The structural basis for MCM2–7 helicase activation by GINS and Cdc45 (original) (raw)
References
Davey, M.J. & O'Donnell, M. Replicative helicase loaders: ring breakers and ring makers. Curr. Biol.13, R594–R596 (2003). ArticleCASPubMed Google Scholar
Funnell, B.E., Baker, T.A. & Kornberg, A. In vitro assembly of a prepriming complex at the origin of the Escherichia coli chromosome. J. Biol. Chem.262, 10327–10334 (1987). CASPubMed Google Scholar
Davey, M.J., Fang, L., McInerney, P., Georgescu, R.E. & O'Donnell, M. The DnaC helicase loader is a dual ATP/ADP switch protein. EMBO J.21, 3148–3159 (2002). ArticleCASPubMedPubMed Central Google Scholar
Valle, M., Gruss, C., Halmer, L., Carazo, J.M. & Donate, L.E. Large T-antigen double hexamers imaged at the simian virus 40 origin of replication. Mol. Cell. Biol.20, 34–41 (2000). ArticleCASPubMedPubMed Central Google Scholar
Kumar, A. et al. Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA. J. Virol.81, 4808–4818 (2007). ArticleCASPubMedPubMed Central Google Scholar
Schuck, S. & Stenlund, A. Assembly of a double hexameric helicase. Mol. Cell20, 377–389 (2005). ArticleCASPubMed Google Scholar
Enemark, E.J. & Joshua-Tor, L. Mechanism of DNA translocation in a replicative hexameric helicase. Nature442, 270–275 (2006). ArticleCASPubMed Google Scholar
Bowers, J.L., Randell, J.C., Chen, S. & Bell, S.P. ATP hydrolysis by ORC catalyzes reiterative Mcm2–7 assembly at a defined origin of replication. Mol. Cell16, 967–978 (2004). ArticleCASPubMed Google Scholar
Remus, D. et al. Concerted loading of Mcm2–7 double hexamers around DNA during DNA replication origin licensing. Cell139, 719–730 (2009). ArticleCASPubMedPubMed Central Google Scholar
Evrin, C. et al. A double-hexameric MCM2–7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc. Natl. Acad. Sci. USA106, 20240–20245 (2009). ArticleCASPubMedPubMed Central Google Scholar
Moyer, S.E., Lewis, P.W. & Botchan, M.R. Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl. Acad. Sci. USA103, 10236–10241 (2006). ArticleCASPubMedPubMed Central Google Scholar
Gambus, A. et al. GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat. Cell Biol.8, 358–366 (2006). ArticleCASPubMed Google Scholar
Remus, D. & Diffley, J.F. Eukaryotic DNA replication control: lock and load, then fire. Curr. Opin. Cell Biol.21, 771–777 (2009). ArticleCASPubMed Google Scholar
Calzada, A., Hodgson, B., Kanemaki, M., Bueno, A. & Labib, K. Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev.19, 1905–1919 (2005). ArticleCASPubMedPubMed Central Google Scholar
Ilves, I., Petojevic, T., Pesavento, J.J. & Botchan, M.R. Activation of the MCM2–7 helicase by association with Cdc45 and GINS proteins. Mol. Cell37, 247–258 (2010). ArticleCASPubMedPubMed Central Google Scholar
Pacek, M., Tutter, A.V., Kubota, Y., Takisawa, H. & Walter, J.C. Localization of MCM2–7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol. Cell21, 581–587 (2006). ArticleCASPubMed Google Scholar
MacNeill, S.A. Structure and function of the GINS complex, a key component of the eukaryotic replisome. Biochem. J.425, 489–500 (2010). ArticleCASPubMed Google Scholar
Fletcher, R.J. et al. The structure and function of MCM from archaeal M. thermoautotrophicum. Nat. Struct. Biol.10, 160–167 (2003). ArticleCASPubMed Google Scholar
