Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells (original) (raw)

• Komuro, H. & Yacubova, E. Recent advances in cerebellar granule cell migration. Cell. Mol. Life Sci. 60, 1084–1098 (2003).
  Article CAS PubMed Google Scholar
• Zmuda, J.F. & Rivas, R.J. Actin filament disruption blocks cerebellar granule neurons at the unipolar stage of differentiation in vitro. J. Neurobiol. 43, 313–328 (2000).
  Article CAS PubMed Google Scholar
• Solecki, D.J., Model, L., Gaetz, J., Kapoor, T.M. & Hatten, M.E. Par6α signaling controls glial-guided neuronal migration. Nat. Neurosci. 7, 1195–1203 (2004).
  Article CAS PubMed Google Scholar
• Umeshima, H., Hirano, T. & Kengaku, M. Microtubule-based nuclear movement occurs independently of centrosome positioning in migrating neurons. Proc. Natl. Acad. Sci. USA 104, 16182–16187 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Kholmanskikh, S.S., Dobrin, J.S., Wynshaw-Boris, A., Letourneau, P.C. & Ross, M.E. Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons. J. Neurosci. 23, 8673–8681 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Guan, C.B., Xu, H.T., Jin, M., Yuan, X.B. & Poo, M.M. Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2. Cell 129, 385–395 (2007).
  Article CAS PubMed Google Scholar
• Kerjan, G. et al. The transmembrane semaphorin Sema6A controls cerebellar granule cell migration. Nat. Neurosci. 8, 1516–1524 (2005).
  Article CAS PubMed Google Scholar
• Tamagnone, L. et al. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. Cell 99, 71–80 (1999).
  Article CAS PubMed Google Scholar
• Toyofuku, T. et al. Guidance of myocardial patterning in cardiac development by Sema6D reverse signaling. Nat. Cell Biol. 6, 1204–1211 (2004).
  Article CAS PubMed Google Scholar
• Suto, F. et al. Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J. Neurosci. 25, 3628–3637 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Suto, F. et al. Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers. Neuron 53, 535–547 (2007).
  Article CAS PubMed Google Scholar
• Weyer, A. & Schilling, K. Developmental and cell type–specific expression of the neuronal marker NeuN in the murine cerebellum. J. Neurosci. Res. 73, 400–409 (2003).
  Article CAS PubMed Google Scholar
• Sakagami, H., Umemiya, M., Kobayashi, T., Saito, S. & Kondo, H. Immunological evidence that the beta isoform of Ca2+/calmodulin-dependent protein kinase IV is a cerebellar granule cell–specific product of the CaM kinase IV gene. Eur. J. Neurosci. 11, 2531–2536 (1999).
  Article CAS PubMed Google Scholar
• Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. & Nishimune, Y. 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407, 313–319 (1997).
  Article CAS PubMed Google Scholar
• Sasaki, Y. et al. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35, 907–920 (2002).
  Article CAS PubMed Google Scholar
• Bellion, A., Baudoin, J.P., Alvarez, C., Bornens, M. & Metin, C. Nucleokinesis in tangentially migrating neurons comprises two alternating phases: forward migration of the Golgi/centrosome associated with centrosome splitting and myosin contraction at the rear. J. Neurosci. 25, 5691–5699 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Schaar, B.T. & McConnell, S.K. Cytoskeletal coordination during neuronal migration. Proc. Natl. Acad. Sci. USA 102, 13652–13657 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Tsai, J.W., Bremner, K.H. & Vallee, R.B. Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue. Nat. Neurosci. 10, 970–979 (2007).
  Article CAS PubMed Google Scholar
• Higginbotham, H., Tanaka, T., Brinkman, B.C. & Gleeson, J.G. GSK3beta and PKCzeta function in centrosome localization and process stabilization during Slit-mediated neuronal repolarization. Mol. Cell. Neurosci. 32, 118–132 (2006).
  Article CAS PubMed Google Scholar
• Chedotal, A., Kerjan, G. & Moreau-Fauvarque, C. The brain within the tumor: new roles for axon guidance molecules in cancers. Cell Death Differ. 12, 1044–1056 (2005).
  Article CAS PubMed Google Scholar
• Ding, S., Luo, J.H. & Yuan, X.B. Semaphorin-3F attracts the growth cone of cerebellar granule cells through cGMP signaling pathway. Biochem. Biophys. Res. Commun. 356, 857–863 (2007).
  Article CAS PubMed Google Scholar
• Chen, G. et al. Semaphorin-3A guides radial migration of cortical neurons during development. Nat. Neurosci. 11, 36–44 (2007).
  Article PubMed Google Scholar
• Tsai, L.H. & Gleeson, J.G. Nucleokinesis in neuronal migration. Neuron 46, 383–388 (2005).
