The power and the promise of oncogene-induced senescence markers (original) (raw)

• Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614–636 (1965).
  Article CAS Google Scholar
• Serrano, M. & Blasco, M. A. Putting the stress on senescence. Curr. Opin. Cell Biol. 13, 748–753 (2001).
  Article CAS Google Scholar
• Shay, J. W. & Roninson, I. B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23, 2919–2933 (2004).
  Article CAS Google Scholar
• Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997).
  Article CAS Google Scholar
• Lowe, S. W., Cepero, E. & Evan, G. Intrinsic tumour suppression. Nature 432, 307–315 (2004).
  Article CAS Google Scholar
• Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660–665 (2005).
  Article CAS Google Scholar
• Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725–730 (2005).
  Article CAS Google Scholar
• Collado, M. et al. Tumour biology: senescence in premalignant tumours. Nature 436, 642 (2005).
  Article CAS Google Scholar
• Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720–724 (2005).
  Article CAS Google Scholar
• Guerra, C. et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 4, 111–120 (2003).
  Article CAS Google Scholar
• Tuveson, D. A. et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5, 375–387 (2004).
  Article CAS Google Scholar
• Lo, T. L. et al. Sprouty and cancer: the first terms report. Cancer Lett. 6 Feb 2006 [epub ahead of print].
• Furukawa, T., Sunamura, M., Motoi, F., Matsuno, S. & Horii, A. Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am. J. Pathol. 162, 1807–1815 (2003).
  Article CAS Google Scholar
• Hoornaert, I., Marynen, P., Goris, J., Sciot, R. & Baens, M. MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12–13, reduces BCR-ABL-induced transformation. Oncogene 22, 7728–7736 (2003).
  Article CAS Google Scholar
• Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).
  Article CAS Google Scholar
• Kurz, D. J., Decary, S., Hong, Y. & Erusalimsky, J. D. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J. Cell Sci. 113, 3613–3622 (2000).
  CAS PubMed Google Scholar
• Severino, J., Allen, R. G., Balin, S., Balin, A. & Cristofalo, V. J. Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp. Cell Res. 257, 162–171 (2000).
  Article CAS Google Scholar
• Yang, N. C. & Hu, M. L. A fluorimetric method using fluorescein di-beta-D-galactopyranoside for quantifying the senescence-associated beta-galactosidase activity in human foreskin fibroblast Hs68 cells. Anal. Biochem. 325, 337–343 (2004).
  Article CAS Google Scholar
• Campisi, J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513–522 (2005).
  Article CAS Google Scholar
• Hollstein, M., Sidransky, D., Vogelstein, B. & Harris, C. C. p53 mutations in human cancers. Science 253, 49–53 (1991).
  Article CAS Google Scholar
• Ruas, M. & Peters, G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys. Acta. 1378, F115–F177 (1998).
  CAS PubMed Google Scholar
• Sharpless, N. E. & DePinho, R. A. The INK4A/ARF locus and its two gene products. Curr. Opin. Genet. Dev. 9, 22–30 (1999).
  Article CAS Google Scholar
• Lazzerini Denchi, E., Attwooll, C., Pasini, D. & Helin, K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol. Cell. Biol. 25, 2660–2672 (2005).
  Article Google Scholar
• Shapiro, G. I. et al. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res. 55, 505–509 (1995).
  CAS PubMed Google Scholar
• Masumoto, N. et al. P16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix. Hum. Pathol. 34, 778–783 (2003).
  Article CAS Google Scholar
• Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703–716 (2003).
  Article CAS Google Scholar
• Zhang, R. et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev. Cell 8, 19–30 (2005).
  Article CAS Google Scholar
• Malumbres, M. et al. Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b). Mol. Cell. Biol. 20, 2915–2925 (2000).
  Article CAS Google Scholar
• Nagane, M., Huang, H. J. & Cavenee, W. K. The potential of TRAIL for cancer chemotherapy. Apoptosis 6, 191–197 (2001).
  Article CAS Google Scholar
• Giatromanolaki, A. et al. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. J. Pathol. 200, 222–228 (2003).
  Article CAS Google Scholar
• Liu, X., Yue, P., Khuri, F. R. & Sun, S. Y. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer. Res. 65, 9169–9175 (2005).
  Article CAS Google Scholar
• Yamada, K. & Miyamoto, K. Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli. Front. Biosci. 10, 3151–3171 (2005).
  Article CAS Google Scholar
• Barradas, M. et al. Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp. Cell Res. 273, 127–137 (2002).
  Article CAS Google Scholar
• Hama, T. et al. Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival. J. Biol. Chem. 276, 31929–31935 (2001).
  Article CAS Google Scholar
• Brunk, U. T. & Terman, A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic. Biol. Med. 33, 611–619 (2002).
  Article CAS Google Scholar
• Gerland, L. M. et al. Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging. Exp. Gerontol. 38, 887–895 (2003).
  Article CAS Google Scholar
• Mu, X. C. & Higgins, P. J. Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts. J. Cell. Physiol. 165, 647–657 (1995).
  Article CAS Google Scholar
• Mason, D. X., Jackson, T. J. & Lin, A. W. Molecular signature of oncogenic ras-induced senescence. Oncogene 23, 9238–9246 (2004).
  Article CAS Google Scholar
• Chang, B. D. et al. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl Acad. Sci. USA 99, 389–394 (2002).
  Article CAS Google Scholar
• Schmitt, C. A. Senescence, apoptosis and therapy – cutting the lifelines of cancer. Nature Rev. Cancer. 3, 286–295 (2003).
  Article CAS Google Scholar
• Rebbaa, A., Zheng, X., Chou, P. M. & Mirkin, B. L. Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene 22, 2805–2811 (2003).
  Article CAS Google Scholar
• Zheng, X., Chou, P. M., Mirkin, B. L. & Rebbaa, A. Senescence-initiated reversal of drug resistance: specific role of cathepsin L. Cancer Res. 64, 1773–1780 (2004).
  Article CAS Google Scholar
• te Poele, R. H., Okorokov, A. L., Jardine, L., Cummings, J. & Joel, S. P. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 62, 1876–1883 (2002).
  CAS PubMed Google Scholar
• Roberson, R. S., Kussick, S. J., Vallieres, E., Chen, S. Y. & Wu, D. Y. Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res. 65, 2795–2803 (2005).
  Article CAS Google Scholar
• Sedelnikova, O. A. et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biol. 6, 168–170 (2004).
  Article CAS Google Scholar
• Shelton, D. N., Chang, E., Whittier, P. S., Choi, D. & Funk, W. D. Microarray analysis of replicative senescence. Curr. Biol. 9, 939–645 (1999).
  Article CAS Google Scholar
• Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. Y. & Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl Acad. Sci. USA 98, 12072–12077 (2001).
  Article CAS Google Scholar
• Alcorta, D. A. et al. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl Acad. Sci. USA 93, 13742–13747 (1996).
  Article CAS Google Scholar
• Afshari, C. A. et al. Investigation of the role of G1/S cell cycle mediators in cellular senescence. Exp. Cell Res. 209, 231–237 (1993).
  Article CAS Google Scholar
• Kamijo, T. et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649–659 (1997).
  Article CAS Google Scholar
• Tahara, H., Sato, E., Noda, A. & Ide, T. Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene 10, 835–840 (1995).
  CAS PubMed Google Scholar