A guide to disorders causing transient loss of consciousness: focus on syncope (original) (raw)

References

  1. Landau, W. M. & Nelson, D. A. Clinical neuromythology XV. Feinting science: neurocardiogenic syncope and collateral vasovagal confusion. Neurology 46, 609–618 (1996).
    Article CAS PubMed Google Scholar
  2. Josephson, C. B., Rahey, S. & Sadler, R. M. Neurocardiogenic syncope: frequency and consequences of its misdiagnosis as epilepsy. Can. J. Neurol. Sci. 34, 221–224 (2007).
    Article PubMed Google Scholar
  3. Carreño, M. Recognition of nonepileptic events. Semin. Neurol. 28, 297–304 (2008).
    Article PubMed Google Scholar
  4. Chowdhury, F. A., Nashef, L. & Elwes, R. D. Misdiagnosis in epilepsy: a review and recognition of diagnostic uncertainty. Eur. J. Neurol. 15, 1034–1042 (2008).
    Article CAS PubMed Google Scholar
  5. Colman, N. et al. Epidemiology of reflex syncope. Clin. Auton. Res. 14 (Suppl. 1), 9–17 (2004).
    Article PubMed Google Scholar
  6. Ganzeboom, K. S., Colman, N., Reitsma, J. B., Shen, W. K. & Wieling, W. Prevalence and triggers of syncope in medical students. Am. J. Cardiol. 15, 1006–1008 (2003).
    Article Google Scholar
  7. Ganzeboom, K. S. et al. Lifetime cumulative incidence of syncope in the general population: a study of 549 Dutch subjects aged 35–60 years. J. Cardiovasc. Electrophysiol. 17, 1172–1176 (2006).
    Article PubMed Google Scholar
  8. van Dijk, J. G. Explaining syncope: faints need not confuse. Europace 7, 392–395 (2005).
    Article PubMed Google Scholar
  9. van Dijk, J. G. & Fitzpatrick, A. P. What is syncope and what is not syncope: the importance of definitions. In The Evaluation and Treatment of Syncope. A Handbook for Clinical Practice 2nd edn (Eds Benditt, D. G., Blanc, J. J., Brignole, M. & Sutton, R.) 10–15 (Wiley-Blackwell, Oxford 2006).
    Book Google Scholar
  10. Thijs, R. D., Granneman, E., Wieling, W. & van Dijk, J. G. Terms in use for transient loss of consciousness in the emergency ward; an inventory [Dutch]. Ned. Tijdschr. Geneeskd. 149, 1625–1630 (2005).
    CAS PubMed Google Scholar
  11. Thijs, R. D. et al. Unconscious confusion—a literature search for definitions of syncope and related disorders. Clin. Auton. Res. 15, 35–39 (2005).
    Article PubMed Google Scholar
  12. Brignole, M. et al. Guidelines on management (diagnosis and treatment) of syncope. Eur. Heart J. 22, 1256–1306 (2001).
    Article CAS PubMed Google Scholar
  13. The Task Force on Syncope, European Society of Cardiology. Guidelines on management (diagnosis and treatment) of syncope—update 2004. Europace 6, 467–537 (2004).
  14. Thijs, R. D., Wieling, W., Kaufmann, H. & van Dijk, J. G. Defining and classifying syncope. Clin. Auton. Res. 14 (Suppl. 1), 4–8 (2004).
    Article PubMed Google Scholar
  15. Jhanjee, R., van Dijk, J. G., Sakaguchi, S. & Benditt, D. G. Syncope in adults: terminology, classification, and diagnostic strategy. Pacing Clin. Electrophysiol. 29, 1160–1169 (2006).
    Article PubMed Google Scholar
  16. Posner, J. B., Saper, C. B., Schiff, N. & Plum, F. Plum and Posner's Diagnosis of Stupor and Coma 4th edn (Oxford University Press, New York, 2007).
    Google Scholar
  17. Bloem, R., Overeem, S. & van Dijk, J. G. Syncopal falls, drop attacks and their mimics. In Clinical Disorders of Balance, Posture and Gait 2nd edn (Eds Bronstein, A. M., Brandt, T., Woollacott, M. J. & Nutt, J. G.) 287–316 (Hodder Arnold, London, 2004).
