Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport (original) (raw)
Clement, A.M. et al. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science302, 113–117 (2003). ArticleCAS Google Scholar
McGeer, P.L. et al. Microglia in degenerative neurological disease. Glia7, 84–92 (1993). ArticleCAS Google Scholar
Raeber, A.J. et al. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J.16, 6057–6065 (1997). ArticleCAS Google Scholar
Yazawa, I. et al. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron45, 847–859 (2005). ArticleCAS Google Scholar
Forman, M.S. et al. Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. J. Neurosci.25, 3539–3550 (2005). ArticleCAS Google Scholar
Voogd, J. & Glickstein, M. The anatomy of the cerebellum. Trends Neurosci.21, 370–375 (1998). ArticleCAS Google Scholar
Taroni, F. & DiDonato, S. Pathways to motor incoordination: the inherited ataxias. Nat. Rev. Neurosci.5, 641–655 (2004). ArticleCAS Google Scholar
Konigsmark, B.W. & Weiner, L.P. The olivopontocerebellar atrophies: a review. Medicine (Baltimore)49, 227–241 (1970). ArticleCAS Google Scholar
Zoghbi, H.Y. & Orr, H.T. Glutamine repeats and neurodegeneration. Annu. Rev. Neurosci.23, 217–247 (2000). ArticleCAS Google Scholar
Garden, G.A. et al. Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice. J. Neurosci.22, 4897–4905 (2002). ArticleCAS Google Scholar
La Spada, A.R. et al. Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron31, 913–927 (2001). ArticleCAS Google Scholar
Borchelt, D.R. et al. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet. Anal.13, 159–163 (1996). ArticleCAS Google Scholar
Gu, X. et al. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant huntingtin contribute to cortical pathogenesis in HD mice. Neuron46, 433–444 (2005). ArticleCAS Google Scholar
Grosche, J. et al. Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells. Nat. Neurosci.2, 139–143 (1999). ArticleCAS Google Scholar
Yamada, K. et al. Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth and synapse formation of cerebellar Purkinje cells. J. Comp. Neurol.418, 106–120 (2000). ArticleCAS Google Scholar
Brenner, M., Kisseberth, W.C., Su, Y., Besnard, F. & Messing, A. GFAP promoter directs astrocyte-specific expression in transgenic mice. J. Neurosci.14, 1030–1037 (1994). ArticleCAS Google Scholar
Brenner, M. & Messing, A. GFAP transgenic mice. Methods10, 351–364 (1996). ArticleCAS Google Scholar
Strahlendorf, J.C., Brandon, T., Miles, R. & Strahlendorf, H.K. AMPA receptor-mediated alterations of intracellular calcium homeostasis in rat cerebellar Purkinje cells in vitro: correlates to dark cell degeneration. Neurochem. Res.23, 1355–1362 (1998). ArticleCAS Google Scholar
Strahlendorf, J.C. & Strahlendorf, H.K. Enduring changes in Purkinje cell electrophysiology following transient exposure to AMPA: correlates to dark cell degeneration. Neurosci. Res.33, 155–162 (1999). ArticleCAS Google Scholar
Leranth, C. & Hamori, J. “Dark” Purkinje cells of the cerebellar cortex. Acta Biol. Acad. Sci. Hung.21, 405–419 (1970). CASPubMed Google Scholar
Furuta, A., Rothstein, J.D. & Martin, L.J. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. J. Neurosci.17, 8363–8375 (1997). ArticleCAS Google Scholar
Yoo, S.Y. et al. SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron37, 383–401 (2003). ArticleCAS Google Scholar
Cui, W., Allen, N.D., Skynner, M., Gusterson, B. & Clark, A.J. Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain. Glia34, 272–282 (2001). ArticleCAS Google Scholar
Fields, R.D. & Stevens-Graham, B. New insights into neuron-glia communication. Science298, 556–562 (2002). ArticleCAS Google Scholar
