Integrative oncology: really the best of both worlds? (original) (raw)
Glymour, C. & Stalker, D. Sounding board. Engineers, cranks, physicians, magicians. N. Engl. J. Med.308, 960–964 (1983). ArticleCASPubMed Google Scholar
Wechsler, M. E. et al. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N. Engl. J. Med.365, 119–126 (2011). ArticleCASPubMedPubMed Central Google Scholar
Berman, B. M., Langevin, H. M., Witt, C. M. & Dubner, R. Acupuncture for chronic low back pain. N. Engl. J. Med.363, 454–461 (2010). ArticleCASPubMed Google Scholar
Cramer, H., Cohen, L., Dobos, G. & Witt, C. M. Integrative oncology: best of both worlds-theoretical, practical, and research issues. Evid. Based Complement. Alternat. Med.2013, 383142 (2013). PubMedPubMed Central Google Scholar
Kiser, K. Integrative oncology. The best of both worlds. Minn. Med. 93 8, 10 (2010). Google Scholar
Sagar, S. M. & Leis, A. M. Integrative oncology: a Canadian and international perspective. Curr. Oncol.15 (Suppl. 2), s71–s73 (2008). PubMedPubMed Central Google Scholar
Kim, J. I., Lee, M. S., Kang, J. W., Choi do, Y. & Ernst, E. Reflexology for the symptomatic treatment of breast cancer: a systematic review. Integr. Cancer Ther.9, 326–330 (2010). ArticlePubMed Google Scholar
Reddy, S. A. Top hospital opens up to chinese herbs as medicines. Wall Street Journal[online] (April 21, 2014)
Mease, M. R. Reiki at University Medical Center, Tucson, Arizona, a magnet hospital: Mega, R. Mease is interviewed by William Lee Rand. Holist Nurs. Pract.25, 233–237 (2011). ArticlePubMed Google Scholar
Rosa, L., Rosa, E., Sarner, L. & Barrett, S. A close look at therapeutic touch. JAMA279, 1005–1010 (1998). ArticleCASPubMed Google Scholar
Ernst, E. Is reflexology an effective intervention? A systematic review of randomised controlled trials. Med. J. Aust.191, 263–266 (2009). PubMed Google Scholar
White, A. R., Williamson, J., Hart, A. & Ernst, E. A blinded investigation into the accuracy of reflexology charts. Complement Ther. Med.8, 166–172 (2000). ArticleCASPubMed Google Scholar
Colquhoun, D. & Novella, S. P. Acupuncture is theatrical placebo. Anesth. Analg.116, 1360–1363 (2013). ArticlePubMed Google Scholar
Smith, K. Against homeopathy—a utilitarian perspective. Bioethics26, 398–409 (2012). ArticlePubMed Google Scholar
Smith, K. Homeopathy is unscientific and unethical. Bioethics26, 508–512 (2012). Article Google Scholar
Atwood, K. C. Naturopathy, pseudoscience, and medicine: myths and fallacies versus truth. MedGenMed6, 33 (2004). PubMedPubMed Central Google Scholar
Abrams, D. I. An overview of integrative oncology. Clin. Adv. Hematol. Oncol.5, 45–47 (2007). PubMed Google Scholar
Barton, D. & Bauer-Wu, S. The emerging discipline of integrative oncology. Oncol. (Williston Park)23, 46–49 (2009). Google Scholar
Berk, L. B. Primer on integrative oncology. Hematol. Oncol. Clin. North Am.20, 213–231 (2006). ArticlePubMed Google Scholar
Pineda, M. J. & Singh, D. K. What is integrative oncology and can it help my patients? Obstet. Gynecol. Clin. North Am.39, 285–312 (2012). ArticlePubMed Google Scholar
Standish, L. J., Sweet, E., Naydis, E. & Andersen, M. R. Can we demonstrate that breast cancer “integrative oncology” is effective? A methodology to evaluate the effectiveness of integrative oncology offered in community clinics. Integr. Cancer Ther.12, 126–135 (2013). ArticlePubMed Google Scholar
Cassileth, B. R. & Vickers, A. J. High prevalence of complementary and alternative medicine use among cancer patients: implications for research and clinical care. J. Clin. Oncol.23, 2590–2592 (2005). ArticlePubMed Google Scholar
Marcus, D. M. & Grollman, A. P. Science and government. Review for NCCAM is overdue. Science313, 301–302 (2006). ArticleCASPubMed Google Scholar
Mielczarek, E. V. & Engler, B. D. Measuring mythology: Startling concepts in NCCAM grants. Skeptical Inquirer36, 36–43 (2012). Google Scholar
Mielczarek, E. V. & Engler, B. D. Selling pseudoscience: a rent in the fabric of American medicine. Skeptical Inquirer38, 44–51 (2014). Google Scholar
NCCAM. Facts-at-a-glance and mission access date, [online] (August 11 2014).
