The pathophysiology of hypertension in patients with obesity (original) (raw)
Malik, V. S., Willett, W. C. & Hu, F. B. Global obesity: trends, risk factors and policy implications. Nat. Rev. Endocrinol.9, 13–27 (2013). PubMed Google Scholar
Thomsen, B. L., Ekstrøm, C. T. & Sørensen, T. I. Development of the obesity epidemic in Denmark: cohort, time and age effects among boys born 1930–1975. Int. J. Obes. Relat. Metab. Disord.23, 693–701 (1999). CASPubMed Google Scholar
Heimburger, D. C. et al. A festschrift for Roland L. Weinsier: nutrition scientist, educator, and clinician. Obes. Res.11, 1246–1262 (2003). PubMed Google Scholar
Keith, S. W. et al. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int. J. Obes (Lond.)30, 1585–1594 (2006). CAS Google Scholar
McAllister, E. J. et al. Ten putative contributors to the obesity epidemic. Crit. Rev. Food Sci. Nutr.49, 868–913 (2009). PubMedPubMed Central Google Scholar
Sørensen, T. I. Conference on “Multidisciplinary approaches to nutritional problems”. Symposium on “Diabetes and health”. Challenges in the study of causation of obesity. Proc. Nutr. Soc.68, 43–54 (2009). PubMed Google Scholar
Sowers, J. R. Diabetes mellitus and vascular disease. Hypertension61, 943–947 (2013). CASPubMed Google Scholar
Flegal, K. M., Carroll, M. D., Ogden, C. L. & Curtin, L. R. Prevalence and trends in obesity among US adults, 1999–2008. JAMA303, 235–241 (2010). CASPubMed Google Scholar
Ogden, C. L. et al. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA295, 1549–1555 (2006). CASPubMed Google Scholar
Sowers, J. R., Whaley-Connel, A. T. & Hayden, M. R. The role of overweight and obesity in the cardiorenal syndrome. Cardiorenal Med.1, 5–12 (2011). PubMedPubMed Central Google Scholar
Yach, D., Stuckler, D. & Brownell, K. D. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat. Med.12, 62–66 (2006). CASPubMed Google Scholar
Kannel, W. B., Brand, N., Skinner, J. J. Jr, Dawber, T. R. & McNamara, P. M. The relation of adiposity to blood pressure and development of hypertension. The Framingham study. Ann. Intern. Med.67, 48–59 (1967). CASPubMed Google Scholar
Bramlage, P. et al. Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled. Am. J. Hypertens.17, 904–910 (2004). PubMed Google Scholar
Krauss, R. M., Winston, M., Fletcher, B. J. & Grundy, S. M. Obesity: impact on cardiovascular disease. Circulation98, 1472–1476 (1998). PubMed Google Scholar
Garrison, R. J., Kannel, W. B., Stokes, J. 3rd & Castelli, W. P. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev. Med.16, 235–251 (1987). CASPubMed Google Scholar
Brown, C. D. et al. Body mass index and the prevalence of hypertension and dyslipidemia. Obes. Res.8, 605–619 (2000). CASPubMed Google Scholar
Shihab, H. M. et al. Body mass index and risk of incident hypertension over the life course: the Johns Hopkins Precursors Study. Circulation126, 2983–2989 (2012). PubMedPubMed Central Google Scholar
Droyvold, W. B., Midthjell, K., Nilsen, T. I. & Holmen, J. Change in body mass index and its impact on blood pressure: a prospective population study. Int. J. Obes. (Lond.)29, 650–655 (2005). CAS Google Scholar
Vague, J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am. J. Clin. Nutr.4, 20–34 (1956). CASPubMed Google Scholar
Kissebah, A. H. et al. Relation of body fat distribution to metabolic complications of obesity. J. Clin. Endocrinol. Metab.54, 254–260 (1982). CASPubMed Google Scholar
Krotkiewski, M., Björntorp, P., Sjöström, L. & Smith, U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J. Clin. Invest.72, 1150–1162 (1983). CASPubMedPubMed Central Google Scholar
Cassano, P. A., Segal, M. R., Vokonas, P. S. & Weiss, S. T. Body fat distribution, blood pressure, and hypertension. A prospective cohort study of men in the normative aging study. Ann. Epidemiol.1, 33–48 (1990). CASPubMed Google Scholar
Lapidus, L. et al. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br. Med. J. (Clin. Res. Ed.)289, 1257–1261 (1984). CAS Google Scholar
Larsson, B. et al. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br. Med. J. (Clin. Res. Ed.)288, 1401–1404 (1984). CAS Google Scholar
Alberti, K. G. & Zimmet, P. Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med.15, 539–553 (1998). CASPubMed Google Scholar
Alberti, K. G. et al. Harmonizing the metabolic syndrome. A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation120, 1640–1645 (2009). CASPubMed Google Scholar
Neter, J. E., Stam, B. E., Kok, F. J., Grobbee, D. E. & Geleijnse, J. M. Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension42, 878–884 (2003). CASPubMed Google Scholar
Appel, L. J. et al. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension47, 296–308 (2006). CASPubMed Google Scholar
