The molecular repertoire of the 'almighty' stem cell (original) (raw)

• Jiang, Y. et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41–49 (2002).
  CAS PubMed Google Scholar
• Evans, M. J. & Kaufman, M. H. Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154–156 (1981).
  Article CAS PubMed Google Scholar
• Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147 (1998).
  Article CAS PubMed Google Scholar
• Labosky, P. A., Barlow, D. P. & Hogan, B. L. Embryonic germ cell lines and their derivation from mouse primordial germ cells. Ciba. Found. Symp. 182, 157–168; discussion 168–178 (1994).
  CAS PubMed Google Scholar
• Pain, B. et al. Long-term in vitro culture and characterisation of avian embryonic stem cells with multiple morphogenetic potentialities. Development 122, 2339–2348 (1996).
  CAS PubMed Google Scholar
• Thomson, J. A. & Marshall, V. S. Primate embryonic stem cells. Curr. Top. Dev. Biol. 38, 133–165 (1998).
  CAS PubMed Google Scholar
• Ogawa, M. Differentiation and proliferation of hematopoietic stem cells. Blood 81, 2844–2853 (1993).
  CAS PubMed Google Scholar
• Ivanova, N. B. et al. A stem cell molecular signature. Science 298, 601–604 (2002).
  CAS PubMed Google Scholar
• Ramalho-Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C. & Melton, D. A. 'Stemness': transcriptional profiling of embryonic and adult stem cells. Science 298, 597–600 (2002). References 8 and 9 are the first analyses of global gene-expression profiling of multiple adult and embryonic stem-cell populations to identify conserved stem-cell genes.
  CAS PubMed Google Scholar
• Fortunel, N. O. et al. Comment on “'Stemness': transcriptional profiling of embryonic and adult stem cells” and “A stem cell molecular signature”. Science 302, 393; author reply 393 (2003). Similar to references 8 and 9, reports another global gene-expression analysis of multiple adult and embryonic stem-cell populations, and compares the stem-cell genes identified in references 8–10 pointing out the discordance of these studies.
  CAS PubMed Google Scholar
• Abeyta, M. J. et al. Unique gene expression signatures of independently-derived human embryonic stem cell lines. Hum. Mol. Genet. 13, 601–608 (2004). This extensive work identifies genes expressed in multiple human ESC lines as well as comparing these genes to mouse ES and adult stem-cell profiles.
  CAS PubMed Google Scholar
• Sato, N. et al. Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev. Biol. 260, 404–413 (2003).
  CAS PubMed Google Scholar
• Sperger, J. M. et al. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc. Natl Acad. Sci. USA 100, 13350–13355 (2003).
  CAS PubMed PubMed Central Google Scholar
• Brandenberger, R. et al. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nature Biotechnol. 22, 707–716 (2004).
  Google Scholar
• Hu, M. et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 11, 774–785 (1997).
  CAS PubMed Google Scholar
• Terskikh, A. V., Miyamoto, T., Chang, C., Diatchenko, L. & Weissman, I. L. Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Blood 102, 94–101 (2003).
  CAS PubMed Google Scholar
• Akashi, K. et al. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101, 383–389 (2003).
  CAS PubMed Google Scholar
• Ye, M. et al. Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19, 689–699 (2003).
  CAS PubMed Google Scholar
• Arney, K. L. & Fisher, A. G. Epigenetic aspects of differentiation. J. Cell Sci. 117, 4355–4363 (2004).
  CAS PubMed Google Scholar
• Tanaka, T. S. et al. Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. Genome Res. 12, 1921–1928 (2002).
  CAS PubMed PubMed Central Google Scholar
• Sharov, A. A. et al. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 1, E74 (2003).
  PubMed PubMed Central Google Scholar
• Nichols, J. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379–391 (1998).
  CAS PubMed Google Scholar
• Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643–655 (2003).
  CAS PubMed Google Scholar
• Mitsui, K. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113, 631–642 (2003).
  Article CAS PubMed Google Scholar
• Rao, M. Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells. Dev. Biol. 275, 269–286 (2004).
  CAS PubMed Google Scholar
• Niwa, H. Molecular mechanism to maintain stem cell renewal of ES cells. Cell Struct. Funct. 26, 137–148 (2001). An excellent review on OCT4 signalling in ESCs that describes the achievements and the difficulties of confirming gene function in stem cells.
