Differential Activity by Polymorphic Variants of a Remote Enhancer that Supports Galanin Expression in the Hypothalamus and Amygdala: Implications for Obesity, Depression and Alcoholism (original) (raw)

• Adams AC, Clapham JC, Wynick D, Speakman JR (2008). Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference. J Neuroendocrinol 20: 199–206.
  Article CAS Google Scholar
• Azumaya Y, Tsutsui K (1996). Localization of galanin and its binding sites in the quail brain. Brain Res 727: 187–195.
  Article CAS Google Scholar
• Bacon A, Kerr NC, Holmes FE, Gaston K, Wynick D (2007). Characterization of an enhancer region of the galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy. J Neurosci 27: 6573–6580.
  Article CAS Google Scholar
• Barker-Gibb ML, Clarke IJ (1996). Increased galanin and neuropeptide-Y immunoreactivity within the hypothalamus of ovariectomised ewes following a prolonged period of reduced body weight is associated with changes in plasma growth hormone but not gonadotropin levels. Neuroendocrinology 64: 194–207.
  Article CAS Google Scholar
• Barr AM, Kinney JW, Hill MN, Lu X, Biros S, Rebek Jr J et al (2006). A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neurosci Lett 405: 111–115.
  Article CAS Google Scholar
• Belfer I, Hipp H, McKnight C, Evans C, Buzas B, Bollettino A et al (2006). Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations. Mol Psychiatry 11: 301–311.
  Article CAS Google Scholar
• Ceccatelli S, Eriksson M, Hokfelt T (1989). Distribution and coexistence of corticotropin-releasing factor-, neurotensin-, enkephalin-, cholecystokinin-, galanin- and vasoactive intestinal polypeptide/peptide histidine isoleucine-like peptides in the parvocellular part of the paraventricular nucleus. Neuroendocrinology 49: 309–323.
  Article CAS Google Scholar
• Ceccatelli S, Giardino L, Calza L (1992). Response of hypothalamic peptide mRNAs to thyroidectomy. Neuroendocrinology 56: 694–703.
  Article CAS Google Scholar
• Cortes R, Villar MJ, Verhofstad A, Hokfelt T (1990). Effects of central nervous system lesions on the expression of galanin: a comparative in situ hybridization and immunohistochemical study. Proc Natl Acad Sci USA 87: 7742–7746.
  Article CAS Google Scholar
• Crawley JN, Mufson EJ, Hohmann JG, Teklemichael D, Steiner RA, Holmberg K et al (2002). Galanin overexpressing transgenic mice. Neuropeptides 36: 145–156.
  Article CAS Google Scholar
• Davidson S, Miller KA, Dowell A, Gildea A, Mackenzie A (2006a). Cellular co-expression of a LacZ marker gene driven by the amygdala-specific ECR1 enhancer with the substance P neuropeptide. Mol Psychiatry 11: 323.
  Article CAS Google Scholar
• Davidson S, Miller KA, Dowell A, Gildea A, Mackenzie A (2006b). A remote and highly conserved enhancer supports amygdala specific expression of the gene encoding the anxiogenic neuropeptide substance-P. Mol Psychiatry 11: 410–421.
  Article CAS Google Scholar
• Evans HF, Huntley GW, Morrison JH, Shine J (1993). Localisation of mRNA encoding the protein precursor of galanin in the monkey hypothalamus and basal forebrain. J Comp Neurol 328: 203–212.
  Article CAS Google Scholar
• Gillies SG, Haddley K, Vasiliou SA, Jacobson GM, von Mentzer B, Bubb VJ et al (2010). Distinct gene expression profiles directed by the isoforms of the transcription factor neuron-restrictive silencer factor in human SK-N-AS neuroblastoma cells. J Mol Neurosci 44: 77–90.
  Article Google Scholar
• Hindorff LA, Burke W, Laberge AM, Rice KM, Lumley T, Leppig K et al (2009). Motivating factors for physician ordering of factor V Leiden genetic tests. Arch Intern Med 169: 68–74.