Landsberg, L. et al. Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment—a position paper of the The Obesity Society and The American Society of Hypertension. Obesity (Silver Spring)21, 8–24 (2013). Google Scholar
Kotchen, T. A. Obesity-related hypertension: epidemiology, pathophysiology, and clinical management. Am. J. Hypertens.23, 1170–1178 (2010). CASPubMed Google Scholar
Esler, M. et al. Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension48, 787–796 (2006). CASPubMed Google Scholar
Henry, S. L. et al. Developmental origins of obesity-related hypertension. Clin. Exp. Pharmacol. Physiol.39, 799–806 (2012). CASPubMed Google Scholar
Rumantir, M. S. et al. Neural mechanisms in human obesity-related hypertension. J. Hypertens.17, 1125–1133 (1999). CASPubMed Google Scholar
Grassi, G. et al. Adrenergic and reflex abnormalities in obesity-related hypertension. Hypertension36, 538–542 (2000). CASPubMed Google Scholar
Zhao, D. et al. Dietary factors associated with hypertension. Nat. Rev. Cardiol.8, 456–465 (2011). CASPubMed Google Scholar
Aghamohammadzadeh, R. & Heagerty, A. M. Obesity-related hypertension: epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue. Ann. Med.44 (Suppl. 1), S74–S84 (2012). CASPubMed Google Scholar
Jordan, J. et al. Joint statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and difficult to treat arterial hypertension. J. Hypertens.30, 1047–1055 (2012). CASPubMed Google Scholar
Messerli, F. H. et al. Disparate cardiovascular findings in men and women with essential hypertension. Ann. Intern. Med.107, 158–161 (1987). CASPubMed Google Scholar
Aroor, A. R., McKarns, S., Demarco, V. G., Jia, G. & Sowers, J. R. Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance. Metabolism62, 1543–1552 (2013). CASPubMed Google Scholar
Huxley, R., Barzi, F. & Woodward, M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ332, 73–78 (2006). PubMedPubMed Central Google Scholar
Barrett-Connor, E. et al. Women and heart disease: the role of diabetes and hyperglycemia. Arch. Intern. Med.164, 934–942 (2004). PubMed Google Scholar
Howard, B. V. et al. Adverse effects of diabetes on multiple cardiovascular disease risk factors in women. The Strong Heart Study. Diabetes Care21, 1258–1265 (1998). CASPubMed Google Scholar
Okosun, I. S., Prewitt, T. E. & Cooper, R. S. Abdominal obesity in the United States: prevalence and attributable risk of hypertension. J. Hum. Hypertens.13, 425–430 (1999). CASPubMed Google Scholar
Huang, Z. et al. Body weight, weight change, and risk for hypertension in women. Ann. Intern. Med.128, 81–88 (1998). CASPubMed Google Scholar
Engeli, S. et al. Weight loss and the renin-angiotensin-aldosterone system. Hypertension45, 356–362 (2005). CASPubMed Google Scholar
Li, M., Sloboda, D. M. & Vickers, M. H. Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models. Exp. Diabetes Res.2011, 592408 (2011). CASPubMedPubMed Central Google Scholar
Fullston, T. et al. Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB J.27, 4226–4243 (2013). CASPubMed Google Scholar
Bray, G. A., Nielsen, S. J. & Popkin, B. M. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am. J. Clin. Nutr.79, 537–543 (2004). CASPubMed Google Scholar
Khitan, Z. & Kim, D. H. Fructose: a key factor in the development of metabolic syndrome and hypertension. J. Nutr. Metab.2013, 682673 (2013). PubMedPubMed Central Google Scholar
Hallfrisch, J. Metabolic effects of dietary fructose. FASEB J.4, 2652–2660 (1990). CASPubMed Google Scholar
Nguyen, S., Choi, H. K., Lustig, R. H. & Hsu, C. Y. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J. Pediatr.154, 807–813 (2009). CASPubMedPubMed Central Google Scholar
D'Angelo, G., Elmarakby, A. A., Pollock, D. M. & Stepp, D. W. Fructose feeding increases insulin resistance but not blood pressure in Sprague-Dawley rats. Hypertension46, 806–811 (2005). CASPubMed Google Scholar
Vasdev, S., Gill, V., Parai, S. & Gadag, V. Fructose-induced hypertension in Wistar-Kyoto rats: interaction with moderately high dietary salt. Can. J. Physiol. Pharmacol.85, 413–421 (2007). CASPubMed Google Scholar
Tapia, E. et al. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am. J. Physiol. Renal Physiol.304, F727–F736 (2013). CASPubMed Google Scholar
Weisbrod, R. M. et al. Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension62, 1105–1110 (2013). CASPubMed Google Scholar
Madero, M., Perez-Pozo, S. E., Jalal, D., Johnson, R. J. & Sanchez-Lozada, L. G. Dietary fructose and hypertension. Curr. Hypertens. Rep.13, 29–35 (2011). CASPubMed Google Scholar
He, F. J. & MacGregor, G. A. Effect of modest salt reduction on blood pressure: a meta-analysis of randomized trials. Implications for public health. J. Hum. Hypertens.16, 761–770 (2002). CASPubMed Google Scholar
[No authors listed] Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group. BMJ297, 319–328 (1988).
