The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis (original) (raw)
Samuels, J., Krasnokutsky, S. & Abramson, S. B. Osteoarthritis: a tale of three tissues. Bull. NYU Hosp. Jt Dis.66, 244–250 (2008). PubMed Google Scholar
Sellam, J., Herrero-Beaumont, G. & Berenbaum, F. Osteoarthritis: pathogenesis, clinical aspects and diagnosis. In EULAR Compendium on Rheumatic Diseases (ed. Bijlsma, H.) 444–463 (BMJ Publishing Group Ltd, London, 2009). Google Scholar
Krasnokutsky, S., Attur, M., Palmer, G., Samuels, J. & Abramson, S. B. Current concepts in the pathogenesis of osteoarthritis. Osteoarthritis Cartilage16 (Suppl. 3), S1–S3 (2008). ArticlePubMed Google Scholar
Ayral, X. et al. Arthroscopic evaluation of post-traumatic patellofemoral chondropathy. J. Rheumatol.26, 1140–1147 (1999). CASPubMed Google Scholar
Lindblad, S. & Hedfors, E. Intraarticular variation in synovitis. Local macroscopic and microscopic signs of inflammatory activity are significantly correlated. Arthritis Rheum.28, 977–986 (1985). ArticleCASPubMed Google Scholar
Benito, M. J., Veale, D. J., FitzGerald, O., van den Berg, W. B. & Bresnihan, B. Synovial tissue inflammation in early and late osteoarthritis. Ann. Rheum. Dis.64, 1263–1267 (2005). ArticleCASPubMedPubMed Central Google Scholar
Loeuille, D. et al. Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity. Arthritis Rheum.52, 3492–3501 (2005). ArticlePubMed Google Scholar
Iagnocco, A. & Coari, G. Usefulness of high resolution US in the evaluation of effusion in osteoarthritic first carpometacarpal joint. Scand. J. Rheumatol.29, 170–173 (2000). ArticleCASPubMed Google Scholar
Dougados, M. Clinical assessment of osteoarthritis in clinical trials. Curr. Opin. Rheumatol.7, 87–91 (1995). ArticleCASPubMed Google Scholar
Sellam, J. & Berenbaum, F. Clinical features of osteoarthritis. In Kelley's Textbook of Rheumatology, 8th edn Vol. 1 (ed. Firestein, G. S.) 1547–1560 (Saunders/Elsevier, Philadelphia, 2008). Google Scholar
Ayral, X., Pickering, E. H., Woodworth, T. G., Mackillop, N. & Dougados, M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis—results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage13, 361–367 (2005). ArticleCASPubMed Google Scholar
Ledingham, J., Regan, M., Jones, A. & Doherty, M. Factors affecting radiographic progression of knee osteoarthritis. Ann. Rheum. Dis.54, 53–58 (1995). ArticleCASPubMedPubMed Central Google Scholar
Fernandez-Madrid, F. et al. Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis. Magn. Reson. Imaging13, 177–183 (1995). ArticleCASPubMed Google Scholar
Ostergaard, M. et al. Magnetic resonance imaging-determined synovial membrane and joint effusion volumes in rheumatoid arthritis and osteoarthritis: comparison with the macroscopic and microscopic appearance of the synovium. Arthritis Rheum.40, 1856–1867 (1997). ArticleCASPubMed Google Scholar
Hill, C. L. et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann. Rheum. Dis.66, 1599–1603 (2007). ArticlePubMedPubMed Central Google Scholar
Roemer, F. W. et al. Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology252, 772–780 (2009). ArticlePubMedPubMed Central Google Scholar
Pelletier, J. P. et al. A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI. Osteoarthritis Cartilage16 (Suppl. 3), S8–S13 (2008). ArticlePubMed Google Scholar
Meenagh, G. et al. Ultrasound imaging for the rheumatologist VIII. Ultrasound imaging in osteoarthritis. Clin. Exp. Rheumatol.25, 172–175 (2007). CASPubMed Google Scholar
Kristoffersen, H. et al. Indications of inflammation visualized by ultrasound in osteoarthritis of the knee. Acta Radiol.47, 281–286 (2006). ArticleCASPubMed Google Scholar
Fiocco, U. et al. Long-term sonographic follow-up of rheumatoid and psoriatic proliferative knee joint synovitis. Br. J. Rheumatol.35, 155–163 (1996). ArticleCASPubMed Google Scholar
Walther, M. et al. Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum.44, 331–338 (2001). ArticleCASPubMed Google Scholar
Iagnocco, A. et al. High resolution ultrasonography in detection of bone erosions in patients with hand osteoarthritis. J. Rheumatol.32, 2381–2383 (2005). PubMed Google Scholar
