- Negrin, R. S. & Blume, K. in Williams Hematology 7th edn Ch. 22 (eds Lichtman, M. A. et al.) 209–247 (McGraw-Hill Professional, 2005).
Google Scholar
- Ferrara, J. L. & Deeg, H. J. Graft-versus-host disease. N. Engl. J. Med. 324, 667–674 (1991).
Article CAS Google Scholar
- Kaitin, K. I. Graft-versus-host disease. N. Engl. J. Med. 325, 357–358 (1991).
CAS PubMed Google Scholar
- Sykes, M. & Nikolic, B. Treatment of severe autoimmune disease by stem-cell transplantation. Nature 435, 620–627 (2005).
Article CAS Google Scholar
- Thomas, E. D., Storb, R. & Clift, R. A. Bone-marrow transplantation. N. Engl. J. Med. 292, 832–843 (1975).
Article CAS Google Scholar
- Thomas, E. D., Storb, R. & Clift, R. A. Bone-marrow transplantation. N. Engl. J. Med. 292, 895–902 (1975).
Article CAS Google Scholar
- Storb, R. et al. Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood 94, 2523–2529 (1999).
CAS PubMed Google Scholar
- McSweeney, P. A. et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood 97, 3390–3400 (2001).
Article CAS Google Scholar
- Lowsky, R. et al. Protective conditioning for acute graft-versus-host disease. N. Engl. J. Med. 353, 1321–1331 (2005).
Article CAS Google Scholar
- Wu, Y. L. et al. In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc. Natl Acad. Sci. USA 103, 1852–1857 (2006).
Article CAS Google Scholar
- Sumen, C., Mempel, T. R., Mazo, I. B. & von Andrian, U. H. Intravital microscopy: visualizing immunity in context. Immunity 21, 315–329 (2004).
CAS PubMed Google Scholar
- Contag, C. H. et al. Photonic detection of bacterial pathogens in living hosts. Mol. Microbiol. 18, 593–603 (1995).
Article CAS Google Scholar
- Contag, C. et al. Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66, 523–531 (1997).
Article CAS Google Scholar
- Lipshutz, G. S., Flebbe-Rehwaldt, L. & Gaensler, K. M. Reexpression following readministration of an adenoviral vector in adult mice after initial in utero adenoviral administration. Mol. Ther. 2, 374–380 (2000).
Article CAS Google Scholar
- Sweeney, T. J. et al. Visualizing the kinetics of tumor cell clearance in living animals. Proc. Natl Acad. Sci. USA 96, 12044–12049 (1999).
Article CAS Google Scholar
- Massoud, T. F., Paulmurugan, R. & Gambhir, S. S. Molecular imaging of homodimeric protein–protein interactions in living subjects. FASEB J. 18, 1105–1107 (2004).
Article CAS Google Scholar
- Cao, Y. A. et al. Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc. Natl Acad. Sci. USA 101, 221–226 (2004).
Article CAS Google Scholar
- Jobsis, F. F. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198, 1264–1267 (1977).
Article CAS Google Scholar
- Zhao, H. et al. Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo. J. Biomed. Opt. 10, 41210 (2005).
Article Google Scholar
- Lipshutz, G. S. et al. In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression. Mol. Ther. 3, 284–292 (2001).
Article CAS Google Scholar
- Rehemtulla, A. et al. Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging. Neoplasia 2, 491–495 (2000).
Article CAS Google Scholar
- Zhao, H. et al. Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Mol. Imaging 3, 43–54 (2004).
Article CAS Google Scholar
- Bhaumik, S. & Gambhir, S. S. Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc. Natl Acad. Sci. USA 99, 377–382 (2002).
Article CAS Google Scholar
- Edinger, M. et al. Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence. Blood 101, 640–648 (2003).
Article CAS Google Scholar
- Beilhack, A. et al. In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood 106, 1113–1122 (2005).
Article CAS Google Scholar
- Wang, X. et al. Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood 102, 3478–3482 (2003).
Article CAS Google Scholar
- Edinger, M. et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nature Med. 9, 1144–1150 (2003).
Article CAS Google Scholar
- Panoskaltsis-Mortari, A. et al. In vivo imaging of graft-versus-host-disease in mice. Blood 103, 3590–3598 (2004).
Article CAS Google Scholar
- Murakami, T. et al. Immune evasion by murine melanoma mediated through CC chemokine receptor-10. J. Exp. Med. 198, 1337–1347 (2003).
Article CAS Google Scholar
- Murai, M. et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nature Immunol. 4, 154–160 (2003).
Article CAS Google Scholar
- Welniak, L. A. et al. Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation. Blood 107, 410–412 (2005).