Simopoulos, A. P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed. Pharmacother.56, 365–379 (2002). CASPubMed Google Scholar
Morris, M. C., Sacks, F. & Rosner, B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation88, 523–533 (1993). CASPubMed Google Scholar
Appel, L. J., Miller, E. R. 3rd, Seidler, A. J. & Whelton, P. K. Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Arch. Intern. Med.153, 1429–1438 (1993). CASPubMed Google Scholar
Hu, F. B. & Manson, J. E. Omega-3 fatty acids and secondary prevention of cardiovascular disease—is it just a fish tale?: comment on “Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease”. Arch. Intern. Med.172, 694–696 (2012). CASPubMed Google Scholar
Appel, L. J. et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N. Engl. J. Med.336, 1117–1124 (1997). CASPubMed Google Scholar
Hord, N. G., Tang, Y. & Bryan, N. S. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am. J. Clin. Nutr.90, 1–10 (2009). CASPubMed Google Scholar
Coles, L. T. & Clifton, P. M. Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial. Nutr. J.11, 106 (2012). PubMedPubMed Central Google Scholar
Siervo, M., Lara, J., Ogbonmwan, I. & Mathers, J. C. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J. Nutr.143, 818–826 (2013). CASPubMed Google Scholar
Moncada, S., Palmer, R. M. & Higgs, E. A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev.43, 109–142 (1991). CASPubMed Google Scholar
Harris, K., Kassis, A., Major, G. & Chou, C. J. Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? J. Obes.2012, 879151 (2012). PubMedPubMed Central Google Scholar
Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature444, 1027–1031 (2006). PubMed Google Scholar
Geurts, L. et al. Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue. Front. Microbiol.2, 149 (2011). CASPubMedPubMed Central Google Scholar
Murphy, E. F. et al. Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut59, 1635–1642 (2010). CASPubMed Google Scholar
Shen, J., Obin, M. S. & Zhao, L. The gut microbiota, obesity and insulin resistance. Mol. Aspects Med.34, 39–58 (2013). CASPubMed Google Scholar
Kootte, R. S. et al. The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes. Metab.14, 112–120 (2012). CASPubMed Google Scholar
Delzenne, N. M., Neyrinck, A. M., Backhed, F. & Cani, P. D. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat. Rev. Endocrinol.7, 639–646 (2011). CASPubMed Google Scholar
Kurukulasuriya, L. R., Stas, S., Lastra, G., Manrique, C. & Sowers, J. R. Hypertension in obesity. Med. Clin. North Am.95, 903–917 (2011). PubMed Google Scholar
Slomko, H., Heo, H. J. & Einstein, F. H. Minireview: Epigenetics of obesity and diabetes in humans. Endocrinology153, 1025–1030 (2012). CASPubMedPubMed Central Google Scholar
Sharma, A. M. Is there a rationale for angiotensin blockade in the management of obesity hypertension? Hypertension44, 12–19 (2004). CASPubMed Google Scholar
Messerli, F. H. et al. Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion, and plasma renin activity. Arch. Intern. Med.141, 81–85 (1981). CASPubMed Google Scholar
Strazzullo, P. et al. Altered renal sodium handling in men with abdominal adiposity: a link to hypertension. J. Hypertens.19, 2157–2164 (2001). CASPubMed Google Scholar
McCurley, A. et al. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat. Med.18, 1429–1433 (2012). CASPubMedPubMed Central Google Scholar
Bender, S. B., McGraw, A. P., Jaffe, I. Z. & Sowers, J. R. Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease? Diabetes62, 313–319 (2013). CASPubMedPubMed Central Google Scholar
Hayden, M. R. & Tyagi, S. C. Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutr. Metab. (Lond.)1, 10 (2004). Google Scholar
Zhong, J., Rao, X. & Rajagopalan, S. An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease. Atherosclerosis226, 305–314 (2013). CASPubMed Google Scholar
Schleithoff, C., Voelter-Mahlknecht, S., Dahmke, I. N. & Mahlknecht, U. On the epigenetics of vascular regulation and disease. Clin. Epigenetics4, 7 (2012). PubMedPubMed Central Google Scholar
Ortega, F. J. et al. Targeting the circulating microRNA signature of obesity. Clin. Chem.59, 781–792 (2013). CASPubMed Google Scholar
Williams, M. D. & Mitchell, G. M. MicroRNAs in insulin resistance and obesity. Exp. Diabetes Res.2012, 484696 (2012). PubMedPubMed Central Google Scholar
Nistala, R. et al. Prenatal programming and epigenetics in the genesis of the cardiorenal syndrome. Cardiorenal Med.1, 243–254 (2011). CASPubMedPubMed Central Google Scholar