D'Agostino, M. A. et al. EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: prevalence of inflammation in osteoarthritis. Ann. Rheum. Dis.64, 1703–1709 (2005). ArticleCASPubMedPubMed Central Google Scholar
Keen, H. I. et al. An ultrasonographic study of osteoarthritis of the hand: synovitis and its relationship to structural pathology and symptoms. Arthritis Rheum.59, 1756–1763 (2008). ArticlePubMed Google Scholar
Conaghan, P. G. et al. Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3 year, prospective EULAR study. Ann. Rheum. Dis.69, 644–647 (2009). ArticlePubMed Google Scholar
Ayral, X. Efficacy and role of topical treatment of gonarthrosis [French]. Presse Med.28, 1195–1200 (1999). CASPubMed Google Scholar
Ayral, X. et al. Arthroscopic evaluation of potential structure-modifying drug in osteoarthritis of the knee. A multicenter, randomized, double-blind comparison of tenidap sodium vs piroxicam. Osteoarthritis Cartilage11, 198–207 (2003). ArticleCASPubMed Google Scholar
Ayral, X., Mayoux-Benhamou, A. & Dougados, M. Proposed scoring system for assessing synovial membrane abnormalities at arthroscopy in knee osteoarthritis. Br. J. Rheumatol.35 (Suppl. 3), 14–17 (1996). ArticlePubMed Google Scholar
Pearle, A. D. et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage15, 516–523 (2007). ArticleCASPubMed Google Scholar
Uson, J. et al. Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies. J. Rheumatol.24, 2069–2075 (1997). CASPubMed Google Scholar
Sharif, M., Shepstone, L., Elson, C. J., Dieppe, P. A. & Kirwan, J. R. Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann. Rheum. Dis.59, 71–74 (2000). ArticleCASPubMedPubMed Central Google Scholar
Spector, T. D. et al. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum.40, 723–727 (1997). ArticleCASPubMed Google Scholar
Sturmer, T., Brenner, H., Koenig, W. & Gunther, K. P. Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein. Ann. Rheum. Dis.63, 200–205 (2004). ArticleCASPubMedPubMed Central Google Scholar
Wolfe, F. The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee or hip. J. Rheumatol.24, 1486–1488 (1997). CASPubMed Google Scholar
Engstrom, G., Gerhardsson de Verdier, M., Rollof, J., Nilsson, P. M. & Lohmander, L. S. C-reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study. Osteoarthritis Cartilage17, 168–173 (2009). ArticleCASPubMed Google Scholar
Livshits, G. et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum.60, 2037–2045 (2009). ArticleCASPubMedPubMed Central Google Scholar
Conrozier, T. et al. Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study. Ann. Rheum. Dis.59, 828–831 (2000). ArticleCASPubMedPubMed Central Google Scholar
Charni-Ben Tabassi, N. & Garnero, P. Monitoring cartilage turnover. Current Rheumatol. Rep.9, 16–24 (2007). ArticleCAS Google Scholar
Masuhara, K., Nakai, T., Yamaguchi, K., Yamasaki, S. & Sasaguri, Y. Significant increases in serum and plasma concentrations of matrix metalloproteinases 3 and 9 in patients with rapidly destructive osteoarthritis of the hip. Arthritis Rheum.46, 2625–2631 (2002). ArticleCASPubMed Google Scholar
Myers, S. L. et al. Synovial inflammation in patients with early osteoarthritis of the knee. J. Rheumatol.17, 1662–1669 (1990). CASPubMed Google Scholar
Smith, M. D., Triantafillou, S., Parker, A., Youssef, P. P. & Coleman, M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J. Rheumatol.24, 365–371 (1997). CASPubMed Google Scholar
Neame, R. L., Carr, A. J., Muir, K. & Doherty, M. UK community prevalence of knee chondrocalcinosis: evidence that correlation with osteoarthritis is through a shared association with osteophyte. Ann. Rheum. Dis.62, 513–518 (2003). ArticleCASPubMedPubMed Central Google Scholar
Walsh, D. A. et al. Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis Cartilage15, 743–751 (2007). ArticleCASPubMed Google Scholar
Walsh, D. A. Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomes. Curr. Opin. Rheumatol.16, 609–615 (2004). ArticlePubMed Google Scholar
Hutton, C. W., Hinton, C. & Dieppe, P. A. Intra-articular variation of synovial changes in knee arthritis: biopsy study comparing changes in patellofemoral synovium and the medial tibiofemoral synovium. Br. J. Rheumatol.26, 5–8 (1987). ArticleCASPubMed Google Scholar