  CAS PubMed Google Scholar
• Chambers, I. The molecular basis of pluripotency in mouse embryonic stem cells. Cloning Stem Cells 6, 386–391 (2004).
  CAS PubMed Google Scholar
• Richards, M., Tan, S. P., Tan, J. H., Chan, W. K. & Bongso, A. The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells 22, 51–64 (2004).
  CAS PubMed Google Scholar
• Bhattacharya, B. et al. Gene expression in human embryonic stem cell lines: unique molecular signature. Blood 103, 2956–2964 (2004).
  CAS PubMed Google Scholar
• Brandenberger, R. et al. MPSS profiling of human embryonic stem cells. BMC Dev. Biol. 4, 10 (2004).
  PubMed PubMed Central Google Scholar
• Ying, Q. L., Nichols, J., Chambers, I. & Smith, A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115, 281–292 (2003).
  CAS PubMed Google Scholar
• Xu, R. H. et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nature Biotechnol. 20, 1261–1264 (2002).
  CAS Google Scholar
• Xu, R. H. et al. Basic FGF and supression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nature Methods 2, 185–190 (2005).
  CAS PubMed Google Scholar
• Osawa, M., Hanada, K., Hamada, H. & Nakauchi, H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273, 242–245 (1996).
  CAS PubMed Google Scholar
• Ellisen, L. W. et al. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649–661 (1991).
  CAS PubMed Google Scholar
• Begley, C. G. et al. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor δ-chain diversity region and results in a previously unreported fusion transcript. Proc. Natl Acad. Sci. USA 86, 2031–2035 (1989).
  CAS PubMed PubMed Central Google Scholar
• Finger, L. R. et al. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc. Natl Acad. Sci. USA 86, 5039–5043 (1989).
  CAS PubMed PubMed Central Google Scholar
• Royer-Pokora, B., Loos, U. & Ludwig, W. D. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 6, 1887–1893 (1991).
  CAS PubMed Google Scholar
• Varnum-Finney, B. et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nature Med. 6, 1278–1281 (2000).
  CAS PubMed Google Scholar
• Lecuyer, E. & Hoang, T. SCL: from the origin of hematopoiesis to stem cells and leukemia. Exp. Hematol. 32, 11–24 (2004).
  CAS PubMed Google Scholar
• Yamada, Y. et al. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc. Natl Acad. Sci. USA 95, 3890–3895 (1998).
  CAS PubMed PubMed Central Google Scholar
• Varnum-Finney, B., Brashem-Stein, C. & Bernstein, I. D. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood 101, 1784–1789 (2003).
  CAS PubMed Google Scholar
• Karanu, F. N. et al. Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells. Blood 97, 1960–1967 (2001).
  CAS PubMed Google Scholar
• Ohishi, K., Varnum-Finney, B. & Bernstein, I. D. Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38− cord blood cells. J. Clin. Invest. 110, 1165–1174 (2002).
  CAS PubMed PubMed Central Google Scholar
• Calvi, L. M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841–846 (2003).
  CAS PubMed Google Scholar
• Sauvageau, G. et al. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc. Natl Acad. Sci. USA 91, 12223–12227 (1994).
  CAS PubMed PubMed Central Google Scholar
• Lessard, J., Baban, S. & Sauvageau, G. Stage-specific expression of polycomb group genes in human bone marrow cells. Blood 91, 1216–1224 (1998).
  CAS PubMed Google Scholar
• Austin, T. W., Solar, G. P., Ziegler, F. C., Liem, L. & Matthews, W. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89, 3624–3635 (1997).
  CAS PubMed Google Scholar
• Antonchuk, J., Sauvageau, G. & Humphries, R. K. HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp. Hematol. 29, 1125–1134 (2001).
  CAS PubMed Google Scholar
• Antonchuk, J., Sauvageau, G. & Humphries, R. K. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109, 39–45 (2002).
  CAS PubMed Google Scholar
• Buske, C. et al. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 100, 862–868 (2002).
  CAS PubMed Google Scholar
• Reya, T. et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423, 409–414 (2003).
  CAS PubMed Google Scholar
• Lessard, J. & Sauvageau, G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255–260 (2003).
  CAS PubMed Google Scholar
• Bhardwaj, G. et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nature Immunol. 2, 172–180 (2001).