    Google Scholar
  18. Rossen, R., Kabat, H. & Anderson, J. P. Acute arrest of cerebral circulation in man. Arch. Neurol. Psychiatry 50, 510–528 (1943).
    Article Google Scholar
  19. Lempert, T., Bauer, M. & Schmidt, D. Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. Ann. Neurol. 36, 233–237 (1994).
    Article CAS PubMed Google Scholar
  20. Lempert, T. & von Brevern, M. The eye movements of syncope. Neurology 46, 1086–1088 (1996).
    Article CAS PubMed Google Scholar
  21. Stephenson, J. B. P. Fits and Faints (MacKeith Press, Oxford, 1990).
    Google Scholar
  22. Lin, J. T., Ziegler, D. K., Lai, C. W. & Bayer, W. Convulsive syncope in blood donors. Ann. Neurol. 11, 525–528 (1982).
    Article CAS PubMed Google Scholar
  23. Newman, B. H. & Graves, S. A study of 178 consecutive vasovagal syncopal reactions from the perspective of safety. Transfusion 41, 1475–1479 (2001).
    Article CAS PubMed Google Scholar
  24. Hoefnagels, W. A., Padberg, G. W., Overweg, J., van der Velde, E. A. & Roos, R. A. Transient loss of consciousness: the value of the history for distinguishing seizure from syncope. J. Neurol. 238, 39–43 (1991).
    Article CAS PubMed Google Scholar
  25. Romme, J. J. et al. Influence of age and gender on the occurrence and presentation of reflex syncope. Clin. Auton. Res. 18, 127–133 (2008).
    Article PubMed Google Scholar
  26. Benbadis, S. R., Wolgamuth, B. R., Goren, H., Brener, S. & Fouad-Tarazi, F. Value of tongue biting in the diagnosis of seizures. Arch. Intern. Med. 155, 2346–2349 (1995).
    Article CAS PubMed Google Scholar
  27. Serletis, A., Rose, S., Sheldon, A. G. & Sheldon, R. S. Vasovagal syncope in medical students and their first-degree relatives. Eur. Heart J. 27, 1965–1970 (2006).
    Article PubMed Google Scholar
  28. Olde Nordkamp, L. R., Wieling, W., Zwinderman, A. H., Wilde, A. A. & van Dijk, N. Genetic aspects of vasovagal syncope: a systematic review of current evidence. Europace 11, 414–420 (2009).
    Article PubMed Google Scholar
  29. Sheldon, R. S. et al. Age of first faint in patients with vasovagal syncope. J. Cardiovasc. Electrophysiol. 17, 49–54 (2006).
    Article PubMed Google Scholar
  30. Alboni, P., Alboni, M. & Bertorelle, G. The origin of vasovagal syncope: to protect the heart or to escape predation? Clin. Auton. Res. 18, 170–178 (2008).
    Article PubMed Google Scholar
  31. van Dijk, J. G. Fainting in animals. Clin. Auton. Res. 13, 247–255 (2003).
    Article PubMed Google Scholar
  32. van Dijk, J. G. & Sheldon, R. Is there any point to vasovagal syncope? Clin. Auton. Res. 18, 167–169 (2008).
    Article PubMed Google Scholar
  33. Hainsworth, R. Pathophysiology of syncope. Clin. Auton. Res. 14 (Suppl. 1), 18–24 (2004).
    Google Scholar
  34. Verheyden, B. et al. Steep fall in cardiac output is main determinant of hypotension during drug-free and nitroglycerine-induced orthostatic vasovagal syncope. Heart Rhythm 5, 1695–1701 (2008).
    Article PubMed Google Scholar
  35. Gracie, J., Newton, J. L., Norton, M., Baker, C. & Freeston, M. The role of psychological factors in response to treatment in neurocardiogenic (vaovagal) syncope. Europace 8, 636–643 (2006).
    Article PubMed Google Scholar
  36. Fucà, G. et al. The venous system is the main determinant of hypotension in patients with vasovagal syncope. Europace 8, 839–845 (2006).
    Article PubMed Google Scholar
  37. Verheyden, B. et al. Impact of age on the vasovagal response provoked by sublingual nitroglycerine in routine tilt testing. Clin. Sci. (Lond.) 113, 329–337 (2007).