Shibakawa, A. et al. Presence of pannus-like tissue on osteoarthritic cartilage and its histological character. Osteoarthritis Cartilage11, 133–140 (2003). ArticleCASPubMed Google Scholar
Sutton, S. et al. The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Vet. J.179, 10–24 (2009). ArticleCASPubMed Google Scholar
Furuzawa-Carballeda, J., Macip-Rodriguez, P. M. & Cabral, A. R. Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. Clin. Exp. Rheumatol.26, 554–560 (2008). CASPubMed Google Scholar
Yuan, G. H. et al. Characterization of cells from pannus-like tissue over articular cartilage of advanced osteoarthritis. Osteoarthritis Cartilage12, 38–45 (2004). ArticlePubMed Google Scholar
Nakamura, H., Yoshino, S., Kato, T., Tsuruha, J. & Nishioka, K. T-cell mediated inflammatory pathway in osteoarthritis. Osteoarthritis Cartilage7, 401–402 (1999). ArticleCASPubMed Google Scholar
Haywood, L. et al. Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum.48, 2173–2177 (2003). ArticleCASPubMed Google Scholar
Sakkas, L. I., Koussidis, G., Avgerinos, E., Gaughan, J. & Platsoucas, C. D. Decreased expression of the CD3zeta chain in T cells infiltrating the synovial membrane of patients with osteoarthritis. Clin. Diagn. Lab. Immunol.11, 195–202 (2004). CASPubMedPubMed Central Google Scholar
Sakkas, L. I. & Platsoucas, C. D. The role of T cells in the pathogenesis of osteoarthritis. Arthritis Rheum.56, 409–424 (2007). ArticlePubMed Google Scholar
Sakkas, L. I. et al. T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis. Clin. Diagn. Lab. Immunol.5, 430–437 (1998). CASPubMedPubMed Central Google Scholar
Williams, W. V. et al. Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. J. Clin. Invest.90, 326–333 (1992). ArticleCASPubMedPubMed Central Google Scholar
Alsalameh, S. et al. Cellular immune response toward human articular chondrocytes. T cell reactivities against chondrocyte and fibroblast membranes in destructive joint diseases. Arthritis Rheum.33, 1477–1486 (1990). ArticleCASPubMed Google Scholar
Kim, H. Y. et al. Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255–274) in patients with rheumatoid arthritis. Arthritis Rheum.42, 2085–2093 (1999). ArticleCASPubMed Google Scholar
Kotzin, B. L. et al. Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis. Proc. Natl Acad. Sci. USA97, 291–296 (2000). ArticleCASPubMedPubMed Central Google Scholar
Martel-Pelletier, J., Alaaeddine, N. & Pelletier, J. P. Cytokines and their role in the pathophysiology of osteoarthritis. Front. Biosci.4, D694–D703 (1999). ArticleCASPubMed Google Scholar
Tan, L. C. et al. Specificity of T cells in synovial fluid: high frequencies of CD8+ T cells that are specific for certain viral epitopes. Arthritis Res. Ther.2, 154–164 (2000). ArticleCAS Google Scholar
Jasin, H. E. Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum.28, 241–248 (1985). ArticleCASPubMed Google Scholar
Smith, M. D. et al. Immunohistochemical analysis of synovial membranes from inflammatory and non-inflammatory arthritides: scarcity of CD5 positive B cells and IL2 receptor bearing T cells. Pathology24, 19–26 (1992). ArticleCASPubMed Google Scholar
Shi, K. et al. Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J. Immunol.166, 650–655 (2001). ArticleCASPubMed Google Scholar
Cooke, T. D., Bennett, E. L. & Ohno, O. The deposition of immunoglobulins and complement in osteoarthritic cartilage. Int. Orthop.4, 211–217 (1980). ArticleCASPubMed Google Scholar
Radstake, T. R. et al. Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum.50, 3856–3865 (2004). ArticleCASPubMed Google Scholar
Bonnet, C. S. & Walsh, D. A. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford)44, 7–16 (2005). ArticleCAS Google Scholar
Walsh, D. A., Wade, M., Mapp, P. I. & Blake, D. R. Focally regulated endothelial proliferation and cell death in human synovium. Am. J. Pathol.152, 691–702 (1998). CASPubMedPubMed Central Google Scholar
