Chambers, A. F., Groom, A. C. & MacDonald, I. C. Dissemination and growth of cancer cells in metastatic sites. Nature Rev. Cancer2, 563–572 (2002). ArticleCAS Google Scholar
Heyn, C. et al. In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain. Magn. Reson. Med.56, 1001–1010 (2006). Article Google Scholar
Townson, J. L. et al. Three-dimensional imaging and quantification of both solitary cells and metastases in whole mouse liver by magnetic resonance imaging. Cancer Res.69, 8326–8331 (2009). ArticleCAS Google Scholar
Luzzi, K. J. et al. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am. J. Pathol.153, 865–873 (1998). ArticleCAS Google Scholar
Naumov, G. N. et al. Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res.62, 2162–2168 (2002). CASPubMed Google Scholar
Cameron, M. D. et al. Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res.60, 2541–2546 (2000). CASPubMed Google Scholar
Holmgren, L., O'Reilly, M. S. & Folkman, J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med.1, 149–153 (1995). ArticleCAS Google Scholar
Aguirre-Ghiso, J. A. Models, mechanisms and clinical evidence for cancer dormancy. Nature Rev. Cancer7, 834–846 (2007). ArticleCAS Google Scholar
Muller, V., Alix-Panabieres, C. & Pantel, K. Insights into minimal residual disease in cancer patients: implications for anti-cancer therapies. Eur. J. Cancer46, 1189–1197 (2010). Article Google Scholar
Pantel, K., Alix-Panabieres, C. & Riethdorf, S. Cancer micrometastases. Nature Rev. Clin. Oncol.6, 339–351 (2009). CAS Google Scholar
Naumov, G. N. et al. A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. J. Natl Cancer Inst.98, 316–325 (2006). Article Google Scholar
Naumov, G. N., Akslen, L. A. & Folkman, J. Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle5, 1779–1787 (2006). ArticleCAS Google Scholar
Indraccolo, S., Favaro, E. & Amadori, A. Dormant tumors awaken by a short-term angiogenic burst: the spike hypothesis. Cell Cycle5, 1751–1755 (2006). ArticleCAS Google Scholar
Favaro, E., Amadori, A. & Indraccolo, S. Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy. APMIS116, 648–659 (2008). ArticleCAS Google Scholar
Indraccolo, S. et al. Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. Cancer Res.69, 1314–1323 (2009). ArticleCAS Google Scholar
Ranganathan, A. C., Adam, A. P., Zhang, L. & Aguirre-Ghiso, J. A. Tumor cell dormancy induced by p38SAPK and ER-stress signaling: an adaptive advantage for metastatic cells? Cancer Biol. Ther.5, 729–735 (2006). ArticleCAS Google Scholar
Allgayer, H. & Aguirre-Ghiso, J. A. The urokinase receptor (u-PAR)-a link between tumor cell dormancy and minimal residual disease in bone marrow? APMIS116, 602–614 (2008). ArticleCAS Google Scholar
Adam, A. P. et al. Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence. Cancer Res.69, 5664–5672 (2009). ArticleCAS Google Scholar
Rak, J. W., McEachern, D. & Miller, F. R. Sequential alteration of peanut agglutinin binding-glycoprotein expression during progression of murine mammary neoplasia. Br. J. Cancer65, 641–648 (1992). ArticleCAS Google Scholar
Morris, V. L., Tuck, A. B., Wilson, S. M., Percy, D. & Chambers, A. F. Tumor progression and metastasis in murine D2 hyperplastic alveolar nodule mammary tumor cell lines. Clin. Exp. Metastasis11, 103–112 (1993). ArticleCAS Google Scholar
Naumov, G. N. et al. Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast Cancer Res. Treat.82, 199–206 (2003). ArticleCAS Google Scholar
Barkan, D. et al. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res.68, 6241–6250 (2008). ArticleCAS Google Scholar
Barkan, D. et al. Metastatic growth from dormant cells induced by a Col-I-enriched fibrotic environment. Cancer Res.70, 5706–5716 (2010). ArticleCAS Google Scholar
