The CBC social network (original) (raw)

RNA metabolism

Nature Reviews Molecular Cell Biology volume 15, page 1 (2014)Cite this article

Subjects

Bertrand and colleagues show that the CBC forms a complex with arsenite-resistance 2 (ARS2), which they term CBCA. They further report that the CBC and ARS2 bind to a similar set of capped, non-coding and coding RNA species, and that their knockdown results in increased read-through of 3′ end sites of small nuclear RNAs (snRNAs) and polyadenylated mRNAs. This suggests that ARS2 promotes 3′ end processing in the context of the CBC. Interestingly, increasing the distance between the cap and 3′ end processing signal decreased the read-through phenotype upon CBC and ARS2 knockdown, suggesting that CBCA promotes cap-proximal 3′ end cleavage.

human CBC subcomplexes that have specific functions in RNA metabolism

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

References

  1. Hallais, M. et al. CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing. Nature Struc. Mol. Biol. http://dx.doi.org/10.1038/nsmb.2720 (2013)
  2. Refsing Andersen, R. et al. The human cap-binding complex is functionally connected to the nuclear RNA exosome. Nature Struc. Mol. Biol. http://dx.doi.org/10.1038/nsmb.2703 (2013)

Download references

Rights and permissions

About this article

Cite this article

Du Toit, A. The CBC social network.Nat Rev Mol Cell Biol 15, 1 (2014). https://doi.org/10.1038/nrm3718

Download citation

This article is cited by