  CAS Google Scholar
• Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804–1808 (2000).
  CAS PubMed Google Scholar
• Phillips, R. L. et al. The genetic program of hematopoietic stem cells. Science 288, 1635–1640 (2000). One of the first attempts to generate a global differential gene-expression profile of a stem-cell population compared to its progeny using subtractive hybridization of cDNA libraries.
  CAS PubMed Google Scholar
• Terskikh, A. V. et al. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc. Natl Acad. Sci. USA 98, 7934–7939 (2001).
  CAS PubMed PubMed Central Google Scholar
• Arai, F. et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149–161 (2004).
  CAS PubMed Google Scholar
• Li, L. & Akashi, K. Unraveling the molecular components and genetic blueprints of stem cells. Biotechniques 35, 1233–1239 (2003).
  CAS PubMed Google Scholar
• Rebel, V. I., Miller, C. L., Eaves, C. J. & Lansdorp, P. M. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood 87, 3500–3507 (1996).
  CAS PubMed Google Scholar
• Park, I. K. et al. Differential gene expression profiling of adult murine hematopoietic stem cells. Blood 99, 488–498 (2002).
  CAS PubMed Google Scholar
• Liu, H. & Verfaillie, C. M. Myeloid-lymphoid initiating cells (ML-IC) are highly enriched in the rhodamine-c-kit+CD33−CD38− fraction of umbilical cord CD34+ cells. Exp. Hematol. 30, 582–589 (2002).
  CAS PubMed Google Scholar
• Hess, D. A. et al. Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity. Blood 104, 1648–1655 (2004).
  CAS PubMed Google Scholar
• Gage, F. H. Mammalian neural stem cells. Science 287, 1433–1438 (2000).
  CAS PubMed Google Scholar
• Uchida, N. et al. Direct isolation of human central nervous system stem cells. Proc. Natl Acad. Sci. USA 97, 14720–14725 (2000).
  CAS PubMed PubMed Central Google Scholar
• Geschwind, D. H. et al. A genetic analysis of neural progenitor differentiation. Neuron 29, 325–339 (2001).
  CAS PubMed Google Scholar
• Karsten, S. L. et al. Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks. Dev. Biol. 261, 165–182 (2003).
  CAS PubMed Google Scholar
• Wright, L. S. et al. Gene expression in human neural stem cells: effects of leukemia inhibitory factor. J. Neurochem. 86, 179–195 (2003).
  CAS PubMed Google Scholar
• Livesey, F. J., Young, T. L. & Cepko, C. L. An analysis of the gene expression program of mammalian neural progenitor cells. Proc. Natl Acad. Sci. USA 101, 1374–1379 (2004).
  CAS PubMed PubMed Central Google Scholar
• Luo, Y. et al. Microarray analysis of selected genes in neural stem and progenitor cells. J. Neurochem. 83, 1481–1497 (2002).
  CAS PubMed Google Scholar
• Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L. & Fuchs, E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118, 635–648 (2004). Identifies two spatially distinct stem-cell populations in the bulge-cell pool and characterizes their expression profile, in vivo and in vitro potential and niche.
  CAS PubMed Google Scholar
• Morris, R. J. et al. Capturing and profiling adult hair follicle stem cells. Nature Biotechnol. 22, 411–417 (2004).
  CAS Google Scholar
• Tumbar, T. et al. Defining the epithelial stem cell niche in skin. Science 303, 359–363 (2004).
  CAS PubMed Google Scholar
• Mills, J. C., Andersson, N., Hong, C. V., Stappenbeck, T. S. & Gordon, J. I. Molecular characterization of mouse gastric epithelial progenitor cells. Proc. Natl Acad. Sci. USA 99, 14819–14824 (2002).
  CAS PubMed PubMed Central Google Scholar
• Stappenbeck, T. S., Mills, J. C. & Gordon, J. I. Molecular features of adult mouse small intestinal epithelial progenitors. Proc. Natl Acad. Sci. USA 100, 1004–1009 (2003).
  CAS PubMed PubMed Central Google Scholar
• Gilboa, L. & Lehmann, R. How different is Venus from Mars? The genetics of germ-line stem cells in Drosophila females and males. Development 131, 4895–4905 (2004).