Boyle, E. W. The politics of alternative medicine at the National Institutes of Health. Federal Hist.1, 16–32 (2011). Google Scholar
Block, B. NCCAM reaches out to scientists and general public. Altern. Ther. Health Med.8, 24–26 (2002). PubMed Google Scholar
Ernst, E. & Posadzki, P. An independent review of NCCAM-funded studies of chiropractic. Clin. Rheumatol30, 593–600 (2011). ArticlePubMed Google Scholar
Folkman, S. et al. Debating the worth of NCCAM research. Science314, 1083–1084; author reply 1083–1084 (2006). ArticleCASPubMed Google Scholar
Straus, S. E. & Chesney, M. A. Science and government. Enhanced: in defense of NCCAM. Science313, 303–304 (2006). ArticleCASPubMed Google Scholar
Muscat, M. National Cancer Institute's OCCAM partners with NCCAM to expand research on unconventional cancer treatments. Altern. Ther. Health Med.5, 26–30 (1999). CASPubMed Google Scholar
Office of Cancer Complementary and Alternative Medicine. Annual report on complementary and alternative medicine. [online] (2011).
National Institutes of Health. What is complementary and alternative, medicine? [online] (U. S. Department of Health and Human Services, 2012).
National Institutes of Health. What is complementary and alternative medicine? [online] (U. S. Department of Health and Human Services, 2007).
NCCAM.Complementary, Alternative, or Integrative Health: What's In a Name? [online] (2008).
Tomlinson, D., Diorio, C., Beyene, J. & Sung, L. Effect of exercise on cancer-related fatigue: a meta-analysis. Am. J. Phys. Med. Rehabil.93, 675–686 (2014). ArticlePubMed Google Scholar
Zeng, Y., Huang, M., Cheng, A. S., Zhou, Y. & So, W. K. Meta-analysis of the effects of exercise intervention on quality of life in breast cancer survivors. Breast Cancer21, 262–274 (2014). ArticlePubMed Google Scholar
Zou, L. Y., Yang, L., He, X. L., Sun, M. & Xu, J. J. Effects of aerobic exercise on cancer-related fatigue in breast cancer patients receiving chemotherapy: a meta-analysis. Tumour Biol.35, 5659–5667 (2014). ArticleCASPubMed Google Scholar
Grosso, G. et al. Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects. BMC Surg.13(Suppl. 2), S14 (2013). ArticlePubMedPubMed Central Google Scholar
Reedy, J. et al. Higher Diet Quality Is Associated with Decreased Risk of All-Cause, Cardiovascular Disease, and Cancer Mortality among Older Adults. J. Nutr.144, 881–889 (2014). ArticleCASPubMedPubMed Central Google Scholar
Lynton, H., Kligler, B. & Shiflett, S. Yoga in stroke rehabilitation: a systematic review and results of a pilot study. Top. Stroke Rehabil.14, 1–8 (2007). ArticlePubMed Google Scholar
American Diabetes Association. Standards of medical care in diabetes—2014. Diabetes Care37 (Suppl. 1), S14–80 (2014).