Lee, S. S. et al. Vascular endothelial growth factor levels in the serum and synovial fluid of patients with rheumatoid arthritis. Clin. Exp. Rheumatol.19, 321–324 (2001). CASPubMed Google Scholar
Koch, A. E. et al. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J. Immunol.152, 4149–4156 (1994). CASPubMed Google Scholar
Koch, A. E. et al. Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues. Lab. Invest.64, 313–320 (1991). CASPubMed Google Scholar
Farahat, M. N., Yanni, G., Poston, R. & Panayi, G. S. Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann. Rheum. Dis.52, 870–875 (1993). ArticleCASPubMedPubMed Central Google Scholar
Furuzawa-Carballeda, J. & Alcocer-Varela, J. Interleukin-8, interleukin-10, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression levels are higher in synovial tissue from patients with rheumatoid arthritis than in osteoarthritis. Scand. J. Immunol.50, 215–222 (1999). ArticleCASPubMed Google Scholar
Sadouk, M. B. et al. Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. Lab. Invest.73, 347–355 (1995). CASPubMed Google Scholar
Alaaeddine, N. et al. Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha. J. Rheumatol.24, 1985–1994 (1997). CASPubMed Google Scholar
Bondeson, J., Wainwright, S. D., Lauder, S., Amos, N. & Hughes, C. E. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res. Ther.8, R187 (2006). ArticleCASPubMedPubMed Central Google Scholar
Honorati, M., Neri, S., Cattini, L. & Facchini, A. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. Osteoarthritis Cartilage14, 345–352 (2005). ArticlePubMed Google Scholar
Honorati, M., Bovara, M., Cattini, L., Piacentini, A. & Facchini, A. Contribution of interleukin-17 to human cartilage degradation and synovial inflammation in osteoarthritis. Osteoarthritis Cartilage10, 799–807 (2002). ArticleCASPubMed Google Scholar
Chabaud, M. et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum.42, 963–970 (1999). ArticleCASPubMed Google Scholar
Scanzello, C. R. et al. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthritis Cartilage17, 1040–1048 (2009). ArticleCASPubMed Google Scholar
Brentano, F. et al. Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities. Arthritis Rheum.56, 2829–2839 (2007). ArticleCASPubMed Google Scholar
Presle, N. et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage14, 690–695 (2006). ArticleCASPubMed Google Scholar
Suri, S. et al. Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann. Rheum. Dis.66, 1423–1428 (2007). ArticlePubMedPubMed Central Google Scholar
Felson, D. T. The sources of pain in knee osteoarthritis. Curr. Opin. Rheum.17, 624–628 (2005). Article Google Scholar
Nissalo, S., Hukkanen, M., Imai, S., Törnwall, J. & Konttinen, Y. T. Neuropeptides in experimental and degenerative arthritis. Ann. NY Acad. Sci.966, 384–399 (2002). Article Google Scholar
Kidd, B. L., Photiou, A. & Inglis, J. J. The role of inflammatory mediators on nociception and pain in arthritis. Novartis Found. Symp.260, 122–133 (2004). CASPubMed Google Scholar
Meini, S. & Maggi, C. A. Knee osteoarthritis: a role for bradykinin? Inflamm. Res.57, 351–361 (2008). ArticleCASPubMed Google Scholar
Perrot, S. & Guilbaud, G. Pathophysiology of joint pain. Rev. Rhum. Engl. Ed.63, 485–492 (1996). CASPubMed Google Scholar
Mapp, P. I. et al. Substance P-, calcitonin gene-related peptide- and C-flanking peptide of neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted in patients with rheumatoid arthritis. Neuroscience37, 143–153 (1990). ArticleCASPubMed Google Scholar
Fortier, L. A. & Nixon, A. J. Distributional changes in substance P nociceptive fiber patterns in naturally osteoarthritic articulations. J. Rheumatol.24, 524–530 (1997). CASPubMed Google Scholar
Lotz, M., Carson, D. A. & Vaughan, J. H. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science235, 893–895 (1987). ArticleCASPubMed Google Scholar
Mousa, S. A., Straub, R. H., Schafer, M. & Stein, C. Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis. Ann. Rheum. Dis.66, 871–879 (2007). ArticleCASPubMedPubMed Central Google Scholar
Seidel, M. F., Herguijuela, M., Forkert, R. & Otten, U. Nerve growth factor in rheumatic diseases. Semin. Arthritis Rheum. doi: 10.1016/j.semarthrit.2009.03.002.