  CAS PubMed Google Scholar
• Yamashita, Y. M., Fuller, M. T. & Jones, D. L. Signaling in stem cell niches: lessons from the Drosophila germline. J. Cell Sci. 118, 665–672 (2005).
  CAS PubMed Google Scholar
• Xie, T. & Spradling, A. C. A niche maintaining germ line stem cells in the Drosophila ovary. Science 290, 328–330 (2000).
  CAS PubMed Google Scholar
• Tulina, N. & Matunis, E. Control of stem cell self-renewal in Drosophila spermatogenesis by JAK–STAT signaling. Science 294, 2546–2549 (2001).
  CAS PubMed Google Scholar
• Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B. & Fuller, M. T. Stem cell self-renewal specified by JAK–STAT activation in response to a support cell cue. Science 294, 2542–2545 (2001).
  CAS PubMed Google Scholar
• Gonczy, P. & DiNardo, S. The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis. Development 122, 2437–24347 (1996).
  CAS PubMed Google Scholar
• Song, X., Zhu, C. H., Doan, C. & Xie, T. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science 296, 1855–1857 (2002).
  CAS PubMed Google Scholar
• Tran, J., Brenner, T. J. & DiNardo, S. Somatic control over the germline stem cell lineage during Drosophila spermatogenesis. Nature 407, 754–757 (2000).
  CAS PubMed Google Scholar
• Deng, W. & Lin, H. Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. Dev. Biol. 189, 79–94 (1997).
  CAS PubMed Google Scholar
• Kiger, A. A., White-Cooper, H. & Fuller, M. T. Somatic support cells restrict germline stem cell self-renewal and promote differentiation. Nature 407, 750–754 (2000).
  CAS PubMed Google Scholar
• Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836–841 (2003).
  CAS PubMed Google Scholar
• Shen, Q. et al. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304, 1338–1340 (2004).
  CAS PubMed Google Scholar
• Doetsch, F. A niche for adult neural stem cells. Curr. Opin. Genet. Dev. 13, 543–550 (2003).
  CAS PubMed Google Scholar
• Nishimura, E. K. et al. Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416, 854–860 (2002).
  CAS PubMed Google Scholar
• Driessen, R. L., Johnston, H. M. & Nilsson, S. K. Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region. Exp. Hematol. 31, 1284–1291 (2003).
  CAS PubMed Google Scholar
• Hackney, J. A. et al. A molecular profile of a hematopoietic stem cell niche. Proc. Natl Acad. Sci. USA 99, 13061–13066 (2002). Provides a complementary analysis of gene expression in a stem-cell niche, specifically the haematopoietic stem-cell niche, as a means to understand the extrinsic signals that regulate stem-cell function.
  CAS PubMed PubMed Central Google Scholar
• Yamashita, Y. M., Jones, D. L. & Fuller, M. T. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 301, 1547–1550 (2003).
  CAS PubMed Google Scholar
• Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843–850 (2005).
  CAS PubMed Google Scholar
• Cobas, M. et al. β-catenin is dispensable for hematopoiesis and lymphopoiesis. J. Exp. Med. 199, 221–229 (2004).
  CAS PubMed PubMed Central Google Scholar
• Molofsky, A. V., Pardal, R. & Morrison, S. J. Diverse mechanisms regulate stem cell self-renewal. Curr. Opin. Cell Biol. 16, 700–707 (2004).
  CAS PubMed Google Scholar
• Espinosa, L., Ingles-Esteve, J., Aguilera, C. & Bigas, A. Phosphorylation by glycogen synthase kinase-3β down-regulates Notch activity, a link for Notch and Wnt pathways. J. Biol. Chem. 278, 32227–32235 (2003).
  CAS PubMed Google Scholar
• Zipori, D. The nature of stem cells: state rather than entity. Nature Rev. Genet. 5, 873–878 (2004). A critical analysis of reported stem-cell gene-expression data that raises questions regarding the validity of the concept of conserved stem-cell genes.
  CAS PubMed Google Scholar
• Gygi, S. P., Rochon, Y., Franza, B. R. & Aebersold, R. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19, 1720–1730 (1999).
  CAS PubMed PubMed Central Google Scholar
• Miyamoto, T. et al. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev. Cell 3, 137–147 (2002).
  CAS PubMed Google Scholar
• Lian, Z. et al. Genomic and proteomic analysis of the myeloid differentiation program. Blood 98, 513–524 (2001).