Ganu, R. S., Harris, R. A., Collins, K. & Aagaard, K. M. Early origins of adult disease: approaches for investigating the programmable epigenome in humans, nonhuman primates, and rodents. ILAR J.53, 306–321 (2012). PubMedPubMed Central Google Scholar
Barker, D. J. Intrauterine programming of adult disease. Mol. Med. Today1, 418–423 (1995). CASPubMed Google Scholar
Femia, R. et al. Carotid intima-media thickness in confirmed prehypertensive subjects: predictors and progression. Arterioscler. Thromb. Vasc. Biol.27, 2244–2249 (2007). CASPubMed Google Scholar
Cavalcante, J. L., Lima, J. A., Redheuil, A. & Al-Mallah, M. H. Aortic stiffness: current understanding and future directions. J. Am. Coll. Cardiol.57, 1511–1522 (2011). PubMed Google Scholar
Liao, D. et al. Arterial stiffness and the development of hypertension. The ARIC study. Hypertension34, 201–206 (1999). CASPubMed Google Scholar
Aroor, A. R. et al. The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front. Endocrinol.4, 161 (2013). Google Scholar
Stenmark, K. R. et al. The adventitia: essential regulator of vascular wall structure and function. Ann. Rev. Physiol.75, 23–47 (2013). CAS Google Scholar
Sehgel, N. L. et al. Increased vascular smooth muscle cell stiffness; a novel mechanism for aortic stiffness in hypertension. Am. J. Physiol. Heart Circ. Physiol.305, H1281–H1287 (2013). CASPubMedPubMed Central Google Scholar
Sandoo, A., van Zanten, J. J., Metsios, G. S., Carroll, D. & Kitas, G. D. The endothelium and its role in regulating vascular tone. Open Cardiovasc. Med. J.4, 302–312 (2010). PubMedPubMed Central Google Scholar
Li, R. et al. Vascular insulin resistance in prehypertensive rats: role of PI3-kinase/Akt/eNOS signaling. Eur. J. Pharmacol.628, 140–147 (2010). CASPubMed Google Scholar
Muniyappa, R. & Sowers, J. R. Role of insulin resistance in endothelial dysfunction. Rev. Endocr. Metab. Disord.14, 5–12 (2013). CASPubMedPubMed Central Google Scholar
Aroor, A. R., Mandavia, C. H. & Sowers, J. R. Insulin resistance and heart failure: molecular mechanisms. Heart Fail. Clin.8, 609–617 (2012). PubMedPubMed Central Google Scholar
Brillante, D. G., O'Sullivan, A. J. & Howes, L. G. Arterial stiffness in insulin resistance: the role of nitric oxide and angiotensin II receptors. Vasc. Health Risk Manag.5, 73–78 (2009). PubMedPubMed Central Google Scholar
DeMarco, V. G., Johnson, M. S., Whaley-Connell, A. T. & Sowers, J. R. Cytokine abnormalities in the etiology of the cardiometabolic syndrome. Curr. Hypertens. Rep.12, 93–98 (2010). CASPubMed Google Scholar
Leal Vde, O. & Mafra, D. Adipokines in obesity. Clin. Chim. Acta419, 87–94 (2013). PubMed Google Scholar
Dorresteijn, J. A., Visseren, F. L. & Spiering, W. Mechanisms linking obesity to hypertension. Obes. Rev.13, 17–26 (2012). CASPubMed Google Scholar
Brown, N. J. Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nat. Rev. Nephrol.9, 459–469 (2013). CASPubMedPubMed Central Google Scholar
Johnson, R. J., Rodriguez-Iturbe, B., Kang, D. H., Feig, D. I. & Herrera-Acosta, J. A unifying pathway for essential hypertension. Am. J. Hypertens.18, 431–440 (2005). PubMed Google Scholar
Montecucco, F., Pende, A., Quercioli, A. & Mach, F. Inflammation in the pathophysiology of essential hypertension. J. Nephrol.24, 23–34 (2011). PubMed Google Scholar
Harrison, D. G., Marvar, P. J. & Titze, J. M. Vascular inflammatory cells in hypertension. Front. Physiol.3, 128 (2012). CASPubMedPubMed Central Google Scholar
DeFronzo, R. A., Davidson, J. A. & Del Prato, S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes. Metab.14, 5–14 (2012). CASPubMed Google Scholar
Kanai, Y., Lee, W. S., You, G., Brown, D. & Hediger, M. A. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J. Clin. Invest.93, 397–404 (1994). CASPubMedPubMed Central Google Scholar
Rahmoune, H. et al. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes54, 3427–3434 (2005). CASPubMed Google Scholar
Tabatabai, N. M., Sharma, M., Blumenthal, S. S. & Petering, D. H. Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats. Diabetes Res. Clin. Pract.83, e27–e30 (2009). CASPubMed Google Scholar
Vallon, V. et al. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am. J. Physiol. Renal Physiol.304, F156–F167 (2013). CASPubMed Google Scholar
Vallon, V., Richter, K., Blantz, R. C., Thomson, S. & Osswald, H. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J. Am. Soc. Nephrol.10, 2569–2576 (1999). CASPubMed Google Scholar
Lee, Y. J., Lee, Y. J. & Han, H. J. Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells. Kidney Int. Suppl.106, S27–S35 (2007). CAS Google Scholar
Bautista, R. et al. Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension. Am. J. Physiol. Renal Physiol.286, F127–F133 (2004). CASPubMed Google Scholar