    Article CAS Google Scholar
  38. Krediet, C. T., Wilde, A. A., Wieling, W. & Halliwill, J. R. Exercise related syncope, when it's not the heart. Clin. Auton. Res. 14 (Suppl. 1), 25–36 (2004).
    Article PubMed Google Scholar
  39. Kerr, S. R., Pearce, M. S., Brayne, C., Davis, R. J. & Kenny, R. A. Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls. Arch. Intern. Med. 166, 515–520 (2006).
    Article PubMed Google Scholar
  40. Parry, S. W., Steen, N., Bexton, R., Tynan, M. & Kenny, R. A. Pacing in elderly recurrent fallers with carotid sinus hypersensitivity: a randomised, double-blind, placebo controlled cross-over trial. Heart 95, 405–409 (2009).
    Article CAS PubMed Google Scholar
  41. van Dijk, N. et al. Clinical factors associated with quality of life in patients with transient loss of consciousness. J. Cardiovasc. Electrophysiol. 17, 998–1003 (2006).
    Article PubMed Google Scholar
  42. van Dijk, N. et al. Quality of life within one year following presentation after transient loss of consciousness. Am. J. Cardiol. 100, 672–676 (2007).
    Article PubMed Google Scholar
  43. Ross, R., Parry, S., Norton, M. & Newton, J. L. Self-reported symptom burden; outcome in 418 patients from the Newcastle Vasovagal (Neurocardiogenic) cohort. QJM 101, 127–135 (2008).
    Article CAS PubMed Google Scholar
  44. Ammirati, F. et al. Management of syncope: clinical and economic impact of a Syncope Unit. Europace 10, 471–476 (2008).
    Article PubMed Google Scholar
  45. Kaufmann, H. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin. Auton. Res. 6, 125–126 (1996).
    Article CAS PubMed Google Scholar
  46. Low, P. A. & Singer, W. Management of neurogenic orthostatic hypotension: an update. Lancet Neurol. 7, 451–458 (2008).
    Article PubMed PubMed Central Google Scholar
  47. Lahrmann, H. et al. EFNS guidelines on the diagnosis and management of orthostatic hypotension. Eur. J. Neurol. 13, 930–936 (2006).
    Article CAS PubMed Google Scholar
  48. Robertson, D. The pathophysiology and diagnosis of orthostatic hypotension. Clin. Auton. Res. 18 (Suppl. 1), 2–7 (2008).
    Article Google Scholar
  49. Naschitz, J. E. & Rosner, I. Orthostatic hypotension: framework of the syndrome. Postgrad. Med. J. 83, 568–574 (2007).
    Article PubMed PubMed Central Google Scholar
  50. Freeman, R. Clinical Practice. Neurogenic orthostatic hypotension. N. Engl. J. Med. 358, 615–624 (2008).
    Article CAS PubMed Google Scholar
  51. Wieling, W. & Schatz, I. The consensus statement on the definition of orthostatic hypotension. A revisit after 13 years. J. Hypertension 27, 935–938 (2009).
    Article CAS Google Scholar
  52. Gehrking, J. A. et al. What is the minimum duration of head-up tilt necessary to detect orthostatic hypotension? Clin. Auton. Res. 15, 71–75 (2005).
    Article PubMed Google Scholar
  53. Gibbons, C. H. & Freeman, R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology 67, 28–32 (2006).
    Article PubMed Google Scholar
  54. Bleasdale-Barr, K. M. & Mathias, C. J. Neck and other muscle pains in autonomic failure: their association with orthostatic hypotension. J. R. Soc. Med. 91, 355–359 (1998).
    Article CAS PubMed PubMed Central Google Scholar
  55. Smith, G. D., Watson, L. P., Pavitt, D. V. & Mathias, C. J. Abnormal cardiovascular and catecholamine responses to supine exercise in human subjects with sympathetic dysfunction. J. Physiol. 484, 255–265 (1995).
    Article CAS PubMed PubMed Central Google Scholar
  56. Smith, G. D. & Mathias, C. J. Postural hypotension enhanced by exercise in patients with chronic autonomic failure. QJM 88, 251–256 (1995).
    CAS PubMed Google Scholar
  57. Wieling, W., Krediet, C. T., van Dijk, N., Linzer, M. & Tschakovsky, M. E. Initial orthostatic hypotension: review of a forgotten condition. Clin. Sci. (Lond.) 112, 157–165 (2007).