  Article Google Scholar
• Hobson SA, Holmes FE, Kerr NC, Pope RJ, Wynick D (2006). Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour. J Neurochem 99: 1000–1010.
  Article CAS Google Scholar
• Holmes A, Kinney JW, Wrenn CC, Li Q, Yang RJ, Ma L et al (2003). Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze. Neuropsychopharmacology 28: 1031–1044.
  Article CAS Google Scholar
• Holmes A, Picciotto MR (2006). Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction? CNS Neurol Disord Drug Targets 5: 225–232.
  Article CAS Google Scholar
• Kaplan LM, Spindel ER, Isselbacher KJ, Chin WW (1988). Tissue-specific expression of the rat galanin gene. Proc Natl Acad Sci USA 85: 1065–1069.
  Article CAS Google Scholar
• Karatayev O, Barson JR, Chang GQ, Leibowitz SF (2009a). Hypothalamic injection of non-opioid peptides increases gene expression of the opioid enkephalin in hypothalamic and mesolimbic nuclei: possible mechanism underlying their behavioral effects. Peptides 30: 2423–2431.
  Article CAS Google Scholar
• Karatayev O, Baylan J, Leibowitz SF (2009b). Increased intake of ethanol and dietary fat in galanin overexpressing mice. Alcohol 43: 571–580.
  Article CAS Google Scholar
• Karatayev O, Baylan J, Weed V, Chang S, Wynick D, Leibowitz SF (2009c). Galanin knockout mice show disturbances in ethanol consumption and expression of hypothalamic peptides that stimulate ethanol intake. Alcohol Clin Exp Res 34: 72–80.
  Article Google Scholar
• Karlsson RM, Holmes A (2006). Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease. Amino Acids 31: 231–239.
  Article CAS Google Scholar
• Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM et al (2002). The human genome browser at UCSC. Genome Res 12: 996–1006.
  Article CAS Google Scholar
• Kuteeva E, Hokfelt T, Wardi T, Ogren SO (2008a). Galanin, galanin receptor subtypes and depression-like behaviour. Cell Mol Life Sci 65: 1854–1863.
  Article CAS Google Scholar
• Kuteeva E, Wardi T, Hokfelt T, Ogren SO (2007). Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat. Eur Neuropsychopharmacol 17: 64–69.
  Article CAS Google Scholar
• Kuteeva E, Wardi T, Lundstrom L, Sollenberg U, Langel U, Hokfelt T et al (2008b). Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level. Neuropsychopharmacology 33: 2573–2585.
  Article CAS Google Scholar
• Leibowitz SF (2005). Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis. Neuropeptides 39: 327–332.
  Article CAS Google Scholar
• Leibowitz SF (2007). Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides. Physiol Behav 91: 513–521.
  Article CAS Google Scholar
• Leibowitz SF, Avena NM, Chang GQ, Karatayev O, Chau DT, Hoebel BG (2003). Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. Physiol Behav 79: 103–111.
  Article CAS Google Scholar
• Leibowitz SF, Kim T (1992). Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion. Brain Res 599: 148–152.
  Article CAS Google Scholar
• Lu X, Sharkey L, Bartfai T (2007). The brain galanin receptors: targets for novel antidepressant drugs. CNS Neurol Disord Drug Targets 6: 183–192.
  Article CAS Google Scholar
• Mackenzie A, Miller KA, Collinson JM (2004a). Is there a functional link between gene interdigitation and multi-species conservation of synteny blocks? Bioessays 26: 1217–1224.
  Article CAS Google Scholar
• MacKenzie A, Purdie L, Davidson D, Collinson M, Hill RE (1997). Two enhancer domains control early aspects of the complex expression pattern of Msx1. Mech Dev 62: 29–40.
  Article CAS Google Scholar
• MacKenzie A, Quinn JP (2004b). Post-genomic approaches to exploring neuropeptide gene mis-expression in disease. Neuropeptides 38: 1–15.