Ghezzi, C. & Wright, E. M. Regulation of the human Na+-dependent glucose cotransporter hSGLT2. Am. J. Physiol. Cell Physiol.303, C348–C354 (2012). CASPubMedPubMed Central Google Scholar
Ferrannini, E., Ramos, S. J., Salsali, A., Tang, W. & List, J. F. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care33, 2217–2224 (2010). PubMedPubMed Central Google Scholar
Bailey, C. J., Gross, J. L., Pieters, A., Bastien, A. & List, J. F. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet375, 2223–2233 (2010). CASPubMed Google Scholar
Nauck, M. A. et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care34, 2015–2022 (2011). CASPubMedPubMed Central Google Scholar
Hall, J. E. et al. Impact of the obesity epidemic on hypertension and renal disease. Curr. Hypertens. Rep.5, 386–392 (2003). PubMed Google Scholar
O'Dea, K., Esler, M., Leonard, P., Stockigt, J. R. & Nestel, P. Noradrenaline turnover during under- and over-eating in normal weight subjects. Metabolism31, 896–899 (1982). CASPubMed Google Scholar
Kassab, S. et al. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension25, 893–897 (1995). CASPubMed Google Scholar
Egan, B. M., Schork, N. J. & Weder, A. B. Regional hemodynamic abnormalities in overweight men. Focus on alpha-adrenergic vascular responses. Am. J. Hypertens.2, 428–434 (1989). CASPubMed Google Scholar
Agapitov, A. V., Correia, M. L., Sinkey, C. A. & Haynes, W. G. Dissociation between sympathetic nerve traffic and sympathetically mediated vascular tone in normotensive human obesity. Hypertension52, 687–695 (2008). CASPubMed Google Scholar
Lambert, G. W., Straznicky, N. E., Lambert, E. A., Dixon, J. B. & Schlaich, M. P. Sympathetic nervous activation in obesity and the metabolic syndrome—causes, consequences and therapeutic implications. Pharmacol. Ther.126, 159–172 (2010). CASPubMed Google Scholar
Hall, J. E. et al. Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J. Biol. Chem.285, 17271–17276 (2010). CASPubMedPubMed Central Google Scholar
Lohmeier, T. E. & Iliescu, R. The sympathetic nervous system in obesity hypertension. Curr. Hypertens. Rep.15, 409–416 (2013). PubMedPubMed Central Google Scholar
Sawicki, P. T., Baba, T., Berger, M. & Starke, A. Normal blood pressure in patients with insulinoma despite hyperinsulinemia and insulin resistance. J. Am. Soc. Nephrol.3, S64–S68 (1992). CASPubMed Google Scholar
Anderson, E. A., Hoffman, R. P., Balon, T. W., Sinkey, C. A. & Mark, A. L. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J. Clin. Invest.87, 2246–2252 (1991). CASPubMedPubMed Central Google Scholar
Gao, Q. et al. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl Acad. Sci. USA101, 4661–4666 (2004). CASPubMedPubMed Central Google Scholar
Smith, M. M. & Minson, C. T. Obesity and adipokines: effects on sympathetic overactivity. J. Physiol.590, 1787–1801 (2012). CASPubMedPubMed Central Google Scholar
Lurbe, E. et al. Added impact of obesity and insulin resistance in nocturnal blood pressure elevation in children and adolescents. Hypertension51, 635–641 (2008). CASPubMed Google Scholar
Demarco, V. G. et al. Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice. Endocrinology154, 159–171 (2013). CASPubMed Google Scholar
Ohkubo, T. et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J. Hypertens.20, 2183–2189 (2002). CASPubMed Google Scholar
Dangardt, F. et al. Reduced cardiac vagal activity in obese children and adolescents. Clin. Physiol. Funct. Imaging31, 108–113 (2011). PubMed Google Scholar
Silverberg, D. S. & Oksenberg, A. Are sleep-related breathing disorders important contributing factors to the production of essential hypertension? Curr. Hypertens. Rep.3, 209–215 (2001). CASPubMed Google Scholar
Logan, A. G. et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J. Hypertens.19, 2271–2277 (2001). CASPubMed Google Scholar
Lavie, P. & Hoffstein, V. Sleep apnea syndrome: a possible contributing factor to resistant. Sleep24, 721–725 (2001). CASPubMed Google Scholar
Grassi, G. et al. Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity. Hypertension46, 321–325 (2005). CASPubMed Google Scholar
Narkiewicz, K., van de Borne, P. J., Cooley, R. L., Dyken, M. E. & Somers, V. K. Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation98, 772–776 (1998). CASPubMed Google Scholar
Goodfriend, T. L. & Calhoun, D. A. Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension43, 518–524 (2004). CASPubMed Google Scholar
Witkowski, A. et al. Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea. Hypertension58, 559–565 (2011). CASPubMed Google Scholar
