Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (original) (raw)

• Bennett, M. R. Monoaminergic synapses and schizophrenia: 45 years of neuroleptics. J. Psychopharmacol. 12, 289–304 (1998).
  Article CAS Google Scholar
• Kraepelin, E., Barclay, R. M. & Robertson, G. M. Dementia Præcox and Paraphrenia (E. & S. Livingstone, Edinburgh, 1919).
  Google Scholar
• Lewis, D. A. & Anderson, S. A. The functional architecture of the prefrontal cortex and schizophrenia. Psychol. Med. 25, 887–894 (1995).
  Article CAS Google Scholar
• Laruelle, M. & Abi-Dargham, A. Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies. J. Psychopharmacol. 13, 358–371 (1999).
  Article CAS Google Scholar
• Jaskiw, G. E., Karoum, F. K. & Weinberger, D. R. Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex. Brain. Res. 534, 321–323 (1990).
  Article CAS Google Scholar
• Pycock, C. J., Kerwin, R. W. & Carter, C. J. Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats. Nature 286, 74–76 (1980).
  Article CAS Google Scholar
• Weinberger, D. R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry 44, 660–669 (1987).
  Article CAS Google Scholar
• Weinberger, D. R., Berman, K. F. & Illowsky, B. P. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. Arch. Gen. Psychiatry 45, 609–615 (1988).
  Article CAS Google Scholar
• Grace, A. A. Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia. J. Neural Transm. Gen. Sect. 91, 111–134 (1993).
  Article CAS Google Scholar
• Deutch, A. Y. The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. J. Neural Transm. Suppl. 36, 61–89 (1992).
  CAS PubMed Google Scholar
• Weinberger, D. R., Berman, K. F. & Zec, R. F. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch. Gen. Psychiatry 43, 114–124 (1986).
  Article CAS Google Scholar
• Weinberger, D. R. & Berman, K. F. Prefrontal function in schizophrenia: confounds and controversies. Phil. Trans. R. Soc. Lond. B Biol. Sci. 351, 1495–1503 (1996).
  Article CAS Google Scholar
• Hietala, J. et al. Depressive symptoms and presynaptic dopamine function in neuroleptic- naive schizophrenia. Schizophr. Res. 35, 41–50 (1999).
  Article CAS Google Scholar
• Hietala, J. et al. Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients. Lancet 346, 1130–1131 (1995).
  Article CAS Google Scholar
• Lindstrom, L. H. et al. Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by l-(β-11C) DOPA and PET. Biol. Psychiatry 46, 681–688 (1999).
  Article CAS Google Scholar
• Reith, J. et al. Elevated dopa decarboxylase activity in living brain of patients with psychosis. Proc. Natl. Acad. Sci. USA 91, 11651–11654 (1994).
  Article CAS Google Scholar
• Dao-Castellana, M. H. et al. Presynaptic dopaminergic function in the striatum of schizophrenic patients. Schizophr. Res. 23, 167–174 (1997).
  Article CAS Google Scholar
• Elkashef, A. M. et al. 6-(18)F-DOPA PET study in patients with schizophrenia. Positron emission tomography. Psychiatry Res. 100, 1–11 (2000).
  Article CAS Google Scholar
• Cumming, P., Kuwabara, H., Ase, A. & Gjedde, A. Regulation of DOPA decarboxylase activity in brain of living rat. J. Neurochem. 65, 1381–1390 (1995).
  Article CAS Google Scholar
• Gjedde, A. et al. Dopa decarboxylase activity of the living human brain. Proc. Natl. Acad. Sci. USA 88, 2721–2725 (1991).
  Article CAS Google Scholar
• Abi-Dargham, A. et al. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. Am. J. Psychiatry 155, 761–767 (1998).
  Article CAS Google Scholar
• Wong, D. F. et al. Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234, 1558–1563 (1986).
  Article CAS Google Scholar
• Abi-Dargham, A. et al. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc. Natl. Acad. Sci. USA 97, 8104–8109 (2000).
  Article CAS Google Scholar
• Bertolino, A. et al. The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia. Neuropsychopharmacology 22, 125–132 (2000).
  Article CAS Google Scholar
• Jackson, M. E., Frost, A. S. & Moghaddam, B. Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens. J. Neurochem. 78, 920–923 (2001).
  Article CAS Google Scholar
• Murase, S., Grenhoff, J., Chouvet, G., Gonon, F. G. & Svensson, T. H. Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo. Neurosci. Lett. 157, 53–56 (1993).
  Article CAS Google Scholar
• Christie, M. J., Bridge, S., James, L. B. & Beart, P. M. Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area. Brain Res. 333, 169–172 (1985).
  Article CAS Google Scholar
• Kegeles, L. S. et al. Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol. Psychiatry 48, 627–640 (2000).
  Article CAS Google Scholar
• Carr, D. B. & Sesack, S. R. Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. J. Neurosci. 20, 3864–3873 (2000).
  Article CAS Google Scholar
• Carlsson, A. et al. Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence. Annu. Rev. Pharmacol. Toxicol. 41, 237–260 (2001).
  Article CAS Google Scholar
• Saunders, R. C., Kolachana, B. S., Bachevalier, J. & Weinberger, D. R. Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine. Nature 393, 169–171 (1998).
  Article CAS Google Scholar
• Swerdlow, N. R. & Geyer, M. A. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr. Bull. 24, 285–301 (1998).
  Article CAS Google Scholar
• Grace, A. A. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41, 1–24 (1991).
  Article CAS Google Scholar
• Daniel, D. G. et al. The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia. J. Neurosci. 11, 1907–1917 (1991).
  Article CAS Google Scholar
• Okubo, Y. et al. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature 385, 634–636 (1997).
  Article CAS Google Scholar
• Napier, T. C. & Chrobak, J. J. Evaluations of ventral pallidal dopamine receptor activation in behaving rats. Neuroreport 3, 609–611 (1992).
  Article CAS Google Scholar
• Muller, U., von Cramon, D. Y. & Pollmann, S. D1- versus D2-receptor modulation of visuospatial working memory in humans. J. Neurosci. 18, 2720–2728 (1998).
  Article CAS Google Scholar
• Goldman-Rakic, P. S. The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia. Biol. Psychiatry 46, 650–661 (1999).
  Article CAS Google Scholar
• Weinberger, D. R. & Lipska, B. K. Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground. Schizophr. Res. 16, 87–110 (1995).
  Article CAS Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-III-R (American Psychiatric Association, Washington, DC, 1987).
• Miletich, R. S. et al. 6-[18F]fluoro-L-dihydroxyphenylalanine metabolism and positron emission tomography after catechol-O-methyltransferase inhibition in normal and hemiparkinsonian monkeys. Brain Res. 626, 1–13 (1993).
  Article CAS Google Scholar
• Berman, K. F. et al. Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: a positron emission tomography study. Neuropsychologia 33, 1027–1046 (1995).
  Article CAS Google Scholar
• Woods, R. P., Mazziotta, J. C. & Cherry, S. R. MRI-PET registration with automated algorithm. J. Comput. Assist. Tomogr. 17, 536–546 (1993).
  Article CAS Google Scholar
• Talairach, J. & Tournoux, P. Co-planar Stereotaxic Atlas of the Human Brain (Thieme, Stuttgart New York, 1988).
  Google Scholar
• Brooks, D. J. et al. Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Ann. Neurol. 28, 547–555 (1990).
  Article CAS Google Scholar
• Patlak, C. S., Blasberg, R. G. & Fenstermacher, J. D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 3, 1–7 (1983).
  Article CAS Google Scholar