Protein kinase A regulates calcium permeability of NMDA receptors (original) (raw)

References

  1. Cull-Candy, S.G., Brickley, S. & Farrant, M. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11, 327–335 (2001).
    Article CAS Google Scholar
  2. Carroll, R.C. & Zukin, R.S. NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci. 25, 571–577 (2002).
    Article CAS Google Scholar
  3. Cull-Candy, S.G. & Leszkiewicz, D.N. Role of distinct NMDA receptor subtypes at central synapses. Sci. STKE 2004, re16 (2004).
  4. Mayer, M.L. & Westbrook, G.L. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J. Physiol. (Lond.) 394, 501–527 (1987).
    Article CAS Google Scholar
  5. Schneggenburger, R., Zhou, Z., Konnerth, A. & Neher, E. Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron 11, 133–143 (1993).
    Article CAS Google Scholar
  6. Burnashev, N., Zhou, Z., Neher, E. & Sakmann, B. Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J. Physiol. (Lond.) 485, 403–418 (1995).
    Article CAS Google Scholar
  7. Rogers, M. & Dani, J.A. Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels. Biophys. J. 68, 501–506 (1995).
    Article CAS Google Scholar
  8. Garaschuk, O., Schneggenburger, R., Schirra, C., Tempia, F. & Konnerth, A. Fractional Ca2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones. J. Physiol. (Lond.) 491, 757–772 (1996).
    Article CAS Google Scholar
  9. Malenka, R.C. & Bear, M.F. LTP and LTD: an embarrassment of riches. Neuron 44, 5–21 (2004).
    Article CAS Google Scholar
  10. Scannevin, R.H. & Huganir, R.L. Postsynaptic organization and regulation of excitatory synapses. Nat. Rev. Neurosci. 1, 133–141 (2000).
    Article CAS Google Scholar
  11. Sheng, M. Molecular organization of the postsynaptic specialization. Proc. Natl. Acad. Sci. USA 98, 7058–7061 (2001).
    Article CAS Google Scholar
  12. Winder, D.G. & Sweatt, J.D. Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat. Rev. Neurosci. 2, 461–474 (2001).
    Article CAS Google Scholar
  13. Westphal, R.S. et al. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285, 93–96 (1999).
    Article CAS Google Scholar
  14. Leonard, A.S. & Hell, J.W. Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites. J. Biol. Chem. 272, 12107–12115 (1997).
    Article CAS Google Scholar
  15. Tingley, W.G. et al. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J. Biol. Chem. 272, 5157–5166 (1997).
    Article CAS Google Scholar
  16. Wang, L.Y., Orser, B.A., Brautigan, D.L. & MacDonald, J.F. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature 369, 230–232 (1994).
    Article CAS Google Scholar
  17. Raman, I.M., Tong, G. & Jahr, C.E. Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase. Neuron 16, 415–421 (1996).
    Article CAS Google Scholar
  18. Blank, T. et al. The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses. Proc. Natl. Acad. Sci. USA 94, 14859–14864 (1997).
    Article CAS Google Scholar
  19. Snyder, G.L., Fienberg, A.A., Huganir, R.L. & Greengard, P. A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor. J. Neurosci. 18, 10297–10303 (1998).
    Article CAS Google Scholar
  20. Otmakhova, N.A., Otmakhov, N., Mortenson, L.H. & Lisman, J.E. Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J. Neurosci. 20, 4446–4451 (2000).
    Article CAS Google Scholar
  21. Yasuda, H., Barth, A.L., Stellwagen, D. & Malenka, R.C. A developmental switch in the signaling cascades for LTP induction. Nat. Neurosci. 6, 15–16 (2003).
    Article CAS Google Scholar
  22. Blitzer, R.D. et al. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science 280, 1940–1942 (1998).
    Article CAS Google Scholar
  23. Huang, Y.Y. & Kandel, E.R. Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization. Learn. Mem. 1, 74–82 (1994).
    CAS PubMed Google Scholar
  24. Qi, M. et al. Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 93, 1571–1576 (1996).
    Article CAS Google Scholar
  25. Abel, T. et al. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88, 615–626 (1997).
    Article CAS Google Scholar
  26. Wong, S.T. et al. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23, 787–798 (1999).
    Article CAS Google Scholar
