.D. Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia. Neurochem. Res. 27, 1193–1200 (2002).
  Article CAS PubMed Google Scholar
• Hof, P.R. et al. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol. Psychiatry 53, 1075–1085 (2003).
  Article CAS PubMed Google Scholar
• Bartzokis, G. et al. Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study. Biol. Psychiatry 53, 412–421 (2003).
  Article PubMed Google Scholar
• Flynn, S.W. et al. Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Mol. Psychiatry 8, 811–820 (2003).
  Article CAS PubMed Google Scholar
• Foong, J. et al. Investigating regional white matter in schizophrenia using diffusion tensor imaging. Neuroreport 13, 333–336 (2002).
  Article CAS PubMed Google Scholar
• Walker, E. & Bollini, A.M. Pubertal neurodevelopment and the emergence of psychotic symptoms. Schizophr. Res. 54, 17–23 (2002).
  Article PubMed Google Scholar
• Freedman, R., Hall, M., Adler, L.E. & Leonard, S. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol. Psychiatry 38, 22–33 (1995).
  Article CAS PubMed Google Scholar
• Court, J. et al. Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus. J. Neurochem. 73, 1590–1597 (1999).
  Article CAS PubMed Google Scholar
• Guan, Z.Z., Zhang, X., Blennow, K. & Nordberg, A. Decreased protein level of nicotinic receptor alpha7 subunit in the frontal cortex from schizophrenic brain. Neuroreport 10, 1779–1782 (1999).
  Article CAS PubMed Google Scholar
• Stefansson, H. et al. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am. J. Hum. Genet. 72, 83–87 (2003).
  Article CAS PubMed Google Scholar
• Williams, N.M. et al. Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Mol. Psychiatry 8, 485–487 (2003).
  Article CAS PubMed Google Scholar
• Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S. & Hirschhorn, J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33, 177–182 (2003).
  Article CAS PubMed Google Scholar
• Yang, J.Z. et al. Association study of neuregulin 1 gene with schizophrenia. Mol. Psychiatry 8, 706–709 (2003).
  Article CAS PubMed Google Scholar
• Tang, J.X. et al. Polymorphisms within 5′ end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population. Mol. Psychiatry 9, 11–12 (2004).
  Article CAS PubMed Google Scholar
• Iwata, N. et al. No association with the neuregulin 1 haplotype to Japanese schizophrenia. Mol. Psychiatry 9, 126–127 (2004).
  Article CAS PubMed Google Scholar
• Hashimoto, R. et al. Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia. Mol. Psychiatry 21, 21 (2003).
  Google Scholar
• Arnold, S.E. & Trojanowski, J.Q. Recent advances in defining the neuropathology of schizophrenia. Acta Neuropathol. (Berl) 92, 217–231 (1996).
  Article CAS Google Scholar
• Harrison, P.J. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122, 593–624 (1999).
  Article PubMed Google Scholar
• Blum, B.P. & Mann, J.J. The GABAergic system in schizophrenia. Int. J. Neuropsychopharmacol. 5, 159–179 (2002).
  Article CAS PubMed Google Scholar
• Konradi, C. & Heckers, S. Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol. Ther. 97, 153–179 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Benes, F.M. & Berretta, S. GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 25, 1–27 (2001).
  Article CAS PubMed Google Scholar
• Bartzokis, G. Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation. Neuropsychopharmacology 27, 672–683 (2002).
  Article PubMed Google Scholar
• Davis, K.L. et al. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch. Gen. Psychiatry 60, 443–456 (2003).
  Article PubMed Google Scholar
• Pongrac, J., Middleton, F.A., Lewis, D.A., Levitt, P. & Mirnics, K. Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders. Neurochem. Res. 27, 1049–1063 (2002).
  Article CAS PubMed Google Scholar
• Moises, H.W., Zoega, T. & Gottesman, II. The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia. BMC Psychiatry 2, 8 (2002).
  Article PubMed PubMed Central Google Scholar
• Hakola, H.P. Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia. Acta Psychiatr. Scand. Suppl. 232, 1–173 (1972).
  CAS PubMed Google Scholar
• Friston, K.J. & Frith, C.D. Schizophrenia: a disconnection syndrome? Clin. Neurosci. 3, 89–97 (1995).
  CAS PubMed Google Scholar
• Cannon, T.D. et al. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch. Gen. Psychiatry 55, 1084–1091 (1998).
  Article CAS PubMed Google Scholar