Watase, K. et al. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci.10, 976–988 (1998). ArticleCAS Google Scholar
Huang, H. & Bordey, A. Glial glutamate transporters limit spillover activation of presynaptic NMDA receptors and influence synaptic inhibition of Purkinje neurons. J. Neurosci.24, 5659–5669 (2004). ArticleCAS Google Scholar
Arriza, J.L. et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci.14, 5559–5569 (1994). ArticleCAS Google Scholar
Shin, J.Y. et al. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J. Cell Biol.171, 1001–1012 (2005). ArticleCAS Google Scholar
Iino, M. et al. Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia. Science292, 926–929 (2001). ArticleCAS Google Scholar
Gong, Y.H., Parsadanian, A.S., Andreeva, A., Snider, W.D. & Elliott, J.L. Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration. J. Neurosci.20, 660–665 (2000). ArticleCAS Google Scholar
Yvert, G. et al. Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Hum. Mol. Genet.9, 2491–2506 (2000). ArticleCAS Google Scholar
Probst-Cousin, S. et al. Spinocerebellar ataxia type 2 with glial cell cytoplasmic inclusions. J. Neurol. Neurosurg. Psychiatry75, 503–505 (2004). ArticleCAS Google Scholar
Palhan, V.B. et al. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc. Natl. Acad. Sci. USA102, 8472–8477 (2005). ArticleCAS Google Scholar
Helmlinger, D. et al. Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Hum. Mol. Genet.13, 1257–1265 (2004). ArticleCAS Google Scholar
La Spada, A.R. & Taylor, J.P. Polyglutamines placed into context. Neuron38, 681–684 (2003). ArticleCAS Google Scholar
Robinson, M.B. & Dowd, L.A. Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system. Adv. Pharmacol.37, 69–115 (1997). ArticleCAS Google Scholar
Gegelashvili, G. et al. Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes. Neuroreport8, 261–265 (1996). ArticleCAS Google Scholar
Duan, S., Anderson, C.M., Stein, B.A. & Swanson, R.A. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. J. Neurosci.19, 10193–10200 (1999). ArticleCAS Google Scholar
Lehre, K.P. & Danbolt, N.C. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J. Neurosci.18, 8751–8757 (1998). ArticleCAS Google Scholar
Dehnes, Y. et al. The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia. J. Neurosci.18, 3606–3619 (1998). ArticleCAS Google Scholar
Lin, X., Antalffy, B., Kang, D., Orr, H.T. & Zoghbi, H.Y. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. Nat. Neurosci.3, 157–163 (2000). ArticleCAS Google Scholar
Serra, H.G. et al. Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice. Hum. Mol. Genet.13, 2535–2543 (2004). ArticleCAS Google Scholar
Ikeda, Y. et al. Spectrin mutations cause spinocerebellar ataxia type 5. Nat. Genet.38, 184–190 (2006). ArticleCAS Google Scholar
Rothstein, J.D., Van Kammen, M., Levey, A.I., Martin, L.J. & Kuncl, R.W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol.38, 73–84 (1995). ArticleCAS Google Scholar
Rothstein, J.D. et al. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature433, 73–77 (2005). ArticleCAS Google Scholar
Lin, C.H. et al. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum. Mol. Genet.10, 137–144 (2001). ArticleCAS Google Scholar
Ortega, A., Eshhar, N. & Teichberg, V.I. Properties of kainate receptor/channels on cultured Bergmann glia. Neuroscience41, 335–349 (1991). ArticleCAS Google Scholar
Shimada, F. et al. The neuroprotective agent MS-153 stimulates glutamate uptake. Eur. J. Pharmacol.386, 263–270 (1999). ArticleCAS Google Scholar
Lievens, J.C. et al. Impaired glutamate uptake in the R6 Huntington's disease transgenic mice. Neurobiol. Dis.8, 807–821 (2001). ArticleCAS Google Scholar