Barkan, D., Green, J. E. & Chambers, A. F. Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. Eur. J. Cancer46, 1181–1188 (2010). ArticleCAS Google Scholar
Shibue, T. & Weinberg, R. A. Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc. Natl Acad. Sci. USA106, 10290–10295 (2009). ArticleCAS Google Scholar
Goodison, S. et al. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein. Clin. Cancer Res.9, 3808–3814 (2003). CASPubMed Google Scholar
Suzuki, M., Mose, E. S., Montel, V. & Tarin, D. Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency. Am. J. Pathol.169, 673–681 (2006). ArticleCAS Google Scholar
Husemann, Y. et al. Systemic spread is an early step in breast cancer. Cancer Cell13, 58–68 (2008). PubMed Google Scholar
Eyles, J. et al. Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J. Clin. Invest.120, 2030–2039 (2010). ArticleCAS Google Scholar
Meng, S. et al. Circulating tumor cells in patients with breast cancer dormancy. Clin. Cancer Res.10, 8152–8162 (2004). Article Google Scholar
Sargent, D. J. et al. End points for colon cancer adjuvant trials: observations and recommendations based on individual patient data from 20,898 patients enrolled onto 18 randomized trials from the ACCENT Group. J. Clin. Oncol.25, 4569–4574 (2007). Article Google Scholar
Saphner, T., Tormey, D. C. & Gray, R. Annual hazard rates of recurrence for breast cancer after primary therapy. J. Clin. Oncol.14, 2738–2746 (1996). ArticleCAS Google Scholar
Retsky, M. W., Demicheli, R., Hrushesky, W. J., Baum, M. & Gukas, I. D. Dormancy and surgery-driven escape from dormancy help explain some clinical features of breast cancer. APMIS116, 730–741 (2008). ArticleCAS Google Scholar
Hanin, L. & Korosteleva, O. Does extirpation of the primary breast tumor give boost to growth of metastases? Evidence revealed by mathematical modeling. Math. Biosci.223, 133–141 (2010). Article Google Scholar
Riethmuller, G. & Klein, C. A. Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients. Semin. Cancer Biol.11, 307–311 (2001). ArticleCAS Google Scholar
Demicheli, R., Terenziani, M. & Bonadonna, G. Estimate of tumor growth time for breast cancer local recurrences: rapid growth after wake-up? Breast Cancer Res. Treat.51, 133–137 (1998). ArticleCAS Google Scholar
Braun, S. et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N. Engl. J. Med.353, 793–802 (2005). ArticleCAS Google Scholar
Ragaz, J. et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N. Engl. J. Med.337, 956–962 (1997). ArticleCAS Google Scholar
Overgaard, M. et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N. Engl. J. Med.337, 949–955 (1997). ArticleCAS Google Scholar
Slade, M. J. et al. Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment. Br. J. Cancer100, 160–166 (2009). ArticleCAS Google Scholar
Wikman, H., Vessella, R. & Pantel, K. Cancer micrometastasis and tumour dormancy. APMIS116, 754–770 (2008). ArticleCAS Google Scholar
Flores, L. M. et al. Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer. Br. J. Cancer102, 1495–1502 (2010). ArticleCAS Google Scholar
Maheswaran, S. et al. Detection of mutations in EGFR in circulating lung-cancer cells. N. Engl. J. Med.359, 366–377 (2008). ArticleCAS Google Scholar
Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell100, 57–70 (2000). ArticleCAS Google Scholar
Pantel, K. & Brakenhoff, R. H. Dissecting the metastatic cascade. Nature Rev. Cancer4, 448–456 (2004). ArticleCAS Google Scholar
Kendal, W. S. Chance mechanisms affecting the burden of metastases. BMC Cancer5, 138 (2005). Article Google Scholar
Chambers, A. F. Influence of diet on metastasis and tumor dormancy. Clin. Exp. Metastasis26, 61–66 (2009). ArticleCAS Google Scholar
Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet365, 1687–1717 (2005).