Article Google Scholar
- Mora, J. R. et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424, 88–93 (2003).
Article CAS Google Scholar
- Anderson, B. E. et al. Memory CD4+ T cells do not induce graft-versus-host disease. J. Clin. Invest. 112, 101–108 (2003).
Article CAS Google Scholar
- Foster, A. E. et al. Human CD62L− memory T cells are less responsive to alloantigen stimulation than CD62L+ naive T cells: potential for adoptive immunotherapy and allodepletion. Blood 104, 2403–2409 (2004).
Article CAS Google Scholar
- Dutt, S. et al. L-selectin and β7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft versus host disease. Blood 106, 4009–4015 (2005).
Article CAS Google Scholar
- Rooney, C. M. et al. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92, 1549–1555 (1998).
CAS PubMed Google Scholar
- Baker, J., Verneris, M. R., Ito, M., Shizuru, J. A. & Negrin, R. S. Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production. Blood 97, 2923–2931 (2001).
Article CAS Google Scholar
- Asai, O. et al. Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J. Clin. Invest. 101, 1835–1842 (1998).
Article CAS Google Scholar
- Ruggeri, L. et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295, 2097–2100 (2002).
Article CAS Google Scholar
- Miller, J. S. et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 105, 3051–3057 (2005).
Article CAS Google Scholar
- Bendelac, A. et al. CD1 recognition by mouse NK1+ T lymphocytes. Science 268, 863–865 (1995).
Article CAS Google Scholar
- Lan, F., Zeng, D., Higuchi, M., Higgins, J. P. & Strober, S. Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versus-host disease: the role of CD1-reactive natural killer T cells. Biol. Blood Marrow Transplant. 9, 355–363 (2003).
Article Google Scholar
- Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151–1164 (1995).
CAS PubMed Google Scholar
- Hoffmann, R., Ermann, J., Edinger, M., Fathman, C. G. & Strober, S. Donor type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196, 389–399 (2002).
Article CAS Google Scholar
- Taylor, P. A., Lees, C. J. & Blazar, B. R. The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99, 3493–3499 (2002).
Article CAS Google Scholar
- Cohen, J. L., Trenado, A., Vasey, D., Klatzmann, D. & Salomon, B. L. CD4+CD25+ immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196, 401–406 (2002).
Article CAS Google Scholar
- Trenado, A. et al. Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J. Clin. Invest. 112, 1688–1696 (2003).
Article CAS Google Scholar
- Ermann, J. et al. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 105, 2220–2226 (2005).
Article CAS Google Scholar
- Herschman, H. R. Molecular imaging: looking at problems, seeing solutions. Science 302, 605–608 (2003).
Article CAS Google Scholar
- Ponomarev, V. et al. Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo. Neoplasia 3, 480–488 (2001).
Article CAS Google Scholar
- Dubey, P. et al. Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proc. Natl Acad. Sci. USA 100, 1232–1237 (2003).
Article CAS Google Scholar
- van Montfrans, C. et al. In vivo evaluation of 111In-labeled T-lymphocyte homing in experimental colitis. J. Nucl. Med. 45, 1759–1765 (2004).
CAS PubMed Google Scholar
- Bulte, J. W. & Kraitchman, D. L. Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed. 17, 484–499 (2004).
Article CAS Google Scholar
- McCaffrey, A., Kay, M. A. & Contag, C. H. Advancing molecular therapies through in vivo bioluminescent imaging. Mol. Imaging 2, 75–86 (2003).
Article CAS Google Scholar
- Contag, C. H. & Ross, B. D. It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology. J. Magn. Reson. Imaging 16, 378–387 (2002).
Article Google Scholar
- Ntziachristos, V., Ripoll, J., Wang, L. V. & Weissleder, R. Looking and listening to light: the evolution of whole-body photonic imaging. Nature Biotechnol. 23, 313–320 (2005).
Article CAS Google Scholar
- Hildebrandt, I. J. & Gambhir, S. S. Molecular imaging applications for immunology. Clin. Immunol. 111, 210–224 (2004).
Article CAS Google Scholar
- Contag, C. H. & Bachmann, M. H. Advances in in vivo bioluminescence imaging of gene expression. Annu. Rev. Biomed. Eng. 4, 235–260 (2002).
Article CAS Google Scholar
- Rice, B. W., Cable, M. D. & Nelson, M. B. In vivo imaging of light-emitting probes. J. Biomed. Opt. 6, 432–440 (2001).
Article CAS Google Scholar
- Troy, T., Jekic-McMullen, D., Sambucetti, L. & Rice, B. Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models. Mol. Imaging 3, 9–23 (2004).
Article CAS Google Scholar