Chang, C. & Gershwin, M. E. Integrative medicine in allergy and immunology. Clin. Rev. Allergy Immunol.44, 208–228 (2013). ArticleCASPubMed Google Scholar
Cooper, E. L. & Hirabayashi, K. Origin of innate immune responses: revelation of food and medicinal applications. J. Tradit Complement. Med.3, 204–212 (2013). ArticlePubMedPubMed Central Google Scholar
DeBusk, R., Sierpina, V. S. & Kreitzer, M. J. Applying functional nutrition for chronic disease prevention and management: bridging nutrition and functional medicine in 21st century healthcare. Explore7, 55–57 (2011). ArticlePubMed Google Scholar
NCCAM National, Center for Complementary and Alternative Medicine Third Strategic Plan 2011-2015: Exploring the Science of Complementary and Alternative Medicine [online] (U. S. Department of Health and Human Services, 2011).
[no authors listed] Questionable methods of cancer management: 'nutritional' therapies. CA Cancer J. Clin.43, 309–319 (1993).
[no authors listed] Unproven methods of cancer management: Gerson, Method. CA Cancer J. Clin.40, 252–256 (1990).
Benson, H. et al. Study of the Therapeutic Effects of Intercessory Prayer (STEP) in cardiac bypass patients: a multicenter randomized trial of uncertainty and certainty of receiving intercessory prayer. Am. Heart J.151, 934–942 (2006). ArticlePubMed Google Scholar
da Rosa, M. I. et al. A randomized clinical trial on the effects of remote intercessory prayer in the adverse outcomes of pregnancies. Cien. Saude Colet.18, 2379–2384 (2013). ArticlePubMed Google Scholar
Masters, K. S., Spielmans, G. I. & Goodson, J. T. Are there demonstrable effects of distant intercessory prayer? A meta-analytic review. Ann. Behav. Med.32, 21–26 (2006). ArticlePubMed Google Scholar
Baldwin, A. L. & Hammerschlag, R. Biofield-based therapies: a systematic review of physiological effects on practitioners during healing. Explore10, 150–161 (2014). ArticlePubMed Google Scholar
Ernst, E. Homeopathy, a “helpful placebo” or an unethical intervention? Trends Pharmacol. Sci.31, 1 (2010). ArticleCASPubMed Google Scholar
Atwood, K. C. Naturopathy: a critical appraisal. MedGenMed5, 39 (2003). PubMed Google Scholar
Cassileth, B. R. & Yarett, I. R. Cancer quackery: the persistent popularity of useless, irrational 'alternative' treatments. Oncology (Williston Park)26, 754–758 (2012). Google Scholar
[no authors listed] Questionable methods of cancer management: Cancell/Entelev. CA Cancer J. Clin.43, 57–62 (1993).
[no authors listed] Unproven methods of cancer management. Laetrile. CA Cancer J. Clin.41, 187–192 (1991).
Moertel, C. G. et al. A clinical trial of amygdalin (Laetrile) in the treatment of human cancer. N. Engl. J. Med.306, 201–206 (1982). ArticleCASPubMed Google Scholar
Deng, G. & Cassileth, B. Complementary or alternative medicine in cancer care-myths and realities. Nature Rev. Clin. Oncol.10, 656–664 (2013). Article Google Scholar
Dobos, G., Cramer, H., Anant, S., Witt, C. M. & Cohen, L. Integrative oncology. Evid. Based Complement. Alternat. Med.2013, 124032 (2013). ArticlePubMedPubMed Central Google Scholar
Smyth, J. F. Integrative oncology—what's in a name? Eur. J. Cancer42, 572–573 (2006). ArticlePubMed Google Scholar
Ning, A. M. How 'alternative' is CAM? Rethinking conventional dichotomies between biomedicine and complementary/alternative medicine. Health (Lond.)17, 135–158 (2013). Article Google Scholar
Morange, M. The recent evolution of the question “What is life”? Hist. Philos. Life Sci.34, 425–436; discussion 436–438 (2012). PubMed Google Scholar
Lee, M. S., Pittler, M. H. & Ernst, E. Effects of reiki in clinical practice: a systematic review of randomised clinical trials. Int. J. Clin. Pract.62, 947–954 (2008). ArticleCASPubMed Google Scholar
Ernst, E. Chiropractic: a critical evaluation. J. Pain Symptom Manage.35, 544–562 (2008). ArticlePubMed Google Scholar