  CAS PubMed Google Scholar
• He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. Nature Rev. Genet. 5, 522–531 (2004).
  CAS PubMed Google Scholar
• Suh, M. R. et al. Human embryonic stem cells express a unique set of microRNAs. Dev. Biol. 270, 488–498 (2004).
  CAS PubMed Google Scholar
• Chen, C. Z., Li, L., Lodish, H. F. & Bartel, D. P. MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83–86 (2004).
  CAS PubMed Google Scholar
• Pickart, M. A. et al. Functional genomics tools for the analysis of zebrafish pigment. Pigment Cell Res. 17, 461–470 (2004).
  CAS PubMed Google Scholar
• Nasevicius, A. & Ekker, S. C. Effective targeted gene 'knockdown' in zebrafish. Nature Genet. 26, 216–220 (2000).
  CAS PubMed Google Scholar
• Ekker, S. C. Morphants: a new systematic vertebrate functional genomics approach. Yeast 17, 302–306 (2000).
  CAS PubMed Google Scholar
• Heasman, J. Morpholino oligos: making sense of antisense? Dev. Biol. 243, 209–214 (2002).
  CAS PubMed Google Scholar
• Bargmann, C. I. High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans. Genome Biol. 2, REVIEWS1005 (2001).
  CAS PubMed PubMed Central Google Scholar
• Eckfeldt, C. E. et al. Functional analysis of hematopoietic stem cell gene expressin using zebrafish. PLoS Biol. 3, e254 (2005). One of the first descriptions of global gene-expression profiling of a human stem-cell population coupled with high-throughput functional genomics screening using zebrafish.
  PubMed PubMed Central Google Scholar
• Pomerantz, J. & Blau, H. M. Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nature Cell Biol. 6, 810–816 (2004).
  CAS PubMed Google Scholar
• Grove, J. E., Bruscia, E. & Krause, D. S. Plasticity of bone marrow-derived stem cells. Stem Cells 22, 487–500 (2004).
  PubMed Google Scholar
• Wagers, A. J. & Weissman, I. L. Plasticity of adult stem cells. Cell 116, 639–648 (2004).
  CAS PubMed Google Scholar
• Camargo, F. D., Chambers, S. M. & Goodell, M. A. Stem cell plasticity: from transdifferentiation to macrophage fusion. Cell Prolif. 37, 55–65 (2004).
  CAS PubMed PubMed Central Google Scholar
• Verfaillie, C. M. Adult stem cells: assessing the case for pluripotency. Trends Cell Biol. 12, 502–508 (2002).
  CAS PubMed Google Scholar
• Khavari, P. A. Profiling epithelial stem cells. Nature Biotechnol. 22, 393–394 (2004).
  CAS Google Scholar
• Gronthos, S. et al. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J. Cell Sci. 116, 1827–1835 (2003).
  CAS PubMed Google Scholar
• Oh, H. et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl Acad. Sci. USA 100, 12313–12318 (2003).
  CAS PubMed PubMed Central Google Scholar
• Paku, S., Schnur, J., Nagy, P. & Thorgeirsson, S. S. Origin and structural evolution of the early proliferating oval cells in rat liver. Am. J. Pathol. 158, 1313–1323 (2001).
  CAS PubMed PubMed Central Google Scholar
• Petkov, P. M. et al. Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays. Hepatology 39, 617–627 (2004).
  CAS PubMed Google Scholar
• Arai, M. et al. Gene expression profiles in liver regeneration with oval cell induction. Biochem. Biophys. Res. Comm. 317, 370–376 (2004).
  CAS PubMed Google Scholar
• Seaberg, R. M. et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nature Biotechnol. 22, 1115–1124 (2004).
  CAS Google Scholar
• Bonner-Weir, S. et al. The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr. Diabetes 5, 16–22 (2004).
  PubMed Google Scholar
• Hawke, T. J. & Garry, D. J. Myogenic satellite cells: physiology to molecular biology. J. Appl. Physiol. 91, 534–551 (2001).
  CAS PubMed Google Scholar
• de Rooij, D. G. & Grootegoed, J. A. Spermatogonial stem cells. Curr. Opin. Cell Biol. 10, 694–701 (1998).
  CAS PubMed Google Scholar