Analysing immune cell migration (original) (raw)

References

1. Bousso, P., Bhakta, N. R., Lewis, R. S. & Robey, E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296, 1876–1880 (2002).
   Article CAS PubMed Google Scholar
2. Miller, M. J., Wei, S. H., Parker, I. & Cahalan, M. D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869–1873 (2002).
   Article CAS PubMed Google Scholar
3. Stoll, S., Delon, J., Brotz, T. N. & Germain, R. N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873–1876 (2002).
   Article PubMed Google Scholar
4. Lindquist, R. L. et al. Visualizing dendritic cell networks in vivo. Nature Immunol. 5, 1243–1250 (2004).
   Article CAS Google Scholar
5. Mempel, T. R., Henrickson, S. E. & von Andrian, U. H. T cell priming by dendritic cells in lymph nodes occurs in three distict phases. Nature 427, 154–159 (2004).
   Article CAS PubMed Google Scholar
6. Allen, C. D., Okada, T., Tang, H. L. & Cyster, J. G. Imaging of germinal center selection events during affinity maturation. Science 315, 528–531 (2007).
   Article CAS PubMed Google Scholar
7. Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L. & Germain, R. N. SAP-controlled T–B cell interactions underlie germinal centre formation. Nature 455, 764–769 (2008).
   Article CAS PubMed PubMed Central Google Scholar
8. Miller, M. J., Safrina, O., Parker, I. & Cahalan, M. D. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J. Exp. Med. 200, 847–856 (2004).
   Article CAS PubMed PubMed Central Google Scholar
9. Sumen, C., Mempel, T. R., Mazo, I. B. & von Andrian, U. H. Intravital microscopy: visualizing immunity in context. Immunity 21, 315–329 (2004).
   CAS PubMed Google Scholar
10. Beauchemin, C., Dixit, N. M. & Perelson, A. S. Characterizing T cell movement within lymph nodes in the absence of antigen. J. Immunol. 178, 5505–5512 (2007).
    Article CAS PubMed Google Scholar
11. le Borgne, M. et al. The impact of negative selection on thymocyte migration in the medulla. Nature Immunol. 10, 823–830 (2009).
    Article CAS Google Scholar
12. Doi, M. & Edwards, S. F. The Theory of polymer Dynamics (Clarendon, Oxford, UK,1986).
    Google Scholar
13. Rubinstein, M. & Colby, R. H. Polymer Physics (Oxford Univ. Press, New York, 2003).
    Google Scholar
14. Wieser, S. & Schütz, G. J. Tracking single molecules in the live cell plasma membrane — do's and don't's. Methods 46, 131–140 (2008).
    Article CAS PubMed Google Scholar
15. Beltman, J. B., Marée, A. F. M., Lynch, J. N., Miller, M. J. & de Boer, R. J. Lymph node topology dictates T cell migration behaviour. J. Exp. Med. 204, 771–780 (2007).
    Article CAS PubMed PubMed Central Google Scholar
16. Benhamou, S. How to reliably estimate the tortuosity of an animal's path: straightness, sinuosity, or fractal dimension? J. Theor. Biol. 229, 209–220 (2004).
    Article PubMed Google Scholar
17. Bogle, G. & Dunbar, P. R. Simulating T-cell motility in the lymph node paracortex with a packed lattice geometry. Immunol. Cell Biol. 86, 676–687 (2008).
    Article CAS PubMed PubMed Central Google Scholar
18. Mrass, P. et al. CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity 29, 971–985 (2008).
    Article CAS PubMed PubMed Central Google Scholar
19. Preston, S. P., Waters, S. L., Jensen, O. E., Heaton, P. R. & Pritchard, D. I. T-cell motility in the early stages of the immune response modeled as a random walk amongst targets. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 74, 011910 (2006).
    Article CAS PubMed Google Scholar
20. Beltman, J. B., Marée, A. F. M. & de Boer, R. J. Spatial modelling of brief and long interactions between T cells and dendritic cells. Immunol. Cell Biol. 85, 306–314 (2007).
    Article CAS PubMed Google Scholar
21. Castellino, F. et al. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440, 890–895 (2006). This report is an example of how migration angles can be used to find evidence for directed migration: sites of CD4+ T cell–dendritic cell interaction were found to attract naive CD8+ T cells by chemokines.
    Article CAS PubMed Google Scholar
22. Germain, R. N. et al. An extended vision for dynamic high-resolution intravital immune imaging. Semin. Immunol. 17, 431–441 (2005).