McCurley, A., McGraw, A., Pruthi, D. & Jaffe, I. Z. Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease. Pflugers Arch.465, 1661–1670 (2013). CASPubMed Google Scholar
Ruster, C. & Wolf, G. The role of the renin-angiotensin-aldosterone system in obesity-related renal diseases. Semin. Nephrol.33, 44–53 (2013). PubMed Google Scholar
Hall, J. E. et al. Hypertension: physiology and pathophysiology. Compr. Physiol.2, 2393–2442 (2012). PubMed Google Scholar
Hayden, M. R. et al. Possible mechanisms of local tissue renin-angiotensin system activation in the cardiorenal metabolic syndrome and type 2 diabetes mellitus. Cardiorenal Med.1, 193–210 (2011). CASPubMedPubMed Central Google Scholar
Engeli, S., Negrel, R. & Sharma, A. M. Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension35, 1270–1277 (2000). CASPubMed Google Scholar
Kumar, R., Thomas, C. M., Yong, Q. C., Chen, W. & Baker, K. M. The intracrine renin-angiotensin system. Clin. Sci. (Lond.)123, 273–284 (2012). CAS Google Scholar
Szasz, T., Bomfim, G. F. & Webb, R. C. The influence of perivascular adipose tissue on vascular homeostasis. Vasc. Health Risk Manag.9, 105–116 (2013). CASPubMedPubMed Central Google Scholar
Yiannikouris, F. et al. Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice. Hypertension60, 1524–1530 (2012). CASPubMed Google Scholar
Bentley-Lewis, R. et al. Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. J. Clin. Endocrinol. Metab.92, 4472–4475 (2007). CASPubMed Google Scholar
Ehrhart-Bornstein, M., Arakelyan, K., Krug, A. W., Scherbaum, W. A. & Bornstein, S. R. Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr. Res.30, 865–870 (2004). CASPubMed Google Scholar
Ehrhart-Bornstein, M. et al. Human adipocytes secrete mineralocorticoid-releasing factors. Proc. Natl Acad. Sci. USA100, 14211–14216 (2003). CASPubMedPubMed Central Google Scholar
Jeon, J. H. et al. A novel adipokine CTRP1 stimulates aldosterone production. FASEB J.22, 1502–1511 (2008). CASPubMed Google Scholar
Blanco-Rivero, J. et al. Participation of prostacyclin in endothelial dysfunction induced by aldosterone in normotensive and hypertensive rats. Hypertension46, 107–112 (2005). CASPubMed Google Scholar
Garg, R., Hurwitz, S., Williams, G. H., Hopkins, P. N. & Adler, G. K. Aldosterone production and insulin resistance in healthy adults. J. Clin. Endocrinol. Metab.95, 1986–1990 (2010). CASPubMedPubMed Central Google Scholar
Kithas, P. A. & Supiano, M. A. Spironolactone and hydrochlorothiazide decrease vascular stiffness and blood pressure in geriatric hypertension. J. Am. Geriatr. Soc.58, 1327–1332 (2010). PubMedPubMed Central Google Scholar
Druppel, V. et al. Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome. FASEB J.27, 3652–3659 (2013). PubMed Google Scholar
Garg, R., Kneen, L., Williams, G. H. & Adler, G. K. Effect of mineralocorticoid receptor antagonist on insulin resistance and endothelial function in obese subjects. Diabetes Obes. Metab.165, 268–272 (2014). Google Scholar
Pulakat, L. et al. Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities. Am. J. Physiol. Regul. Integr. Comp. Physiol.301, R885–R895 (2011). CASPubMedPubMed Central Google Scholar
Hwang, M. H. et al. Mineralocorticoid receptors modulate vascular endothelial function in human obesity. Clin. Sci. (Lond.)125, 513–520 (2013). CAS Google Scholar
Schafer, N. et al. Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity. Eur. Heart J.34, 3515–3524 (2013). PubMedPubMed Central Google Scholar
Byrd, J. B. & Brook, R. D. A critical review of the evidence supporting aldosterone in the etiology and its blockade in the treatment of obesity-associated hypertension. J. Hum. Hypertens.28, 3–9 (2014). CASPubMed Google Scholar
Tomaschitz, A., Pilz, S., Ritz, E., Obermayer-Pietsch, B. & Pieber, T. R. Aldosterone and arterial hypertension. Nat. Rev. Endocrinol.6, 83–93 (2010). CASPubMed Google Scholar
Ryan, M. J. An update on immune system activation in the pathogenesis of hypertension. Hypertension62, 226–230 (2013). CASPubMed Google Scholar
Schiffrin, E. L. Immune mechanisms in hypertension and vascular injury. Clin. Sci. (Lond.)126, 267–274 (2014). CAS Google Scholar
Lumeng, C. N., Bodzin, J. L. & Saltiel, A. R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest.117, 175–184 (2007). CASPubMedPubMed Central Google Scholar
Kalupahana, N. S., Moustaid-Moussa, N. & Claycombe, K. J. Immunity as a link between obesity and insulin resistance. Mol. Aspects Med.33, 26–34 (2012). CASPubMed Google Scholar
Zhong, J. et al. T cell costimulation protects obesity-induced adipose inflammation and insulin resistance. Diabeteshttp://dx.doi.org/10.2337/db13-1094.