Fisher, B. et al. Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. J. Natl Cancer Inst.88, 1529–1542 (1996). ArticleCAS Google Scholar
Fisher, B., Dignam, J., Bryant, J. & Wolmark, N. Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. J. Natl Cancer Inst.93, 684–690 (2001). ArticleCAS Google Scholar
Stewart, H. J. et al. Randomised comparison of 5 years of adjuvant tamoxifen with continuous therapy for operable breast cancer. The Scottish Cancer Trials Breast Group. Br. J. Cancer74, 297–299 (1996). ArticleCAS Google Scholar
Tormey, D. C., Gray, R. & Falkson, H. C. Postchemotherapy adjuvant tamoxifen therapy beyond five years in patients with lymph node-positive breast cancer. Eastern Cooperative Oncology Group. J. Natl Cancer Inst.88, 1828–1833 (1996). ArticleCAS Google Scholar
Delozier, T. et al. Delayed adjuvant tamoxifen: ten-year results of a collaborative randomized controlled trial in early breast cancer (TAM-02 trial). Ann. Oncol.11, 515–519 (2000). ArticleCAS Google Scholar
Goss, P. E. et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N. Engl. J. Med.349, 1793–1802 (2003). ArticleCAS Google Scholar
Goss, P. E. et al. Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J. Natl Cancer Inst.97, 1262–1271 (2005). ArticleCAS Google Scholar
Goss, P. E. et al. Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen. J. Clin. Oncol.26, 1948–1955 (2008). ArticleCAS Google Scholar
Sabnis, G., Goloubeva, O., Gilani, R., Macedo, L. & Brodie, A. Sensitivity to the aromatase inhibitor letrozole is prolonged after a “break” in treatment. Mol. Cancer Ther.9, 46–56 (2010). ArticleCAS Google Scholar
Moy, B. & Goss, P. E. TEACH: Tykerb evaluation after chemotherapy. Clin. Breast Cancer7, 489–492 (2007). ArticleCAS Google Scholar
Tsao, H., Cosimi, A. B. & Sober, A. J. Ultra-late recurrence (15 years or longer) of cutaneous melanoma. Cancer79, 2361–2370 (1997). ArticleCAS Google Scholar
Farrar, J. D. et al. Cancer dormancy. VII. A regulatory role for CD8+ T cells and IFN-γ in establishing and maintaining the tumor-dormant state. J. Immunol.162, 2842–2849 (1999). CASPubMed Google Scholar
Muller-Hermelink, N. et al. TNFR1 signaling and IFN-γ signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis. Cancer Cell13, 507–518 (2008). Article Google Scholar
Quesnel, B. Tumor dormancy and immunoescape. APMIS116, 685–694 (2008). Article Google Scholar
Zhu, D., Corral, L. G., Fleming, Y. W. & Stein, B. Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation. Cancer Immunol. Immunother.57, 1849–1859 (2008). ArticleCAS Google Scholar
Delea, T. E. et al. Cost-effectiveness of extended adjuvant letrozole therapy after 5 years of adjuvant tamoxifen therapy in postmenopausal women with early-stage breast cancer. Am. J. Manag. Care12, 374–386 (2006). PubMed Google Scholar
Chapman, J. A. et al. Competing causes of death from a randomized trial of extended adjuvant endocrine therapy for breast cancer. J. Natl Cancer Inst.100, 252–260 (2008). Article Google Scholar
Whelan, T. J. et al. Assessment of quality of life in MA.17: a randomized, placebo-controlled trial of letrozole after 5 years of tamoxifen in postmenopausal women. J. Clin. Oncol.23, 6931–6940 (2005). ArticleCAS Google Scholar
Pantel, K., Braun, S., Schlimok, G. & Riethmuller, G. Micrometastatic tumour cells in bone marrow in colorectal cancer. Lancet341, 501 (1993). ArticleCAS Google Scholar
Pantel, K. et al. Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells. J. Natl Cancer Inst.85, 1419–1424 (1993). ArticleCAS Google Scholar
Murphy, J. E. & Ryan, D. P. American Society of Clinical Oncology 2010 colorectal update. Expert Rev. Anticancer Ther.10, 1371–1373 (2010). Article Google Scholar
Allegra, C. J. et al. Initial safety report of NSABP C-08: a randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J. Clin. Oncol.27, 3385–3390 (2009). ArticleCAS Google Scholar
Wolmark, N. et al. A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: results of NSABP Protocol C-08. J. Clin. Oncol. Abstr.27, LBA4 (2009). Article Google Scholar