Raychaudhuri, S. P. & Raychaudhuri, S. K. The regulatory role of nerve growth factor and its receptor system in fibroblast-like synovial cells. Scand. J. Rheumatol.38, 207–215 (2009). ArticleCASPubMed Google Scholar
Lane, N. E., Schnitser, T. J., Smith, M. D. & Brown, M. T. Tanezumab relieves moderate to severe pain due to osteoarthritis (OA) of the knee: a phase 2 trial [abstract 1989]. Arthritis Rheum.58 (Suppl.), S896–S897 (2008). Google Scholar
Wittenberg, R. H., Willburger, R. E., Kleemeyer, K. S. & Peskar, B. A. In vitro release of prostaglandins and leukotrienes from synovial tissue, cartilage, and bone in degenerative joint diseases. Arthritis Rheum.36, 1444–1450 (1993). ArticleCASPubMed Google Scholar
Okada, Y. et al. Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab. Invest.66, 680–690 (1992). CASPubMed Google Scholar
Clegg, P. D., Burke, R. M., Coughlan, A. R., Riggs, C. M. & Carter, S. D. Characterisation of equine matrix metalloproteinase 2 and 9; and identification of the cellular sources of these enzymes in joints. Equine Vet. J.29, 335–342 (1997). ArticleCASPubMed Google Scholar
Blom, A. B. et al. Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. Arthritis Rheum.56, 147–157 (2007). ArticleCASPubMed Google Scholar
Dreier, R., Grassel, S., Fuchs, S., Schaumburger, J. & Bruckner, P. Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade. Exp. Cell Res.297, 303–312 (2004). ArticleCASPubMed Google Scholar
Blom, A. B. et al. Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage12, 627–635 (2004). ArticlePubMed Google Scholar
van Lent, P. L. et al. Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. Arthritis Rheum.50, 103–111 (2004). ArticleCASPubMed Google Scholar
Pelletier, J. P., Martel-Pelletier, J. & Abramson, S. B. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum.44, 1237–1247 (2001). ArticleCASPubMed Google Scholar
Adamopulos, I. et al. Synovial fluid macrophages are capable of osteoclast formation and resorption. J. Pathol.1, 35–43 (2006). ArticleCAS Google Scholar
Ogawa, K. et al. Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis. J. Bone Miner. Metab.25, 354–360 (2007). ArticlePubMed Google Scholar
Iovu, M., Dumais, G. & du Souich, P. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage16 (Suppl. 3), S14–S18 (2008). ArticlePubMed Google Scholar
Berenbaum, F. Targeted therapies in osteoarthritis: a systematic review of the trials on www.clinicaltrials.gov. Best Pract. Res. Clin. Rheumatol.24, 107–119 (2010).
Abdiche, Y. N., Malashock, D. S. & Pons, J. Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors. Protein Sci.17, 1326–1335 (2008). ArticleCASPubMedPubMed Central Google Scholar
Roach, H. I., Aigner, T., Soder, S., Haag, J. & Welkerling, H. Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets. Curr. Drug Targets8, 271–282 (2007). ArticleCASPubMed Google Scholar
Krasnokutsky, S., Samuels, J. & Abramson, S. B. Osteoarthritis in 2007. Bull. NYU Hosp. Jt Dis.65, 222–228 (2007). PubMed Google Scholar
Malemud, C. J. Anticytokine therapy for osteoarthritis: evidence to date. Drugs Aging27, 95–115 (2010). ArticleCASPubMed Google Scholar
Chevalier, X. et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum.61, 344–352 (2009). ArticleCASPubMed Google Scholar
Ley, C., Ekman, S., Roneus, B. & Eloranta, M. L. Interleukin-6 and high mobility group box protein-1 in synovial membranes and osteochondral fragments in equine osteoarthritis. Res. Vet. Sci.86, 490–497 (2009). ArticleCASPubMed Google Scholar
Sanchez, C., Gabay, O., Salvat, C., Henrotin, Y. E. & Berenbaum, F. Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts. Osteoarthritis Cartilage17, 473–481 (2009). ArticleCASPubMed Google Scholar
Keen, H. I. et al. Can ultrasonography improve on radiographic assessment in osteoarthritis of the hands? A comparison between radiographic and ultrasonographic detected pathology. Ann. Rheum. Dis.67, 1116–1120 (2008). ArticleCASPubMed Google Scholar