    Article CAS PubMed PubMed Central Google Scholar
23. Bajénoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989–1001 (2006).
    Article PubMed PubMed Central Google Scholar
24. Bajénoff, M., Glaichenhaus, N. & Germain, R. N. Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone. J. Immunol. 181, 3947–3954 (2008).
    Article PubMed Google Scholar
25. Mueller, S. N. & Germain, R. N. Stromal cell contributions to the homeostasis and functionality of the immune system. Nature Rev. Immunol. 9, 618–629 (2009).
    Article CAS Google Scholar
26. Sergé, A., Bertaux, N., Rigneault, H. & Marguet, D. Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes. Nature Methods 5, 687–694 (2008).
    Article PubMed Google Scholar
27. Jaqaman, K. et al. Robust single-particle tracking in live-cell time-lapse sequences. Nature Methods 5, 695–702 (2008).
    Article CAS PubMed PubMed Central Google Scholar
28. Wei, S. H., Parker, I., Miller, M. J. & Cahalan, M. D. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol. Rev. 195, 136–159 (2003).
    Article CAS PubMed Google Scholar
29. Germain, R. N., Miller, M. J., Dustin, M. L. & Nussenzweig, M. C. Dynamic imaging of the immune system: progress, pitfalls and promise. Nature Rev. Immunol. 6, 497–507 (2006). This report provides an overview of technical issues related to dynamic imaging experiments, such as different fluorescent labelling methods and a comparison between intravital and explant experiments.
    Article CAS Google Scholar
30. Miller, M. J., Wei, S. H., Cahalan, M. D. & Parker, I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc. Natl Acad. Sci. USA 100, 2604–2609 (2003).
    Article CAS PubMed PubMed Central Google Scholar
31. Bousso, P. & Robey, E. Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes. Nature Immunol. 4, 579–585 (2003).
    Article CAS Google Scholar
32. Gretz, J. E., Anderson, A. O. & Shaw, S. Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol. Rev. 156, 11–24 (1997).
    Article CAS PubMed Google Scholar
33. Gretz, J. E., Norbury, C. C., Anderson, A. O., Proudfoot, A. E. & Shaw, S. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med. 192, 1425–1440 (2000).
    Article CAS PubMed PubMed Central Google Scholar
34. Sixt, M. et al. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22, 19–29 (2005).
    Article CAS PubMed Google Scholar
35. Allen, C. D. & Cyster, J. G. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin. Immunol. 20, 14–25 (2008).
    Article CAS PubMed PubMed Central Google Scholar
36. Witt, C. M., Raychaudhuri, S., Schaefer, B., Chakraborty, A. K. & Robey, E. A. Directed migration of positively selected thymocytes visualized in real time. PLoS Biol. 3, 1062–1069 (2005).
    CAS Google Scholar
37. Davis, D. M. Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nature Rev. Immunol. 9, 543–555 (2009).
    Article CAS Google Scholar
38. Henrickson, S. et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nature Immunol. 9, 282–291 (2008).
    Article CAS Google Scholar
39. Mrass, P. et al. Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J. Exp. Med. 203, 2749–2761 (2006).
    Article CAS PubMed PubMed Central Google Scholar
40. Beltman, J. B., Henrickson, S. E., Von Andrian, U. H., De Boer, R. J. & Marée, A. F. M. Towards estimating the true duration of dendritic cell interactions with T cells. J. Immunol. Methods 347, 54–69 (2009). This report presents a computational method to estimate the true rather than the underestimated distribution of contact times between cells using a mathematical approach.
    Article CAS PubMed PubMed Central Google Scholar
41. Gardner, J. M. et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 321, 843–847 (2008).
    Article CAS PubMed PubMed Central Google Scholar
42. Keller, P. J., Schmidt, A. D., Wittbrodt, J. & Stelzer, E. H. Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy. Science 322, 1065–1069 (2008).
    Article CAS PubMed Google Scholar
43. Waters, J. C. Accuracy and precision in quantitative fluorescence microscopy. J. Cell Biol. 185, 1135–1148 (2009).
    Article CAS PubMed PubMed Central Google Scholar

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