    Article Google Scholar
  58. Podoleanu, C. et al. Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: a randomized single-blind controlled study. J. Am. Coll. Cardiol. 48, 1425–1432 (2006).
    Article PubMed Google Scholar
  59. Soteriades, E. S. et al. Incidence and prognosis of syncope. N. Engl. J. Med. 347, 878–885 (2002).
    Article PubMed Google Scholar
  60. Kannankeril, P. J. & Roden, D. M. Drug-induced long QT and torsade de pointes: recent advances. Curr. Opin. Cardiol. 22, 39–43 (2007).
    Article PubMed Google Scholar
  61. Meyer, J. S., Mehdirad, A., Salem, B. I., Kulikowska, A. & Kulikowski, P. Sudden arrhythmia death syndrome: importance of the long QT syndrome. Am. Fam. Physician 68, 483–488 (2003).
    PubMed Google Scholar
  62. Vohra, J. The long QT syndrome. Heart Lung Circ. 16 (Suppl. 3), S5–S12 (2007).
    Article PubMed Google Scholar
  63. Alboni, P. et al. Diagnostic value of history in patients with syncope with or without heart disease. J. Am. Coll. Cardiol. 37, 1921–1928 (2001).
    Article CAS PubMed Google Scholar
  64. Sheldon, R. et al. Diagnostic criteria for vasovagal syncope based on a quantitative history. Eur. Heart J. 27, 344–350 (2006).
    Article PubMed Google Scholar
  65. Wieling, W., Krediet, C. T. & Wilde, A. A. Flush after syncope: not always an arrhythmia. J. Cardiovasc. Electrophysiol. 17, 804–805 (2006).
    Article CAS PubMed Google Scholar
  66. So, N. K. Atonic phenomena and partial seizures. A reappraisal. Adv. Neurol. 67, 29–39 (1995).
    CAS PubMed Google Scholar
  67. Trenité, D. G. Photosensitivity, visually sensitive seizures and epilepsies. Epilepsy Res. 70 (Suppl. 1), S269–S279 (2006).
    Article PubMed Google Scholar
  68. Bakker, M. J., van Dijk, J. G., van den Maagdenberg, A. M. & Tijssen, M. A. Startle syndromes. Lancet Neurol. 5, 513–524 (2006).
    Article PubMed Google Scholar
  69. Tibussek, D., Wohlrab, G., Boltshauser, E. & Schmitt, B. Proven startle-provoked epileptic seizures in childhood: semiologic and electrophysiologic variability. Epilepsia 47, 1050–1058 (2006).
    Article PubMed Google Scholar
  70. Levine, E. et al. Congenital long QT syndrome: considerations for primary care physicians. Cleve. Clin. J. Med. 75, 591–600 (2008).
    Article PubMed Google Scholar
  71. van Donselaar, C. A., Geerts, A. T. & Schimsheimer, R. J. Usefulness of an aura for classification of a first generalized seizure. Epilepsia 31, 529–535 (1990).
    Article CAS PubMed Google Scholar
  72. Colman, N. et al. Diagnostic value of history taking in reflex syncope. Clin. Auton. Res. 14 (Suppl. 1), 37–44 (2004).
    Article PubMed Google Scholar
  73. Sheldon, R. et al. Historical criteria that distinguish syncope from seizures. J. Am. Coll. Cardiol. 40, 142–148 (2002).
    Article PubMed Google Scholar
  74. Ghearing, G. R., Munger, T. M., Jaffe, A. S., Benarroch, E. E. & Britton, J. W. Clinical clues for detecting ictal asystole. Clin. Auton. Res. 17, 221–226 (2007).
    Article PubMed Google Scholar
  75. Horrocks, I. A., Nechay, A., Stephenson, J. B. & Zuberi, S. M. Anoxic-epileptic seizures: observational study of epileptic seizures induced by syncopes. Arch. Dis. Child. 90, 1283–1287 (2005).
    CAS PubMed PubMed Central Google Scholar
  76. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR Fourth Edition (Text Revision) 4th edn (American Psychiatric Publishing, Inc., Arlington, VA, 2000).