  Article CAS Google Scholar
• Madaan V, Wilson DR (2009). Neuropeptides: relevance in treatment of depression and anxiety disorders. Drug News Perspect 22: 319–324.
  Article CAS Google Scholar
• Mercer JG, Lawrence CB, Atkinson T (1996). Regulation of galanin gene expression in the hypothalamic paraventricular nucleus of the obese Zucker rat by manipulation of dietary macronutrients. Brain Res Mol Brain Res 43: 202–208.
  Article CAS Google Scholar
• Miller KA, Barrow J, Collinson JM, Davidson S, Lear M, Hill RE et al (2007). A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells. Dev Biol 311: 665–678.
  Article CAS Google Scholar
• Miller KA, Davidson S, Liaros A, Barrow J, Lear M, Heine D et al (2008). Prediction and characterisation of a highly conserved, remote and cAMP responsive enhancer that regulates Msx1 gene expression in cardiac neural crest and outflow tract. Dev Biol 317: 686–694.
  Article CAS Google Scholar
• Miller MA, Kolb PE, Raskind MA (1993a). Extra-hypothalamic vasopressin neurons coexpress galanin messenger RNA as shown by double in situ hybridization histochemistry. J Comp Neurol 329: 378–384.
  Article CAS Google Scholar
• Miller MA, Kolb PE, Raskind MA (1993b). Testosterone regulates galanin gene expression in the bed nucleus of the stria terminalis. Brain Res 611: 338–341.
  Article CAS Google Scholar
• Mongin E, Dewar K, Blanchette M (2009). Long-range regulation is a major driving force in maintaining genome integrity. BMC Evol Biol 9: 203.
  Article Google Scholar
• Nagy AG, Vinterstein M, K, Behringer R (2003). Manipulating the Mouse Embryo 3rd edn Cold Spring Harbor Laboratory Press: Cold Spring Harbor.
  Google Scholar
• Naito S, Shimizu S, Matsuu M, Nakashima M, Nakayama T, Yamashita S et al (2002). Ets-1 upregulates matrix metalloproteinase-1 expression through extracellular matrix adhesion in vascular endothelial cells. Biochem Biophys Res Commun 291: 130–138.
  Article CAS Google Scholar
• Navratilova P, Becker TS (2009a). Genomic regulatory blocks in vertebrates and implications in human disease. Brief Funct Genomic Proteomic 8: 333–342.
  Article Google Scholar
• Navratilova P, Fredman D, Hawkins TA, Turner K, Lenhard B, Becker TS (2009b). Systematic human/Zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes. Dev Biol 327: 526–540.
  Article CAS Google Scholar
• Ovcharenko I, Nobrega MA, Loots GG, Stubbs L (2004). ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Res 32 (Web Server issue): W280–W286.
  Article CAS Google Scholar
• Paschos KA, Veletza S, Chatzaki E (2009). Neuropeptide and sigma receptors as novel therapeutic targets for the pharmacotherapy of depression. CNS Drugs 23: 755–772.
  Article CAS Google Scholar
• Paxinos KBJFaG (1997). The Mouse Brain in Stereotaxic Coordinates. Academic Press: San Diego, CA.
  Google Scholar
• Picciotto MR, Brabant C, Einstein EB, Kamens HM, Neugebauer NM (2010). Effects of galanin on monoaminergic systems and HPA axis: potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors. Brain Res 1314: 206–218.
  Article CAS Google Scholar
• Plaisier CL, Kyttala M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A, Riba L et al (2009). Galanin preproprotein is associated with elevated plasma triglycerides. Arterioscler Thromb Vasc Biol 29: 147–152.
  Article CAS Google Scholar
• Planas B, Kolb PE, Raskind MA, Miller MA (1994a). Activation of galanin pathways across puberty in the male rat: galanin gene expression in the bed nucleus of the stria terminalis and medial amygdala. Neuroscience 63: 851–858.
