- Davidson, A.L., Dassa, E., Orelle, C. & Chen, J. Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol. Mol. Biol. Rev. 72, 317–364 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Seeger, M.A. & van Veen, H.W. Molecular basis of multidrug transport by ABC transporters. Biochim. Biophys. Acta 1794, 725–737 (2009).
Article CAS PubMed Google Scholar
- Gottesman, M.M. & Ling, V. The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett. 580, 998–1009 (2006).
Article CAS PubMed Google Scholar
- Pajic, M. et al. Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Cancer Res. 69, 6396–6404 (2009).
Article CAS PubMed Google Scholar
- Gadsby, D.C., Vergani, P. & Csanady, L. The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature 440, 477–483 (2006).
Article CAS PubMed PubMed Central Google Scholar
- Garvey, M.I., Baylay, A.J., Wong, R.L. & Piddock, L.J. Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 55, 190–196 (2011).
Article CAS PubMed Google Scholar
- Lubelski, J., van Merkerk, R., Konings, W.N. & Driessen, A.J. Nucleotide-binding sites of the heterodimeric LmrCD ABC-multidrug transporter of Lactococcus lactis are asymmetric. Biochemistry 45, 648–656 (2006).
Article CAS PubMed Google Scholar
- Aittoniemi, J. et al. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator. Phil. Trans. R. Soc. Lond. B 364, 257–267 (2009).
Article CAS Google Scholar
- Higgins, C.F. & Linton, K.J. The ATP switch model for ABC transporters. Nat. Struct. Mol. Biol. 11, 918–926 (2004).
Article CAS PubMed Google Scholar
- Dawson, R.J. & Locher, K.P. Structure of a bacterial multidrug ABC transporter. Nature 443, 180–185 (2006).
Article CAS PubMed Google Scholar
- Schneider, E. & Hunke, S. ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains. FEMS Microbiol. Rev. 22, 1–20 (1998).
Article CAS PubMed Google Scholar
- Jones, P.M. & George, A.M. Subunit interactions in ABC transporters: towards a functional architecture. FEMS Microbiol. Lett. 179, 187–202 (1999).
Article CAS PubMed Google Scholar
- Hopfner, K.P. et al. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101, 789–800 (2000).
Article CAS PubMed Google Scholar
- Chen, J., Lu, G., Lin, J., Davidson, A.L. & Quiocho, F.A. A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Mol. Cell 12, 651–661 (2003).
Article CAS PubMed Google Scholar
- Orelle, C., Dalmas, O., Gros, P., Di Pietro, A. & Jault, J.M. The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA. J. Biol. Chem. 278, 47002–47008 (2003).
Article CAS PubMed Google Scholar
- Zaitseva, J., Jenewein, S., Jumpertz, T., Holland, I.B. & Schmitt, L. H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB. EMBO J. 24, 1901–1910 (2005).
Article CAS PubMed PubMed Central Google Scholar
- Oldham, M.L. & Chen, J. Snapshots of the maltose transporter during ATP hydrolysis. Proc. Natl. Acad. Sci. USA 108, 15152–15156 (2011).
Article CAS PubMed PubMed Central Google Scholar
- Smith, P.C. et al. ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol. Cell 10, 139–149 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Venter, H., Shilling, R.A., Velamakanni, S., Balakrishnan, L. & Van Veen, H.W. An ABC transporter with a secondary-active multidrug translocator domain. Nature 426, 866–870 (2003).
Article CAS PubMed Google Scholar
- Doerrler, W.T., Reedy, M.C. & Raetz, C.R. An Escherichia coli mutant defective in lipid export. J. Biol. Chem. 276, 11461–11464 (2001).
Article CAS PubMed Google Scholar
- Velamakanni, S., Yao, Y., Gutmann, D.A. & van Veen, H.W. Multidrug Transport by the ABC Transporter Sav1866 from Staphylococcus aureus. Biochemistry 47, 9300–9308 (2008).
Article CAS PubMed Google Scholar
- Procko, E., O'Mara, M.L., Bennett, W.F., Tieleman, D.P. & Gaudet, R. The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter. FASEB J. 23, 1287–1302 (2009).
Article CAS PubMed Google Scholar
- Parcej, D. & Tampe, R. ABC proteins in antigen translocation and viral inhibition. Nat. Chem. Biol. 6, 572–580 (2010).
Article CAS PubMed Google Scholar
- Torres, C., Galian, C., Freiberg, C., Fantino, J.R. & Jault, J.M. The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter. Biochim. Biophys. Acta 1788, 615–622 (2009).
Article CAS PubMed Google Scholar
- Zutz, A. et al. Asymmetric ATP hydrolysis cycle of the heterodimeric multidrug ABC transport complex TmrAB from Thermus thermophilus. J. Biol. Chem. 286, 7104–7115 (2011).
Article CAS PubMed Google Scholar
- Dawson, R.J. & Locher, K.P. Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP. FEBS Lett. 581, 935–938 (2007).