  77. Kroenke, K., Sharpe, M. & Sykes, R. Revising the classification of somatoform disorders: key questions and preliminary recommendations. Psychosomatics 48, 277–285 (2007).
    Article PubMed Google Scholar
  78. Kroenke, K. & Rosmalen, J. G. Symptoms, syndromes, and the value of psychiatric diagnostics in patients who have functional somatic disorders. Med. Clin. North Am. 90, 603–626 (2006).
    Article PubMed Google Scholar
  79. Reuber, M., Howlet, S., Khan, A. & Grünewald, R. A. Non-epileptic seizures and other functional neurological symptoms: predisposing, precipitating, and perpetuating factors. Psychosomatics 48, 230–238 (2007).
    Article PubMed Google Scholar
  80. Strassnig, M., Stowell, K. R., First, M. B. & Pincus, H. A. General medical and psychiatric perspectives on somatoform disorders: separated by an uncommon language. Curr. Opin. Psychiatry 19, 194–200 (2006).
    Article PubMed Google Scholar
  81. Benbadis, S. R. The problem of psychogenic symptoms: is the psychiatric community in denial? Epilepsy Behav. 6, 9–14 (2005).
    Article PubMed Google Scholar
  82. Reuber, M., Mitchell, A. J., Howlett, S. J., Crimlisk, H. L. & Grünewald, R. A. Functional symptoms in neurology: questions and answers. J. Neurol. Neurosurg. Psychiatry 76, 307–314 (2005).
    Article CAS PubMed PubMed Central Google Scholar
  83. Stone, J. et al. What should we call pseudoseizures? The patient's perspective. Seizure 12, 568–572 (2003).
    Article PubMed Google Scholar
  84. Oliva, M. et al. The diagnostic value of oral lacerations and incontinence during convulsive 'seizures'. Epilepsia 49, 962–967 (2008).
    Article PubMed Google Scholar
  85. LaFrance, W. C. Jr. Psychogenic nonepileptic seizures. Curr. Opin. Neurol. 21, 195–201 (2008).
    Article PubMed Google Scholar
  86. Chung, S. S., Gerber, P. & Kirlin, K. A. Ictal eye closure is a reliable indicator for psychogenic nonepileptic seizures. Neurology 66, 1730–1731 (2006).
    Article PubMed Google Scholar
  87. Syed, T. U. et al. Do observer and self-reports of ictal eye closure predict psychogenic nonepileptic seizures? Epilepsia 49, 898–904 (2008).
    Article PubMed Google Scholar
  88. Thijs, R. D., Wagenaar, W. A., Middelkoop, H. A., Wieling, W. & van Dijk, J. G. Transient loss of consciousness through the eyes of a witness. Neurology 71, 1713–1718 (2008).
    Article CAS PubMed Google Scholar
  89. Zaidi, A., Crampton, S., Clough, P., Fitzpatrick, A. & Scheepers, B. Head-up tilting is a useful provocative test for psychogenic non-epileptic seizures. Seizure 8, 353–355 (1999).
    Article CAS PubMed Google Scholar
  90. Ribaï, P., Tugendhaft, P. & Legros, B. Usefulness of prolonged video-EEG monitoring and provocative procedure with saline injection for the diagnosis of nonepileptic seizures of psychogenic origin. J. Neurol. 253, 328–332 (2006).
    Article PubMed Google Scholar
  91. Petersen, M. E., Williams, T. R. & Sutton, R. Psychogenic syncope diagnosed by prolonged head-up tilt testing. QJM 88, 209–213 (1995).
    CAS PubMed Google Scholar
  92. van Dijk, N. et al. High diagnostic yield and accuracy of history, physical examination, and ECG in patients with transient loss of consciousness in FAST: the Fainting Assessment study. J. Cardiovasc. Electrophysiol. 19, 48–55 (2008).
    Article PubMed Google Scholar
  93. Benbadis, S. R. & Chichkova, R. Psychogenic pseudosyncope: an underestimated and provable diagnosis. Epilepsy Behav. 9, 106–110 (2006).
    Article PubMed Google Scholar
  94. Savitz, S. I. & Caplan, L. R. Vertebrobasilar disease. N. Engl. J. Med. 352, 2618–2626 (2005).
    Article CAS PubMed Google Scholar
  95. Hennerici, M., Klemm, C. & Rautenberg, W. The subclavian steal phenomenon: a common vascular disorder with rare neurologic deficits. Neurology 38, 669–673 (1988).