  Article CAS Google Scholar
• Planas B, Kolb PE, Raskind MA, Miller MA (1994b). Galanin in the bed nucleus of the stria terminalis and medial amygdala of the rat: lack of sexual dimorphism despite regulation of gene expression across puberty. Endocrinology 134: 1999–2004.
  Article CAS Google Scholar
• Poritsanos NJ, Mizuno TM, Lautatzis ME, Vrontakis M (2009). Chronic increase of circulating galanin levels induces obesity and marked alterations in lipid metabolism similar to metabolic syndrome. Int J Obes (Lond) 33: 1381–1389.
  Article CAS Google Scholar
• Rada P, Mark GP, Hoebel BG (1998). Galanin in the hypothalamus raises dopamine and lowers acetylcholine release in the nucleus accumbens: a possible mechanism for hypothalamic initiation of feeding behavior. Brain Res 798: 1–6.
  Article CAS Google Scholar
• Rokaeus A, Waschek JA (1998). Tissue-specific enhancement and restriction of galanin gene expression in transgenic mice by 5′ flanking sequences. Brain Res Mol Brain Res 60: 150–159.
  Article CAS Google Scholar
• Rotzinger S, Lovejoy DA, Tan LA (2009). Behavioral effects of neuropeptides in rodent models of depression and anxiety. Peptides 31: 736–756.
  Article Google Scholar
• Ruano G, Windemuth A, Kocherla M, Holford T, Fernandez ML, Forsythe CE et al (2006). Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction. Nutr Metab (Lond) 3: 20.
  Article Google Scholar
• Schauble N, Reichwald K, Grassl W, Bechstein H, Muller HC, Scherag A et al (2005). Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. J Nutr 135: 1387–1392.
  Article Google Scholar
• Scott IG, Akerman KE, Heikkila JE, Kaila K, Andersson LC (1986). Development of a neural phenotype in differentiating ganglion cell-derived human neuroblastoma cells. J Cell Physiol 128: 285–292.
  Article CAS Google Scholar
• Sergeyev V, Fetissov S, Mathe AA, Jimenez PA, Bartfai T, Mortas P et al (2005). Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacology (Berl) 178: 115–124.
  Article CAS Google Scholar
• Shanley L, Davidson S, Lear M, Thotakura AK, McEwan IJ, Ross RA et al (2010). Long-range regulatory synergy is required to allow control of the TAC1 locus by MEK/ERK signalling in sensory neurones. Neurosignals 18: 173–85.
  Article CAS Google Scholar
• Shanley L, Lear M, Davidson S, Ross R, Mackenzie A (2011). Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones. J Neuroinflammation 8: 10.
  Article CAS Google Scholar
• Singleton AB, Hardy J, Traynor BJ, Houlden H (2010). Towards a complete resolution of the genetic architecture of disease. Trends Genet 26: 438–442.
  Article CAS Google Scholar
• Unschuld PG, Ising M, Erhardt A, Lucae S, Kohli M, Kloiber S et al (2008). Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder. J Affect Disord 105: 177–184.
  Article CAS Google Scholar
• Unschuld PG, Ising M, Roeske D, Erhardt A, Specht M, Kloiber S et al (2010). Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response. Neuropsychopharmacology 35: 1583–1592.
  Article CAS Google Scholar
• Vetter M, Blumenthal SG, Lindemann RK, Manns J, Wesselborg S, Thomssen C et al (2005). Ets1 is an effector of protein kinase Calpha in cancer cells. Oncogene 24: 650–661.
  Article CAS Google Scholar
• Wray GA (2007). The evolutionary significance of cis-regulatory mutations. Nat Rev Genet 8: 206–216.
  Article CAS Google Scholar
• Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR et al (2010). Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry.
• Wynick D, Bacon A (2002). Targeted disruption of galanin: new insights from knock-out studies. Neuropeptides 36: 132–144.
  Article CAS Google Scholar
• Yee SP, Rigby PW (1993). The regulation of myogenin gene expression during the embryonic development of the mouse. Genes Dev 7: 1277–1289.
  Article CAS Google Scholar