McGeoch, A.T., Trakselis, M.A., Laskey, R.A. & Bell, S.D. Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism. Nat. Struct. Mol. Biol.12, 756–762 (2005). ArticleCASPubMed Google Scholar
Iyer, L.M., Leipe, D.D., Koonin, E.V. & Aravind, L. Evolutionary history and higher order classification of AAA+ ATPases. J. Struct. Biol.146, 11–31 (2004). ArticleCASPubMed Google Scholar
Davey, M.J., Indiani, C. & O'Donnell, M. Reconstitution of the Mcm2–7p heterohexamer, subunit arrangement, and ATP site architecture. J. Biol. Chem.278, 4491–4499 (2003). ArticleCASPubMed Google Scholar
Crevel, G., Ivetic, A., Ohno, K., Yamaguchi, M. & Cotterill, S. Nearest neighbour analysis of MCM protein complexes in Drosophila melanogaster. Nucleic Acids Res.29, 4834–4842 (2001). ArticleCASPubMedPubMed Central Google Scholar
Bochman, M.L., Bell, S.P. & Schwacha, A. Subunit organization of Mcm2–7 and the unequal role of active sites in ATP hydrolysis and viability. Mol. Cell. Biol.28, 5865–5873 (2008). ArticleCASPubMedPubMed Central Google Scholar
Brewster, A.S. et al. Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase. Proc. Natl. Acad. Sci. USA105, 20191–20196 (2008). ArticleCASPubMedPubMed Central Google Scholar
Bae, B. et al. Insights into the architecture of the replicative helicase from the structure of an archaeal MCM homolog. Structure17, 211–222 (2009). ArticleCASPubMed Google Scholar
Gómez-Llorente, Y., Fletcher, R.J., Chen, X.S., Carazo, J.M. & San Martin, C. Polymorphism and double hexamer structure in the archaeal minichromosome maintenance (MCM) helicase from Methanobacterium thermoautotrophicum. J. Biol. Chem.280, 40909–40915 (2005). ArticlePubMed Google Scholar
Costa, A. et al. Structural basis of the Methanothermobacter thermautotrophicus MCM helicase activity. Nucleic Acids Res.34, 5829–5838 (2006). ArticleCASPubMedPubMed Central Google Scholar
Chong, J.P., Hayashi, M.K., Simon, M.N., Xu, R.M. & Stillman, B. A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase. Proc. Natl. Acad. Sci. USA97, 1530–1535 (2000). ArticleCASPubMedPubMed Central Google Scholar
Kelman, Z., Lee, J.K. & Hurwitz, J. The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity. Proc. Natl. Acad. Sci. USA96, 14783–14788 (1999). ArticleCASPubMedPubMed Central Google Scholar
Bochman, M.L. & Schwacha, A. The Mcm2–7 complex has in vitro helicase activity. Mol. Cell31, 287–293 (2008). ArticleCASPubMed Google Scholar
Kanemaki, M., Sanchez-Diaz, A., Gambus, A. & Labib, K. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature423, 720–724 (2003). ArticleCASPubMed Google Scholar
Takayama, Y. et al. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev.17, 1153–1165 (2003). ArticleCASPubMedPubMed Central Google Scholar
Chang, Y.P., Wang, G., Bermudez, V., Hurwitz, J. & Chen, X.S. Crystal structure of the GINS complex and functional insights into its role in DNA replication. Proc. Natl. Acad. Sci. USA104, 12685–12690 (2007). ArticleCASPubMedPubMed Central Google Scholar
Kamada, K., Kubota, Y., Arata, T., Shindo, Y. & Hanaoka, F. Structure of the human GINS complex and its assembly and functional interface in replication initiation. Nat. Struct. Mol. Biol.14, 388–396 (2007). ArticleCASPubMed Google Scholar
Grob, P. et al. Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues. Structure14, 511–520 (2006). ArticleCASPubMed Google Scholar