Green, C., Martin, C. W., Bassett, K. & Kazanjian, A. A systematic review of craniosacral therapy: biological plausibility, assessment reliability and clinical effectiveness. Complement Ther. Med.7, 201–207 (1999). ArticleCASPubMed Google Scholar
Ernst, E. Craniosacral therapy: A systematic review of the clinical evidence. FACT17, 197–201 (2012). Article Google Scholar
Ernst, E., Posadzki, P. & Lee, M. S. Reflexology: an update of a systematic review of randomised clinical trials. Maturitas68, 116–120 (2011). ArticleCASPubMed Google Scholar
Anastasi, J. K., Currie, L. M. & Kim, G. H. Understanding diagnostic reasoning in TCM practice: tongue diagnosis. Altern Ther. Health Med.15, 18–28 (2009). PubMed Google Scholar
Chan, K. Progress in traditional Chinese medicine. Trends Pharmacol. Sci.16, 182–187 (1995). ArticleCASPubMed Google Scholar
Cheng, J. T. Review: drug therapy in Chinese traditional medicine. J. Clin. Pharmacol.40, 445–450 (2000). ArticleCASPubMed Google Scholar
Yapijakis, C. Hippocrates of Kos, the father of clinical medicine, and Asclepiades of Bithynia, the father of molecular medicine. Review. In Vivo23, 507–514 (2009). PubMed Google Scholar
Sakorafas, G. H. & Safioleas, M. Breast cancer surgery: an historical narrative. Part, I. From prehistoric times to Renaissance. Eur. J. Cancer Care18, 530–544 (2009). Article Google Scholar
Ernst, E. Homeopathy: what does the “best” evidence tell us? Med. J. Aust.192, 458–460 (2010). PubMed Google Scholar
Tonelli, M. R. The limits of evidence-based medicine. Respir. Care46, 1435–1440; discussion 1440–1441 (2001). CASPubMed Google Scholar
Tonelli, M. R. & Callahan, T. C. Why alternative medicine cannot be evidence-based. Acad. Med.76, 1213–1220 (2001). ArticleCASPubMed Google Scholar
Miles, A. On a medicine of the whole person: away from scientistic reductionism and towards the embrace of the complex in clinical practice. J. Eval. Clin. Pract.15, 941–949 (2009). ArticlePubMed Google Scholar
Vickers, A. J. Message to complementary and alternative medicine: evidence is a better friend than power. BMC Complement Altern Med.1, 1 (2001). ArticleCASPubMedPubMed Central Google Scholar
Seshia, S. S. & Young, G. B. The evidence-based medicine paradigm: where are we 20 years later? Part 2. Can. J. Neurol. Sci.40, 475–481 (2013). ArticlePubMed Google Scholar
Seshia, S. S. & Young, G. B. The evidence-based medicine paradigm: where are we 20 years later? Part 1. Can. J. Neurol. Sci.40, 465–474 (2013). ArticlePubMed Google Scholar
DeVita, V. T. Jr & Chu, E. A history of cancer chemotherapy. Cancer Res.68, 8643–8653 (2008). ArticleCASPubMed Google Scholar
Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials. Lancet379, 432–444 (2011).
Shang, A. et al. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet366, 726–732 (2005). ArticlePubMed Google Scholar
Altunc, U., Pittler, M. H. & Ernst, E. Homeopathy for childhood and adolescence ailments: systematic review of randomized clinical trials. Mayo Clin. Proc.82, 69–75 (2007). ArticlePubMed Google Scholar
Gorski, D. H. & Novella, S. P. Clinical trials of integrative medicine: testing whether magic works? Trends Mol. Med.20, 473–476 (2014). ArticlePubMed Google Scholar
Linde, K. et al. Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials. Lancet350, 834–843 (1997). ArticleCASPubMed Google Scholar
Ludtke, R. & Rutten, A. L. The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials. J. Clin. Epidemiol.61, 1197–1204 (2008). ArticleCASPubMed Google Scholar
Ernst, E. & Pittler, M. H. Re-analysis of previous meta-analysis of clinical trials of homeopathy. J. Clin. Epidemiol.53, 1188 (2000). ArticleCASPubMed Google Scholar
Linde, K. et al. Impact of study quality on outcome in placebo-controlled trials of homeopathy. J. Clin. Epidemiol.52, 631–636 (1999). ArticleCASPubMed Google Scholar
Kassab, S., Cummings, M., Berkovitz, S., van Haselen, R. & Fisher, P. Homeopathic medicines for adverse effects of cancer treatments. Cochrane Database Syst. Rev. CD004845 (2009).