    Article CAS PubMed Google Scholar
  96. Taylor, C. L., Selman, W. R. & Ratchson, R. A. Steal affecting the central nervous system. Neurosurgery 50, 679–689 (2002).
    Article PubMed Google Scholar
  97. Stark, R. J. & Wodak, J. Primary orthostatic cerebral ischaemia. J. Neurol. Neurosurg. Psychiatry 46, 883–891 (1983).
    Article CAS PubMed PubMed Central Google Scholar
  98. American Academy of Sleep Medicine. The International Classification of Sleep Disorders. Diagnostic and Coding Manual 2nd edn (American Academy of Sleep Medicine, Westchester, Illinois, 2005).
  99. Overeem, S., Mignot, E., van Dijk, J. G. & Lammers, G. J. Narcolepsy: clinical features, new pathophysiological insights, and future perspectives. J. Clin. Neurophysiol. 18, 78–105 (2001).
    Article CAS PubMed Google Scholar
  100. Macleod, S., Ferrie, C. & Zuberi, S. M. Symptoms of narcolepsy in children misinterpreted as epilepsy. Epileptic Disord. 7, 13–17 (2005).
    PubMed Google Scholar
  101. Zeman, A., Douglas, N. & Aylward, R. Lesson of the week: narcolepsy mistaken for epilepsy. BMJ 322, 216–218 (2001).
    Article CAS PubMed PubMed Central Google Scholar
  102. Calabrò, R. S. et al. Status cataplecticus misdiagnosed as recurrent syncope. Neurol. Sci. 28, 336–338 (2007).
    Article PubMed Google Scholar
  103. Stevens, D. L. & Matthews, W. B. Cryptogenic drop attacks: an affliction of women. BMJ 1, 439–442 (1973).
    Article CAS PubMed PubMed Central Google Scholar
  104. Friedman, M. J., Mull, C. C., Sharieff, G. Q. & Tsarouhas, N. Prolonged QT syndrome in children: an uncommon but potentially fatal entity. J. Emerg. Med. 24, 173–179 (2003).
    Article PubMed Google Scholar
  105. Kotsopoulos, I. et al. Incidence of epilepsy and predictive factors of epileptic and non-epileptic seizures. Seizure 14, 175–182 (2005).
    Article PubMed Google Scholar
  106. Olafsson, E. et al. Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. Lancet Neurol. 4, 627–634 (2005).
    Article PubMed Google Scholar
  107. Sillanpää, M., Kälviäinen, R., Klaukka, T., Helenius, H. & Shinnar, S. Temporal changes in the incidence of epilepsy in Finland: nationwide study. Epilepsy Res. 71, 206–215 (2006).
    Article PubMed Google Scholar
  108. Olde Noordkamp, L. R. et al. Syncope prevalence in the ED compared to that in the genral practice and population: a strong selection process. Am. J. Emergency Med. 27, 271–279 (2009).
    Article Google Scholar
  109. Martikainen, K. et al. Transient loss of consciousness with and without injuries: where to treat these patients? Eur. J. Gen. Pract. 9, 91–95 (2003).
    Article PubMed Google Scholar
  110. Martikainen, K. et al. Transient loss of consciousness as reason for admission to primary health care emergency room. Scand. J. Prim. Health Care 21, 61–64 (2003).
    Article PubMed Google Scholar
  111. Bartoletti, A. et al. Physical injuries caused by a transient loss of consciousness: main clinical characteristics of patients and diagnostic contribution of carotid sinus massage. Eur. Heart J. 29, 618–624 (2008).
    Article PubMed Google Scholar
  112. Gilbert, D. L., Sthuraman, G., Kotagal, U. & Buncher, R. Meta-analysis of EEG test performance shows wide variation among studies. Neurology 60, 564–570 (2002).
    Article Google Scholar
  113. van Donselaar, C. A., Stroink, H., Arts, W. F. & Dutch Study Group of Epilepsy in Childhood. How confident are we of the diagnosis of epilepsy? Epilepsia 47 (Suppl. 1), 9–13 (2006).
    Google Scholar

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