  Article CAS PubMed Google Scholar
• Love, C.A. et al. The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. Nat. Struct. Biol. 10, 843–848 (2003).
  Article CAS PubMed Google Scholar
• Bellenchi, G.C. et al. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 21, 2347–2357 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Rivas, R.J. & Hatten, M.E. Motility and cytoskeletal organization of migrating cerebellar granule neurons. J. Neurosci. 15, 981–989 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Gomes, E.R., Jani, S. & Gundersen, G.G. Nuclear movement regulated by Cdc42, MRCK, myosin and actin flow establishes MTOC polarization in migrating cells. Cell 121, 451–463 (2005).
  Article CAS PubMed Google Scholar
• Kholmanskikh, S.S. et al. Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility. Nat. Neurosci. 9, 50–57 (2006).
  Article CAS PubMed Google Scholar
• Tanaka, T. et al. Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. J. Cell Biol. 165, 709–721 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Jaffe, A.B. & Hall, A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247–269 (2005).
  Article CAS PubMed Google Scholar
• Rohm, B., Rahim, B., Kleiber, B., Hovatta, I. & Puschel, A.W. The semaphorin 3A receptor may directly regulate the activity of small GTPases. FEBS Lett. 486, 68–72 (2000).
  Article CAS PubMed Google Scholar
• Oinuma, I., Ishikawa, Y., Katoh, H. & Negishi, M. The Semaphorin 4D receptor plexin-B1 is a GTPase-activating protein for R-Ras. Science 305, 862–865 (2004).
  Article CAS PubMed Google Scholar
• Turner, L.J., Nicholls, S. & Hall, A. The activity of the plexin-A1 receptor is regulated by Rac. J. Biol. Chem. 279, 33199–33205 (2004).
  Article CAS PubMed Google Scholar
• Tong, Y. et al. Binding of Rac1, Rnd1 and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J. Biol. Chem. 282, 37215–37224 (2007).
  Article CAS PubMed Google Scholar
• Barberis, D. et al. p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signaling. J. Cell Sci. 118, 4689–4700 (2005).
  Article CAS PubMed Google Scholar
• Toyofuku, T. et al. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat. Neurosci. 8, 1712–1719 (2005).
  Article CAS PubMed Google Scholar
• Etienne-Manneville, S. & Hall, A. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell 106, 489–498 (2001).
  Article CAS PubMed Google Scholar
• Xie, Z., Samuels, B.A. & Tsai, L.H. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling—a hypothesis on neuronal migration. Cereb. Cortex 16 Suppl 1, i64–i68 (2006).
  Article PubMed Google Scholar
• Ohshima, T. et al. Migration defects of cdk5 −/− neurons in the developing cerebellum is cell autonomous. J. Neurosci. 19, 6017–6026 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Xie, Z., Sanada, K., Samuels, B.A., Shih, H. & Tsai, L.H. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement and neuronal migration. Cell 114, 469–482 (2003).
  Article CAS PubMed Google Scholar
• Kawauchi, T., Chihama, K., Nabeshima, Y. & Hoshino, M. Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat. Cell Biol. 8, 17–26 (2006).
  Article CAS PubMed Google Scholar
• Clapcote, S.J. et al. Behavioral phenotypes of Disc1 missense mutations in mice. Neuron 54, 387–402 (2007).
  Article CAS PubMed Google Scholar
• Shu, T. et al. Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron 44, 263–277 (2004).
  Article CAS PubMed Google Scholar
• Sasaki, S. et al. Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol. Cell. Biol. 25, 7812–7827 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Mah, S. et al. Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. Mol. Psychiatry 11, 471–478 (2006).
  Article CAS PubMed Google Scholar
• Takeshita, M. et al. Genetic examination of the PLXNA2 gene in Japanese and Chinese schizophrenics. Schizophr. Res. 99, 359–364 (2008).
  Article PubMed Google Scholar
• Fujii, T. et al. Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population. Prog. Neuropsychopharmacol. Biol. Psychiatry 31, 873–877 (2007).
  Article CAS PubMed Google Scholar
• Wray, N.R. et al. Anxiety and comorbid measures associated with PLXNA2. Arch. Gen. Psychiatry 64, 318–326 (2007).
  Article CAS PubMed Google Scholar
• Fatemi, S.H., Reutiman, T.J., Folsom, T.D. & Sidwell, R.W. The role of cerebellar genes in pathology of autism and schizophrenia. Cerebellum published online doi:10.1080/14734220701392969 (16 May 2007).
• Marillat, V. et al. Spatiotemporal expression patterns of slit and robo genes in the rat brain. J. Comp. Neurol. 442, 130–155 (2002).
  Article PubMed Google Scholar