Oberbaum, M. et al. A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer92, 684–690 (2001). ArticleCASPubMed Google Scholar
Pommier, P. et al. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J. Clin. Oncol.22, 1447–1453 (2004). ArticleCASPubMed Google Scholar
Vinceti, M. et al. Selenium for preventing cancer. Cochrane Database Syst. Rev.3, CD005195 (2014). Google Scholar
Klein, E. A. et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA306, 1549–1556 (2011). ArticleCASPubMedPubMed Central Google Scholar
The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and β carotene on the incidence of lung cancer and other cancers in male smokers. The α-Tocopherol, β Carotene Cancer Prevention Study Group. N. Engl. J. Med.330, 1029–1035 (1994).
Virtamo, J. et al. Incidence of cancer and mortality following α-tocopherol and β-carotene supplementation: a postintervention follow-up. JAMA290, 476–485 (2003). ArticleCASPubMed Google Scholar
Chen, Q. et al. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc. Natl Acad. Sci. USA105, 11105–11109 (2008). ArticleCASPubMedPubMed Central Google Scholar
Espey, M. G. et al. Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic. Biol. Med.50, 1610–1619 (2011). ArticleCASPubMedPubMed Central Google Scholar
Ma, Y. et al. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci. Transl. Med.6, 222ra18 (2014). ArticlePubMedCAS Google Scholar
Junio, H. A. et al. Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis). J. Nature Prod.74, 1621–1629 (2011). ArticleCAS Google Scholar
Yang, Y. et al. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. Fitoterapia92, 133–147 (2014). ArticleCASPubMed Google Scholar
Wu, J. J. et al. Interactions between phytochemicals from traditional Chinese medicines and human cytochrome P450 enzymes. Curr. Drug Metab.13, 599–614 (2012). ArticleCASPubMed Google Scholar
Worthley, L. I. & Holt, A. W. Digoxin in the critically ill patient. Crit. Care Resusc1, 252–264 (1999). CASPubMed Google Scholar
World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA310, 2191–2194 (2013).
Goldman, N. et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nature Neurosci.13, 883–888 (2010). ArticleCASPubMed Google Scholar
Hurt, J. K. & Zylka, M. J. PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain. Mol. Pain8, 28 (2012). ArticleCASPubMedPubMed Central Google Scholar
Garcia, M. K. et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J. Clin. Oncol.31, 952–960 (2013). ArticlePubMedPubMed Central Google Scholar
Cho, S. H., Lee, H. & Ernst, E. Acupuncture for pain relief in labour: a systematic review and meta-analysis. BJOG117, 907–920 (2010). ArticlePubMed Google Scholar
Ernst, E., Lee, M. S. & Choi, T. Y. Acupuncture: does it alleviate pain and are there serious risks? A review of reviews. Pain152, 755–764 (2011). ArticleCASPubMed Google Scholar
Gilby, A. Y., Ernst, E. & Tani, K. A systematic review of reviews of systematic reviews of acupuncture. FACT18, 8–18 (2013). Article Google Scholar
Posadzki, P. et al. Acupuncture for cancer-related fatigue: a systematic review of randomized clinical trials. Support Care Cancer, 21, 2067–2073 (2013). ArticlePubMed Google Scholar
Street, R. L. Jr., Cox, V., Kallen, M. A. & Suarez-Almazor, M. E. Exploring communication pathways to better health: clinician communication of expectations for acupuncture effectiveness. Patient Educ. Couns.89, 245–251 (2012). ArticlePubMedPubMed Central Google Scholar
White, P. et al. Practice, practitioner, or placebo? A multifactorial, mixed-methods randomized controlled trial of acupuncture. Pain153, 455–462 (2012). ArticlePubMed Google Scholar
Dodin, S. et al. Acupuncture for menopausal hot flushes. Cochrane Database Syst. Rev.7, CD007410 (2013). Google Scholar
Franconi, G., Manni, L., Schroder, S., Marchetti, P. & Robinson, N. A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy. Evid. Based Complement Alternat. Med.2013, 516916 (2013). ArticlePubMedPubMed Central Google Scholar