Liu, G. et al. Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice. Immunol. Cell Biol.89, 130–142 (2011). CASPubMed Google Scholar
Kassan, M., Galan, M., Partyka, M., Trebak, M. & Matrougui, K. Interleukin-10 released by CD4(+)CD25(+) natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice. Arterioscler. Thromb. Vasc. Biol.31, 2534–2542 (2011). CASPubMedPubMed Central Google Scholar
Ohshima, K. et al. Roles of interleukin 17 in angiotensin II type 1 receptor-mediated insulin resistance. Hypertension59, 493–499 (2012). CASPubMed Google Scholar
Stienstra, R., Tack, C. J., Kanneganti, T. D., Joosten, L. A. & Netea, M. G. The inflammasome puts obesity in the danger zone. Cell Metab.15, 10–18 (2012). CASPubMed Google Scholar
Akasheh, R. T., Pang, J., York, J. M. & Fantuzzi, G. New pathways to control inflammatory responses in adipose tissue. Curr. Opin. Pharmacol.13, 613–617 (2013). CASPubMedPubMed Central Google Scholar
Rathinam, V. A., Vanaja, S. K. & Fitzgerald, K. A. Regulation of inflammasome signaling. Nat. Immunol.13, 333–332 (2012). CASPubMedPubMed Central Google Scholar
Conforti-Andreoni, C. et al. Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. J. Immunol.187, 5842–5850 (2011). CASPubMed Google Scholar
Guzik, T. J. et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J. Exp. Med.204, 2449–2460 (2007). CASPubMedPubMed Central Google Scholar
Kasal, D. A. et al. T regulatory lymphocytes prevent aldosterone-induced vascular injury. Hypertension59, 324–330 (2012). CASPubMed Google Scholar
de Kloet, A. D. et al. Neuroimmune communication in hypertension and obesity: a new therapeutic angle? Pharmacol. Ther.138, 428–440 (2013). CASPubMedPubMed Central Google Scholar
Harrison, D. G. et al. Inflammation, immunity, and hypertension. Hypertension57, 132–140 (2011). CASPubMed Google Scholar
Abboud, F. M., Harwani, S. C. & Chapleau, M. W. Autonomic neural regulation of the immune system: implications for hypertension and cardiovascular disease. Hypertension59, 755–762 (2012). CASPubMed Google Scholar
Dias da Silva, V. J. & Paton, J. F. Introduction: the interplay between the autonomic and immune systems. Exp. Physiol.97, 1143–1145 (2012). PubMed Google Scholar
Ganta, C. K. et al. Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system. Am. J. Physiol. Heart Circ. Physiol.289, H1683–H1691 (2005). CASPubMed Google Scholar
Turak, O. et al. Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J. Clin. Hypertens. (Greenwich)15, 7–13 (2013). CAS Google Scholar
Perez-Pozo, S. E. et al. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int. J. Obes. (Lond.)34, 454–461 (2010). CAS Google Scholar
Chaudhary, K., Kunal, M., Sowers, J. & Aroor, A. Uric acid—key ingredient in the recipe for cardiorenal metabolic syndrome. Cardiorenal Med.3, 208–220 (2013). CASPubMedPubMed Central Google Scholar
Baldwin, W. et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes60, 1258–1269 (2011). CASPubMedPubMed Central Google Scholar
Mazzali, M. et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension38, 1101–1106 (2001). CASPubMed Google Scholar
Tran, L. T., Yuen, V. G. & McNeill, J. H. The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol. Cell. Biochem.332, 145–159 (2009). CASPubMed Google Scholar
Aroor, A. et al. DPP-4 inhibitors as therapeutic modulators of immune cell function and associated cardiovascular and renal insulin resistance in obesity and diabetes. Cardiorenal Med.3, 48–56 (2013). CASPubMedPubMed Central Google Scholar
Ussher, J. R. & Drucker, D. J. Cardiovascular biology of the incretin system. Endocr. Rev.33, 187–215 (2012). CASPubMed Google Scholar
Lamers, D. et al. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes60, 1917–1925 (2011). CASPubMedPubMed Central Google Scholar
Wang, B. et al. Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide: a meta-analysis of clinical trials. Diabetes Obes. Metab.15, 737–749 (2013). CASPubMed Google Scholar
Aroor, A. R. et al. Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin resistant male Zucker obese rats. Endocrinology154, 2501–2513 (2013). CASPubMedPubMed Central Google Scholar
Kroller-Schon, S. et al. Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition. Cardiovasc. Res.96, 140–149 (2012). PubMed Google Scholar