van Heel, M., Harauz, G., Orlova, E.V., Schmidt, R. & Schatz, M. A new generation of the IMAGIC image processing system. J. Struct. Biol.116, 17–24 (1996). ArticleCASPubMed Google Scholar
Im, J.S. et al. Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc. Natl. Acad. Sci. USA106, 15628–15632 (2009). ArticleCASPubMedPubMed Central Google Scholar
Makarova, K.S., Wolf, Y.I., Mekhedov, S.L., Mirkin, B.G. & Koonin, E.V. Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Res.33, 4626–4638 (2005). ArticleCASPubMedPubMed Central Google Scholar
Dean, F.B., Borowiec, J.A., Eki, T. & Hurwitz, J. The simian virus 40 T antigen double hexamer assembles around the DNA at the replication origin. J. Biol. Chem.267, 14129–14137 (1992). CASPubMed Google Scholar
Fouts, E.T., Yu, X., Egelman, E.H. & Botchan, M.R. Biochemical and electron microscopic image analysis of the hexameric E1 helicase. J. Biol. Chem.274, 4447–4458 (1999). ArticleCASPubMed Google Scholar
Bochman, M.L. & Schwacha, A. Differences in the single-stranded DNA binding activities of MCM2–7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J. Biol. Chem.282, 33795–33804 (2007). ArticleCASPubMed Google Scholar
Labib, K. & Gambus, A. A key role for the GINS complex at DNA replication forks. Trends Cell Biol.17, 271–278 (2007). ArticleCASPubMed Google Scholar
Takahashi, T.S., Wigley, D.B. & Walter, J.C. Pumps, paradoxes and ploughshares: mechanism of the MCM2–7 DNA helicase. Trends Biochem. Sci.30, 437–444 (2005). ArticleCASPubMed Google Scholar
Takara, T.J. & Bell, S.P. Putting two heads together to unwind DNA. Cell139, 652–654 (2009). ArticleCASPubMed Google Scholar
Yardimci, H., Loveland, A.B., Habuchi, S., van Oijen, A.M. & Walter, J.C. Uncoupling of sister replisomes during eukaryotic DNA replication. Mol. Cell40, 834–840 (2010). ArticleCASPubMedPubMed Central Google Scholar
Gould, A.D. & Shilton, B.H. Studies of the maltose transport system reveal a mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate. J. Biol. Chem.285, 11290–11296 (2010). ArticleCASPubMedPubMed Central Google Scholar
Ludtke, S.J., Baldwin, P.R. & Chiu, W. EMAN: semiautomated software for high-resolution single-particle reconstructions. J. Struct. Biol.128, 82–97 (1999). ArticleCASPubMed Google Scholar
Voss, N.R., Yoshioka, C.K., Radermacher, M., Potter, C.S. & Carragher, B. DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy. J. Struct. Biol.166, 205–213 (2009). ArticleCASPubMedPubMed Central Google Scholar
van Heel, M. et al. Single-particle electron cryo-microscopy: towards atomic resolution. Q. Rev. Biophys.33, 307–369 (2000). ArticleCASPubMed Google Scholar
Frank, J. et al. SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J. Struct. Biol.116, 190–199 (1996). ArticleCASPubMed Google Scholar
Boekema, E.J., Berden, J.A. & van Heel, M.G. Structure of mitochondrial F1-ATPase studied by electron microscopy and image processing. Biochim. Biophys. Acta851, 353–360 (1986). ArticleCASPubMed Google Scholar
Pettersen, E.F. et al. UCSF Chimera—a visualization system for exploratory research and analysis. J. Comput. Chem.25, 1605–1612 (2004). ArticleCASPubMed Google Scholar
Arnold, K., Bordoli, L., Kopp, J. & Schwede, T. The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics22, 195–201 (2006). ArticleCASPubMed Google Scholar
Krissinel, E. & Henrick, K. Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr. D Biol. Crystallogr.60, 2256–2268 (2004). ArticleCASPubMed Google Scholar