O'Sullivan, E. M. & Higginson, I. J. Clinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: a systematic review. Acupunct Med.28, 191–199 (2010). ArticleCASPubMed Google Scholar
Cheuk, D. K. & Wong, V. Acupuncture for epilepsy. Cochrane Database Syst. Rev.5, CD005062 (2014). Google Scholar
Kim, T. H. et al. Acupuncture for treating acute ankle sprains in adults. Cochrane Database Syst. Rev.6, CD009065 (2014). Google Scholar
White, A. R., Rampes, H., Liu, J. P., Stead, L. F. & Campbell, J. Acupuncture and related interventions for smoking cessation. Cochrane Database Syst. Rev.1, CD000009 (2014). Google Scholar
Chiu, H. Y., Pan, C. H., Shyu, Y. K., Han, B. C. & Tsai, P. S. Effects of acupuncture on menopause-related symptoms and quality of life in women on natural menopause: a meta-analysis of randomized controlled trials. Menopausehttp://dx.doi.org/10.1097/GME.0000000000000260 (2014).
Cherkin, D. C. et al. A randomized trial comparing acupuncture, simulated acupuncture, and usual care for chronic low back pain. Arch. Intern. Med.169, 858–866 (2009). ArticlePubMedPubMed Central Google Scholar
Linde, K. et al. Acupuncture for patients with migraine: a randomized controlled trial. JAMA293, 2118–2125 (2005). ArticleCASPubMed Google Scholar
Pastore, L. M., Williams, C. D., Jenkins, J. & Patrie, J. T. True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab.96, 3143–3150 (2011). ArticleCASPubMedPubMed Central Google Scholar
Manheimer, E. et al. The effects of acupuncture on rates of clinical pregnancy among women undergoing in vitro fertilization: a systematic review and meta-analysis. Hum. Reprod. Update19, 696–713 (2013). ArticlePubMedPubMed Central Google Scholar
Bao, T. et al. Patient-reported outcomes in women with breast cancer enrolled in a dual-center, double-blind, randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms. Cancer120, 381–389 (2014). ArticlePubMed Google Scholar
Goldman, R. H. et al. Acupuncture for treatment of persistent arm pain due to repetitive use: a randomized controlled clinical trial. Clin. J. Pain24, 211–218 (2008). ArticlePubMed Google Scholar
Vickers, A. J. et al. Acupuncture for chronic pain: individual patient data meta-analysis. Arch. Intern. Med.172, 1444–1453 (2012). ArticlePubMedPubMed Central Google Scholar
Stauffer, M. E., Taylor, S. D., Watson, D. J., Peloso, P. M. & Morrison, A. Definition of nonresponse to analgesic treatment of arthritic pain: an analytical literature review of the smallest detectable difference, the minimal detectable change, and the minimal clinically important difference on the pain visual analog scale. Int. J. Inflam.2011, 231926 (2011). ArticlePubMedPubMed Central Google Scholar
Tubach, F. et al. Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: Results from a prospective multinational study. Arthritis Care Res.64, 1699–1707 (2012). ArticleCAS Google Scholar
Atwood, K. C., Woeckner, E., Baratz, R. S. & Sampson, W. I. Why the NIH Trial to Assess Chelation Therapy (TACT) should be abandoned. Medscape J. Med.10, 115 (2008). PubMedPubMed Central Google Scholar
Nissen, S. E. Concerns about reliability in the Trial to Assess Chelation Therapy (TACT). JAMA309, 1293–1294 (2013). ArticleCASPubMed Google Scholar
Chabot, J. A. et al. Pancreatic proteolytic enzyme therapy compared with gemcitabine-based chemotherapy for the treatment of pancreatic cancer. J. Clin. Oncol.28, 2058–2063 (2010). ArticleCASPubMed Google Scholar
Vitale, A. Introduction for “Reiki at University Medical Center, Tucson, Arizona, a magnet hospital”: Mega, R. Mease is interviewed by William Lee Rand. Holist Nurs. Pract.25, 231–232 (2011). ArticlePubMed Google Scholar
Paley, C. A., Johnson, M. I., Tashani, O. A. & Bagnall, A. M. Acupuncture for cancer pain in adults. Cochrane Database Syst. Rev. CD007753 (2011).
