Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis (original) (raw)

• Rosen, D.R. et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59–62 (1993).
  Article CAS Google Scholar
• Gurney, M.E. et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772–1775 (1994).
  Article CAS Google Scholar
• Subramaniam, J.R. et al. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat. Neurosci. 5, 301–307 (2002).
  Article CAS Google Scholar
• Wang, J., Xu, G. & Borchelt, D.R. High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation. Neurobiol. Dis. 9, 139–148 (2002).
  Article CAS Google Scholar
• Julien, J.P. Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded. Cell 104, 581–591 (2001).
  Article CAS Google Scholar
• Cleveland, D.W. & Rothstein, J.D. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2, 806–819 (2001).
  Article CAS Google Scholar
• Wiedau-Pazos, M. et al. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 271, 515–518 (1996).
  Article CAS Google Scholar
• Raoul, C. et al. Motoneuron death triggered by a specific pathway downstream of Fas: potentiation by ALS-linked SOD1 mutations. Neuron 35, 1067–1083 (2002).
  Article CAS Google Scholar
• Durham, H.D., Roy, J., Dong, L. & Figlewicz, D.A. Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS. J. Neuropathol. Exp. Neurol. 56, 523–530 (1997).
  Article CAS Google Scholar
• Johnston, J.A., Dalton, M.J., Gurney, M.E. & Kopito, R.R. Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 97, 12571–12576 (2000).
  Article CAS Google Scholar
• Urushitani, M., Kurisu, J., Tsukita, K. & Takahashi, R. Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J. Neurochem. 83, 1030–1042 (2002).
  Article CAS Google Scholar
• Pramatarova, A., Laganière, J., Roussel, J., Brisebois, K. & Rouleau, G.A. Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment. J. Neurosci. 21, 3369–3374 (2001).
  Article CAS Google Scholar
• Lino, M.M., Schneider, C. & Caroni, P. Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease. J. Neurosci. 22, 4825–4832 (2002).
  Article CAS Google Scholar
• Clement, A.M. et al. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302, 113–117 (2003).
  Article CAS Google Scholar
• Shinder, G.A., Lacourse, M.C., Minotti, S. & Durham, H.D. Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis. J. Biol. Chem. 276, 12791–12796 (2001).
  Article CAS Google Scholar
• Urushitani, M. et al. CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J. Neurochem. 90, 231–244 (2004).
  Article CAS Google Scholar
• Taupenot, L., Harper, K.L. & O'Connor, D.T. The chromogranin-secretogranin family. N. Engl. J. Med. 348, 1134–1149 (2003).
  Article CAS Google Scholar
• Rudolf, R., Salm, T., Rustom, A. & Gerdes, H.H. Dynamics of immature secretory granules: role of cytoskeletal elements during transport, cortical restriction, and f-actin-dependent tethering. Mol. Biol. Cell 12, 1353–1365 (2001).
  Article CAS Google Scholar
• Li, J.Y., Leitner, B., Lovisetti-Scamihorn, P., Winkler, H. & Dahlström, A. Proteolytic processing, axonal transport and differential distribution of chromogranins A and B, and secretogranin II (secretoneurin) in rat sciatic nerve and spinal cord. Eur. J. Neurosci. 11, 528–544 (1999).
  Article CAS Google Scholar
• Booj, S., Goldstein, M., Fischer-Colbrie, R. & Dahlstrom, A. Calcitonin gene-related peptide and chromogranin A: presence and intra-axonal transport in lumbar motor neurons in the rat, a comparison with synaptic vesicle antigens in immunohistochemical studies. Neuroscience 30, 479–501 (1989).
  Article CAS Google Scholar
• Marksteiner, J. et al. Distribution of chromogranin B-like immunoreactivity in the human hippocampus and its changes in Alzheimer's disease. Acta Neuropathol. (Berl.) 100, 205–212 (2000).
  Article CAS Google Scholar
• Rangon, C.M. et al. Different chromogranin immunoreactivity between prion and a-beta amyloid plaque. Neuroreport 14, 755–758 (2003).
  Article CAS Google Scholar
• Schiffer, D., Cordera, S., Giordana, M.T., Attanasio, A. & Pezzulo, T. Synaptic vesicle proteins, synaptophysin and chromogranin A in amyotrophic lateral sclerosis. J. Neurol. Sci. 129 Suppl, 68–74 (1995).
  Article Google Scholar
• Taupenot, L. et al. Chromogranin A triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells. Neuroscience 72, 377–389 (1996).