Hocher, B., Reichetzeder, C. & Alter, M. L. Renal and cardiac effects of DPP4 inhibitors—from preclinical development to clinical research. Kidney Blood Press. Res.36, 65–84 (2012). CASPubMed Google Scholar
Asferg, C. L. et al. Relative atrial natriuretic peptide deficiency and inadequate renin and angiotensin II suppression in obese hypertensive men. Hypertension62, 147–153 (2013). CASPubMed Google Scholar
Yazbeck, R., Howarth, G. S. & Abbott, C. A. Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? Trends Pharmacol. Sci.30, 600–607 (2009). CASPubMed Google Scholar
Shirakawa, J. et al. Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice. Diabetes60, 1246–1257 (2011). CASPubMedPubMed Central Google Scholar
Shah, Z. et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation124, 2338–2349 (2011). CASPubMedPubMed Central Google Scholar
Hadjiyanni, I., Siminovitch, K. A., Danska, J. S. & Drucker, D. J. Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells. Diabetologia53, 730–740 (2010). CASPubMed Google Scholar
McGill, J. B. et al. Potentiation of abnormalities in myocardial metabolism with the development of diabetes in women with obesity and insulin resistance. J. Nucl. Cardiol.18, 421–429 (2011). PubMed Google Scholar
Peterson, L. R. et al. Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. J. Am. Coll. Cardiol.43, 1399–1404 (2004). PubMed Google Scholar
Manrique, C. et al. Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a western diet. Endocrinology154, 3632–3642 (2013). CASPubMedPubMed Central Google Scholar
Hinojosa-Laborde, C., Chapa, I., Lange, D. & Haywood, J. R. Gender differences in sympathetic nervous system regulation. Clin. Exp. Pharmacol. Physiol.26, 122–126 (1999). CASPubMed Google Scholar
Johnson, M. S. et al. Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat. Am. J. Physiol. Heart Circ. Physiol.301, H1540–H1550 (2011). CASPubMedPubMed Central Google Scholar
Denton, K. M., Hilliard, L. M. & Tare, M. Sex-related differences in hypertension: seek and ye shall find. Hypertension62, 674–677 (2013). CASPubMed Google Scholar
Pal, S. & Radavelli-Bagatini, S. Association of arterial stiffness with obesity in Australian women: a pilot study. J. Clin. Hypertens. (Greenwich)15, 118–123 (2013). CAS Google Scholar
Berry, K. L. et al. Large-artery stiffness contributes to the greater prevalence of systolic hypertension in elderly women. J. Am. Geriatr. Soc.52, 368–373 (2004). PubMed Google Scholar
Scuteri, A. et al. Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study. Atherosclerosis221, 189–197 (2012). CASPubMed Google Scholar
Meyer, M. R., Clegg, D. J., Prossnitz, E. R. & Barton, M. Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiol. (Oxf.)203, 259–269 (2011). CAS Google Scholar
Ribas, V. et al. Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc. Natl Acad. Sci. USA108, 16457–16462 (2011) CASPubMedPubMed Central Google Scholar
Maric-Bilkan, C. & Manigrasso, M. B. Sex differences in hypertension: contribution of the renin-angiotensin system. Gend. Med.9, 287–291 (2012). PubMed Google Scholar
Lindsey, S. H., Yamaleyeva, L. M., Brosnihan, K. B., Gallagher, P. E. & Chappell, M. C. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension58, 665–671 (2011). CASPubMed Google Scholar
Ricchiuti, V. et al. Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats. J. Endocrinol.200, 75–84 (2009). CASPubMed Google Scholar
Lindsey, S. H. & Chappell, M. C. Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen. Gend. Med.8, 343–354 (2011). PubMedPubMed Central Google Scholar
Zhang, R. & Reisin, E. Obesity-hypertension: the effects on cardiovascular and renal systems. Am. J. Hypertens.13, 1308–1314 (2000). CASPubMed Google Scholar
Smink, P. A. et al. An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials. J. Hypertens.30, 1022–1028 (2012). CASPubMed Google Scholar
Gupta, A. K. et al. Baseline predictors of resistant hypertension in the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT): a risk score to identify those at high-risk. J. Hypertens.29, 2004–2013 (2011). CASPubMed Google Scholar
Mancia, G. et al. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J. Hypertens.31, 1925–1938 (2013). CAS Google Scholar