Paley, C. A., Tashani, O. A., Bagnall, A. M. & Johnson, M. I. A. Cochrane systematic review of acupuncture for cancer pain in adults. BMJ Support Palliat Care1, 51–55 (2011). ArticlePubMed Google Scholar
Moerman, D. E. Meaningful placebos—controlling the uncontrollable. N. Engl. J. Med.365, 171–172 (2011). ArticleCASPubMed Google Scholar
Kaptchuk, T. J. et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS ONE5, e15591 (2010). ArticleCASPubMedPubMed Central Google Scholar
Spiegel, D., Bloom, J. R., Kraemer, H. C. & Gottheil, E. Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet2, 888–891 (1989). ArticleCASPubMed Google Scholar
Andersen, B. L. et al. Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. Cancer113, 3450–3458 (2008). ArticlePubMed Google Scholar
Boesen, E. H. & Johansen, C. Impact of psychotherapy on cancer survival: time to move on? Curr. Opin. Oncol.20, 372–377 (2008). ArticlePubMed Google Scholar
Young, D. C. & Hade, E. M. Holidays, birthdays, and postponement of cancer death. JAMA292, 3012–3016 (2004). ArticleCASPubMed Google Scholar
Pearson, N. J. & Chesney, M. A. The CAM Education Program of the National Center for Complementary and Alternative Medicine: an overview. Acad. Med.82, 921–926 (2007). ArticlePubMed Google Scholar
Caspi, O., Bell, I. R., Rychener, D., Gaudet, T. W. & Weil, A. T. The Tower of Babel: communication and medicine: An essay on medical education and complementary-alternative medicine. Arch. Intern. Med.160, 3193–3195 (2000). ArticleCASPubMed Google Scholar
Amri, H., Haramati, A., Sierpina, V. S. & Kreitzer, M. J. Georgetown University's graduate program in complementary and alternative medicine: training future practitioners of integrative healthcare. Explore8, 258–261 (2012). ArticlePubMed Google Scholar
Smith, K. R. Factors influencing the inclusion of complementary and alternative medicine (CAM) in undergraduate medical education. BMJ Open1, e000074 (2011). ArticlePubMedPubMed Central Google Scholar
Dossett, M. L. et al. A medical student elective promoting humanism, communication skills, complementary and alternative medicine and physician self-care: an evaluation of the HEART program. Explore9, 292–298 (2013). ArticlePubMed Google Scholar
Locke, A. B., Gordon, A., Guerrera, M. P., Gardiner, P. & Lebensohn, P. Recommended integrative medicine competencies for family medicine residents. Explore9, 308–313 (2013). ArticlePubMed Google Scholar
Marcus, D. M. & McCullough, L. An evaluation of the evidence in “evidence-based” integrative medicine programs. Acad. Med.84, 1229–1234 (2009). ArticlePubMed Google Scholar
Brokaw, J. J., Tunnicliff, G., Raess, B. U. & Saxon, D. W. The teaching of complementary and alternative medicine in U. S. medical schools: a survey of course directors. Acad. Med.77, 876–881 (2002). ArticlePubMed Google Scholar
Eyigor, S. & Kanyilmaz, S. Exercise in patients coping with breast cancer: An overview. World J. Clin. Oncol.5, 406–411 (2014). ArticlePubMedPubMed Central Google Scholar