  Article CAS Google Scholar
• Ciesielski-Treska, J. et al. Mechanisms underlying neuronal death induced by chromogranin A-activated microglia. J. Biol. Chem. 276, 13113–13120 (2001).
  Article CAS Google Scholar
• Taylor, D.L., Diemel, L.T. & Pocock, J.M. Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity. J. Neurosci. 23, 2150–2160 (2003).
  Article CAS Google Scholar
• Chanat, E., Weiss, U., Huttner, W.B. & Tooze, S.A. Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathways. EMBO J. 12, 2159–2168 (1993).
  Article CAS Google Scholar
• Cowley, D.J., Moore, Y.R., Darling, D.S., Joyce, P.B. & Gorr, S.U. N- and C-terminal domains direct cell type-specific sorting of chromogranin A to secretory granules. J. Biol. Chem. 275, 7743–7748 (2000).
  Article CAS Google Scholar
• Li, J.Y., Kling-Petersen, A. & Dahlstrom, A. Influence of spinal cord transection on the presence and axonal transport of CGRP-, chromogranin A-, VIP-, synapsin I-, and synaptophysin-like immunoreactivities in rat motor nerve. J. Neurobiol. 23, 1094–1110 (1992).
  Article CAS Google Scholar
• Kato, A. et al. Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem. Brain Res. 852, 444–452 (2000).
  Article CAS Google Scholar
• Stieber, A. et al. Disruption of the structure of the Golgi apparatus and the function of the secretory pathway by mutants G93A and G85R of Cu, Zn superoxide dismutase (SOD1) of familial amyotrophic lateral sclerosis. J. Neurol. Sci. 219, 45–53 (2004).
  Article CAS Google Scholar
• Ciesielski-Treska, J. et al. Chromogranin A induces a neurotoxic phenotype in brain microglial cells. J. Biol. Chem. 273, 14339–14346 (1998).
  Article CAS Google Scholar
• Huh, Y.H., Jeon, S.H. & Yoo, S.H. Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. J. Biol. Chem. 278, 40581–40589 (2003).
  Article CAS Google Scholar
• Turner, B.J. et al. Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis. J. Neurosci. 25, 108–117 (2005).
  Article CAS Google Scholar
• Jacobsson, J., Jonsson, P.A., Andersen, P.M., Forsgren, L. & Marklund, S.L. Superoxide dismutase in CSF from amyotrophic lateral sclerosis patients with and without CuZn-superoxide dismutase mutations. Brain 124, 1461–1466 (2001).
  Article CAS Google Scholar
• Sharpless, N. et al. The restricted nature of HIV-1 tropism for cultured neural cells. Virology 191, 813–825 (1992).
  Article CAS Google Scholar
• Miyakawa, K. & Imamura, T. Secretion of FGF-16 requires an uncleaved bipartite signal sequence. J. Biol. Chem. 278, 35718–35724 (2003).
  Article CAS Google Scholar
• Tiwari, A. & Hayward, L.J. Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction. J. Biol. Chem. 278, 5984–5992 (2003).
  Article CAS Google Scholar
• Tobisawa, S. et al. Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice. Biochem. Biophys. Res. Commun. 303, 496–503 (2003).
  Article CAS Google Scholar
• Lafon-Cazal, M. et al. Proteomic analysis of astrocytic secretion in the mouse. Comparison with the cerebrospinal fluid proteome. J. Biol. Chem. 278, 24438–24448 (2003).
  Article CAS Google Scholar
• Cimini, V. et al. CuZn-superoxide dismutase in human thymus: immunocytochemical localisation and secretion in thymus-derived epithelial and fibroblast cell lines. Histochem. Cell Biol. 118, 163–169 (2002).
  CAS PubMed Google Scholar
• Nickel, W. The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. Eur. J. Biochem. 270, 2109–2119 (2003).
  Article CAS Google Scholar
• Elam, J.S. et al. Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. Nat. Struct. Biol. 10, 461–467 (2003).
  Article CAS Google Scholar
• Nguyen, M.D., D'Aigle, T., Gowing, G., Julien, J.P. & Rivest, S. Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. 24, 1340–1349 (2004).
  Article CAS Google Scholar
• Zhu, S. et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417, 74–78 (2002).
  Article CAS Google Scholar
• Parkin, E.T., Hussain, I., Karran, E.H., Turner, A.J. & Hooper, N.M. Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins. J. Neurochem. 72, 1534–1543 (1999).
  Article CAS Google Scholar
• Stephens, D.J. & Banting, G. Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin. J. Biol. Chem. 274, 30080–30086 (1999).
  Article CAS Google Scholar