Making a tumour's bed: glioblastoma stem cells and the vascular niche (original) (raw)

• Clarke, M. F. & Fuller, M. Stem cells and cancer: two faces of eve. Cell 124, 1111–1115 (2006).
  Article CAS Google Scholar
• Clarke, M. F. et al. Cancer stem cells — perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res. 66, 9339–9344 (2006).
  Article CAS Google Scholar
• Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645–648 (1994).
  Article CAS Google Scholar
• Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. From the cover: prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983–3988. (2003).
  Article CAS Google Scholar
• O'Brien, C. A., Pollett, A., Gallinger, S. & Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106–110 (2007).
  Article CAS Google Scholar
• Taylor, M. D. et al. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell 8, 323–335. (2005).
  Article CAS Google Scholar
• Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396–401. (2004).
  Article CAS Google Scholar
• Phillips, H. S. et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157–173. (2006).
  Article CAS Google Scholar
• Ligon, K. L. et al. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 53, 503–517 (2007).
  Article CAS Google Scholar
• Jackson, E. L. et al. PDGFRα-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51, 187–199 (2006).
  Article CAS Google Scholar
• Zhu, Y. et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8, 119–130 (2005).
  Article CAS Google Scholar
• Kuo, C. T. et al. Postnatal deletion of numb/numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127, 1253–1264 (2006).
  Article CAS Google Scholar
• Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756–760 (2006).
  Article CAS Google Scholar
• Moore, K. A. & Lemischka, I. R. Stem cells and their niches. Science 311, 1880–1885 (2006).
  Article CAS Google Scholar
• Scheres, B. Stem-cell niches: nursery rhymes across kingdoms. Nature Rev. Mol. Cell Biol. 8, 345–354 (2007).
  Article CAS Google Scholar
• Scadden, D. T. The stem-cell niche as an entity of action. Nature 441, 1075–1079 (2006).
  Article CAS Google Scholar
• Gage, F. H. Mammalian neural stem cells. Science 287, 1433–1438 (2000).
  Article CAS Google Scholar
• Sanai, N. et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 427, 740 (2004).
  Article CAS Google Scholar
• Merkle, F. T., Tramontin, A. D., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Radial glia give rise to adult neural stem cells in the subventricular zone. Proc. Natl Acad. Sci. USA 101, 17528–17532 (2004).
  Article CAS Google Scholar
• Louissaint, A. Jr., Rao, S., Leventhal, C. & Goldman, S. A. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34, 945–960. (2002).
  Article CAS Google Scholar
• Palmer, T. D., Willhoite, A. R. & Gage, F. H. Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425, 479–494 (2000).
  Article CAS Google Scholar
• Ramirez-Castillejo, C. et al. Pigment epithelium-derived factor is a niche signal for neural stem cell renewal. Nature Neurosci. 9, 331–339 (2006).
  Article CAS Google Scholar
• Shen, Q. et al. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304, 1338–1340 (2004).
  Article CAS Google Scholar
• Riquelme, P. A., Drapeau, E. & Doetsch, F. Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philos. Trans. R. Soc. Lond. B Biol. Sci. 23, 23 (2007).
  Google Scholar
• Cleaver, O. & Melton, D. A. Endothelial signaling during development. Nature Med. 9, 661–668 (2003).
  Article CAS Google Scholar
• Leventhal, C., Rafii, S., Rafii, D., Shahar, A. & Goldman, S. A. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol. Cell. Neurosci. 13, 450–464 (1999).
  Article CAS Google Scholar
• Le Bras, B. et al. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nature Neurosci. 9, 340–348 (2006).
  Article CAS Google Scholar
• Garcion, E., Halilagic, A., Faissner, A. & French-Constant, C. Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. Development 131, 3423–3432 (2004).
  Article CAS Google Scholar
• Sirko, S., von Holst, A., Wizenmann, A., Gotz, M. & Faissner, A. Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells. Development 134, 2727–2738 (2007).
  Article CAS Google Scholar
• Li, Q., Ford, M. C., Lavik, E. B. & Madri, J. A. Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells: an in vitro study. J. Neurosci. Res. 84, 1656–1668 (2006).
  Article CAS Google Scholar
• Kai, T. & Spradling, A. C. An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells. Proc. Natl Acad. Sci. USA 100, 4633–4638 (2003).
  Article CAS Google Scholar
• Calabrese, C. et al. A perivascular niche for brain tumor stem cells. Cancer Cell 11, 69–82 (2007).
  Article CAS Google Scholar
• Bao, S. et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 66, 7843–7848 (2006).
  Article CAS Google Scholar
• Folkins, C. et al. Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res. 67, 3560–3564 (2007).
  Article CAS Google Scholar
• Scherer, H. Cerebral astrocytomas and their derivatives. Am. J. Cancer 1, 159–198 (1940).
  Google Scholar
• Leon, S. P., Folkerth, R. D. & Black, P. M. Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 77, 362–372 (1996).
  Article CAS Google Scholar
• Vredenburgh, J. J. et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin. Cancer Res. 13, 1253–1259 (2007).
  Article CAS Google Scholar
• Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E. & Orkin, S. H. Rb Regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129, 1081–1095 (2007).
  Article CAS Google Scholar
• Piccirillo, S. G. et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444, 761–765 (2006).
  Article CAS Google Scholar
• Batchelor, T. T. et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11, 83–95 (2007).
  Article CAS Google Scholar