  27. Zorumski, C.F., Yang, J. & Fischbach, G.D. Calcium-dependent, slow desensitization distinguishes different types of glutamate receptors. Cell. Mol. Neurobiol. 9, 95–104 (1989).
    Article CAS Google Scholar
  28. Legendre, P., Rosenmund, C. & Westbrook, G.L. Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium. J. Neurosci. 13, 674–684 (1993).
    Article CAS Google Scholar
  29. Tong, G., Shepherd, D. & Jahr, C.E. Synaptic desensitization of NMDA receptors by calcineurin. Science 267, 1510–1512 (1995).
    Article CAS Google Scholar
  30. Kaczmarek, L.K., Jennings, K.R. & Strumwasser, F. An early sodium and a late calcium phase in the afterdischarge of peptide-secreting neurons of Aplysia. Brain Res. 238, 105–115 (1982).
    Article CAS Google Scholar
  31. Lan, J.Y. et al. Protein kinase C modulates NMDA receptor trafficking and gating. Nat. Neurosci. 4, 382–390 (2001).
    Article CAS Google Scholar
  32. Quinlan, E.M., Philpot, B.D., Huganir, R.L. & Bear, M.F. Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat. Neurosci. 2, 352–357 (1999).
    Article CAS Google Scholar
  33. Beaver, C.J., Ji, Q., Fischer, Q.S. & Daw, N.W. Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex. Nat. Neurosci. 4, 159–163 (2001).
    Article CAS Google Scholar
  34. Hille, B. Ion Channels of Excitable Membranes 3rd edn. (Sinauer Associates, Sunderland, Massachusetts, 2001).
    Google Scholar
  35. Schneggenburger, R. Simultaneous measurement of Ca2+ influx and reversal potentials in recombinant N-methyl-D-aspartate receptor channels. Biophys. J. 70, 2165–2174 (1996).
    Article CAS Google Scholar
  36. Hoffmann, H., Gremme, T., Hatt, H. & Gottmann, K. Synaptic activity-dependent developmental regulation of NMDA receptor subunit expression in cultured neocortical neurons. J. Neurochem. 75, 1590–1599 (2000).
    Article CAS Google Scholar
  37. Zhong, J., Russell, S.L., Pritchett, D.B., Molinoff, P.B. & Williams, K. Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Mol. Pharmacol. 45, 846–853 (1994).
    CAS PubMed Google Scholar
  38. Yuste, R., Majewska, A., Cash, S.S. & Denk, W. Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis. J. Neurosci. 19, 1976–1987 (1999).
    Article CAS Google Scholar
  39. Yuste, R. & Denk, W. Dendritic spines as basic functional units of neuronal integration. Nature 375, 682–684 (1995).
    Article CAS Google Scholar
  40. Malenka, R.C. Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus. Neuron 6, 53–60 (1991).
    Article CAS Google Scholar
  41. Cummings, J.A., Mulkey, R.M., Nicoll, R.A. & Malenka, R.C. Ca2+ signaling requirements for long-term depression in the hippocampus. Neuron 16, 825–833 (1996).
    Article CAS Google Scholar
  42. Sobczyk, A., Scheuss, V. & Svoboda, K. NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines. J. Neurosci. 25, 6037–6046 (2005).
    Article CAS Google Scholar
  43. Thomas, M.J., Moody, T.D., Makhinson, M. & O'Dell, T.J. Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region. Neuron 17, 475–482 (1996).
    Article CAS Google Scholar
  44. Otmakhova, N.A. & Lisman, J.E. D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses. J. Neurosci. 16, 7478–7486 (1996).
    Article CAS Google Scholar
  45. Lieberman, D.N. & Mody, I. Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Nature 369, 235–239 (1994).
    Article CAS Google Scholar
  46. Scemes, E., Suadicani, S.O. & Spray, D.C. Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation. J. Neurosci. 20, 1435–1445 (2000).
    Article CAS Google Scholar
  47. Matsuzaki, M. et al. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat. Neurosci. 4, 1086–1092 (2001).
    Article CAS Google Scholar
  48. Wang, S.S. & Augustine, G.J. Confocal imaging and local photolysis of caged compounds: dual probes of synaptic function. Neuron 15, 755–760 (1995).
    Article CAS Google Scholar
  49. Lin, Y., Skeberdis, V.A., Francesconi, A., Bennett, M.V. & Zukin, R.S. Postsynaptic density protein-95 regulates NMDA channel gating and surface expression. J. Neurosci. 24, 10138–10148 (2004).
    Article CAS Google Scholar
  50. Majewska, A., Yiu, G. & Yuste, R. A custom-made two-photon microscope and deconvolution system. Pflugers Arch. 441, 398–408 (2000).
    Article CAS Google Scholar

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