Article CAS PubMed Google Scholar
- Ward, A., Reyes, C.L., Yu, J., Roth, C.B. & Chang, G. Flexibility in the ABC transporter MsbA: Alternating access with a twist. Proc. Natl. Acad. Sci. USA 104, 19005–19010 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Aller, S.G. et al. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 323, 1718–1722 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Lubelski, J. et al. LmrCD is a major multidrug resistance transporter in Lactococcus lactis. Mol. Microbiol. 61, 771–781 (2006).
Article CAS PubMed Google Scholar
- Venter, H., Velamakanni, S., Balakrishnan, L. & van Veen, H.W. On the energy-dependence of Hoechst 33342 transport by the ABC transporter LmrA. Biochem. Pharmacol. 75, 866–874 (2008).
Article CAS PubMed Google Scholar
- Shapiro, A.B. & Ling, V. Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein. Eur. J. Biochem. 250, 122–129 (1997).
Article CAS PubMed Google Scholar
- Ambudkar, S.V. et al. Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc. Natl. Acad. Sci. USA 89, 8472–8476 (1992).
Article CAS PubMed PubMed Central Google Scholar
- Eckford, P.D. & Sharom, F.J. Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates. J. Biol. Chem. 283, 12840–12850 (2008).
Article CAS PubMed Google Scholar
- Yang, R., Cui, L., Hou, Y.X., Riordan, J.R. & Chang, X.B. ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport. J. Biol. Chem. 278, 30764–30771 (2003).
Article CAS PubMed Google Scholar
- Basso, C., Vergani, P., Nairn, A.C. & Gadsby, D.C. Prolonged nonhydrolytic interaction of nucleotide with CFTR′s NH2-terminal nucleotide binding domain and its role in channel gating. J. Gen. Physiol. 122, 333–348 (2003).
Article CAS PubMed PubMed Central Google Scholar
- Perria, C.L., Rajamanickam, V., Lapinski, P.E. & Raghavan, M. Catalytic site modifications of TAP1 and TAP2 and their functional consequences. J. Biol. Chem. 281, 39839–39851 (2006).
Article CAS PubMed Google Scholar
- Tsai, M.F., Li, M. & Hwang, T.C. Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel. J. Gen. Physiol. 135, 399–414 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Masia, R. & Nichols, C.G. Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor. J. Biol. Chem. 283, 30322–30329 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Quick, M. & Javitch, J.A. Monitoring the function of membrane transport proteins in detergent-solubilized form. Proc. Natl. Acad. Sci. USA 104, 3603–3608 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Smriti, Z.P. & McHaourab, H.S. Mapping daunorubicin-binding Sites in the ATP-binding cassette transporter MsbA using site-specific quenching by spin labels. J. Biol. Chem. 284, 13904–13913 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Pleban, K. et al. P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach. Mol. Pharmacol. 67, 365–374 (2005).
Article CAS PubMed Google Scholar
- Borbat, P.P. et al. Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis. PLoS Biol. 5, e271 (2007).
Article PubMed PubMed Central Google Scholar
- Doshi, R., Woebking, B. & van Veen, H.W. Dissection of the conformational cycle of the multidrug/lipid A ABC exporter MsbA. Proteins 78, 2867–2872 (2010).
Article CAS PubMed Google Scholar
- Lewis, H.A. et al. Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J. 23, 282–293 (2004).
Article CAS PubMed Google Scholar
- Ramaen, O. et al. Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site. J. Mol. Biol. 359, 940–949 (2006).
Article CAS PubMed Google Scholar
- Procko, E., Ferrin-O'Connell, I., Ng, S.L. & Gaudet, R. Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. Mol. Cell 24, 51–62 (2006).
Article CAS PubMed Google Scholar
- Jardetzky, O. Simple allosteric model for membrane pumps. Nature 211, 969–970 (1966).
Article CAS PubMed Google Scholar
- Huber, R. et al. Thermotoga maritima sp. nov. represents a new genus of unique extremely thermophilic eubacteria growing up to 90°C. Arch. Microbiol. 144, 324–333 (1986).
Article CAS Google Scholar
- Geertsma, E.R. & Dutzler, R. A versatile and efficient high-throughput cloning tool for structural biology. Biochemistry 50, 3272–3278 (2011).
Article CAS PubMed Google Scholar
- Seeger, M.A. et al. Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB. Nat. Struct. Mol. Biol. 15, 199–205 (2008).
Article CAS PubMed Google Scholar
- Geertsma, E.R. & Poolman, B. High-throughput cloning and expression in recalcitrant bacteria. Nat. Methods 4, 705–707 (2007).
Article CAS PubMed Google Scholar
- Geertsma, E.R., Nik Mahmood, N.A., Schuurman-Wolters, G.K. & Poolman, B. Membrane reconstitution of ABC transporters and assays of translocator function. Nat. Protoc. 3, 256–266 (2008).
Article CAS PubMed Google Scholar
- Woebking, B. et al. Functional role of transmembrane helix 6 in drug binding and transport by the ABC transporter MsbA. Biochemistry 47, 10904–10914 (2008).
Article CAS PubMed Google Scholar